细胞内分子马达运输的集体效应：协调、合作与竞争
Collective effects in intra-cellular molecular motor transport: coordination, cooperation and competetion
摘要：
分子马达不能单独工作{ \it in-vivo}。我们强调了一些协调，合作和竞争，决定了在真核细胞中的分子马达的集体属性。在交通样运动的汽车在轨道上的背景下，我们强调的重要性，单电机的生化循环和酶的活动，他们的集体时空组织。我们的建模策略是基于一个合成-相同的模型描述了单电机机械化学在足够低的密度，而在较高的密度，它占集体流动性能和密度分布的电机。我们考虑两个具体的例子，即交通的单头驱动蛋白马达KIF 1A的微管轨道和核糖体交通的信使RNA轨道。
英文摘要：
Molecular motors do not work in isolation {\it in-vivo}. We highlight some of the coordinations, cooperations and competitions that determine the collective properties of molecular motors in eukaryotic cells. In the context of traffic-like movement of motors on a track, we emphasize the importance of single-motor bio-chemical cycle and enzymatic activity on their collective spatio-temporal organisation. Our modelling strategy is based on a synthesis- the same model describes the single-motor mechano-chemistry at sufficiently low densities whereas at higher densities it accounts for the collective flow properties and the density profiles of the motors. We consider two specific examples, namely, traffic of single-headed kinesin motors KIF1A on a microtubule track and ribosome traffic on a messenger RNA track.
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