Gliomas are the most common primary brain malignancies, with different degrees of aggressiveness, variable prognosis and various heterogeneous histological sub-regions, i.e., peritumoral edema, necrotic core, enhancing and non-enhancing tumour core. Although brain tumours can easily be detected using multi-modal MRI, accurate tumor segmentation is a challenging task. Hence, using the data provided by the BraTS Challenge 2020, we propose a 3D volume-to-volume Generative Adversarial Network for segmentation of brain tumours. The model, called Vox2Vox, generates realistic segmentation outputs from multi-channel 3D MR images, segmenting the whole, core and enhancing tumor with mean values of 87.20%, 81.14%, and 78.67% as dice scores and 6.44mm, 24.36mm, and 18.95mm for Hausdorff distance 95 percentile for the BraTS testing set after ensembling 10 Vox2Vox models obtained with a 10-fold cross-validation.
How we won BraTS 2023 Adult Glioma challenge? Just faking it! Enhanced Synthetic Data Augmentation and Model Ensemble for brain tumour segmentation
University of Minho（米尼奥大学）；Institute for Artificial Intelligence in Medicine（人工智能医学研究所）；Graz University of Technology（格拉茨工业大学）；University Medicine Essen（埃森大学医学中心）；Cancer Research Center Cologne Essen (CCCE)（科隆-埃森癌症研究中心）；University Hospital Essen（埃森大学医院）；German Cancer Consortium (DKTK)（德国癌症联盟）
Brain Tumour Removing and Missing Modality Generation using 3D WDM
Center Algoritmi / LASI, University of Minho（米尼奥大学Algoritmi中心 / LASI）；Computer Algorithms for Medicine Laboratory（计算机医学算法实验室）；Institute for AI in Medicine (IKIM), University Medicine Essen（埃森大学医学医院医学人工智能研究所）；Institute of Medical Informatics, University Hospital RWTH Aachen（亚琛工业大学医学院医学信息学研究所）；Department of Oral and Maxillofacial Surgery, University Hospital RWTH Aachen（亚琛工业大学医学院口腔颌面外科）；Institute of Computer Graphics and Vision, Graz University of Technology（格拉茨工业大学计算机图形学与视觉研究所）；Cancer Research Center Cologne Essen (CCCE), University Medicine Essen（埃森大学医学医院科隆埃森癌症研究中心）；German Cancer Consortium (DKTK), Partner Site Essen（德国癌症联盟埃森合作站点）；Department of Physics, TU Dortmund University（多特蒙德工业大学物理系）
Otto von Guericke University Magdeburg（马格德堡奥托·冯·格里克大学）；Center for Behavioral Brain Sciences（行为脑科学研究中心）；German Center for Neurodegenerative Disease（德国神经退行性疾病研究中心）
Expert interpretation of anatomical images of the human brain is the central part of neuro-radiology. Several machine learning-based techniques have been proposed to assist in the analysis process. However, the ML models typically need to be trained to perform a specific task, e.g., brain tumour segmentation or classification. Not only do the corresponding training data require laborious manual annotations, but a wide variety of abnormalities can be present in a human brain MRI - even more than one simultaneously, which renders representation of all possible anomalies very challenging. Hence, …
Romanian Institute of Science and Technology（罗马尼亚科学技术研究所）；Babeş-Bolyai University（巴贝什-博尧依大学）
Anomaly detection for Magnetic Resonance Images (MRIs) can be solved with unsupervised methods by learning the distribution of healthy images and identifying anomalies as outliers. In presence of an additional dataset of unlabelled data containing also anomalies, the task can be framed as a semi-supervised task with negative and unlabelled sample points. Recently, in Albu et al., 2020, we have proposed a slice-wise semi-supervised method for tumour detection based on the computation of a dissimilarity function in the latent space of a Variational AutoEncoder, trained on unlabelled data. The di…
Pre- to Post-Contrast Breast MRI Synthesis for Enhanced Tumour Segmentation
Universitat de Barcelona（巴塞罗那大学）；Helmholtz Center Munich（慕尼黑亥姆霍兹中心）；Technical University of Munich（慕尼黑工业大学）；Karolinska Institutet（卡罗林斯卡学院）；King’s College London（伦敦国王学院）
Durham University（杜伦大学）；University of Exeter（埃克塞特大学）；County Durham and Darlington NHS Foundation Trust（达勒姆郡和达灵顿国民保健服务基金会信托）
Medical segmentation is performed to determine the bounds of regions of interest (ROI) prior to surgery. By allowing the study of growth, structure, and behaviour of the ROI in the planning phase, critical information can be obtained, increasing the likelihood of a successful operation. Usually, segmentations are performed manually or via machine learning methods trained on manual annotations. In contrast, this paper proposes a fully automatic, unsupervised inpainting-based brain tumour segmentation system for T1-weighted MRI. First, a deep convolutional neural network (DCNN) is trained to rec…
