In this study, we examine the representation learning abilities of Denoising Diffusion Models (DDM) that were originally purposed for image generation. Our philosophy is to deconstruct a DDM, gradually transforming it into a classical Denoising Autoencoder (DAE). This deconstructive procedure allows us to explore how various components of modern DDMs influence self-supervised representation learning. We observe that only a very few modern components are critical for learning good representations, while many others are nonessential. Our study ultimately arrives at an approach that is highly simplified and to a large extent resembles a classical DAE. We hope our study will rekindle interest in a family of classical methods within the realm of modern self-supervised learning.
Magnetic resonance imaging (MRI) is a common and life-saving medical imaging technique. However, acquiring high signal-to-noise ratio MRI scans requires long scan times, resulting in increased costs and patient discomfort, and decreased throughput. Thus, there is great interest in denoising MRI scans, especially for the subtype of diffusion MRI scans that are severely SNR-limited. While most prior MRI denoising methods are supervised in nature, acquiring supervised training datasets for the multitude of anatomies, MRI scanners, and scan parameters proves impractical. Here, we propose Denoising…
Indiana University Bloomington（印第安纳大学伯明顿分校）；CZ Biohub（CZ生物中心）
Diffusion-weighted magnetic resonance imaging (DWI) is the only noninvasive method for quantifying microstructure and reconstructing white-matter pathways in the living human brain. Fluctuations from multiple sources create significant additive noise in DWI data which must be suppressed before subsequent microstructure analysis. We introduce a self-supervised learning method for denoising DWI data, Patch2Self, which uses the entire volume to learn a full-rank locally linear denoiser for that volume. By taking advantage of the oversampled q-space of DWI data, Patch2Self can separate structure f…
Self-supervised Deep Unrolled Reconstruction Using Regularization by Denoising
State University of New York at Buffalo（纽约州立大学布法罗分校）；Cleveland Clinic（克利夫兰诊所）；Paul C. Lauterbur Research Center for Biomedical Imaging, SIAT, CAS（中国科学院深圳先进技术研究院保罗·C·劳特伯生物医学成像研究中心）
Investigating Self-Supervised Image Denoising with Denaturation
Institute of Science Tokyo（东京科学研究所）；Fujitsu Limited（富士通有限公司）；RIKEN Center for Computational Science（理化学研究所计算科学中心）；RIKEN Center for Advanced Intelligence Project（理化学研究所先进智能项目中心）
With the advent of advances in self-supervised learning, paired clean-noisy data are no longer required in deep learning-based image denoising. However, existing blind denoising methods still require the assumption with regard to noise characteristics, such as zero-mean noise distribution and pixel-wise noise-signal independence; this hinders wide adaptation of the method in the medical domain. On the other hand, unpaired learning can overcome limitations related to the assumption on noise characteristics, which makes it more feasible for collecting the training data in real-world scenarios. I…
This paper presents an open and comprehensive framework to systematically evaluate state-of-the-art contributions to self-supervised monocular depth estimation. This includes pretraining, backbone, architectural design choices and loss functions. Many papers in this field claim novelty in either architecture design or loss formulation. However, simply updating the backbone of historical systems results in relative improvements of 25%, allowing them to outperform the majority of existing systems. A systematic evaluation of papers in this field was not straightforward. The need to compare like-w…
Self-Supervised Noise2Noise-Enhanced Denoising for Continuous-Scan Air-Plasma THz Spectroscopy
Institute of Digital Communication Systems, Ruhr University Bochum（鲁尔大学波鸿分校数字通信系统研究所）；Photonics and Ultrafast Laser Science, Ruhr University Bochum（鲁尔大学波鸿分校光子学与超快激光科学研究所）
Self-Conditioned Denoising for Atomistic Representation Learning
Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, 02139, MA, USA（麻省理工学院化学系）；Department of Materials Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, 02139, MA, USA（麻省理工学院材料科学与工程系）
Self-supervised frameworks that learn denoising models with merely individual noisy images have shown strong capability and promising performance in various image denoising tasks. Existing self-supervised denoising frameworks are mostly built upon the same theoretical foundation, where the denoising models are required to be J-invariant. However, our analyses indicate that the current theory and the J-invariance may lead to denoising models with reduced performance. In this work, we introduce Noise2Same, a novel self-supervised denoising framework. In Noise2Same, a new self-supervised loss is …
Optical Coherence Tomography (OCT) is pervasive in both the research and clinical practice of Ophthalmology. However, OCT images are strongly corrupted by noise, limiting their interpretation. Current OCT denoisers leverage assumptions on noise distributions or generate targets for training deep supervised denoisers via averaging of repeat acquisitions. However, recent self-supervised advances allow the training of deep denoising networks using only repeat acquisitions without clean targets as ground truth, reducing the burden of supervised learning. Despite the clear advantages of self-superv…
