Deep image prior (DIP) has been successfully applied to positron emission tomography (PET) image restoration, enabling represent implicit prior using only convolutional neural network architecture without training dataset, whereas the general supervised approach requires massive low- and high-quality PET image pairs. To answer the increased need for PET imaging with DIP, it is indispensable to improve the performance of the underlying DIP itself. Here, we propose a self-supervised pre-training model to improve the DIP-based PET image denoising performance. Our proposed pre-training model acquires transferable and generalizable visual representations from only unlabeled PET images by restoring various degraded PET images in a self-supervised approach. We evaluated the proposed method using clinical brain PET data with various radioactive tracers ($^{18}$F-florbetapir, $^{11}$C-Pittsburgh compound-B, $^{18}$F-fluoro-2-deoxy-D-glucose, and $^{15}$O-CO$_{2}$) acquired from different PET scanners. The proposed method using the self-supervised pre-training model achieved robust and state-of-the-art denoising performance while retaining spatial details and quantification accuracy compared to other unsupervised methods and pre-training model. These results highlight the potential that the proposed method is particularly effective against rare diseases and probes and helps reduce the scan time or the radiotracer dose without affecting the patients.
Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School（哈佛医学院麻省总医院戈登医学成像中心）；Center for Advanced Medical Computing and Analysis, Massachusetts General Hospital, Harvard Medical School（哈佛医学院麻省总医院高级医学计算与分析中心）；University of Texas MD Anderson Cancer Center（德克萨斯大学MD安德森癌症中心）
Due to various physical degradation factors and limited counts received, PET image quality needs further improvements. The denoising diffusion probabilistic models (DDPM) are distribution learning-based models, which try to transform a normal distribution into a specific data distribution based on iterative refinements. In this work, we proposed and evaluated different DDPM-based methods for PET image denoising. Under the DDPM framework, one way to perform PET image denoising is to provide the PET image and/or the prior image as the network input. Another way is to supply the prior image as th…
Hamamatsu Photonics K. K.（滨松光子学株式会社）；Hamamatsu University School of Medicine（滨松医科大学）
Although supervised convolutional neural networks (CNNs) often outperform conventional alternatives for denoising positron emission tomography (PET) images, they require many low- and high-quality reference PET image pairs. Herein, we propose an unsupervised 3D PET image denoising method based on an anatomical information-guided attention mechanism. The proposed magnetic resonance-guided deep decoder (MR-GDD) utilizes the spatial details and semantic features of MR-guidance image more effectively by introducing encoder-decoder and deep decoder subnetworks. Moreover, the specific shapes and pat…
Center of Advanced Medical Computing and Analysis, MGH/HMS（麻省总医院/哈佛医学院高级医学计算与分析中心）；Johns Hopkins University（约翰斯·霍普金斯大学）；GE Healthcare（通用电气医疗）；University of Bern（伯尔尼大学）
In PET, the amount of relative (signal-dependent) noise present in different body regions can be significantly different and is inherently related to the number of counts present in that region. The number of counts in a region depends, in principle and among other factors, on the total administered activity, scanner sensitivity, image acquisition duration, radiopharmaceutical tracer uptake in the region, and patient local body morphometry surrounding the region. In theory, less amount of denoising operations is needed to denoise a high-count (low relative noise) image than images a low-count …
This paper evaluates the performance of supervised and unsupervised deep learning models for denoising positron emission tomography (PET) images in the presence of reduced acquisition times. Our experiments consider 212 studies (56908 images), and evaluate the models using 2D (RMSE, SSIM) and 3D (SUVpeak and SUVmax error for the regions of interest) metrics. It was shown that, in contrast to previous studies, supervised models (ResNet, Unet, SwinIR) outperform unsupervised models (pix2pix GAN and CycleGAN with ResNet backbone and various auxiliary losses) in the reconstruction of 2D PET images…
Low-resolution and signal-dependent noise distribution in positron emission tomography (PET) images makes denoising process an inevitable step prior to qualitative and quantitative image analysis tasks. Conventional PET denoising methods either over-smooth small-sized structures due to resolution limitation or make incorrect assumptions about the noise characteristics. Therefore, clinically important quantitative information may be corrupted. To address these challenges, we introduced a novel approach to remove signal-dependent noise in the PET images where the noise distribution was considere…
