In many psychometric applications, the relationship between the mean of an outcome and a quantitative covariate is too complex to be described by simple parametric functions; instead, flexible nonlinear relationships can be incorporated using penalized splines. Penalized splines can be conveniently represented as a linear mixed effects model (LMM), where the coefficients of the spline basis functions are random effects. The LMM representation of penalized splines makes the extension to multivariate outcomes relatively straightforward. In the LMM, no effect of the quantitative covariate on the outcome corresponds to the null hypothesis that a fixed effect and a variance component are both zero. Under the null, the usual asymptotic chi-square distribution of the likelihood ratio test for the variance component does not hold. Therefore, we propose three permutation tests for the likelihood ratio test statistic: one based on permuting the quantitative covariate, the other two based on permuting residuals. We compare via simulation the Type I error rate and power of the three permutation tests obtained from joint models for multiple outcomes, as well as a commonly used parametric test. The tests are illustrated using data from a stimulant use disorder psychosocial clinical trial.
Multivariate meta-analysis is gaining prominence in evidence synthesis research because it enables simultaneous synthesis of multiple correlated outcome data, and random-effects models have generally been used for addressing between-studies heterogeneities. However, coverage probabilities of confidence regions or intervals for standard inference methods for random-effects models (e.g., restricted maximum likelihood estimation) cannot retain their nominal confidence levels in general, especially when the number of synthesized studies is small because their validities depend on large sample appr…
Confidence intervals are central to statistical inference as a tool to evaluate the type I error risk at a given significance level. We devise a method to construct confidence intervals using a single run of a permutation test. This methodology is extended to a multivariate setting, where we are able to handle multiple testing under arbitrary dependence. We demonstrate the method on a weather data set and in a simulation example.
In order to adapt the Wasserstein distance to the large sample multivariate non-parametric two-sample problem, making its application computationally feasible, permutation tests based on the Sinkhorn divergence between probability vectors associated to data dependent partitions are considered. Different ways of implementing these tests are evaluated and the asymptotic distribution of the underlying statistic is established in some cases. The statistics proposed are compared, in simulated examples, with the test of Schilling's, one of the best non-parametric tests available in the literature.
Understanding which phenotypic traits are consistently correlated throughout evolution is a highly pertinent problem in modern evolutionary biology. Here, we propose a multivariate phylogenetic latent liability model for assessing the correlation between multiple types of data, while simultaneously controlling for their unknown shared evolutionary history informed through molecular sequences. The latent formulation enables us to consider in a single model combinations of continuous traits, discrete binary traits and discrete traits with multiple ordered and unordered states. Previous approache…
The asymptotic normality of the maximum likelihood estimator (MLE) under regularity conditions is a cornerstone of statistical theory. In this paper, we give explicit upper bounds on the distributional distance between the distribution of the MLE of a vector parameter, and the multivariate normal distribution. We work with possibly high-dimensional, independent but not necessarily identically distributed random vectors. In addition, we obtain explicit upper bounds even in cases where the MLE cannot be expressed analytically.
In a sequence of multivariate observations or non-Euclidean data objects, such as networks, local dependence is common and could lead to false change-point discoveries. We propose a new way of permutation -- circular block permutation with a random starting point -- to address this problem. This permutation scheme is studied on a non-parametric change-point detection framework based on a similarity graph constructed on the observations, leading to a general framework for change-point detection for data with local dependency. Simulation studies show that this new framework retains the same leve…
Much of the trading activity in Equity markets is directed to brokerage houses. In exchange they provide so-called "soft dollars," which basically are amounts spent in "research" for identifying profitable trading opportunities. Soft dollars represent about USD 1 out of every USD 10 paid in commissions. Obviously they are costly, and it is interesting for an institutional investor to determine whether soft dollar inputs are worth being used (and indirectly paid for) or not, from a statistical point of view. To address this question, we develop association measures between what broker--dealers …
George Mason University（乔治梅森大学）；Baidu Research（百度研究院）；U.S. Census Bureau（美国人口普查局）
A tacit assumption in linear regression is that (response, predictor)-pairs correspond to identical observational units. A series of recent works have studied scenarios in which this assumption is violated under terms such as ``Unlabeled Sensing and ``Regression with Unknown Permutation''. In this paper, we study the setup of multiple response variables and a notion of mismatches that generalizes permutations in order to allow for missing matches as well as for one-to-many matches. A two-stage method is proposed under the assumption that most pairs are correctly matched. In the first stage, th…
