Binomial data with unknown sizes often appear in biological and medical sciences and are usually overdispersed. All previous methods used parametric models and only considered overdispersion due to the variation of sizes. The proposed semiparametric model considers overdispersion due to the variation of sizes and that of probabilities. By doing this, it can include variations caused by observations, missing covariates, and random measurement errors in covariates. An Expectation Conditional Maximization algorithm is provided to stabilize the loglikelihood optimization. Selecting the number of support points of the mixing distributions and the bootstrap methods are also discussed. Simulation is done to evaluate the performance of the proposed model. Two real examples are used to illustrate the proposed model.
Logistic regression with unknown sizes has many important applications in biological and medical sciences. All models about this problem in the literature are parametric ones. A semiparametric regression model is proposed. This model incorporates overdispersion due to the variation of sizes, and allows general dose-response relations. An Expectation Conditional Maximization algorithm is provided to maximize the log likelihood. The bootstrap method can be used to construct confidence intervals for regression coefficients. Simulation is performed to study the behavior of the proposed model. Two …
Analyzing polytomous response from a complex survey scheme, like stratified or cluster sampling is very crucial in several socio-economics applications. We present a class of minimum quasi weighted density power divergence estimators for the polytomous logistic regression model with such a complex survey. This family of semiparametric estimators is a robust generalization of the maximum quasi weighted likelihood estimator exploiting the advantages of the popular density power divergence measure. Accordingly robust estimators for the design effects are also derived. Robust testing of general li…
In this article, the weighted empirical likelihood is applied to a general setting of two-sample semiparametric models, which includes biased sampling models and case-control logistic regression models as special cases. For various types of censored data, such as right censored data, doubly censored data, interval censored data and partly interval-censored data, the weighted empirical likelihood-based semiparametric maximum likelihood estimator $(\tildeθ_n,\tilde{F}_n)$ for the underlying parameter $θ_0$ and distribution $F_0$ is derived, and the strong consistency of $(\tildeθ_n,\tilde{F}_n)$…
Stimulated by the Boston house price data, in this paper, we propose a semiparametric spatial dynamic model, which extends the ordinary spatial autoregressive models to accommodate the effects of some covariates associated with the house price. A profile likelihood based estimation procedure is proposed. The asymptotic normality of the proposed estimators are derived. We also investigate how to identify the parametric/nonparametric components in the proposed semiparametric model. We show how many unknown parameters an unknown bivariate function amounts to, and propose an AIC/BIC of nonparametr…
Consider the semiparametric transformation model $Λ_{θ_o}(Y)=m(X)+ε$, where $θ_o$ is an unknown finite dimensional parameter, the functions $Λ_{θ_o}$ and $m$ are smooth, $ε$ is independent of $X$, and $\esp(ε)=0$. We propose a kernel-type estimator of the density of the error $ε$, and prove its asymptotic normality. The estimated errors, which lie at the basis of this estimator, are obtained from a profile likelihood estimator of $θ_o$ and a nonparametric kernel estimator of $m$. The practical performance of the proposed density estimator is evaluated in a simulation study.