UniPET: a universal network for high-quality PET image denoising across varied dose reduction factors
School of Biological Science and Medical Engineering（生物科学与医学工程学院）；State Key Laboratory of Software Development Environment（软件开发环境国家重点实验室）；Key Laboratory of Biomechanics, Mechanobiology of Ministry of Education（教育部生物力学与机械生物学重点实验室）；Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University（北京生物医学工程先进创新中心，北航）；Department of Biomedical Engineering（生物医学工程系）；Department of Gynecology Oncology（妇科肿瘤科）；National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital（国家癌症中心/国家癌症临床研究中心/癌症医院）；Chinese Academy of Medical Sciences（中国医学科学院）；Peking Union Medical College（北京协和医学院）；Xiaomi Corporation（小米公司）
Self-supervised frameworks that learn denoising models with merely individual noisy images have shown strong capability and promising performance in various image denoising tasks. Existing self-supervised denoising frameworks are mostly built upon the same theoretical foundation, where the denoising models are required to be J-invariant. However, our analyses indicate that the current theory and the J-invariance may lead to denoising models with reduced performance. In this work, we introduce Noise2Same, a novel self-supervised denoising framework. In Noise2Same, a new self-supervised loss is …
Exploiting network optimization stability for enhanced PET image denoising using deep image prior
Central Research Laboratory, Hamamatsu Photonics K. K.（滨松光子学株式会社中央研究所）；Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST)（国立量子科学技术研究开发机构量子医学科学研究所）；J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida（佛罗里达大学J. Crayton Pruitt家族生物医学工程系）
Cycle-Constrained Adversarial Denoising Convolutional Network for PET Image Denoising: Multi-Dimensional Validation on Large Datasets with Reader Study and Real Low-Dose Data
A Kernel Space-based Multidimensional Sparse Model for Dynamic PET Image Denoising
Zhejiang Polytechnic University of Mechanical and Electrical Engineering（浙江机电职业技术学院）；Institute of Artificial Intelligence, Hefei Comprehensive National Science Center（合肥国家综合科学中心人工智能研究院）；School of Electrical and Optical Engineering（南京理工大学电气与光学工程学院）；Zhejiang Lab（浙江实验室）；School of Intelligent Science and Technology（智能科学与技术学院）；Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences（杭州高等研究院，中国科学院大学）；Biomedical Imaging Laboratory (BIG), Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau（澳门大学生物医学成像实验室）；College of Optical Science and Engineering（光学工程学院）；College of Biomedical Engineering and Instrument Science（生物医学工程与仪器科学学院）
U-TTT: Towards Generalizable PET Image Denoising via Test-Time Training
School of Biological Science and Medical Engineering, Beihang University（北京航空航天大学生物科学与医学工程学院）；Department of Biomedical Engineering, Tsinghua University（清华大学生物医学工程系）；School of Aerospace Engineering, Tsinghua University（清华大学航天航空学院）；ByteDance Inc.（字节跳动有限公司）
Center for Advanced Medical Computing and Analysis（高级医学计算与分析中心）；Gordon Center for Medical Imaging（戈登医学成像中心）；Massachusetts General Hospital（麻省总医院）；Harvard Medical School（哈佛医学院）
Dynamic computed tomography perfusion (CTP) imaging is a promising approach for acute ischemic stroke diagnosis and evaluation. Hemodynamic parametric maps of cerebral parenchyma are calculated from repeated CT scans of the first pass of iodinated contrast through the brain. It is necessary to reduce the dose of CTP for routine applications due to the high radiation exposure from the repeated scans, where image denoising is necessary to achieve a reliable diagnosis. In this paper, we proposed a self-supervised deep learning method for CTP denoising, which did not require any high-dose referenc…
Sungkyunkwan University（成均馆大学）；Ulsan National Institute of Science and Technology（蔚山科学技术院）；Shanghai Jiao Tong University（上海交通大学）；Seoul National University（首尔国立大学）
Regression that predicts continuous quantity is a central part of applications using computational imaging and computer vision technologies. Yet, studying and understanding self-supervised learning for regression tasks - except for a particular regression task, image denoising - have lagged behind. This paper proposes a general self-supervised regression learning (SSRL) framework that enables learning regression neural networks with only input data (but without ground-truth target data), by using a designable pseudo-predictor that encapsulates domain knowledge of a specific application. The pa…
California Polytechnic State University（加州州立理工大学）；University of Georgia（佐治亚大学）；Providence College（普罗维登斯学院）；University of Colorado Colorado Springs（科罗拉多大学科罗拉多斯普林斯分校）
