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arXiv 2104.02419stat.ME
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半监督经验贝叶斯组正则化因子回归

Semi-supervised empirical Bayes group-regularized factor regression

Magnus M. Münch, Mark A. van de Wiel, Aad W. van der Vaart, Carel F. W. Peeters

AI总结:

本文提出一种半监督经验贝叶斯组正则化因子回归方法,利用特征先验信息与未标记数据提升高维生物医学预测性能,并通过模拟及流感疫苗效力和口腔癌转移预测应用验证其有效性。

摘要:

高维生物医学预测问题中的特征通常可以用较低维流形很好地描述。一个例子是组织在较小功能网络中的基因。然后可以用因子回归模型来描述结果。因子模型的一个好处是,它允许在模型估计中直接纳入未标记观测,即半监督学习。此外,生物医学预测问题中的高维特征通常具有很好的特征描述。例子包括具有可用注释的基因,以及具有来自先前研究的p值的代谢物。在本文中,关于特征的额外信息被纳入特征先验模型中。额外信息被加权,并通过经验贝叶斯纳入估计,使用变分近似来加速计算。该方法在模拟和两个应用中得到了验证。一个应用考虑基于微阵列数据的流感疫苗效力预测。第二个应用从RNAseq数据预测口腔癌转移。

英文摘要:

The features in high dimensional biomedical prediction problems are often well described with lower dimensional manifolds. An example is genes that are organised in smaller functional networks. The outcome can then be described with the factor regression model. A benefit of the factor model is that is allows for straightforward inclusion of unlabeled observations in the estimation of the model, i.e., semi-supervised learning. In addition, the high dimensional features in biomedical prediction problems are often well characterised. Examples are genes, for which annotation is available, and metabolites with $p$-values from a previous study available. In this paper, the extra information on the features is included in the prior model for the features. The extra information is weighted and included in the estimation through empirical Bayes, with Variational approximations to speed up the computation. The method is demonstrated in simulations and two applications. One application considers influenza vaccine efficacy prediction based on microarray data. The second application predictions oral cancer metastatsis from RNAseq data.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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