The association between two random variables is often of primary interest in statistical research. In this paper semiparametric models for the association between random vectors X and Y are considered which leave the marginal distributions arbitrary. Given that the odds ratio function comprises the whole information about the association the focus is on bilinear log-odds ratio models and in particular on the odds ratio parameter vector θ. The covariance structure of the maximum likelihood estimator θ^ of θ is of major importance for asymptotic inference. To this end different representations o…
Suppose that univariate data are drawn from a mixture of two distributions that are equal up to a shift parameter. Such a model is known to be nonidentifiable from a nonparametric viewpoint. However, if we assume that the unknown mixed distribution is symmetric, we obtain the identifiability of this model, which is then defined by four unknown parameters: the mixing proportion, two location parameters and the cumulative distribution function of the symmetric mixed distribution. We propose estimators for these four parameters when no training data is available. Our estimators are shown to be st…
This paper considers an estimation of semiparametric functional (varying)-coefficient quantile regression with spatial data. A general robust framework is developed that treats quantile regression for spatial data in a natural semiparametric way. The local M-estimators of the unknown functional-coefficient functions are proposed by using local linear approximation, and their asymptotic distributions are then established under weak spatial mixing conditions allowing the data processes to be either stationary or nonstationary with spatial trends. Application to a soil data set is demonstrated wi…
Binomial data with unknown sizes often appear in biological and medical sciences. The previous methods either use the Poisson approximation or the quasi-likelihood approach. A full likelihood approach is proposed by treating unknown sizes as latent variables. This approach simplifies analysis as maximum likelihood estimation can be applied. It also facilitates us to gain a lot more insights into efficiency loss across models and estimation precision within models. Simulation assesses the performance of the proposed model. An application to the surviving jejunal crypt data is discussed. The pro…
We consider the estimation of the location of the pole and memory parameter, λ^0 and α, respectively, of covariance stationary linear processes whose spectral density function f(λ) satisfies f(λ)\sim C| λ-λ^0| ^{-α} in a neighborhood of λ^0. We define a consistent estimator of λ^0 and derive its limit distribution Z_{λ^0}. As in related optimization problems, when the true parameter value can lie on the boundary of the parameter space, we show that Z_{λ^0} is distributed as a normal random variable when λ^0\in (0,π), whereas for λ^0=0 or π, Z_{λ^0} is a mixture of discrete and continuous rando…
A challenge when dealing with survival analysis data is accounting for a cure fraction, meaning that some subjects will never experience the event of interest. Mixture cure models have been frequently used to estimate both the probability of being cured and the time to event for the susceptible subjects, by usually assuming a parametric (logistic) form of the incidence. We propose a new estimation procedure for a parametric cure rate that relies on a preliminary smooth estimator and is independent of the model assumed for the latency. We investigate the theoretical properties of the estimators…
In this article, we study a partially linear single-index model for longitudinal data under a general framework which includes both the sparse and dense longitudinal data cases. A semiparametric estimation method based on a combination of the local linear smoothing and generalized estimation equations (GEE) is introduced to estimate the two parameter vectors as well as the unknown link function. Under some mild conditions, we derive the asymptotic properties of the proposed parametric and nonparametric estimators in different scenarios, from which we find that the convergence rates and asympto…
Robust and semiparametric statistics are of the same historical origin and largely employ the same locally asymptotically normal framework. In our talk, we consider he following more intrinsic connections of both fields: 1) Robust influence curves for semiparametric models with infinite dimensional nuisance parameter; for example, for semiparametric regression (Cox), and mixture models (Neyman--Scott). 2) Adaptiveness in the sense of Stein's necessary condition of robust neighborhood models and estimators with respect to a finite dimensional nuisance parameter; for example, location, linear re…
We investigate the asymptotic behavior of the Nadaraya-Watson estimator for the estimation of the regression function in a semiparametric regression model. On the one hand, we make use of the recursive version of the sliced inverse regression method for the estimation of the unknown parameter of the model. On the other hand, we implement a recursive Nadaraya-Watson procedure for the estimation of the regression function which takes into account the previous estimation of the parameter of the semiparametric regression model. We establish the almost sure convergence as well as the asymptotic nor…
The density ratio model (DRM) provides a flexible and useful platform for combining information from multiple sources. In this paper, we consider statistical inference under two-sample DRMs with additional parameters defined through and/or additional auxiliary information expressed as estimating equations. We examine the asymptotic properties of the maximum empirical likelihood estimators (MELEs) of the unknown parameters in the DRMs and/or defined through estimating equations, and establish the chi-square limiting distributions for the empirical likelihood ratio (ELR) statistics. We show that…
This paper introduces and analyzes a stochastic search method for parameter estimation in linear regression models in the spirit of Beran and Millar (1987). The idea is to generate a random finite subset of a parameter space which will automatically contain points which are very close to an unknown true parameter. The motivation for this procedure comes from recent work of Duembgen, Samworth and Schuhmacher (2011) on regression models with log-concave error distributions.