Hanyang University（汉阳大学）；Chungnam National University（忠南国立大学）；SK T-Brain
Under certain statistical assumptions of noise, recent self-supervised approaches for denoising have been introduced to learn network parameters without true clean images, and these methods can restore an image by exploiting information available from the given input (i.e., internal statistics) at test time. However, self-supervised methods are not yet combined with conventional supervised denoising methods which train the denoising networks with a large number of external training samples. Thus, we propose a new denoising approach that can greatly outperform the state-of-the-art supervised de…
Self2Seg: Single-Image Self-Supervised Joint Segmentation and Denoising
University of Innsbruck（因斯布鲁克大学）；VASCage-Research Centre on Vascular Ageing and Stroke（VASCage血管衰老与中风研究中心）；MRC Laboratory of Molecular Biology（医学研究委员会分子生物学实验室）；Institut Pascal（帕斯卡尔研究所）；Université Clermont Auvergne（克莱蒙奥弗涅大学）；Institut de Mathématiques de Bordeaux（波尔多数学研究所）
Sungkyunkwan University（成均馆大学）；Ulsan National Institute of Science and Technology（蔚山科学技术院）；Shanghai Jiao Tong University（上海交通大学）；Seoul National University（首尔国立大学）
Regression that predicts continuous quantity is a central part of applications using computational imaging and computer vision technologies. Yet, studying and understanding self-supervised learning for regression tasks - except for a particular regression task, image denoising - have lagged behind. This paper proposes a general self-supervised regression learning (SSRL) framework that enables learning regression neural networks with only input data (but without ground-truth target data), by using a designable pseudo-predictor that encapsulates domain knowledge of a specific application. The pa…
California Polytechnic State University（加州州立理工大学）；University of Georgia（佐治亚大学）；Providence College（普罗维登斯学院）；University of Colorado Colorado Springs（科罗拉多大学科罗拉多斯普林斯分校）
We extend the blindspot model for self-supervised denoising to handle Poisson-Gaussian noise and introduce an improved training scheme that avoids hyperparameters and adapts the denoiser to the test data. Self-supervised models for denoising learn to denoise from only noisy data and do not require corresponding clean images, which are difficult or impossible to acquire in some application areas of interest such as low-light microscopy. We introduce a new training strategy to handle Poisson-Gaussian noise which is the standard noise model for microscope images. Our new strategy eliminates hyper…
Korea Advanced Institute of Science and Technology (KAIST)（韩国科学技术院）
Tweedie distributions are a special case of exponential dispersion models, which are often used in classical statistics as distributions for generalized linear models. Here, we reveal that Tweedie distributions also play key roles in modern deep learning era, leading to a distribution independent self-supervised image denoising formula without clean reference images. Specifically, by combining with the recent Noise2Score self-supervised image denoising approach and the saddle point approximation of Tweedie distribution, we can provide a general closed-form denoising formula that can be used fo…
Positive2Negative: Breaking the Information-Lossy Barrier in Self-Supervised Single Image Denoising
School of Computer Science and Technology, Beijing Institute of Technology（北京理工大学计算机科学与技术学院）；School of Artificial Intelligence, Beijing Normal University（北京师范大学人工智能学院）；Aerospace Information Research Institute, Chinese Academy of Sciences（中国科学院空天信息创新研究院）
Recently, Self-supervised learning methods able to perform image denoising without ground truth labels have been proposed. These methods create low-quality images by adding random or Gaussian noise to images and then train a model for denoising. Ideally, it would be beneficial if one can generate high-quality CT images with only a few training samples via self-supervision. However, the performance of CT denoising is generally limited due to the complexity of CT noise. To address this problem, we propose a novel self-supervised learning-based CT denoising method. In particular, we train pre-tra…
Image denoising is of great importance for medical imaging system, since it can improve image quality for disease diagnosis and downstream image analyses. In a variety of applications, dynamic imaging techniques are utilized to capture the time-varying features of the subject, where multiple images are acquired for the same subject at different time points. Although signal-to-noise ratio of each time frame is usually limited by the short acquisition time, the correlation among different time frames can be exploited to improve denoising results with shared information across time frames. With t…
The Chinese University of Hong Kong（香港中文大学）；SenseTime Research（商汤科技研究院）
