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arXiv 0808.0572stat.ME
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基因芯片、经验贝叶斯和两组模型

Microarrays, Empirical Bayes and the Two-Groups Model

Bradley Efron

摘要:

由奈曼、皮尔逊和费舍尔提出的经典的频率论假设检验理论被认为是二十世纪最有影响力的应用数学。21世纪出现了一些新的情况:高通量设备,如微阵列,通常需要同时对数千个单独的案例进行假设检验,这与经典理论所设想的完全不同。在这些情况下,经验贝叶斯信息开始强迫频率论者和贝叶斯论者。两组模型是一个简单的贝叶斯结构,便于经验贝叶斯分析。本文关注的是贝叶斯和频率论思想在两组设置的相互作用,特别注意集中在Benjamini和Hochberg的错误发现率的方法。主题包括在大规模测试情况下原假设的选择和意义,权力的考虑,置换方法的局限性,组的情况下(如微阵列研究中的途径),相关效应,多个置信区间和贝叶斯竞争对手的两组模型的显着性检验。

英文摘要:

The classic frequentist theory of hypothesis testing developed by Neyman, Pearson and Fisher has a claim to being the twentieth century's most influential piece of applied mathematics. Something new is happening in the twenty-first century: high-throughput devices, such as microarrays, routinely require simultaneous hypothesis tests for thousands of individual cases, not at all what the classical theory had in mind. In these situations empirical Bayes information begins to force itself upon frequentists and Bayesians alike. The two-groups model is a simple Bayesian construction that facilitates empirical Bayes analysis. This article concerns the interplay of Bayesian and frequentist ideas in the two-groups setting, with particular attention focused on Benjamini and Hochberg's False Discovery Rate method. Topics include the choice and meaning of the null hypothesis in large-scale testing situations, power considerations, the limitations of permutation methods, significance testing for groups of cases (such as pathways in microarray studies), correlation effects, multiple confidence intervals and Bayesian competitors to the two-groups model.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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