Cardiovascular diseases (CVDs) are disorders impacting the heart and circulatory system. These disorders are the foremost and continuously escalating cause of mortality worldwide. One of the main tasks when working with CVDs is analyzing and identifying pathologies on a 12-lead electrocardiogram (ECG) with a standard 10-second duration. Using machine learning (ML) in automatic ECG analysis increases CVD diagnostics' availability, speed, and accuracy. However, the most significant difficulty in developing ML models is obtaining a sufficient training dataset. Due to the limitations of medical data usage, such as expensiveness, errors, the ambiguity of labels, imbalance of classes, and privacy issues, utilizing synthetic samples depending on specific pathologies bypasses these restrictions and improves algorithm quality. Existing solutions for the conditional generation of ECG signals are mainly built on Generative Adversarial Networks (GANs), and only a few papers consider the architectures based on Variational Autoencoders (VAEs), showing comparable results in recent works. This paper proposes the publicly available conditional Nouveau VAE model for ECG signal generation (cNVAE-ECG), which produces high-resolution ECGs with multiple pathologies. We provide an extensive comparison of the proposed model on various practical downstream tasks, including transfer learning scenarios showing an area under the receiver operating characteristic (AUROC) increase up to 2% surpassing GAN-like competitors.
Lobachevsky State University of Nizhni Novgorod（下诺夫哥罗德国立洛巴切夫斯基大学）
We propose a method for generating an electrocardiogram (ECG) signal for one cardiac cycle using a variational autoencoder. Using this method we extracted a vector of new 25 features, which in many cases can be interpreted. The generated ECG has quite natural appearance. The low value of the Maximum Mean Discrepancy metric, 0.00383, indicates good quality of ECG generation too. The extracted new features will help to improve the quality of automatic diagnostics of cardiovascular diseases. Also, generating new synthetic ECGs will allow us to solve the issue of the lack of labeled ECG for use th…
Columbia University（哥伦比亚大学）；University of California at Berkeley（加州大学伯克利分校）；University of Chicago（芝加哥大学）
An electrocardiogram (EKG) is a common, non-invasive test that measures the electrical activity of a patient's heart. EKGs contain useful diagnostic information about patient health that may be absent from other electronic health record (EHR) data. As multi-dimensional waveforms, they could be modeled using generic machine learning tools, such as a linear factor model or a variational autoencoder. We take a different approach:~we specify a model that directly represents the underlying electrophysiology of the heart and the EKG measurement process. We apply our model to two datasets, including …
University of Toronto（多伦多大学）；Vector Institute（向量研究所）；University of Massachusetts（马萨诸塞大学）
Variational Autoencoders (VAEs) are a popular generative model, but one in which conditional inference can be challenging. If the decomposition into query and evidence variables is fixed, conditional VAEs provide an attractive solution. To support arbitrary queries, one is generally reduced to Markov Chain Monte Carlo sampling methods that can suffer from long mixing times. In this paper, we propose an idea we term cross-coding to approximate the distribution over the latent variables after conditioning on an evidence assignment to some subset of the variables. This allows generating query sam…
School of Computer Science, The University of Sydney（悉尼大学计算机科学学院）；School of Computer Science, University of Technology Sydney（悉尼科技大学计算机科学学院）
Class imbalance occurs in many real-world applications, including image classification, where the number of images in each class differs significantly. With imbalanced data, the generative adversarial networks (GANs) leans to majority class samples. The two recent methods, Balancing GAN (BAGAN) and improved BAGAN (BAGAN-GP), are proposed as an augmentation tool to handle this problem and restore the balance to the data. The former pre-trains the autoencoder weights in an unsupervised manner. However, it is unstable when the images from different categories have similar features. The latter is …
We propose a molecular generative model based on the conditional variational autoencoder for de novo molecular design. It is specialized to control multiple molecular properties simultaneously by imposing them on a latent space. As a proof of concept, we demonstrate that it can be used to generate drug-like molecules with five target properties. We were also able to adjust a single property without changing the others and to manipulate it beyond the range of the dataset.