The assumption that response and predictor belong to the same statistical unit may be violated in practice. Unbiased estimation and recovery of true label ordering based on unlabeled data are challenging tasks and have attracted increasing attentions in the recent literature. In this paper, we present a relatively complete analysis of label permutation problem for the generalized linear model with multivariate responses. The theory is established under different scenarios, with knowledge of true parameters, with partial knowledge of underlying label permutation matrix and without any knowledge…
A framework for assessing the matrix variate normality of three-way data is developed. The framework comprises a visual method and a goodness of fit test based on the Mahalanobis squared distance (MSD). The MSD of multivariate and matrix variate normal estimators, respectively, are used as an assessment tool for matrix variate normality. Specifically, these are used in the form of a distance-distance (DD) plot as a graphical method for visualizing matrix variate normality. In addition, we employ the popular Kolmogorov-Smirnov goodness of fit test in the context of assessing matrix variate norm…
We derive tests of stationarity for univariate time series by combining change-point tests sensitive to changes in the contemporary distribution with tests sensitive to changes in the serial dependence. The proposed approach relies on a general procedure for combining dependent tests based on resampling. After proving the asymptotic validity of the combining procedure under the conjunction of null hypotheses and investigating its consistency, we study rank-based tests of stationarity by combining cumulative sum change-point tests based on the contemporary empirical distribution function and on…
The problem of characterizing a multivariate distribution of a random vector using examination of univariate combinations of vector components is an essential issue of multivariate analysis. The likelihood principle plays a prominent role in developing powerful statistical inference tools. In this context, we raise the question: can the univariate likelihood function based on a random vector be used to provide the uniqueness in reconstructing the vector distribution? In multivariate normal (MN) frameworks, this question links to a reverse of Cochran's theorem that concerns the distribution of …
This paper presents a general framework for obtaining interpretable multivariate discriminative models that allow efficient statistical inference for neuroimage analysis. The framework, termed generative discriminative machine (GDM), augments discriminative models with a generative regularization term. We demonstrate that the proposed formulation can be optimized in closed form and in dual space, allowing efficient computation for high dimensional neuroimaging datasets. Furthermore, we provide an analytic estimation of the null distribution of the model parameters, which enables efficient stat…
A new non-parametric test for multivariate paired data from pair matching or paired designs
School of Data Science, Fudan University（复旦大学数据科学学院）；Department of Statistics, University of California, Davis（加州大学戴维斯分校统计系）；Beijing International Center for Mathematical Research and School of Public Health, Peking University（北京大学北京国际数学研究中心与公共卫生学院）
Population means and standard deviations are the most common estimands to quantify effects in factorial layouts. In fact, most statistical procedures in such designs are built towards inferring means or contrasts thereof. For more robust analyses, we consider the population median, the interquartile range (IQR) and more general quantile combinations as estimands in which we formulate null hypotheses and calculate compatible confidence regions. Based upon simultaneous multivariate central limit theorems and corresponding resampling results, we derive asymptotically correct procedures in general…
In this paper, we propose a test for the equality of multiple distributions based on kernel mean embeddings. Our framework provides a flexible way to handle multivariate or even high-dimensional data by virtue of kernel methods and allows the number of distributions to increase with the sample size. This is in contrast to previous studies that have been mostly restricted to classical low-dimensional settings with a fixed number of distributions. By building on Cramer-type moderate deviation for degenerate two-sample V-statistics, we derive the limiting null distribution of the test statistic a…
The subject of this paper is to introduce a novel permutation-based nonparametric approach for the problem of ranking several multivariate populations with respect to both experimental and observation studies to be referred to the most useful design such as MANOVA (multivariate independent samples) and MRCB (multivariate randomized complete block design, i.e. multivariate dependent samples also known as repeated measures). This topic is not only of theoretical interest but also have a practical relevance, especially to business and industrial research where a reliable global ranking in terms o…