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences（中国科学院深圳先进技术研究院）；University of Chinese Academy of Sciences（中国科学院大学）；Renmin University of China（中国人民大学）；Shenzhen University（深圳大学）
Magnetic resonance imaging plays an important role in computer-aided diagnosis and brain exploration. However, limited by hardware, scanning time and cost, it's challenging to acquire high-resolution (HR) magnetic resonance (MR) image clinically. In this paper, fine perceptive generative adversarial networks (FP-GANs) is proposed to produce HR MR images from low-resolution counterparts. It can cope with the detail insensitive problem of the existing super-resolution model in a divide-and-conquer manner. Specifically, FP-GANs firstly divides an MR image into low-frequency global approximation a…
Deep learning requires large datasets for training (convolutional) networks with millions of parameters. In neuroimaging, there are few open datasets with more than 100 subjects, which makes it difficult to, for example, train a classifier to discriminate controls from diseased persons. Generative adversarial networks (GANs) can be used to synthesize data, but virtually all research is focused on 2D images. In medical imaging, and especially in neuroimaging, most datasets are 3D or 4D. Here we therefore present preliminary results showing that a 3D progressive growing GAN can be used to synthe…
University of British Columbia Data Science Institute（不列颠哥伦比亚大学数据科学研究所）；BC Cancer Research Institute（不列颠哥伦比亚省癌症研究所）；University of British Columbia（不列颠哥伦比亚大学）
Training computer-vision related algorithms on medical images for disease diagnosis or image segmentation is difficult due to the lack of training data, labeled samples, and privacy concerns. For this reason, a robust generative method to create synthetic data is highly sought after. However, most three-dimensional image generators require additional image input or are extremely memory intensive. To address these issues we propose adapting video generation techniques for 3-D image generation. Using the temporal GAN (TGAN) architecture, we show we are able to generate realistic head and neck PE…
Brain vessel image segmentation can be used as a promising biomarker for better prevention and treatment of different diseases. One successful approach is to consider the segmentation as an image-to-image translation task and perform a conditional Generative Adversarial Network (cGAN) to learn a transformation between two distributions. In this paper, we present a novel multi-view approach, MLP-GAN, which splits a 3D volumetric brain vessel image into three different dimensional 2D images (i.e., sagittal, coronal, axial) and then feed them into three different 2D cGANs. The proposed MLP-GAN no…
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences（中国科学院深圳先进技术研究院）
Cross-modal fusion of different types of neuroimaging data has shown great promise for predicting the progression of Alzheimer's Disease(AD). However, most existing methods applied in neuroimaging can not efficiently fuse the functional and structural information from multi-modal neuroimages. In this work, a novel cross-modal transformer generative adversarial network(CT-GAN) is proposed to fuse functional information contained in resting-state functional magnetic resonance imaging (rs-fMRI) and structural information contained in Diffusion Tensor Imaging (DTI). The developed bi-attention mech…
Indian Institute of Technology (IIT), Varanasi (BHU)（印度理工学院（贝拿勒斯印度教大学））；National Institute of Technology (NIT), Tiruchirappalli（国立理工学院蒂鲁奇拉帕利分校）
Brain tumour segmentation is an essential task in medical image processing. Early diagnosis of brain tumours plays a crucial role in improving treatment possibilities and increases the survival rate of the patients. Manual segmentation of the brain tumours for cancer diagnosis, from large number of MRI images, is both a difficult and time-consuming task. There is a need for automatic brain tumour image segmentation. The purpose of this project is to provide an automatic brain tumour segmentation method of MRI images to help locate the tumour accurately and quickly.
