利用光吸引装置在体测量人脑弹性
In vivo measurement of human brain elasticity using a light aspiration device
摘要：
在神经外科手术中发生的脑变形是影响患者“安全”以及脑外科手术的侵入性的严重问题。模型驱动补偿是解决这一问题的一种现实而有效的方法。然而，一个重要的问题是缺乏可靠的和容易获得的患者特定的大脑的机械特性，根据临床医生的经验，可以有很大的不同。我们设计了一种抽吸装置，能够满足手术期间，特别是神经外科手术期间非常严格的灭菌和处理过程。该装置没有电子元件，结构简单，重量轻，可视为辅助仪器。使用外部摄像机通过镜子对抽吸组织的变形进行成像。本文介绍了实验装置，以及它的使用在一个特定的神经外科手术。实验数据被用来校准一个连续模型。我们表明，我们能够提取体内的脑弹性的本构关系：因此，第一次，测量进行术前对病人，就在切除脑实质。本文公开了一项困难的实验结果，并首次提供了关于人脑弹性的活体数据。结果指出了脑组织的柔软性和高度非线性行为。
英文摘要：
The brain deformation that occurs during neurosurgery is a serious issue impacting the patient "safety" as well as the invasiveness of the brain surgery. Model-driven compensation is a realistic and efficient solution to solve this problem. However, a vital issue is the lack of reliable and easily obtainable patient-specific mechanical characteristics of the brain which, according to clinicians' experience, can vary considerably. We designed an aspiration device that is able to meet the very rigorous sterilization and handling process imposed during surgery, and especially neurosurgery. The device, which has no electronic component, is simple, light and can be considered as an ancillary instrument. The deformation of the aspirated tissue is imaged via a mirror using an external camera. This paper describes the experimental setup as well as its use during a specific neurosurgery. The experimental data was used to calibrate a continuous model. We show that we were able to extract an in vivo constitutive law of the brain elasticity: thus for the first time, measurements are carried out per-operatively on the patient, just before the resection of the brain parenchyma. This paper discloses the results of a difficult experiment and provide for the first time in-vivo data on human brain elasticity. The results point out the softness as well as the highly non-linear behavior of the brain tissue.
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