We propose new tests for assessing whether covariates in a treatment group and matched control group are balanced in observational studies. The tests exhibit high power under a wide range of multivariate alternatives, some of which existing tests have little power for. The asymptotic permutation null distributions of the proposed tests are studied and the p-values calculated through the asymptotic results work well in finite samples, facilitating the application of the test to large data sets. The tests are illustrated in a study of the effect of smoking on blood lead levels. The proposed test…
University of Washington（华盛顿大学）；Google Inc（谷歌公司）；University of Wisconsin-Madison（威斯康星大学麦迪逊分校）；Fred Hutchinson Cancer Research Center（弗雷德·哈钦森癌症研究中心）
This paper investigates the theoretical and empirical performance of Fisher-Pitman-type permutation tests for assessing the equality of unknown Poisson mixture distributions. Building on nonparametric maximum likelihood estimators (NPMLEs) of the mixing distribution, these tests are theoretically shown to be able to adapt to complicated unspecified structures of count data and also consistent against their corresponding ANOVA-type alternatives; the latter is a result in parallel to classic claims made by Robinson (Robinson, 1973). The studied methods are then applied to a single-cell RNA-seq d…
Scuola Normale Superiore（意大利高等师范学院）；IMT School for Advanced Studies（IMT高等研究院）；Institute for Advanced Study, University of Amsterdam（阿姆斯特丹大学高级研究所）；Korteweg-de Vries Institute for Mathematics, University of Amsterdam（阿姆斯特丹大学科特韦格-德弗里斯数学研究所）；Istituto Nazionale di Alta Matematica ‘Francesco Severi’ (INdAM-GNAMPA)（弗朗切斯科·塞韦里高等数学国家研究所）
In this paper, our interest is in the problem of simultaneous hypothesis testing when the test statistics corresponding to the individual hypotheses are possibly correlated. Specifically, we consider the case when the test statistics together have a multivariate normal distribution (with equal correlation between each pair) with an unknown mean vector and our goal is to decide which components of the mean vector are zero and which are non-zero. This problem was taken up earlier in Bogdan et al. (2011) for the case when the test statistics are independent normals. Asymptotic optimality in a Bay…
New inference methods for the multivariate coefficient of variation and its reciprocal, the standardized mean, are presented. While there are various testing procedures for both parameters in the univariate case, it is less known how to do inference in the multivariate setting appropriately. There are some existing procedures but they rely on restrictive assumptions on the underlying distributions. We tackle this problem by applying Wald-type statistics in the context of general, potentially heteroscedastic factorial designs. In addition to the $k$-sample case, higher-way layouts can be incorp…
Georgia Institute of Technology（佐治亚理工学院）；University of Cambridge（剑桥大学）
Motivated by models for multiway comparison data, we consider the problem of estimating a coordinate-wise isotonic function on the domain $[0, 1]^d$ from noisy observations collected on a uniform lattice, but where the design points have been permuted along each dimension. While the univariate and bivariate versions of this problem have received significant attention, our focus is on the multivariate case $d \geq 3$. We study both the minimax risk of estimation (in empirical $L_2$ loss) and the fundamental limits of adaptation (quantified by the adaptivity index) to a family of piecewise const…
One size fits all approaches to medicine have become a thing of the past as the understanding of individual differences grows. The paper introduces a test for the presence of heterogeneity in treatment effects in a clinical trial. Heterogeneity is assessed on the basis of the predicted individual treatment effects (PITE) framework and a permutation test is utilized to establish if significant heterogeneity is present. We first use the novel test to show that heterogeneity in the effects of interventions exists in the Amyotrophic Lateral Sclerosis Clinical Trials. We then show, using two differ…
Any decision making process that relies on a probabilistic forecast of future events necessarily requires a calibrated forecast. This paper proposes new methods for empirically assessing forecast calibration in a multivariate setting where the probabilistic forecast is given by an ensemble of equally probable forecast scenarios. Multivariate properties are mapped to a single dimension through a pre-rank function and the calibration is subsequently assessed visually through a histogram of the ranks of the observation's pre-ranks. Average ranking assigns a pre-rank based on the average univariat…
Simulation of Multivariate Extremes: a Wasserstein-Aitchison GAN approach
Institute of Statistics, Biostatistics and Actuarial Sciences, LIDAM, UCLouvain（统计、生物统计与精算科学研究所，LIDAM，UCLouvain）；CREST, ENSAE Paris（ENSAE巴黎CREST）；Department of Mathematical Sciences, Chalmers University of Technology and University of Gothenburg（数学科学系，查尔姆斯理工大学和哥德堡大学）；Department of Mathematics, KU Leuven（数学系，KU莱顿）
Assessing the probability of occurrence of extreme events is a crucial issue in various fields like finance, insurance, telecommunication or environmental sciences. In a multivariate framework, the tail dependence is characterized by the so-called stable tail dependence function (STDF). Learning this structure is the keystone of multivariate extremes. Although extensive studies have proved consistency and asymptotic normality for the empirical version of the STDF, non-asymptotic bounds are still missing. The main purpose of this paper is to fill this gap. Taking advantage of adapted VC-type co…