The lack of large-scale noisy-clean image pairs restricts supervised denoising methods' deployment in actual applications. While existing unsupervised methods are able to learn image denoising without ground-truth clean images, they either show poor performance or work under impractical settings (e.g., paired noisy images). In this paper, we present a practical unsupervised image denoising method to achieve state-of-the-art denoising performance. Our method only requires single noisy images and a noise model, which is easily accessible in practical raw image denoising. It performs two steps it…
Recently, significant progress has been made on image denoising with strong supervision from large-scale datasets. However, obtaining well-aligned noisy-clean training image pairs for each specific scenario is complicated and costly in practice. Consequently, applying a conventional supervised denoising network on in-the-wild noisy inputs is not straightforward. Although several studies have challenged this problem without strong supervision, they rely on less practical assumptions and cannot be applied to practical situations directly. To address the aforementioned challenges, we propose a no…
Institute of Automation, Chinese Academy of Sciences（中国科学院自动化研究所）；School of Artificial Intelligence, University of Chinese Academy of Sciences（中国科学院大学人工智能学院）；School of Future Technology, University of Chinese Academy of Sciences（中国科学院大学未来技术学院）
Self-supervised blind denoising for Poisson-Gaussian noise remains a challenging task. Pseudo-supervised pairs constructed from single noisy images re-corrupt the signal and degrade the performance. The visible blindspots solve the information loss in masked inputs. However, without explicitly noise sensing, mean square error as an objective function cannot adjust denoising intensities for dynamic noise levels, leading to noticeable residual noise. In this paper, we propose Blind2Sound, a simple yet effective approach to overcome residual noise in denoised images. The proposed adaptive re-visi…
Center for Systems Biology Dresden (CSBD)（德累斯顿系统生物学中心）；Max-Planck Institute of Molecular Cell Biology and Genetics（马克斯·普朗克分子细胞生物学与遗传学研究所）
Deep learning (DL) has arguably emerged as the method of choice for the detection and segmentation of biological structures in microscopy images. However, DL typically needs copious amounts of annotated training data that is for biomedical projects typically not available and excessively expensive to generate. Additionally, tasks become harder in the presence of noise, requiring even more high-quality training data. Hence, we propose to use denoising networks to improve the performance of other DL-based image segmentation methods. More specifically, we present ideas on how state-of-the-art sel…
We propose a self-supervised approach for training multi-frame video denoising networks. These networks predict frame t from a window of frames around t. Our self-supervised approach benefits from the video temporal consistency by penalizing a loss between the predicted frame t and a neighboring target frame, which are aligned using an optical flow. We use the proposed strategy for online internal learning, where a pre-trained network is fine-tuned to denoise a new unknown noise type from a single video. After a few frames, the proposed fine-tuning reaches and sometimes surpasses the performan…
Rochester Institute of Technology（罗切斯特理工学院）；Chosun University（朝鲜大学）
Unpaired image denoising has achieved promising development over the last few years. Regardless of the performance, methods tend to heavily rely on underlying noise properties or any assumption which is not always practical. Alternatively, if we can ground the problem from a structural perspective rather than noise statistics, we can achieve a more robust solution. with such motivation, we propose a self-supervised denoising scheme that is unpaired and relies on spatial degradation followed by a regularized refinement. Our method shows considerable improvement over previous methods and exhibit…
Reinforced Label Denoising for Weakly-Supervised Audio-Visual Video Parsing
Shandong University（山东大学）；Qilu University of Technology (Shandong Academy of Sciences)（齐鲁工业大学（山东省科学院））；Shandong Computer Science Center (National Supercomputer Center in Jinan)（山东省计算中心（国家超级计算济南中心））
SwinIA: Self-Supervised Blind-Spot Image Denoising without Convolutions
Institute of Computer Science, University of Tartu（塔尔图大学计算机科学学院）；CAIRO, Technical University of Applied Sciences Würzburg-Schweinfurt（维尔茨堡-施韦因富特应用技术大学CAIRO机构）
Low-dose computed tomography (LDCT) became a clear trend in radiology with an aspiration to refrain from delivering excessive X-ray radiation to the patients. The reduction of the radiation dose decreases the risks to the patients but raises the noise level, affecting the quality of the images and their ultimate diagnostic value. One mitigation option is to consider pairs of low-dose and high-dose CT projections to train a denoising model using deep learning algorithms; however, such pairs are rarely available in practice. In this paper, we present a new self-supervised method for CT denoising…
