arXivDaily arXiv每日学术速递 周一至周五更新
arXiv 2007.01497stat.ME
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一种用于配对匹配或配对设计的多变量配对数据的新非参数检验

A new non-parametric test for multivariate paired data from pair matching or paired designs

School of Data Science, Fudan University(复旦大学数据科学学院);Department of Statistics, University of California, Davis(加州大学戴维斯分校统计系);Beijing International Center for Mathematical Research and School of Public Health, Peking University(北京大学北京国际数学研究中心与公共卫生学院)

Jingru Zhang, Hao Chen, Xiao-Hua Zhou

AI总结:

针对多变量配对数据,提出一种新非参数检验方法,显著提升高维场景下的统计功效,并推导渐近分布便于应用。

摘要:

在观察性研究中,实现治疗组与对照组或暴露组与非暴露组在配对匹配中的协变量平衡至关重要。这种平衡使得在配对匹配数据中检验治疗效果或检查暴露与多变量响应变量之间的关联成为可能。配对设计研究涉及在不同条件下对同一受试者进行多次测量。所有这些都需要对多变量配对数据进行有效的检验。然而,当前评估匹配观察性研究中协变量平衡的方法常常忽略配对结构,导致在某些情况下性能下降。多变量配对Hotelling $T^2$检验可用于配对数据,但其功效随维度增加而迅速下降。为解决这些问题,我们提出了一种新的配对数据非参数检验,显著提高了各种场景下的功效。我们还推导了该检验的渐近分布,使其在实际应用中易于使用。通过对阿尔茨海默病研究真实数据的分析,证明了我们提出的检验的有效性。

英文摘要:

In observational studies, achieving covariate balance in pair matching between treatment and control groups or exposed and unexposed groups is essential. This balance enables testing treatment effects or examining {associations between exposures and} multivariate response variables in pair-matched data. Paired design studies involve taking multiple measurements for the same subjects under different conditions. All these call for an effective test for multivariate paired data. However, current methods for assessing covariate balance in matched observational studies often ignore the paired structure, leading to reduced performance in some cases. The multivariate paired Hotelling's $T^2$ test can be used for paired data, but its power decreases rapidly as dimensions increase. To address these issues, we propose a new non-parametric test for paired data, significantly improving power across various scenarios. We also derive the test's asymptotic distribution, making it user-friendly for practical applications. Our proposed test's effectiveness is demonstrated through an analysis of real data on Alzheimer's disease research.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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