Eurecat Centre Tecnològic de Catalunya（加泰罗尼亚技术中心Eurecat）；Universitat Pompeu Fabra（庞培法布拉大学）；Vall d’Hebron University Hospital（巴尔德希伯伦大学医院）；ICREA（加泰罗尼亚高等研究院）
Early detection and quantification of tumour growth would help clinicians to prescribe more accurate treatments and provide better surgical planning. However, the multifactorial and heterogeneous nature of lung tumour progression hampers identification of growth patterns. In this study, we present a novel method based on a deep hierarchical generative and probabilistic framework that, according to radiological guidelines, predicts tumour growth, quantifies its size and provides a semantic appearance of the future nodule. Unlike previous deterministic solutions, the generative characteristic of…
PLA strategy support force information engineering university（中国人民解放军战略支援部队信息工程大学）
In the visual decoding domain, visually reconstructing presented images given the corresponding human brain activity monitored by functional magnetic resonance imaging (fMRI) is difficult, especially when reconstructing viewed natural images. Visual reconstruction is a conditional image generation on fMRI data and thus generative adversarial network (GAN) for natural image generation is recently introduced for this task. Although GAN-based methods have greatly improved, the fidelity and naturalness of reconstruction are still unsatisfactory due to the small number of fMRI data samples and the …
LPIXEL Inc.（LPIXEL公司）；University of Cambridge（剑桥大学）；National Institute of Informatics（国立信息学研究所）；National Center for Global Health and Medicine（国立国际医疗研究中心）；Juntendo University（顺天堂大学）；ELTE Eötvös Loránd University（厄特沃什·罗兰大学）；The University of Tokyo（东京大学）
Unsupervised learning can discover various unseen abnormalities, relying on large-scale unannotated medical images of healthy subjects. Towards this, unsupervised methods reconstruct a 2D/3D single medical image to detect outliers either in the learned feature space or from high reconstruction loss. However, without considering continuity between multiple adjacent slices, they cannot directly discriminate diseases composed of the accumulation of subtle anatomical anomalies, such as Alzheimer's Disease (AD). Moreover, no study has shown how unsupervised anomaly detection is associated with eith…
Hôpital Erasme（埃拉斯姆医院）；Université libre de Bruxelles（布鲁塞尔自由大学）
Reaction-diffusion models have been proposed for decades to capture the growth of gliomas, the most common primary brain tumours. However, severe limitations regarding the estimation of the initial conditions and parameter values of such models have restrained their clinical use as a personalised tool. In this work, we investigate the ability of deep convolutional neural networks (DCNNs) to address the pitfalls commonly encountered in the field. Based on 1,200 synthetic tumours grown over real brain geometries derived from magnetic resonance (MR) data of 6 healthy subjects, we demonstrate the …
A Systematic Benchmark of Intraoperative Ultrasound-to-MR Synthesis for Brain Tumour Surgery
Department of Neurosurgery, Neurovascular Unit Río Hortega University Hospital（里奥霍尔特ega大学医院神经外科部门，神经血管单元）；Specialized Group in Biomedical Imaging and Computational Analysis (GEIBAC)（生物医学成像与计算分析专项组（GEIBAC））；Instituto de Investigación Biosanitaria de Valladolid (IBioVALL)（瓦尔拉多利德生物医学研究 institute（IBioVALL））
Shanghai Jiao Tong University（上海交通大学）；Huashan Hospital, Shanghai Medical College, Fudan University（复旦大学上海医学院华山医院）；National Center for Neurological Disorders（国家神经疾病中心）；Fudan University（复旦大学）；ShanghaiTech University（上海科技大学）
Brain network analysis for traumatic brain injury (TBI) patients is critical for its consciousness level assessment and prognosis evaluation, which requires the segmentation of certain consciousness-related brain regions. However, it is difficult to construct a TBI segmentation model as manually annotated MR scans of TBI patients are hard to collect. Data augmentation techniques can be applied to alleviate the issue of data scarcity. However, conventional data augmentation strategies such as spatial and intensity transformation are unable to mimic the deformation and lesions in traumatic brain…
Training segmentation networks requires large annotated datasets, but manual annotation is time consuming and costly. We here investigate if the combination of a noise-to-image GAN and an image-to-image GAN can be used to synthesize realistic brain tumor images as well as the corresponding tumor annotations (labels), to substantially increase the number of training images. The noise-to-image GAN is used to synthesize new label images, while the image-to-image GAN generates the corresponding MR image from the label image. Our results indicate that the two GANs can synthesize label images and MR…
