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arXiv 1401.6445cond-mat.stat-mech
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相互作用分子马达动力学过程的理论分析

Theoretical Analysis of Dynamic Processes for Interacting Molecular Motors

Hamid Teimouri, Anatoly B. Kolomeisky, Kareem Mehrabiani

摘要:

生物运输是由酶分子的集体动力学支持的,这些酶分子被称为马达蛋白或分子马达。实验表明,马达蛋白通过短程电位局部相互作用。我们调查这些相互作用的基本作用,通过分析一类新的完全不对称的排斥过程,其中的相互作用占在一个philically一致的方式。结合各种平均场计算和计算机模拟的理论分析表明,分子马达的动力学性质强烈依赖于相互作用,并且相互作用的马达蛋白的相关性更强。令人惊讶的是,发现存在导致最大粒子通量的最佳相互作用强度(弱排斥)。也有人认为,分子马达运输是更敏感的吸引相互作用。这些结果的驱动蛋白马达蛋白的应用进行了讨论。

英文摘要:

Biological transport is supported by collective dynamics of enzymatic molecules that are called motor proteins or molecular motors. Experiments suggest that motor proteins interact locally via short-range potentials. We investigate the fundamental role of these interactions by analyzing a new class of totally asymmetric exclusion processes where interactions are accounted for in a thermodynamically consistent fashion. Theoretical analysis that combines various mean-field cal- culations and computer simulations suggests that dynamic properties of molecular motors strongly depend on interactions, and correlations are stronger for interacting motor proteins. Surprisingly, it is found that there is an optimal strength of interactions (weak repulsion) that leads to a maxi- mal particle flux. It is also argued that molecular motors transport is more sensitive to attractive interactions. Applications of these results for kinesin motor proteins are discussed.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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