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arXiv 2204.01686stat.ME
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贝叶斯半参数协变量信息多元密度反卷积

Bayesian Semiparametric Covariate Informed Multivariate Density Deconvolution

Abhra Sarkar

摘要:

不同膳食成分长期平均摄入量的边际密度和联合密度的估计是营养流行病学中的一个重要问题。由于这些变量无法直接测量,因此通常以24小时回顾摄入量的形式收集数据。估计潜在的长期平均摄入量的密度的问题,从他们的观察,但错误污染的回忆,然后成为一个问题的多变量反卷积的密度。潜在的密度可能会随着受试者的人口统计学特征,如性别,种族,年龄等,在相关的精确测量的协变量的存在下,密度反卷积的问题,但是,从来没有被考虑过,甚至在单变量设置。我们提出了一个灵活的贝叶斯半参数方法协变量知情的多元反卷积。基于Copula反卷积和条件张量分解技术的最新进展,我们提出的方法不仅允许联合和边缘密度随相关预测因子灵活变化,而且允许自动选择最有影响力的预测因子。重要的是,该方法还允许感兴趣的密度和测量误差的密度随潜在的不同预测器组而变化。我们设计了马尔可夫链蒙特卡罗算法,可以实现高效的后验推理,适当地适应分析各个方面的不确定性。通过仿真实验验证了该方法的有效性。它的实际效用在上述营养流行病学应用中被证明是在估计不同膳食成分的协变量调整的长期摄入量。补充材料包括实质性的额外细节和R代码也可在线获得。

英文摘要:

Estimating the marginal and joint densities of the long-term average intakes of different dietary components is an important problem in nutritional epidemiology. Since these variables cannot be directly measured, data are usually collected in the form of 24-hour recalls of the intakes. The problem of estimating the density of the latent long-term average intakes from their observed but error contaminated recalls then becomes a problem of multivariate deconvolution of densities. The underlying densities could potentially vary with the subjects' demographic characteristics such as sex, ethnicity, age, etc. The problem of density deconvolution in the presence of associated precisely measured covariates has, however, never been considered before, not even in the univariate setting. We present a flexible Bayesian semiparametric approach to covariate informed multivariate deconvolution. Building on recent advances in copula deconvolution and conditional tensor factorization techniques, our proposed method not only allows the joint and the marginal densities to vary flexibly with the associated predictors but also allows automatic selection of the most influential predictors. Importantly, the method also allows the density of interest and the density of the measurement errors to vary with potentially different sets of predictors. We design Markov chain Monte Carlo algorithms that enable efficient posterior inference, appropriately accommodating uncertainty in all aspects of our analysis. The empirical efficacy of the proposed method is illustrated through simulation experiments. Its practical utility is demonstrated in the afore-described nutritional epidemiology applications in estimating covariate-adjusted long term intakes of different dietary components. Supplementary materials include substantive additional details and R codes are also available online.

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