Max Planck Institute for Informatics（马克斯·普朗克信息学研究所）；Bosch Center for Artificial Intelligence（博世人工智能中心）；CISPA Helmholtz Center for Information Security（CISPA亥姆霍兹信息安全中心）
Prediction of future states of the environment and interacting agents is a key competence required for autonomous agents to operate successfully in the real world. Prior work for structured sequence prediction based on latent variable models imposes a uni-modal standard Gaussian prior on the latent variables. This induces a strong model bias which makes it challenging to fully capture the multi-modality of the distribution of the future states. In this work, we introduce Conditional Flow Variational Autoencoders (CF-VAE) using our novel conditional normalizing flow based prior to capture compl…
University of Padua（帕多瓦大学）；Fondazione Bruno Kessler（布鲁诺·凯斯勒基金会）
In recent years, deep generative models for graphs have been used to generate new molecules. These models have produced good results, leading to several proposals in the literature. However, these models may have troubles learning some of the complex laws governing the chemical world. In this work, we explore the usage of the histogram of atom valences to drive the generation of molecules in such models. We present Conditional Constrained Graph Variational Autoencoder (CCGVAE), a model that implements this key-idea in a state-of-the-art model, and shows improved results on several evaluation m…
Discrete latent spaces in variational autoencoders have been shown to effectively capture the data distribution for many real-world problems such as natural language understanding, human intent prediction, and visual scene representation. However, discrete latent spaces need to be sufficiently large to capture the complexities of real-world data, rendering downstream tasks computationally challenging. For instance, performing motion planning in a high-dimensional latent representation of the environment could be intractable. We consider the problem of sparsifying the discrete latent space of a…
This paper aims to develop an acoustic signal-based unsupervised anomaly detection method for automatic machine monitoring. Existing approaches such as deep autoencoder (DAE), variational autoencoder (VAE), conditional variational autoencoder (CVAE) etc. have limited representation capabilities in the latent space and, hence, poor anomaly detection performance. Different models have to be trained for each different kind of machines to accurately perform the anomaly detection task. To solve this issue, we propose a new method named as hierarchical conditional variational autoencoder (HCVAE). Th…
The task of predicting stochastic behaviors of road agents in diverse environments is a challenging problem for autonomous driving. To best understand scene contexts and produce diverse possible future states of the road agents adaptively in different environments, a prediction model should be probabilistic, multi-modal, context-driven, and general. We present Conditionalizing Variational AutoEncoders via Hypernetworks (CVAE-H); a conditional VAE that extensively leverages hypernetwork and performs generative tasks for high-dimensional problems like the prediction task. We first evaluate CVAE-…
European Organization for Nuclear Research (CERN)（欧洲核子研究组织（CERN））；Laboratoire de Recherche en Informatique (LRI)（计算机科学研究实验室（LRI））；Université Paris-Saclay（巴黎萨克雷大学）
Exploiting the rapid advances in probabilistic inference, in particular variational Bayes and variational autoencoders (VAEs), for anomaly detection (AD) tasks remains an open research question. Previous works argued that training VAE models only with inliers is insufficient and the framework should be significantly modified in order to discriminate the anomalous instances. In this work, we exploit the deep conditional variational autoencoder (CVAE) and we define an original loss function together with a metric that targets hierarchically structured data AD. Our motivating application is a rea…
We present a novel algorithm to reduce tensor compute required by a conditional image generation autoencoder without sacrificing quality of photo-realistic image generation. Our method is device agnostic, and can optimize an autoencoder for a given CPU-only, GPU compute device(s) in about normal time it takes to train an autoencoder on a generic workstation. We achieve this via a two-stage novel strategy where, first, we condense the channel weights, such that, as few as possible channels are used. Then, we prune the nearly zeroed out weight activations, and fine-tune the autoencoder. To maint…
