生发中心的形态与亲和力成熟的关系
The relation of morphology and affinity maturation in germinal centers
摘要：
在优化体液免疫应答的背景下，分析了生发中心的特定形态。暗区和亮区的亲和力成熟过程的相关性进行了研究的框架内的germinal中心反应的理论模型。特别是，它表明，中间外观的暗区在germinal中心反应是有利的抗体优化的过程。讨论了方法方面的问题。
英文摘要：
The specific morphology of germinal centers is analyzed in the context of the optimization of the humoral immune response. The relevance of dark and light zones for the affinity maturation process is investigated in the framework of a theoretical model for the germinal center reaction. Especially, it is shown that an intermediate appearance of dark zones in germinal center reactions is advantageous for the process of antibody optimization. Methodological aspects are discussed.
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