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arXiv 1803.04877stat.ME
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一种基于机器学习的方法,用于估计和测试与多变量结果的关联

A machine learning-based approach for estimating and testing associations with multivariate outcomes

David Benkeser, Andrew Mertens, Benjamin F. Arnold, John M. Colford, Alan Hubbard, Aryeh Stein, N. Lntshotshole Jumbe, Mark van der Laan

摘要:

我们提出了一种方法来总结一组变量和多变量结果之间的关联强度。当协变量和结果之间存在线性关系时,经典的汇总措施是合适的,而我们的方法提供了一种替代方案,在可能存在复杂关系的情况下是有用的。我们利用集成机器学习来检测非线性关系和协变量相互作用,并提出一种捕获这些关系的关联度量。关于所提出的关联度量的假设检验可用于检验一组变量与多变量结果之间无关联的强原假设。仿真结果表明,这种假设检验有更大的权力比现有的方法对替代品的协变量与结果的非线性关系。我们还提出了变量组的变量重要性的措施,总结了每个组与结果的关联。我们证明了我们的方法使用的数据从出生队列研究儿童健康和营养在菲律宾。

英文摘要:

We propose a method for summarizing the strength of association between a set of variables and a multivariate outcome. Classical summary measures are appropriate when linear relationships exist between covariates and outcomes, while our approach provides an alternative that is useful in situations where complex relationships may be present. We utilize ensemble machine learning to detect nonlinear relationships and covariate interactions and propose a measure of association that captures these relationships. A hypothesis test about the proposed associative measure can be used to test the strong null hypothesis of no association between a set of variables and a multivariate outcome. Simulations demonstrate that this hypothesis test has greater power than existing methods against alternatives where covariates have nonlinear relationships with outcomes. We additionally propose measures of variable importance for groups of variables, which summarize each groups' association with the outcome. We demonstrate our methodology using data from a birth cohort study on childhood health and nutrition in the Philippines.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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