Gliomas are the most common malignant brain tumourswith intrinsic heterogeneity. Accurate segmentation of gliomas and theirsub-regions on multi-parametric magnetic resonance images (mpMRI)is of great clinical importance, which defines tumour size, shape andappearance and provides abundant information for preoperative diag-nosis, treatment planning and survival prediction. Recent developmentson deep learning have significantly improved the performance of auto-mated medical image segmentation. In this paper, we compare severalstate-of-the-art convolutional neural network models for brain tumouri…
University of Cambridge（剑桥大学）；Royal Brompton Hospital（皇家布朗普顿医院）；Imperial College London（帝国理工学院）
Single image super-resolution (SISR) is of great importance as a low-level computer vision task. The fast development of Generative Adversarial Network (GAN) based deep learning architectures realises an efficient and effective SISR to boost the spatial resolution of natural images captured by digital cameras. However, the SISR for medical images is still a very challenging problem. This is due to (1) compared to natural images, in general, medical images have lower signal to noise ratios, (2) GAN based models pre-trained on natural images may synthesise unrealistic patterns in medical images …
Brain age estimation based on magnetic resonance imaging (MRI) is an active research area in early diagnosis of some neurodegenerative diseases (e.g. Alzheimer, Parkinson, Huntington, etc.) for elderly people or brain underdevelopment for the young group. Deep learning methods have achieved the state-of-the-art performance in many medical image analysis tasks, including brain age estimation. However, the performance and generalisability of the deep learning model are highly dependent on the quantity and quality of the training data set. Both collecting and annotating brain MRI data are extreme…
Exploiting learning algorithms under scarce data regimes is a limitation and a reality of the medical imaging field. In an attempt to mitigate the problem, we propose a data augmentation protocol based on generative adversarial networks. We condition the networks at a pixel-level (segmentation mask) and at a global-level information (acquisition environment or lesion type). Such conditioning provides immediate access to the image-label pairs while controlling global class specific appearance of the synthesized images. To stimulate synthesis of the features relevant for the segmentation task, a…
University of Pennsylvania（宾夕法尼亚大学）；Center for AI and Data Science for Integrated Diagnostics（综合诊断人工智能与数据科学中心）；Center for Biomedical Image Computing and Analytics（生物医学图像计算与分析中心）
Generative adversarial networks (GANs) are one powerful type of deep learning models that have been successfully utilized in numerous fields. They belong to a broader family called generative methods, which generate new data with a probabilistic model by learning sample distribution from real examples. In the clinical context, GANs have shown enhanced capabilities in capturing spatially complex, nonlinear, and potentially subtle disease effects compared to traditional generative methods. This review appraises the existing literature on the applications of GANs in imaging studies of various neu…
Monash University Malaysia（莫纳什大学马来西亚分校）；King Abdullah University of Science and Technology（阿卜杜拉国王科技大学）；University College London（伦敦大学学院）
Common measures of brain functional connectivity (FC) including covariance and correlation matrices are semi-positive definite (SPD) matrices residing on a cone-shape Riemannian manifold. Despite its remarkable success for Euclidean-valued data generation, use of standard generative adversarial networks (GANs) to generate manifold-valued FC data neglects its inherent SPD structure and hence the inter-relatedness of edges in real FC. We propose a novel graph-regularized manifold-aware conditional Wasserstein GAN (GR-SPD-GAN) for FC data generation on the SPD manifold that can preserve the globa…
Korea Advanced Institute of Science and Technology（韩国科学技术院）
As deep learning is showing unprecedented success in medical image analysis tasks, the lack of sufficient medical data is emerging as a critical problem. While recent attempts to solve the limited data problem using Generative Adversarial Networks (GAN) have been successful in generating realistic images with diversity, most of them are based on image-to-image translation and thus require extensive datasets from different domains. Here, we propose a novel model that can successfully generate 3D brain MRI data from random vectors by learning the data distribution. Our 3D GAN model solves both i…
