人工硬化红细胞的边缘化
Margination of artificially stiffened red blood cells
AI总结：
通过实验与数值模拟研究人工硬化红细胞在健康细胞悬浮液中的分离行为，发现其分布受通道几何形状影响，且边缘化随红细胞压积和流速呈非单调变化，挑战了高流速增强边缘化的传统观点。
摘要：
边缘化是白细胞从流动血液中迁移至血管壁的基本过程，在生理学中已有充分记载。然而，白细胞与红细胞在细胞尺寸和刚度上的差异如何促成这一现象，仍是一个悬而未决的问题。为探究细胞刚度的具体影响，我们对健康细胞悬浮液中人工硬化红细胞与正常细胞组成的二元混合物进行了实验和数值研究，以考察其分离行为。研究发现，硬化细胞在通道内的分布取决于通道几何形状，这一点通过狭缝、矩形和圆柱形横截面的实验得到了证明。值得注意的是，与模拟结果一致，硬化红细胞分布中出现了一个意外的中心峰，并在角落处伴随有四重峰。我们的结果揭示了分离/边缘化随红细胞压积和流速呈非单调变化，挑战了较高流速会导致边缘化增强的普遍观点。
英文摘要：
Margination, a fundamental process in which leukocytes migrate from the flowing blood to the vessel wall, is well-documented in physiology. However, it is still an open question on how the differences in cell size and stiffness of white and red cells contribute to this phenomenon. To investigate the specific influence of cell stiffness, we conduct experimental and numerical studies on the segregation of a binary mixture of artificially stiffened red blood cells within a suspension of healthy cells. The resulting distribution of stiffened cells within the channel is found to depend on the channel geometry, as demonstrated with slit, rectangular, and cylindrical cross-sections. Notably, an unexpected central peak in the distribution of stiffened RBCs, accompanied by fourfold peaks at the corners, emerges in agreement with simulations. Our results unveil a non-monotonic variation in segregation/margination concerning hematocrit and flow rate, challenging the prevailing belief that higher flow rates lead to enhanced margination.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