We extend the blindspot model for self-supervised denoising to handle Poisson-Gaussian noise and introduce an improved training scheme that avoids hyperparameters and adapts the denoiser to the test data. Self-supervised models for denoising learn to denoise from only noisy data and do not require corresponding clean images, which are difficult or impossible to acquire in some application areas of interest such as low-light microscopy. We introduce a new training strategy to handle Poisson-Gaussian noise which is the standard noise model for microscope images. Our new strategy eliminates hyper…
Korea Advanced Institute of Science and Technology (KAIST)（韩国科学技术院）
Tweedie distributions are a special case of exponential dispersion models, which are often used in classical statistics as distributions for generalized linear models. Here, we reveal that Tweedie distributions also play key roles in modern deep learning era, leading to a distribution independent self-supervised image denoising formula without clean reference images. Specifically, by combining with the recent Noise2Score self-supervised image denoising approach and the saddle point approximation of Tweedie distribution, we can provide a general closed-form denoising formula that can be used fo…
Recently, Self-supervised learning methods able to perform image denoising without ground truth labels have been proposed. These methods create low-quality images by adding random or Gaussian noise to images and then train a model for denoising. Ideally, it would be beneficial if one can generate high-quality CT images with only a few training samples via self-supervision. However, the performance of CT denoising is generally limited due to the complexity of CT noise. To address this problem, we propose a novel self-supervised learning-based CT denoising method. In particular, we train pre-tra…
We propose a new grayscale image denoiser, dubbed as Neural Affine Image Denoiser (Neural AIDE), which utilizes neural network in a novel way. Unlike other neural network based image denoising methods, which typically apply simple supervised learning to learn a mapping from a noisy patch to a clean patch, we formulate to train a neural network to learn an \emph{affine} mapping that gets applied to a noisy pixel, based on its context. Our formulation enables both supervised training of the network from the labeled training dataset and adaptive fine-tuning of the network parameters using the giv…
Positive2Negative: Breaking the Information-Lossy Barrier in Self-Supervised Single Image Denoising
School of Computer Science and Technology, Beijing Institute of Technology（北京理工大学计算机科学与技术学院）；School of Artificial Intelligence, Beijing Normal University（北京师范大学人工智能学院）；Aerospace Information Research Institute, Chinese Academy of Sciences（中国科学院空天信息创新研究院）
Rochester Institute of Technology（罗切斯特理工学院）；Chosun University（朝鲜大学）
Unpaired image denoising has achieved promising development over the last few years. Regardless of the performance, methods tend to heavily rely on underlying noise properties or any assumption which is not always practical. Alternatively, if we can ground the problem from a structural perspective rather than noise statistics, we can achieve a more robust solution. with such motivation, we propose a self-supervised denoising scheme that is unpaired and relies on spatial degradation followed by a regularized refinement. Our method shows considerable improvement over previous methods and exhibit…
Spach Transformer: Spatial and Channel-wise Transformer Based on Local and Global Self-attentions for PET Image Denoising
Gordon Center for Medical Imaging（戈登医学影像中心）；Center for Advanced Medical Computing and Analysis（高级医学计算与分析中心）；Massachusetts General Hospital（麻省总医院）；Harvard Medical School（哈佛医学院）；University of Florida（佛罗里达大学）；University of Texas MD Anderson Cancer Center（德克萨斯大学MD安德森癌症中心）；Johns Hopkins University（约翰斯·霍普金斯大学）
针对 PET 图像噪声及三维全局自注意力计算成本高的问题，提出融合局部与全局 MSA 的空间通道编解码 Transformer，并在多示踪剂数据集上验证其去噪性能优于现有深度学习架构。
The Chinese University of Hong Kong（香港中文大学）；SenseTime Research（商汤科技研究院）
The lack of large-scale noisy-clean image pairs restricts supervised denoising methods' deployment in actual applications. While existing unsupervised methods are able to learn image denoising without ground-truth clean images, they either show poor performance or work under impractical settings (e.g., paired noisy images). In this paper, we present a practical unsupervised image denoising method to achieve state-of-the-art denoising performance. Our method only requires single noisy images and a noise model, which is easily accessible in practical raw image denoising. It performs two steps it…
Recently, significant progress has been made on image denoising with strong supervision from large-scale datasets. However, obtaining well-aligned noisy-clean training image pairs for each specific scenario is complicated and costly in practice. Consequently, applying a conventional supervised denoising network on in-the-wild noisy inputs is not straightforward. Although several studies have challenged this problem without strong supervision, they rely on less practical assumptions and cannot be applied to practical situations directly. To address the aforementioned challenges, we propose a no…
