种子细胞的类型决定了萌发中心反应的效率
The type of seeder cells determines the efficiency of germinal center reactions
摘要：
我们讨论了在体液免疫反应中观察到的两类生发中心的起源：一些生发中心发育良好，产生大量高亲和力抗体产生浆细胞。其他的生发中心反应很弱，几乎没有产出。我们提出了一个解释，这种几乎所有或没有行为的生发中心反应：亲和性的种子B细胞的抗原是决定的生发中心反应的命运的关键参数。这一假设是验证的框架内的时空模拟的germinal中心的反应。
英文摘要：
We discuss the origin of two classes of germinal centers that have been observed during humoral immune responses: Some germinal centers develop very well and give rise to a large number of high affinity antibody producing plasma cells. Other germinal center reaction are very weak and the output production is practically absent. We propose an explanation for this nearly all-or-none behavior of germinal center reactions: The affinity of the seeder B-cells to the antigen is the critical parameter that determines the fate of the germinal center reaction. This hypothesis is verified in the framework of a space-time simulation of germinal center reactions.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