As a powerful technique in medical imaging, image synthesis is widely used in applications such as denoising, super resolution and modality transformation etc. Recently, the revival of deep neural networks made immense progress in the field of medical imaging. Although many deep leaning based models have been proposed to improve the image synthesis accuracy, the evaluation of the model uncertainty, which is highly important for medical applications, has been a missing part. In this work, we propose to use Bayesian conditional generative adversarial network (GAN) with concrete dropout to improv…
Istanbul Technical University（伊斯坦布尔理工大学）；National School for Computer Science (ENSI)（国立计算机科学学院）
Brain connectivity networks, derived from magnetic resonance imaging (MRI), non-invasively quantify the relationship in function, structure, and morphology between two brain regions of interest (ROIs) and give insights into gender-related connectional differences. However, to the best of our knowledge, studies on gender differences in brain connectivity were limited to investigating pairwise (i.e., low-order) relationship ROIs, overlooking the complex high-order interconnectedness of the brain as a network. To address this limitation, brain multiplexes have been introduced to model the relatio…
Machine learning methods applied to complex biomedical data has enabled the construction of disease signatures of diagnostic/prognostic value. However, less attention has been given to understanding disease heterogeneity. Semi-supervised clustering methods can address this problem by estimating multiple transformations from a (e.g. healthy) control (CN) group to a patient (PT) group, seeking to capture the heterogeneity of underlying pathlogic processes. Herein, we propose a novel method, Smile-GANs (SeMi-supervIsed cLustEring via GANs), for semi-supervised clustering, and apply it to brain MR…
Centro Algoritmi, University of Minho（米尼奥大学算法中心）；Université Paris-Saclay, CEA, CNRS, BAOBAB, NeuroSpin（巴黎萨克雷大学、法国原子能与可替代能源委员会、法国国家科学研究中心、BAOBAB、NeuroSpin）
Translational brain research using Magnetic Resonance Imaging (MRI) is becoming increasingly popular as animal models are an essential part of scientific studies and more ultra-high-field scanners are becoming available. Some disadvantages of MRI are the availability of MRI scanners and the time required for a full scanning session (it usually takes over 30 minutes). Privacy laws and the 3Rs ethics rule also make it difficult to create large datasets for training deep learning models. Generative Adversarial Networks (GANs) can perform data augmentation with higher quality than other techniques…
Reconstructing perceived natural images from fMRI signals is one of the most engaging topics of neural decoding research. Prior studies had success in reconstructing either the low-level image features or the semantic/high-level aspects, but rarely both. In this study, we utilized an Instance-Conditioned GAN (IC-GAN) model to reconstruct images from fMRI patterns with both accurate semantic attributes and preserved low-level details. The IC-GAN model takes as input a 119-dim noise vector and a 2048-dim instance feature vector extracted from a target image via a self-supervised learning model (…
The University of Tokyo（东京大学）；National Institute of Informatics（国立信息学研究所）；University of Cambridge（剑桥大学）；Cancer Research UK Cambridge Institute（英国癌症研究院剑桥研究所）；University of Milano-Bicocca（米兰比可卡大学）；Chubu University（中部大学）；Jikei University School of Medicine（东京慈惠会医科大学）；Kyushu University（九州大学）
Convolutional Neural Networks (CNNs) achieve excellent computer-assisted diagnosis with sufficient annotated training data. However, most medical imaging datasets are small and fragmented. In this context, Generative Adversarial Networks (GANs) can synthesize realistic/diverse additional training images to fill the data lack in the real image distribution; researchers have improved classification by augmenting data with noise-to-image (e.g., random noise samples to diverse pathological images) or image-to-image GANs (e.g., a benign image to a malignant one). Yet, no research has reported resul…
Generative adversarial networks (GANs) are recently highly successful in generative applications involving images and start being applied to time series data. Here we describe EEG-GAN as a framework to generate electroencephalographic (EEG) brain signals. We introduce a modification to the improved training of Wasserstein GANs to stabilize training and investigate a range of architectural choices critical for time series generation (most notably up- and down-sampling). For evaluation we consider and compare different metrics such as Inception score, Frechet inception distance and sliced Wasser…
