锗心反应的再循环几率和动力学性质
Recycling probability and dynamical properties of germinal center reactions
摘要：
我们介绍了一个新的模型，在一个生发中心的中心母细胞和中心细胞的动力学。该模型减少了生发中心反应的元素被认为是必不可少的，并嵌入增殖的成中心细胞，点突变的相应的抗体类型中表示的形状空间，分化成中心细胞，选择相对于初始抗原，分化的阳性选择的中心细胞的血浆或记忆细胞和回收的中心细胞的成中心细胞。我们专门使用具有直接生物学解释的参数，这样，一旦通过实验数据确定，模型就获得了预测能力。根据Han等人（1995 b）的实验，我们预测中心细胞向中心母细胞的高循环率是生发中心反应可靠工作所必需的。此外，我们发现血浆和记忆细胞的生产相对于点突变的开始有延迟的开始，这对于在germinal中心反应期间的优化过程是必要的。分析了锗心反应对再循环几率的依赖关系。
英文摘要：
We introduce a new model for the dynamics of centroblasts and centrocytes in a germinal center. The model reduces the germinal center reaction to the elements considered as essential and embeds proliferation of centroblasts, point mutations of the corresponding antibody types represented in a shape space, differentiation to centrocytes, selection with respect to initial antigens, differentiation of positively selected centrocytes to plasma or memory cells and recycling of centrocytes to centroblasts. We use exclusively parameters with a direct biological interpretation such that, once determined by experimental data, the model gains predictive power. Based on the experiment of Han et al. (1995b) we predict that a high rate of recycling of centrocytes to centroblasts is necessary for the germinal center reaction to work reliably. Furthermore, we find a delayed start of the production of plasma and memory cells with respect to the start of point mutations, which turns out to be necessary for the optimization process during the germinal center reaction. The dependence of the germinal center reaction on the recycling probability is analyzed.
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