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arXiv 1306.1678math.STstat.TH
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具有协变量的多变量隐马尔可夫模型中信息丢失的离散时间事件历史方法

A discrete time event-history approach to informative drop-out in multivariate latent Markov models with covariates

Francesco Bartolucci, Alessio Farcomeni

摘要:

当响应变量受到时变的不可观测异质性的影响时,潜在马尔可夫(LM)模型是纵向数据分析的重要工具,这种异质性由隐马尔可夫链来解释。为了避免偏见时,使用这种类型的模型在信息辍学的存在下,我们提出了一个事件历史(EH)的LM方法,可用于多变量纵向数据,其中一个或多个不同性质的结果,在每个时间场合观察到的扩展。所得模型的EH分量被称为区间删失,LM建模中的偏倚通过相关随机效应来避免,这些效应包括在遵循共同马尔可夫链的不同模型分量中。为了用期望最大化算法对模型进行极大似然估计,我们推广了Baum和Welch的向后-向前递推算法。该算法具有相同的复杂性的情况下采用的非信息辍学。参数估计的标准误差是由Oakes恒等式导出的。我们说明了所提出的方法,通过一个应用程序的基础上的数据来自一项关于原发性胆汁性肝硬化的医学研究,其中有两个结果的利益,其中第一个是连续的,第二个是二进制的。

英文摘要:

Latent Markov (LM) models represent an important tool of analysis of longitudinal data when response variables are affected by time-varying unobserved heterogeneity, which is accounted for by a hidden Markov chain. In order to avoid bias when using a model of this type in the presence of informative drop-out, we propose an event-history (EH) extension of the LM approach that may be used with multivariate longitudinal data, in which one or more outcomes of a different nature are observed at each time occasion. The EH component of the resulting model is referred to the interval-censored drop-out, and bias in LM modeling is avoided by correlated random effects, included in the different model components, which follow a common Markov chain. In order to perform maximum likelihood estimation of the proposed model by the Expectation-Maximization algorithm, we extend the usual backward-forward recursions of Baum and Welch. The algorithm has the same complexity of the one adopted in cases of non-informative drop-out. Standard errors for the parameter estimates are derived by using the Oakes' identity. We illustrate the proposed approach through an application based on data coming from a medical study about primary biliary cirrhosis in which there are two outcomes of interest, the first of which is continuous and the second is binary.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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