University of Pennsylvania（宾夕法尼亚大学）；University of California, Los Angeles（加利福尼亚大学洛杉矶分校）
Single image super-resolution (SISR) reconstruction for magnetic resonance imaging (MRI) has generated significant interest because of its potential to not only speed up imaging but to improve quantitative processing and analysis of available image data. Generative Adversarial Networks (GAN) have proven to perform well in recovering image texture detail, and many variants have therefore been proposed for SISR. In this work, we develop an enhancement to tackle GAN-based 3D SISR by introducing a new residual-in-residual dense block (RRDG) generator that is both memory efficient and achieves stat…
Charité Universitätsmedizin Berlin（柏林夏里特医学院）；Technical University Berlin（柏林工业大学）；Birmingham City University（伯明翰城市大学）；Fraunhofer MEVIS（弗劳恩霍夫医学图像计算研究所）；Beuth University of Applied Sciences（拜伊特应用科学大学）
Anonymization and data sharing are crucial for privacy protection and acquisition of large datasets for medical image analysis. This is a big challenge, especially for neuroimaging. Here, the brain's unique structure allows for re-identification and thus requires non-conventional anonymization. Generative adversarial networks (GANs) have the potential to provide anonymous images while preserving predictive properties. Analyzing brain vessel segmentation, we trained 3 GANs on time-of-flight (TOF) magnetic resonance angiography (MRA) patches for image-label generation: 1) Deep convolutional GAN,…
Imperial College London（帝国理工学院）；University of Oxford（牛津大学）
Machine learning has been widely adopted for medical image analysis in recent years given its promising performance in image segmentation and classification tasks. As a data-driven science, the success of machine learning, in particular supervised learning, largely depends on the availability of manually annotated datasets. For medical imaging applications, such annotated datasets are not easy to acquire. It takes a substantial amount of time and resource to curate an annotated medical image set. In this paper, we propose an efficient annotation framework for brain tumour images that is able t…
Proportional Sensitivity in Generative Adversarial Network (GAN)-Augmented Brain Tumor Classification Using Convolutional Neural Network
American International University-Bangladesh（美国国际大学-孟加拉国）；Asian University of Bangladesh（孟加拉国亚洲大学）；Information and Computer Science Department, King Fahd University of Petroleum and Minerals (KFUPM)（石油和矿物大学（KFUPM）信息与计算机科学系）；SDAIA-KFUPM Joint Research Center for AI, King Fahd University of Petroleum and Minerals（人工智能联合研究中心（SDAIA-KFUPM）, 石油和矿物大学）；Interdisciplinary Research Center for Bio Systems and Machines, King Fahd University of Petroleum and Minerals（生物系统与机器交叉研究中心，石油和矿物大学）；Independent University, Bangladesh（独立大学）
Inter-scanner and inter-protocol discrepancy in MRI datasets are known to lead to significant quantification variability. Hence image-to-image or scanner-to-scanner translation is a crucial frontier in the area of medical image analysis with a lot of potential applications. Nonetheless, a significant percentage of existing algorithms cannot explicitly exploit and preserve texture details from target scanners and offers individual solutions towards specialized task-specific architectures. In this paper, we design a multi-scale texture transfer to enrich the reconstruction images with more detai…
Yantai University（烟台大学）；Philips Healthcare（飞利浦医疗保健）；Beijing Institute of Technology（北京理工大学）；Fudan University（复旦大学）；Royal Brompton Hospital（皇家布朗普顿医院）；Imperial College London（帝国理工学院）
Deep learning based generative adversarial networks (GAN) can effectively perform image reconstruction with under-sampled MR data. In general, a large number of training samples are required to improve the reconstruction performance of a certain model. However, in real clinical applications, it is difficult to obtain tens of thousands of raw patient data to train the model since saving k-space data is not in the routine clinical flow. Therefore, enhancing the generalizability of a network based on small samples is urgently needed. In this study, three novel applications were explored based on …
National Yang Ming Chiao Tung Univ.（国立阳明交通大学）；Hiroshima Univ.（广岛大学）
Neuroscience studies have revealed that the brain encodes visual content and embeds information in neural activity. Recently, deep learning techniques have facilitated attempts to address visual reconstructions by mapping brain activity to image stimuli using generative adversarial networks (GANs). However, none of these studies have considered the semantic meaning of latent code in image space. Omitting semantic information could potentially limit the performance. In this study, we propose a new framework to reconstruct facial images from functional Magnetic Resonance Imaging (fMRI) data. Wit…