In recent years, the supervised learning strategy for real noisy image denoising has been emerging and has achieved promising results. In contrast, realistic noise removal for raw noisy videos is rarely studied due to the lack of noisy-clean pairs for dynamic scenes. Clean video frames for dynamic scenes cannot be captured with a long-exposure shutter or averaging multi-shots as was done for static images. In this paper, we solve this problem by creating motions for controllable objects, such as toys, and capturing each static moment for multiple times to generate clean video frames. In this w…
Blind-spot network (BSN) and its variants have made significant advances in self-supervised denoising. Nevertheless, they are still bound to synthetic noisy inputs due to less practical assumptions like pixel-wise independent noise. Hence, it is challenging to deal with spatially correlated real-world noise using self-supervised BSN. Recently, pixel-shuffle downsampling (PD) has been proposed to remove the spatial correlation of real-world noise. However, it is not trivial to integrate PD and BSN directly, which prevents the fully self-supervised denoising model on real-world images. We propos…
FAU Erlangen-Nürnberg（埃尔朗根-纽伦堡大学）；Siemens Healthcare GmbH（西门子医疗有限公司）；Fraunhofer Institute for Ceramic Technologies and Systems IKTS（弗劳恩霍夫陶瓷技术与系统研究所IKTS）；Ewha Womans University（梨花女子大学）
Self-supervised image denoising techniques emerged as convenient methods that allow training denoising models without requiring ground-truth noise-free data. Existing methods usually optimize loss metrics that are calculated from multiple noisy realizations of similar images, e.g., from neighboring tomographic slices. However, those approaches fail to utilize the multiple contrasts that are routinely acquired in medical imaging modalities like MRI or dual-energy CT. In this work, we propose the new self-supervised training scheme Noise2Contrast that combines information from multiple measured …
Korea Advanced Institute of Science and Technology (KAIST)（韩国科学技术院）；Kim Jaechul Graduate School of AI（金在哲人工智能研究生院）
Recently, there has been extensive research interest in training deep networks to denoise images without clean reference. However, the representative approaches such as Noise2Noise, Noise2Void, Stein's unbiased risk estimator (SURE), etc. seem to differ from one another and it is difficult to find the coherent mathematical structure. To address this, here we present a novel approach, called Noise2Score, which reveals a missing link in order to unite these seemingly different approaches. Specifically, we show that image denoising problems without clean images can be addressed by finding the mod…
McGill University（麦吉尔大学）；The Chinese University of Hong Kong, Shenzhen（香港中文大学（深圳））；Shenzhen Institute of Artificial Intelligence and Robotics for Society（深圳人工智能与机器人研究院）
In recent years, self-supervised denoising methods have shown impressive performance, which circumvent painstaking collection procedure of noisy-clean image pairs in supervised denoising methods and boost denoising applicability in real world. One of well-known self-supervised denoising strategies is the blind-spot training scheme. However, a few works attempt to improve blind-spot based self-denoiser in the aspect of network architecture. In this paper, we take an intuitive view of blind-spot strategy and consider its process of using neighbor pixels to predict manipulated pixels as an inpain…
Fluorescence microscopy is a key driver to promote discoveries of biomedical research. However, with the limitation of microscope hardware and characteristics of the observed samples, the fluorescence microscopy images are susceptible to noise. Recently, a few self-supervised deep learning (DL) denoising methods have been proposed. However, the training efficiency and denoising performance of existing methods are relatively low in real scene noise removal. To address this issue, this paper proposed self-supervised image denoising method Noise2SR (N2SR) to train a simple and effective image den…
Although the advances of self-supervised blind denoising are significantly superior to conventional approaches without clean supervision in synthetic noise scenarios, it shows poor quality in real-world images due to spatially correlated noise corruption. Recently, pixel-shuffle downsampling (PD) has been proposed to eliminate the spatial correlation of noise. A study combining a blind spot network (BSN) and asymmetric PD (AP) successfully demonstrated that self-supervised blind denoising is applicable to real-world noisy images. However, PD-based inference may degrade texture details in the t…
Centrum Wiskunde & Informatica（荷兰国家数学与计算机科学研究中心）；Leiden Institute of Advanced Computer Science, Leiden Universiteit（莱顿大学高级计算机科学研究所）
Recovering a high-quality image from noisy indirect measurements is an important problem with many applications. For such inverse problems, supervised deep convolutional neural network (CNN)-based denoising methods have shown strong results, but the success of these supervised methods critically depends on the availability of a high-quality training dataset of similar measurements. For image denoising, methods are available that enable training without a separate training dataset by assuming that the noise in two different pixels is uncorrelated. However, this assumption does not hold for inve…
