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arXiv 0903.1969math.DSq-bio.MN
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具有多个相互作用环的分段仿射基因网络模型的极限环

Limit cycles in piecewise-affine gene network models with multiple interaction loops

Etienne Farcot, Jean-Luc Gouzé

摘要:

本文考虑用分段仿射微分方程对基因网络进行建模。我们的工作与任意的衰减率,并表示为连续焦点的对齐条件下的局部假设。系统的交互图可能相当复杂(任何符号的多个复杂循环,多个阈值.)。我们的主要结果是一个替代定理表明,如果一个序列的区域是定期访问的轨迹,然后在我们的假设下,存在一个唯一的稳定的周期解,或原点吸引所有的轨迹在这个序列的区域。这一结果大大扩展了我们以前对单个负反馈回路的研究。我们给出了几个例子和模拟说明不同的情况下。

英文摘要:

In this paper we consider piecewise affine differential equations modeling gene networks. We work with arbitrary decay rates, and under a local hypothesis expressed as an alignment condition of successive focal points. The interaction graph of the system may be rather complex (multiple intricate loops of any sign, multiple thresholds...). Our main result is an alternative theorem showing that, if a sequence of region is periodically visited by trajectories, then under our hypotheses, there exists either a unique stable periodic solution, or the origin attracts all trajectories in this sequence of regions. This result extends greatly our previous work on a single negative feedback loop. We give several examples and simulations illustrating different cases.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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