The problem of estimating the shift (or, equivalently, the center of symmetry) of an unknown symmetric and periodic function $f$ observed in Gaussian white noise is considered. Using the blockwise Stein method, a penalized profile likelihood with a data-driven penalization is introduced so that the estimator of the center of symmetry is defined as the maximizer of the penalized profile likelihood. This estimator has the advantage of being independent of the functional class to which the signal $f$ si assumed to belong and, furthermore, is shown to be semiparametrically adaptive and efficient. …
We consider X 1 ,. .. , X n a sample of data on the circle S 1 , whose distribution is a twocomponent mixture. Denoting R and Q two rotations on S 1 , the density of the X i 's is assumed to be g(x) = pf (R --1 x) + (1 -- p)f (Q --1 x), where p $\in$ (0, 1) and f is an unknown density on the circle. In this paper we estimate both the parametric part $θ$ = (p, R, Q) and the nonparametric part f. The specific problems of identifiability on the circle are studied. A consistent estimator of $θ$ is introduced and its asymptotic normality is proved. We propose a Fourier-based estimator of f with a p…
Motivated by studies in biological sciences to detect differentially expressed genes, a semiparametric two-component mixture model with one known component is being studied in this paper. Assuming the density of the unknown component to be log-concave, which contains a very broad family of densities, we develop a semiparametric maximum likelihood estimator and propose an EM algorithm to compute it. Our new estimation method finds the mixing proportions and the distribution of the unknown component simultaneously. We establish the identifiability of the proposed semiparametric mixture model and…
In many semiparametric models that are parameterized by two types of parameters---a Euclidean parameter of interest and an infinite-dimensional nuisance parameter---the two parameters are bundled together, that is, the nuisance parameter is an unknown function that contains the parameter of interest as part of its argument. For example, in a linear regression model for censored survival data, the unspecified error distribution function involves the regression coefficients. Motivated by developing an efficient estimating method for the regression parameters, we propose a general sieve M-theorem…
This paper is devoted to the estimation of the shift parameter in a semiparametric regression model when the distribution of the observation times is unknown. Hence, we propose to use a stochastic algorithm which takes into account the estimation of the distribution of the observation times. We establish the almost sure convergence of our estimator and the asymptotic normality. The main result of the paper is that, with little assumptions on the regularity of the regression function, the asymptotic variance obtained is the same as when the distribution is known. In that sense, we improve the r…
We consider estimation in a particular semiparametric regression model for the mean of a counting process with ``panel count'' data. The basic model assumption is that the conditional mean function of the counting process is of the form $E\{\mathbb{N}(t)|Z\}=\exp(β_0^TZ)Λ_0(t)$ where $Z$ is a vector of covariates and $Λ_0$ is the baseline mean function. The ``panel count'' observation scheme involves observation of the counting process $\mathbb{N}$ for an individual at a random number $K$ of random time points; both the number and the locations of these time points may differ across individual…
In this paper we consider a heteroscedastic transformation model, where the transformation belongs to a parametric family of monotone transformations, the regression and variance function are modelled nonparametrically and the error is independent of the multidimensional covariates. In this model, we first consider the estimation of the unknown components of the model, namely the transformation parameter, regression and variance function and the distribution of the error. We show the asymptotic normality of the proposed estimators. Second, we propose tests for the validity of the model, and es…
This paper generalizes a part of the theory of $Z$-estimation which has been developed mainly in the context of modern empirical processes to the case of stochastic processes, typically, semimartingales. We present a general theorem to derive the asymptotic behavior of the solution to an estimating equation $θ\leadsto Ψ_n(θ,\widehat{h}_n)=0$ with an abstract nuisance parameter $h$ when the compensator of $Ψ_n$ is random. As its application, we consider the estimation problem in an ergodic diffusion process model where the drift coefficient contains an unknown, finite-dimensional parameter $θ$ …
Many economic and causal parameters depend on nonparametric or high dimensional first steps. We give a general construction of locally robust/orthogonal moment functions for GMM, where moment conditions have zero derivative with respect to first steps. We show that orthogonal moment functions can be constructed by adding to identifying moments the nonparametric influence function for the effect of the first step on identifying moments. Orthogonal moments reduce model selection and regularization bias, as is very important in many applications, especially for machine learning first steps. We gi…
