化学机械步进循环对分子马达交通量的影响
Effects of the chemomechanical stepping cycle on the traffic of molecular motors
摘要：
我们讨论了步进动力学的分子马达的交通行为的拥挤的细丝使用一个简单的两态化学机械循环的影响。虽然一般的交通行为是相当强大的详细动力学的步骤，一些可观察到的参数表现出强烈的依赖于这些参数。最引人注目的是，电动机的有效解绑率可能会随着交通密度的增加而增加和减少，这取决于电动机步进的细节。同样，运行长度要么表现出强烈的减少或几乎没有依赖于交通密度。我们比较我们的理论结果与最近的实验观察汽车交通。
英文摘要：
We discuss effects of the stepping kinetics of molecular motors on their traffic behavior on crowded filaments using a simple two-state chemomechanical cycle. While the general traffic behavior is quite robust with respect to the detailed kinetics of the step, a few observable parameters exhibit a strong dependence on these parameters. Most strikingly, the effective unbinding rate of the motors may both increase and decrease with increasing traffic density, depending on the details of the motor step. Likewise the run length either exhibits a strong decrease or almost no dependence on the traffic density. We compare our theoretical results with recent experimental observations on motor traffic.
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