趋化性在生发中心形成中的可能作用
A possible role of chemotaxis in germinal center formation
摘要：
在生发中心反应期间，形成特征形态。在最近发展的germinal中心的时空模型的框架内，提出了暗区和亮区形成的机制。其机制是基于滤泡树突状细胞分泌的扩散性分化信号。在这里，我们研究了最近发现的趋化因子的可能影响，在一个单细胞为基础的随机和离散的三维模型的框架中的生发中心的形成。我们还将考虑可能对两个区域的发展发挥作用的替代可能的趋化途径。我们的研究结果表明，从滤泡树突状细胞衍生的趋化因子产生的中心细胞运动必须超过一个下限，使中心母细胞和中心细胞的分离。与光学显微镜相比，暗区呈环形。这表明，FDC衍生的化学引诱剂本身不能解释典型的生发中心形态。
英文摘要：
During the germinal center reaction a characteristic morphology is developed. In the framework of a recently developed space-time-model for the germinal center a mechanism for the formation of dark and light zones has been proposed. The mechanism is based on a diffusing differentiation signal which is secerned by follicular dendritic cells. Here, we investigate a possible influence of recently found chemokines for the germinal center formation in the framework of a single-cell-based stochastic and discrete three-dimensional model. We will also consider alternative possible chemotactic pathways that may play a role for the development of both zones. Our results suggest that the centrocyte motility resulting from a follicular dendritic cell-derived chemokine has to exceed a lower limit to allow the separation of centroblasts and centrocytes. In contrast to light microscopy the dark zone is ring shaped. This suggests that FDC-derived chemoattractants alone cannot explain the typical germinal center morphology.
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