Consider semiparametric estimation where a doubly robust estimating function for a low-dimensional parameter is available, depending on two working models. With high-dimensional data, we develop regularized calibrated estimation as a general method for estimating the parameters in the two working models, such that valid Wald confidence intervals can be obtained for the parameter of interest under suitable sparsity conditions if either of the two working models is correctly specified. We propose a computationally tractable two-step algorithm and provide rigorous theoretical analysis which justi…
University of Chicago Booth School of Business（芝加哥大学布斯商学院）
We study deep neural networks and their use in semiparametric inference. We establish novel rates of convergence for deep feedforward neural nets. Our new rates are sufficiently fast (in some cases minimax optimal) to allow us to establish valid second-step inference after first-step estimation with deep learning, a result also new to the literature. Our estimation rates and semiparametric inference results handle the current standard architecture: fully connected feedforward neural networks (multi-layer perceptrons), with the now-common rectified linear unit activation function and a depth ex…
We consider estimation and inference in a single index regression model with an unknown convex link function. We introduce a convex and Lipschitz constrained least squares estimator (CLSE) for both the parametric and the nonparametric components given independent and identically distributed observations. We prove the consistency and find the rates of convergence of the CLSE when the errors are assumed to have only $q \ge 2$ moments and are allowed to depend on the covariates. When $q\ge 5$, we establish $n^{-1/2}$-rate of convergence and asymptotic normality of the estimator of the parametric …
Logistic regression is a well-known statistical model which is commonly used in the situation where the output is a binary random variable. It has a wide range of applications including machine learning, public health, social sciences, ecology and econometry. In order to estimate the unknown parameters of logistic regression with data streams arriving sequentially and at high speed, we focus our attention on a recursive stochastic algorithm. More precisely, we investigate the asymptotic behavior of a new stochastic Newton algorithm. It enables to easily update the estimates when the data arriv…
Standard logistic regression analysis of case-control data has low power to detect gene-environment interactions, but until recently it was the only method that could be used on complex polygenic data for which parametric distributional models are not feasible. Under the assumption of gene-environment independence in the underlying population, Stalder et al. (2017, Biometrika, 104, 801-812) developed a retrospective method that treats both genetic and environmental variables nonparametrically. However, the mathematical symmetry of genetic and environmental variables is overlooked. We propose a…
We consider the estimation of dynamic discrete choice models in a semiparametric setting, in which the per-period utility functions are known up to a finite number of parameters, but the distribution of utility shocks is left unspecified. This semiparametric setup differs from most of the existing identification and estimation literature for dynamic discrete choice mod- els. To show identification we derive and exploit a new Bellman-like recursive representation for the unknown quantile function of the utility shocks. Our estimators are straightforward to compute; some are simple and require n…
Cure models have been developed as an alternative modelling approach to conventional survival analysis in order to account for the presence of cured subjects that will never experience the event of interest. Mixture cure models, which model separately the cure probability and the survival of uncured subjects depending on a set of covariates, are particularly useful for distinguishing curative from life-prolonging effects. In practice, it is common to assume a parametric model for the cure probability and a semiparametric model for the survival of the susceptibles. Because of the latent cure st…
In the last decade, the secondary use of large data from health systems, such as electronic health records, has demonstrated great promise in advancing biomedical discoveries and improving clinical decision making. However, there is an increasing concern about biases in association studies caused by misclassification in the binary outcomes derived from electronic health records. We revisit the classical logistic regression model with misclassified outcomes. Despite that local identification conditions in some related settings have been previously established, the global identification of such …
The cumulative incidence is the probability of failure from the cause of interest over a certain time period in the presence of other risks. A semiparametric regression model proposed by Fine and Gray (1999) has become the method of choice for formulating the effects of covariates on the cumulative incidence. Its estimation, however, requires modeling of the censoring distribution and is not statistically efficient. In this paper, we present a broad class of semiparametric transformation models which extends the Fine and Gray model, and we allow for unknown causes of failure. We derive the non…
In fitting a mixture of linear regression models, normal assumption is traditionally used to model the error and then regression parameters are estimated by the maximum likelihood estimators (MLE). This procedure is not valid if the normal assumption is violated. To relax the normal assumption on the error distribution hence reduce the modeling bias, we propose semiparametric mixture of linear regression models with unspecified error distributions. We establish a more general identifiability result under weaker conditions than existing results, construct a class of new estimators, and establis…