Inferring linear dependence between time series is central to our understanding of natural and artificial systems. Unfortunately, the hypothesis tests that are used to determine statistically significant directed or multivariate relationships from time-series data often yield spurious associations (Type I errors) or omit causal relationships (Type II errors). This is due to the autocorrelation present in the analysed time series -- a property that is ubiquitous across diverse applications, from brain dynamics to climate change. Here we show that, for limited data, this issue cannot be mediated…
In this paper we describe the testing procedure for assessing the statistical significance of treatment effect under the experimental conditions of baseline imbalance across covariates and attrition from the survey, using the permutation tests proposed by Freedman and Lane (1983) and Romano and Wolf (2016). We discuss the testing procedure for these hypotheses based on a linear regression model and introduce the new Stata command [R] permtest for the implementation of the permutation test in Stata. Moreover, we investigate the finite-sample performance as well as the statistical validity of th…
A Bayesian lattice filtering and smoothing approach is proposed for fast and accurate modeling and inference in multivariate non-stationary time series. This approach offers computational feasibility and interpretable time-frequency analysis in the multivariate context. The proposed framework allows us to obtain posterior estimates of the time-varying spectral densities of individual time series components, as well as posterior measurements of the time-frequency relationships across multiple components, such as time-varying coherence and partial coherence. The proposed formulation considers mu…
Two-sample tests for multivariate data and non-Euclidean data are widely used in many fields. Parametric tests are mostly restrained to certain types of data that meets the assumptions of the parametric models. In this paper, we study a nonparametric testing procedure that utilizes graphs representing the similarity among observations. It can be applied to any data types as long as an informative similarity measure on the sample space can be defined. The classic test based on a similarity graph has a problem when the two sample sizes are different. We solve the problem by applying appropriate …
Identifying compromise solutions across multiple treatment benefit-harm profiles in multivariate network meta-analysis
Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center-University of Freiburg（弗赖堡大学医学院医学生物计量与统计研究所）；Oslo Center for Biostatistics and Epidemiology, Department of Biostatistics, University of Oslo（奥斯陆大学生物统计系奥斯陆生物统计与流行病学中心）
Vast literature on experimental design extends from Fisher and Snedecor to the modern day. When data lies beyond the assumption of univariate normality, nonparametric methods including rank based statistics and permutation tests are enlisted. The permutation test is a versatile exact nonparametric significance test that requires drastically fewer assumptions than similar parametric tests. The main downfall of the permutation test is high computational cost making this approach laborious for complex data and sophisticated experimental designs and completely infeasible in any application requiri…
Recent technological advances in many domains including both genomics and brain imaging have led to an abundance of high-dimensional and correlated data being routinely collected. Classical multivariate approaches like Multivariate Analysis of Variance (MANOVA) and Canonical Correlation Analysis (CCA) can be used to study relationships between such multivariate datasets. Yet, special care is required with high-dimensional data, as the test statistics may be ill-defined and classical inference procedures break down. In this work, we explain how valid p-values can be derived for these multivaria…
Spatial Principal Component Analysis and Moran Statistics for Multivariate Functional Areal Data
Institute of Mathematical Sciences, Faculty of Science, Universiti Malaya（马来亚大学理学院数学科学研究所）；Universiti Malaya Centre for Data Analytics, Universiti Malaya（马来亚大学数据分析中心）；Center of Research for Statistical Modelling and Methodology, Faculty of Science, Universiti Malaya（马来亚大学理学院统计建模与方法研究中心）；Institut de Mathématiques de Bordeaux, UMR 5251, CNRS, Université de Bordeaux, Bordeaux INP（波尔多大学波尔多数学研究所）；Mathematics, Division of Science, New York University Abu Dhabi（纽约大学阿布扎比分校理学院数学系）；CNRS, UMR 8524–Laboratoire Paul Painlevé, Inria-Datavers, Université de Lille（里尔大学保罗·潘勒瓦数学研究中心）；Independent Researcher（独立研究者）
Mediation analysis seeks to identify and quantify the paths by which an exposure affects an outcome. Intermediate variables which are effected by the exposure and which effect the outcome are known as mediators. There exists extensive work on mediation analysis in the context of models with a single mediator and continuous and binary outcomes. However these methods are often not suitable for multi-omic data that include highly interconnected variables measuring biological mechanisms and various types of outcome variables such as censored survival responses. In this article, we develop a genera…
In this paper, we propose a general framework for distribution-free nonparametric testing in multi-dimensions, based on a notion of multivariate ranks defined using the theory of measure transportation. Unlike other existing proposals in the literature, these multivariate ranks share a number of useful properties with the usual one-dimensional ranks; most importantly, these ranks are distribution-free. This crucial observation allows us to design nonparametric tests that are exactly distribution-free under the null hypothesis. We demonstrate the applicability of this approach by constructing e…
