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arXiv 2604.00070eess.IVcs.AIcs.CV

利用3D多对比自注意GAN进行脑部MRI图像合成

Brain MR Image Synthesis with 3D Multi-Contrast Self-Attention GAN

School of Computing and Mathematical Sciences, University of Leicester(利兹大学计算与数学科学学院)

Zaid A. Abod, Furqan Aziz

AI总结:

本文提出3D-MC-SAGAN框架,通过单张T2w图像生成高保真多对比MRI图像,保留肿瘤特征,结合多种损失函数提升全局真实感和肿瘤结构保真度。

摘要:

完整的高质量多模态磁共振成像(MRI)对准确的神经肿瘤评估至关重要,因为每种对比度提供互补的解剖和病理信息。然而,为每位患者获取所有模态(例如T1c、T1n、T2w、T2f)往往不切实际,由于扫描时间长、成本高和患者不适,可能限制全面的肿瘤评估。我们提出3D-MC-SAGAN(3D多对比自注意生成对抗网络),一种统一的3D多对比合成框架,从单个T2w输入生成高保真的缺失模态,同时显式保留肿瘤特征。该模型采用多尺度3D编码器-解码器生成器,带有残差连接和新的内存受限混合注意(MBHA)块,以高效捕捉长距离依赖关系,并通过WGAN-GP批评者和辅助域分类头进行训练,以在统一网络中生成T2f、T1n和T1c体积。为确保解剖和病理保真度,我们整合了一个冻结的3D U-Net基分割网络,强制在训练期间保持肿瘤一致性约束。结合对抗、重建、感知、结构相似性、对比分类和分割引导损失的复合目标进一步促进全局真实感和肿瘤结构保真度。在3D脑部MRI数据集上的广泛实验表明,3D-MC-SAGAN在定量性能上达到最先进的水平,生成视觉上一致、解剖上合理的对比度,具有改进的分布真实感。重要的是,所提出的方法在肿瘤分割准确性方面与使用完全获取多模态输入所获得的相似,突显了其在减少获取负担的同时保留临床有意义信息的潜力。

英文摘要:

Complete and high-quality multi-modal Magnetic Resonance Imaging (MRI) is essential for accurate neuro-oncological assessment, as each contrast provides complementary anatomical and pathological information. However, acquiring all modalities (e.g., T1c, T1n, T2w, T2f) for every patient is often impractical due to prolonged scan times, cost, and patient discomfort, potentially limiting comprehensive tumour evaluation. We propose 3D-MC-SAGAN (3D Multi-Contrast Self-Attention Generative Adversarial Network), a unified 3D multi-contrast synthesis framework that generates high-fidelity missing modalities from a single T2w input while explicitly preserving tumour characteristics. The model employs a multi-scale 3D encoder--decoder generator with residual connections and a novel Memory-Bounded Hybrid Attention (MBHA) block to capture long-range dependencies efficiently, and is trained with a WGAN-GP critic and an auxiliary domain classification head to produce T2f, T1n, and T1c volumes within a unified network. To ensure anatomical and pathological fidelity, we incorporate a frozen 3D U-Net-based segmentation network that enforces a tumour-consistency constraint during training. A composite objective combining adversarial, reconstruction, perceptual, structural similarity, contrast-classification, and segmentation-guided losses further promotes both global realism and tumour-preserving structure. Extensive experiments on 3D brain MRI datasets demonstrate that 3D-MC-SAGAN achieves state-of-the-art quantitative performance and produces visually coherent, anatomically plausible contrasts with improved distributional realism. Importantly, the proposed method maintains tumour segmentation accuracy comparable to that achieved using fully acquired multi-modal inputs, highlighting its potential to reduce acquisition burden while preserving clinically meaningful information.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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