Institute of Automation, Chinese Academy of Sciences（中国科学院自动化研究所）；School of Artificial Intelligence, University of Chinese Academy of Sciences（中国科学院大学人工智能学院）；School of Future Technology, University of Chinese Academy of Sciences（中国科学院大学未来技术学院）
Self-supervised blind denoising for Poisson-Gaussian noise remains a challenging task. Pseudo-supervised pairs constructed from single noisy images re-corrupt the signal and degrade the performance. The visible blindspots solve the information loss in masked inputs. However, without explicitly noise sensing, mean square error as an objective function cannot adjust denoising intensities for dynamic noise levels, leading to noticeable residual noise. In this paper, we propose Blind2Sound, a simple yet effective approach to overcome residual noise in denoised images. The proposed adaptive re-visi…
FAU Erlangen-Nürnberg（埃尔朗根-纽伦堡大学）；Siemens Healthcare GmbH（西门子医疗有限公司）；Fraunhofer Institute for Ceramic Technologies and Systems IKTS（弗劳恩霍夫陶瓷技术与系统研究所IKTS）；Ewha Womans University（梨花女子大学）
Self-supervised image denoising techniques emerged as convenient methods that allow training denoising models without requiring ground-truth noise-free data. Existing methods usually optimize loss metrics that are calculated from multiple noisy realizations of similar images, e.g., from neighboring tomographic slices. However, those approaches fail to utilize the multiple contrasts that are routinely acquired in medical imaging modalities like MRI or dual-energy CT. In this work, we propose the new self-supervised training scheme Noise2Contrast that combines information from multiple measured …
Investigating Self-Supervised Image Denoising with Denaturation
Institute of Science Tokyo（东京科学研究所）；Fujitsu Limited（富士通有限公司）；RIKEN Center for Computational Science（理化学研究所计算科学中心）；RIKEN Center for Advanced Intelligence Project（理化学研究所先进智能项目中心）
SwinIA: Self-Supervised Blind-Spot Image Denoising without Convolutions
Institute of Computer Science, University of Tartu（塔尔图大学计算机科学学院）；CAIRO, Technical University of Applied Sciences Würzburg-Schweinfurt（维尔茨堡-施韦因富特应用技术大学CAIRO机构）
Centrum Wiskunde & Informatica（荷兰国家数学与计算机科学研究中心）；Leiden Institute of Advanced Computer Science, Leiden Universiteit（莱顿大学高级计算机科学研究所）
Recovering a high-quality image from noisy indirect measurements is an important problem with many applications. For such inverse problems, supervised deep convolutional neural network (CNN)-based denoising methods have shown strong results, but the success of these supervised methods critically depends on the availability of a high-quality training dataset of similar measurements. For image denoising, methods are available that enable training without a separate training dataset by assuming that the noise in two different pixels is uncorrelated. However, this assumption does not hold for inve…
In recent years, the supervised learning strategy for real noisy image denoising has been emerging and has achieved promising results. In contrast, realistic noise removal for raw noisy videos is rarely studied due to the lack of noisy-clean pairs for dynamic scenes. Clean video frames for dynamic scenes cannot be captured with a long-exposure shutter or averaging multi-shots as was done for static images. In this paper, we solve this problem by creating motions for controllable objects, such as toys, and capturing each static moment for multiple times to generate clean video frames. In this w…
Korea Advanced Institute of Science and Technology (KAIST)（韩国科学技术院）；Kim Jaechul Graduate School of AI（金在哲人工智能研究生院）
Recently, there has been extensive research interest in training deep networks to denoise images without clean reference. However, the representative approaches such as Noise2Noise, Noise2Void, Stein's unbiased risk estimator (SURE), etc. seem to differ from one another and it is difficult to find the coherent mathematical structure. To address this, here we present a novel approach, called Noise2Score, which reveals a missing link in order to unite these seemingly different approaches. Specifically, we show that image denoising problems without clean images can be addressed by finding the mod…
Renmin University of China（中国人民大学）；Dalian University of Technology（大连理工大学）
In the last few years, image denoising has benefited a lot from the fast development of neural networks. However, the requirement of large amounts of noisy-clean image pairs for supervision limits the wide use of these models. Although there have been a few attempts in training an image denoising model with only single noisy images, existing self-supervised denoising approaches suffer from inefficient network training, loss of useful information, or dependence on noise modeling. In this paper, we present a very simple yet effective method named Neighbor2Neighbor to train an effective image den…