Domain adaptation approaches aim to exploit useful information from the source domain where supervised learning examples are easier to obtain to address a learning problem in the target domain where there is no or limited availability of such examples. In classification problems, domain adaptation has been studied under varying supervised, unsupervised and semi-supervised conditions. However, a common situation when the labelled samples are available for a subset of target domain classes has been overlooked. In this paper, we formulate this particular domain adaptation problem within a general…
Aalto University（阿尔托大学）；University of Helsinki（赫尔辛基大学）；Bayer Pharmaceuticals（拜耳制药）
Conditional variational autoencoders (CVAEs) are versatile deep generative models that extend the standard VAE framework by conditioning the generative model with auxiliary covariates. The original CVAE model assumes that the data samples are independent, whereas more recent conditional VAE models, such as the Gaussian process (GP) prior VAEs, can account for complex correlation structures across all data samples. While several methods have been proposed to learn standard VAEs from partially observed datasets, these methods fall short for conditional VAEs. In this work, we propose a method to …
Vector Institute for Artificial Intelligence（向量人工智能研究院）；University of Toronto（多伦多大学）
In this paper, we describe the "implicit autoencoder" (IAE), a generative autoencoder in which both the generative path and the recognition path are parametrized by implicit distributions. We use two generative adversarial networks to define the reconstruction and the regularization cost functions of the implicit autoencoder, and derive the learning rules based on maximum-likelihood learning. Using implicit distributions allows us to learn more expressive posterior and conditional likelihood distributions for the autoencoder. Learning an expressive conditional likelihood distribution enables t…
Skobeltsyn Institute of Nuclear Physics, Lomonosov Moscow State University（罗蒙诺索夫莫斯科国立大学斯科别利岑核物理研究所）；Applied Physics Institute of Irkutsk State University（伊尔库茨克国立大学应用物理研究所）；Lomonosov Moscow State University（罗蒙诺索夫莫斯科国立大学）
High-energy particles hitting the upper atmosphere of the Earth produce extensive air showers that can be detected from the ground level using imaging atmospheric Cherenkov telescopes. The images recorded by Cherenkov telescopes can be analyzed to separate gamma-ray events from the background hadron events. Many of the methods of analysis require simulation of massive amounts of events and the corresponding images by the Monte Carlo method. However, Monte Carlo simulation is computationally expensive. The data simulated by the Monte Carlo method can be augmented by images generated using faste…
University at Buffalo（布法罗大学）；JD Finance America Corporation（京东金融美国公司）
We investigate large-scale latent variable models (LVMs) for neural story generation -- an under-explored application for open-domain long text -- with objectives in two threads: generation effectiveness and controllability. LVMs, especially the variational autoencoder (VAE), have achieved both effective and controllable generation through exploiting flexible distributional latent representations. Recently, Transformers and its variants have achieved remarkable effectiveness without explicit latent representation learning, thus lack satisfying controllability in generation. In this paper, we a…
Kyungpook National University（庆北国立大学）；Electronics and Telecommunications Research Institute（韩国电子通信研究院）
Deep generative models for audio synthesis have recently been significantly improved. However, the task of modeling raw-waveforms remains a difficult problem, especially for audio waveforms and music signals. Recently, the realtime audio variational autoencoder (RAVE) method was developed for high-quality audio waveform synthesis. The RAVE method is based on the variational autoencoder and utilizes the two-stage training strategy. Unfortunately, the RAVE model is limited in reproducing wide-pitch polyphonic music sound. Therefore, to enhance the reconstruction performance, we adopt the pitch a…
The ultimate goal of various fields is to directly generate molecules with desired properties, such as finding water-soluble molecules in drug development and finding molecules suitable for organic light-emitting diode (OLED) or photosensitizers in the field of development of new organic materials. In this respect, this study proposes a molecular graph generative model based on the autoencoder for de novo design. The performance of molecular graph conditional variational autoencoder (MGCVAE) for generating molecules having specific desired properties is investigated by comparing it to molecula…
Predicting Critical Heat Flux with Uncertainty Quantification and Domain Generalization Using Conditional Variational Autoencoders and Deep Neural Networks