Otto von Guericke University Magdeburg（奥托·冯·格里克马格德堡大学）；Center for Behavioral Brain Sciences（行为脑科学中心）；German Center for Neurodegenerative Disease（德国神经退行性疾病中心）；Leibniz Institute for Neurobiology（莱布尼茨神经生物学研究所）
A brain tumour is a mass or cluster of abnormal cells in the brain, which has the possibility of becoming life-threatening because of its ability to invade neighbouring tissues and also form metastases. An accurate diagnosis is essential for successful treatment planning and magnetic resonance imaging is the principal imaging modality for diagnostic of brain tumours and their extent. Deep Learning methods in computer vision applications have shown significant improvement in recent years, most of which can be credited to the fact that a sizeable amount of data is available to train models on, a…
The Hospital for Sick Children（病童医院）；University of Toronto（多伦多大学）；Vector Institute（矢量研究所）
Deep learning techniques have greatly benefited computer-aided diagnostic systems. However, unlike other fields, in medical imaging, acquiring large fine-grained annotated datasets such as 3D tumour segmentation is challenging due to the high cost of manual annotation and privacy regulations. This has given interest to weakly-supervise methods to utilize the weakly labelled data for tumour segmentation. In this work, we propose a weakly supervised approach to obtain regions of interest using binary class labels. Furthermore, we propose a novel objective function to train the generator model ba…
University of Oxford（牛津大学）；Australian Institute for Machine Learning（澳大利亚机器学习研究所）；The University of Adelaide（阿德莱德大学）；South Australian Health and Medical Research Institute（南澳大利亚健康与医学研究所）
Gliomas appear with wide variation in their characteristics both in terms of their appearance and location on brain MR images, which makes robust tumour segmentation highly challenging, and leads to high inter-rater variability even in manual segmentations. In this work, we propose a triplanar ensemble network, with an independent tumour core prediction module, for accurate segmentation of these tumours and their sub-regions. On evaluating our method on the MICCAI Brain Tumor Segmentation (BraTS) challenge validation dataset, for tumour sub-regions, we achieved a Dice similarity coefficient of…
McGill University（麦吉尔大学）；University of Oxford（牛津大学）
In this paper, we develop a metric designed to assess and rank uncertainty measures for the task of brain tumour sub-tissue segmentation in the BraTS 2019 sub-challenge on uncertainty quantification. The metric is designed to: (1) reward uncertainty measures where high confidence is assigned to correct assertions, and where incorrect assertions are assigned low confidence and (2) penalize measures that have higher percentages of under-confident correct assertions. Here, the workings of the components of the metric are explored based on a number of popular uncertainty measures evaluated on the …
Multiple Sclerosis (MS) is a chronic neurological condition characterized by the development of lesions in the white matter of the brain. T2-fluid attenuated inversion recovery (FLAIR) brain magnetic resonance imaging (MRI) provides superior visualization and characterization of MS lesions, relative to other MRI modalities. Follow-up brain FLAIR MRI in MS provides helpful information for clinicians towards monitoring disease progression. In this study, we propose a novel modification to generative adversarial networks (GANs) to predict future lesion-specific FLAIR MRI for MS at fixed time inte…
Zhejiang University of Technology（浙江工业大学）；Fourth Military Medical University（第四军医大学）；Utron Technology Co., Ltd.（欧创科技有限公司）
Magnetic induction tomography (MIT) is an efficient solution for long-term brain disease monitoring, which focuses on reconstructing bio-impedance distribution inside the human brain using non-intrusive electromagnetic fields. However, high-quality brain image reconstruction remains challenging since reconstructing images from the measured weak signals is a highly non-linear and ill-conditioned problem. In this work, we propose a generative adversarial network (GAN) enhanced MIT technique, named MITNet, based on a complex convolutional neural network (CNN). The experimental results on the real…
Principled Feature Disentanglement for High-Fidelity Unified Brain MRI Synthesis
School of Computing, Korea Advanced Institute of Science（韩国科学技术院计算机学院）；Samsung Research, Seoul 06765, Republic of Korea（三星研究院）；Gordon Center for Medical Imaging, Massachusetts General Hospital（麻省总医院影像中心）；Harvard Medical School, Boston, MA 02114, USA（哈佛医学院）