This paper considers a semiparametric generalized autoregressive conditional heteroskedasticity (S-GARCH) model. For this model, we first estimate the time-varying long run component for unconditional variance by the kernel estimator, and then estimate the non-time-varying parameters in GARCH-type short run component by the quasi maximum likelihood estimator (QMLE). We show that the QMLE is asymptotically normal with the parametric convergence rate. Next, we construct a Lagrange multiplier test for linear parameter constraint and a portmanteau test for model checking, and obtain their asymptot…
Inference based on the penalized density ratio model is proposed and studied. The model under consideration is specified by assuming that the log--likelihood function of two unknown densities is of some parametric form. The model has been extended to cover multiple samples problems while its theoretical properties have been investigated using large sample theory. A main application of the density ratio model is testing whether two, or more, distributions are equal. We extend these results by arguing that the penalized maximum empirical likelihood estimator has less mean square error than that …
This work was motivated by observational studies in pregnancy with spontaneous abortion (SAB) as outcome. Clearly some women experience the SAB event but the rest do not. In addition, the data are left truncated due to the way pregnant women are recruited into these studies. For those women who do experience SAB, their exact event times are sometimes unknown. Finally, a small percentage of the women are lost to follow-up during their pregnancy. All these give rise to data that are left truncated, partly interval and right-censored, and with a clearly defined cured portion. We consider the non-…
Inference over tails is performed by applying only the results of extreme value theory. Whilst such theory is well defined and flexible enough in the univariate case, multivariate inferential methods often require the imposition of arbitrary constraints not fully justifed by the underlying theory. In contrast, our approach uses only the constraints imposed by theory. We build on previous, theoretically justified work for marginal exceedances over a high, unknown threshold, by combining it with flexible, semiparametric copulae specifications to investigate extreme dependence. Whilst giving prob…
This research is motivated by discovering and underpinning genetic causes for the progression of a bilateral eye disease, Age-related Macular Degeneration (AMD), of which the primary outcomes, progression times to late-AMD, are bivariate and interval-censored due to intermittent assessment times. We propose a novel class of copula-based semiparametric transformation models for bivariate data under general interval censoring, which includes the case 1 interval censoring (current status data) and case 2 interval censoring. Specifically, the joint likelihood is modeled through a two-parameter Arc…
When drawing causal inference from observational data, there is always concern about unmeasured confounding. One way to tackle this is to conduct a sensitivity analysis. One widely-used sensitivity analysis framework hypothesizes the existence of a scalar unmeasured confounder U and asks how the causal conclusion would change were U measured and included in the primary analysis. Works along this line often make various parametric assumptions on U, for the sake of mathematical and computational simplicity. In this article, we further this line of research by developing a valid sensitivity analy…
Assume that we observe a large number of curves, all of them with identical, although unknown, shape, but with a different random shift. The objective is to estimate the individual time shifts and their distribution. Such an objective appears in several biological applications like neuroscience or ECG signal processing, in which the estimation of the distribution of the elapsed time between repetitive pulses with a possibly low signal-noise ratio, and without a knowledge of the pulse shape is of interest. We suggest an M-estimator leading to a three-stage algorithm: we split our data set in bl…
We study the problem of estimating a functional or a parameter in the context where outcome is subject to nonignorable missingness. We completely avoid modeling the regression relation, while allowing the propensity to be modeled by a semiparametric logistic relation where the dependence on covariates is unspecified. We discover a surprising phenomenon in that the estimation of the parameter in the propensity model as well as the functional estimation can be carried out without assessing the missingness dependence on covariates. This allows us to propose a general class of estimators for both …
We consider a semiparametric mixture of two univariate density functions where one of them is known while the weight and the other function are unknown. Such mixtures have a history of application to the problem of detecting differentially expressed genes under two or more conditions in microarray data. Until now, some additional knowledge about the unknown component (e.g. the fact that it belongs to a location family) has been assumed. As opposed to this approach, we do not assume any additional structure on the unknown density function. For this mixture model, we derive a new sufficient iden…