Non-parallel many-to-many voice conversion remains an interesting but challenging speech processing task. Many style-transfer-inspired methods such as generative adversarial networks (GANs) and variational autoencoders (VAEs) have been proposed. Recently, AutoVC, a conditional autoencoders (CAEs) based method achieved state-of-the-art results by disentangling the speaker identity and speech content using information-constraining bottlenecks, and it achieves zero-shot conversion by swapping in a different speaker's identity embedding to synthesize a new voice. However, we found that while speak…
Generating power system states that have similar distribution and dependency to the historical ones is essential for the tasks of system planning and security assessment, especially when the historical data is insufficient. In this paper, we described a generative model for load profiles of industrial and commercial customers, based on the conditional variational autoencoder (CVAE) neural network architecture, which is challenging due to the highly variable nature of such profiles. Generated contextual load profiles were conditioned on the month of the year and typical power exchange with the …
Computer poetry generation is our first step towards computer writing. Writing must have a theme. The current approaches of using sequence-to-sequence models with attention often produce non-thematic poems. We present a novel conditional variational autoencoder with a hybrid decoder adding the deconvolutional neural networks to the general recurrent neural networks to fully learn topic information via latent variables. This approach significantly improves the relevance of the generated poems by representing each line of the poem not only in a context-sensitive manner but also in a holistic way…
Fudan University（复旦大学）；The Pennsylvania State University（宾夕法尼亚州立大学）
Facial aging and facial rejuvenation analyze a given face photograph to predict a future look or estimate a past look of the person. To achieve this, it is critical to preserve human identity and the corresponding aging progression and regression with high accuracy. However, existing methods cannot simultaneously handle these two objectives well. We propose a novel generative adversarial network based approach, named the Conditional Multi-Adversarial AutoEncoder with Ordinal Regression (CMAAE-OR). It utilizes an age estimation technique to control the aging accuracy and takes a high-level feat…
School of Computer Science, Harbin Institute of Technology Shenzhen（哈尔滨工业大学（深圳）计算机科学与学院）；Qianhai Financial Holdings Co., Ltd.（前海金融控股有限公司）
Automatically generating financial report from a piece of news is quite a challenging task. Apparently, the difficulty of this task lies in the lack of sufficient background knowledge to effectively generate long financial report. To address this issue, this paper proposes the conditional variational autoencoders (CVAE) based approach which distills external knowledge from a corpus of news-report data. Particularly, we choose Bi-GRU as the encoder and decoder component of CVAE, and learn the latent variable distribution from input news. A higher level latent variable distribution is learnt fro…
Lehigh University（利哈伊大学）；University of Illinois at Chicago（伊利诺伊大学芝加哥分校）；NYU Grossman School of Medicine（纽约大学格罗斯曼医学院）
Normative modeling is an emerging and promising approach to effectively study disorder heterogeneity in individual participants. In this study, we propose a novel normative modeling method by combining conditional variational autoencoder with adversarial learning (ACVAE) to identify brain dysfunction in Alzheimer's Disease (AD). Specifically, we first train a conditional VAE on the healthy control (HC) group to create a normative model conditioned on covariates like age, gender and intracranial volume. Then we incorporate an adversarial training process to construct a discriminative feature sp…
Pontifical Catholic University of Rio de Janeiro（里约热内卢天主教大学）
Non-Intrusive Load Monitoring (NILM) is a computational technique to estimate the power loads' appliance-by-appliance from the whole consumption measured by a single meter. In this paper, we propose a conditional density estimation model, based on deep neural networks, that joins a Conditional Variational Autoencoder with a Conditional Invertible Normalizing Flow model to estimate the individual appliance's power demand. The resulting model is called Prior Flow Variational Autoencoder or, for simplicity PFVAE. Thus, instead of having one model per appliance, the resulting model is responsible …