With the advent of recent advances in unsupervised learning, efficient training of a deep network for image denoising without pairs of noisy and clean images has become feasible. However, most current unsupervised denoising methods are built on the assumption of zero-mean noise under the signal-independent condition. This assumption causes blind denoising techniques to suffer brightness shifting problems on images that are greatly corrupted by extreme noise such as salt-and-pepper noise. Moreover, most blind denoising methods require a random masking scheme for training to ensure the invarianc…
Fluorescence microscopy is a key driver to promote discoveries of biomedical research. However, with the limitation of microscope hardware and characteristics of the observed samples, the fluorescence microscopy images are susceptible to noise. Recently, a few self-supervised deep learning (DL) denoising methods have been proposed. However, the training efficiency and denoising performance of existing methods are relatively low in real scene noise removal. To address this issue, this paper proposed self-supervised image denoising method Noise2SR (N2SR) to train a simple and effective image den…
Supervised neural networks are known to achieve excellent results in various image restoration tasks. However, such training requires datasets composed of pairs of corrupted images and their corresponding ground truth targets. Unfortunately, such data is not available in many applications. For the task of image denoising in which the noise statistics is unknown, several self-supervised training methods have been proposed for overcoming this difficulty. Some of these require knowledge of the noise model, while others assume that the contaminating noise is uncorrelated, both assumptions are too …
Nankai University（南开大学）；Xi’an Jiaotong University（西安交通大学）；Inception Institute of Artificial Intelligence (IIAI)（人工智能 inception 研究院）；Mohamed bin Zayed University of Artificial Intelligence (MBZUAI)（穆罕默德·本·扎耶德人工智能大学）；Chongqing University（重庆大学）
Supervised deep networks have achieved promisingperformance on image denoising, by learning image priors andnoise statistics on plenty pairs of noisy and clean images. Unsupervised denoising networks are trained with only noisy images. However, for an unseen corrupted image, both supervised andunsupervised networks ignore either its particular image prior, the noise statistics, or both. That is, the networks learned from external images inherently suffer from a domain gap problem: the image priors and noise statistics are very different between the training and test images. This problem become…
We describe a novel method for training high-quality image denoising models based on unorganized collections of corrupted images. The training does not need access to clean reference images, or explicit pairs of corrupted images, and can thus be applied in situations where such data is unacceptably expensive or impossible to acquire. We build on a recent technique that removes the need for reference data by employing networks with a "blind spot" in the receptive field, and significantly improve two key aspects: image quality and training efficiency. Our result quality is on par with state-of-t…
Next-Scale Prediction: A Self-Supervised Approach for Real-World Image Denoising
College of Computer Science, Sichuan University（四川大学计算机科学学院）；National Key Laboratory of Fundamental Algorithms and Models for Engineering Numerical Simulation, Sichuan University（四川大学工程数值模拟基础算法与模型全国重点实验室）
Image denoising is a prerequisite for downstream tasks in many fields. Low-dose and photon-counting computed tomography (CT) denoising can optimize diagnostic performance at minimized radiation dose. Supervised deep denoising methods are popular but require paired clean or noisy samples that are often unavailable in practice. Limited by the independent noise assumption, current unsupervised denoising methods cannot process correlated noises as in CT images. Here we propose the first-of-its-kind similarity-based unsupervised deep denoising approach, referred to as Noise2Sim, that works in a non…
We present a method for supervised learning of sparsity-promoting regularizers for image denoising. Sparsity-promoting regularization is a key ingredient in solving modern image reconstruction problems; however, the operators underlying these regularizers are usually either designed by hand or learned from data in an unsupervised way. The recent success of supervised learning (mainly convolutional neural networks) in solving image reconstruction problems suggests that it could be a fruitful approach to designing regularizers. As a first experiment in this direction, we propose to denoise image…
