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arXiv 0912.0440math.DSmath.OCq-bio.GN
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分段仿射系统周期解的定性控制;遗传网络的应用

Qualitative control of periodic solutions in piecewise affine systems; application to genetic networks

Etienne Farcot, Jean-Luc Gouzé

摘要:

混合系统,特别是分段仿射(PWA)系统,经常被用来建模基因调控网络。在本文中,我们阐述了以前的工作,这类模型的控制问题,也使用一些最近的结果,保证存在性和唯一性的极限环,完全基于离散抽象的系统及其相互作用的结构。我们的目标是控制PWA系统的转移图,以获得振荡行为,这在许多生物网络中确实具有主要的功能重要性;我们展示了如何通过对PWA系统的退化率的混合定性作用来控制唯一稳定极限环的出现或消失,通过静态和动态反馈,即控制子网络的充分耦合。这说明了两个经典的基因网络模块,具有混合反馈回路的结构。

英文摘要:

Hybrid systems, and especially piecewise affine (PWA) systems, are often used to model gene regulatory networks. In this paper we elaborate on previous work about control problems for this class of models, using also some recent results guaranteeing the existence and uniqueness of limit cycles, based solely on a discrete abstraction of the system and its interaction structure. Our aim is to control the transition graph of the PWA system to obtain an oscillatory behaviour, which is indeed of primary functional importance in numerous biological networks; we show how it is possible to control the appearance or disappearance of a unique stable limit cycle by hybrid qualitative action on the degradation rates of the PWA system, both by static and dynamic feedback, i.e. the adequate coupling of a controlling subnetwork. This is illustrated on two classical gene network modules, having the structure of mixed feedback loops.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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