For planning of power systems and for the calibration of operational tools, it is essential to analyse system performance in a large range of representative scenarios. When the available historical data is limited, generative models are a promising solution, but modelling high-dimensional dependencies is challenging. In this paper, a multivariate load state generating model on the basis of a conditional variational autoencoder (CVAE) neural network is proposed. Going beyond common CVAE implementations, the model includes stochastic variation of output samples under given latent vectors and co-…
Indian Institute of Technology Kharagpur（印度理工学院卡拉格普尔分校）
With the rapid advancement and increased use of deep learning models in image identification, security becomes a major concern to their deployment in safety-critical systems. Since the accuracy and robustness of deep learning models are primarily attributed from the purity of the training samples, therefore the deep learning architectures are often susceptible to adversarial attacks. Adversarial attacks are often obtained by making subtle perturbations to normal images, which are mostly imperceptible to humans, but can seriously confuse the state-of-the-art machine learning models. What is so …
Institute of Digital Technologies, Loughborough University（拉夫堡大学数字技术研究所）
Synthesizing a realistic image from textual description is a major challenge in computer vision. Current text to image synthesis approaches falls short of producing a highresolution image that represent a text descriptor. Most existing studies rely either on Generative Adversarial Networks (GANs) or Variational Auto Encoders (VAEs). GANs has the capability to produce sharper images but lacks the diversity of outputs, whereas VAEs are good at producing a diverse range of outputs, but the images generated are often blurred. Taking into account the relative advantages of both GANs and VAEs, we pr…
Microsoft Search, Assistance and Intelligence（微软搜索、辅助与智能部门（Microsoft Search, Assistance and Intelligence））
We consider the problem of diversifying automated reply suggestions for a commercial instant-messaging (IM) system (Skype). Our conversation model is a standard matching based information retrieval architecture, which consists of two parallel encoders to project messages and replies into a common feature representation. During inference, we select replies from a fixed response set using nearest neighbors in the feature space. To diversify responses, we formulate the model as a generative latent variable model with Conditional Variational Auto-Encoder (M-CVAE). We propose a constrained-sampling…
Generative models and inferential autoencoders mostly make use of $\ell_2$ norm in their optimization objectives. In order to generate perceptually better images, this short paper theoretically discusses how to use Structural Similarity Index (SSIM) in generative models and inferential autoencoders. We first review SSIM, SSIM distance metrics, and SSIM kernel. We show that the SSIM kernel is a universal kernel and thus can be used in unconditional and conditional generated moment matching networks. Then, we explain how to use SSIM distance in variational and adversarial autoencoders and uncond…
University of Tartu（塔尔图大学）；University of Naples Federico II（那不勒斯费德里科二世大学）
Autonomous driving has a natural bi-level structure. The goal of the upper behavioural layer is to provide appropriate lane change, speeding up, and braking decisions to optimize a given driving task. However, this layer can only indirectly influence the driving efficiency through the lower-level trajectory planner, which takes in the behavioural inputs to produce motion commands. Existing sampling-based approaches do not fully exploit the strong coupling between the behavioural and planning layer. On the other hand, end-to-end Reinforcement Learning (RL) can learn a behavioural layer while in…
Gravitational wave (GW) detection is now commonplace and as the sensitivity of the global network of GW detectors improves, we will observe $\mathcal{O}(100)$s of transient GW events per year. The current methods used to estimate their source parameters employ optimally sensitive but computationally costly Bayesian inference approaches where typical analyses have taken between 6 hours and 5 days. For binary neutron star and neutron star black hole systems prompt counterpart electromagnetic (EM) signatures are expected on timescales of 1 second -- 1 minute and the current fastest method for ale…
Human behavior prediction models enable robots to anticipate how humans may react to their actions, and hence are instrumental to devising safe and proactive robot planning algorithms. However, modeling complex interaction dynamics and capturing the possibility of many possible outcomes in such interactive settings is very challenging, which has recently prompted the study of several different approaches. In this work, we provide a self-contained tutorial on a conditional variational autoencoder (CVAE) approach to human behavior prediction which, at its core, can produce a multimodal probabili…
Vertilas GmbH（Vertilas有限公司）；ADVA Optical Networking SE（ADVA光网络股份公司）；Kiel University (CAU)（基尔大学（克里斯蒂安-阿尔布雷希茨大学））
Semiconductor lasers have been rapidly evolving to meet the demands of next-generation optical networks. This imposes much more stringent requirements on the laser reliability, which are dominated by degradation mechanisms (e.g., sudden degradation) limiting the semiconductor laser lifetime. Physics-based approaches are often used to characterize the degradation behavior analytically, yet explicit domain knowledge and accurate mathematical models are required. Building such models can be very challenging due to a lack of a full understanding of the complex physical processes inducing the degra…
EDF R&D（法国电力集团研发部）；Laboratoire de mathématiques d’Orsay（奥赛数学实验室）；Université Paris-Sud（巴黎南大学）；CNRS（法国国家科学研究中心）；Université Paris-Saclay（巴黎萨克雷大学）；INRIA（法国国家信息与自动化研究所）；Département d’Informatique de l’École Normale Supérieure（巴黎高等师范学院计算机系）；PSL Research University（巴黎文理研究大学）；INESC Technology and Science (INESC TEC)（INESC科技与科学研究所（INESC TEC））
The implementation of efficient demand response (DR) programs for household electricity consumption would benefit from data-driven methods capable of simulating the impact of different tariffs schemes. This paper proposes a novel method based on conditional variational autoencoders (CVAE) to generate, from an electricity tariff profile combined with exogenous weather and calendar variables, daily consumption profiles of consumers segmented in different clusters. First, a large set of consumers is gathered into clusters according to their consumption behavior and price-responsiveness. The clust…
DeNA Co., Ltd.（DeNA有限公司）；University of Tokyo（东京大学）；The University of Electro-Communications（电气通信大学）
Variational autoencoder-based voice conversion (VAE-VC) has the advantage of requiring only pairs of speeches and speaker labels for training. Unlike the majority of the research in VAE-VC which focuses on utilizing auxiliary losses or discretizing latent variables, this paper investigates how an increasing model expressiveness has benefits and impacts on the VAE-VC. Specifically, we first analyze VAE-VC from a rate-distortion perspective, and point out that model expressiveness is significant for VAE-VC because rate and distortion reflect similarity and naturalness of converted speeches. Base…
The application of deep learning to generative molecule design has shown early promise for accelerating lead series development. However, questions remain concerning how factors like training, dataset, and seed bias impact the technology's utility to medicine and computational chemists. In this work, we analyze the impact of seed and training bias on the output of an activity-conditioned graph-based variational autoencoder (VAE). Leveraging a massive, labeled dataset corresponding to the dopamine D2 receptor, our graph-based generative model is shown to excel in producing desired conditioned a…
The University of Hull（赫尔大学）；University of Sunderland（桑德兰大学）
Forecasting short-term motion of nearby vehicles presents an inherently challenging issue as the space of their possible future movements is not strictly limited to a set of single trajectories. Recently proposed techniques that demonstrate plausible results concentrate primarily on forecasting a fixed number of deterministic predictions, or on classifying over a wide variety of trajectories that were previously generated using e.g. dynamic model. This paper focuses on addressing the uncertainty associated with the discussed task by utilising the stochastic nature of generative models in order…
Univariate Conditional Variational Autoencoder for Morphogenic Patterns Design in Frontal Polymerization-Based Manufacturing
National Center for Supercomputing Applications, University of Illinois Urbana–Champaign（伊利诺伊大学厄巴纳-香槟分校国家超级计算应用中心）；Beckman Institute for Advanced Science and Technology, University of Illinois Urbana–Champaign（伊利诺伊大学厄巴纳-香槟分校贝克曼先进科学技术研究所）；Grainger College of Engineering, University of Illinois Urbana–Champaign（伊利诺伊大学厄巴纳-香槟分校格兰杰工程学院）；New York University Abu Dhabi（纽约大学阿布扎比分校）；Kansas State University（堪萨斯州立大学）；Massachusetts Institute of Technology（麻省理工学院）
We address the problem of one-to-many mappings in supervised learning, where a single instance has many different solutions of possibly equal cost. The framework of conditional variational autoencoders describes a class of methods to tackle such structured-prediction tasks by means of latent variables. We propose to incentivise informative latent representations for increasing the generalisation capacity of conditional variational autoencoders. To this end, we modify the latent variable model by defining the likelihood as a function of the latent variable only and introduce an expressive multi…
