We propose an effective deep learning model for signal reconstruction, which requires no signal prior, no noise model calibration, and no clean samples. This model only assumes that the noise is independent of the measurement and that the true signals share the same structured information. We demonstrate its performance on a variety of real-world applications, from sub-Ångström resolution atomic images to sub-arcsecond resolution astronomy images.
Renmin University of China（中国人民大学）；Dalian University of Technology（大连理工大学）
In the last few years, image denoising has benefited a lot from the fast development of neural networks. However, the requirement of large amounts of noisy-clean image pairs for supervision limits the wide use of these models. Although there have been a few attempts in training an image denoising model with only single noisy images, existing self-supervised denoising approaches suffer from inefficient network training, loss of useful information, or dependence on noise modeling. In this paper, we present a very simple yet effective method named Neighbor2Neighbor to train an effective image den…
Sungkyunkwan University（成均馆大学）；Ulsan National Institute of Science and Technology（蔚山科学技术院）；Shanghai Jiao Tong University（上海交通大学）；Seoul National University（首尔国立大学）
Regression that predicts continuous quantity is a central part of applications using computational imaging and computer vision technologies. Yet, studying and understanding self-supervised learning for regression tasks - except for a particular regression task, image denoising - have lagged behind. This paper proposes a general self-supervised regression learning (SSRL) framework that enables learning regression neural networks with only input data (but without ground-truth target data), by using a designable pseudo-predictor that encapsulates domain knowledge of a specific application. The pa…
Xiamen University（厦门大学）；University of Science and Technology of China（中国科学技术大学）；Columbia University（哥伦比亚大学）
We propose a new framework called Noise2Blur (N2B) for training robust image denoising models without pre-collected paired noisy/clean images. The training of the model requires only some (or even one) noisy images, some random unpaired clean images, and noise-free but blurred labels obtained by predefined filtering of the noisy images. The N2B model consists of two parts: a denoising network and a noise extraction network. First, the noise extraction network learns to output a noise map using the noise information from the denoising network under the guidence of the blurred labels. Then, the …
Xiamen University（厦门大学）；The University of Hong Kong（香港大学）；Deepwise（深睿医疗）；Columbia University（哥伦比亚大学）
The effectiveness of existing denoising algorithms typically relies on accurate pre-defined noise statistics or plenty of paired data, which limits their practicality. In this work, we focus on denoising in the more common case where noise statistics and paired data are unavailable. Considering that denoising CNNs require supervision, we develop a new \textbf{adaptive noise imitation (ADANI)} algorithm that can synthesize noisy data from naturally noisy images. To produce realistic noise, a noise generator takes unpaired noisy/clean images as input, where the noisy image is a guide for noise g…
Magnetic resonance imaging (MRI) is a common and life-saving medical imaging technique. However, acquiring high signal-to-noise ratio MRI scans requires long scan times, resulting in increased costs and patient discomfort, and decreased throughput. Thus, there is great interest in denoising MRI scans, especially for the subtype of diffusion MRI scans that are severely SNR-limited. While most prior MRI denoising methods are supervised in nature, acquiring supervised training datasets for the multitude of anatomies, MRI scanners, and scan parameters proves impractical. Here, we propose Denoising…
Recently, Self-supervised learning methods able to perform image denoising without ground truth labels have been proposed. These methods create low-quality images by adding random or Gaussian noise to images and then train a model for denoising. Ideally, it would be beneficial if one can generate high-quality CT images with only a few training samples via self-supervision. However, the performance of CT denoising is generally limited due to the complexity of CT noise. To address this problem, we propose a novel self-supervised learning-based CT denoising method. In particular, we train pre-tra…
The Hong Kong Polytechnic University（香港理工大学）；The Chinese University of Hong Kong (Shenzhen)（香港中文大学（深圳））
Most of existing image denoising methods learn image priors from either external data or the noisy image itself to remove noise. However, priors learned from external data may not be adaptive to the image to be denoised, while priors learned from the given noisy image may not be accurate due to the interference of corrupted noise. Meanwhile, the noise in real-world noisy images is very complex, which is hard to be described by simple distributions such as Gaussian distribution, making real-world noisy image denoising a very challenging problem. We propose to exploit the information in both ext…
Image denoising is of great importance for medical imaging system, since it can improve image quality for disease diagnosis and downstream image analyses. In a variety of applications, dynamic imaging techniques are utilized to capture the time-varying features of the subject, where multiple images are acquired for the same subject at different time points. Although signal-to-noise ratio of each time frame is usually limited by the short acquisition time, the correlation among different time frames can be exploited to improve denoising results with shared information across time frames. With t…
Harbin Institute of Technology（哈尔滨工业大学）；University of Tianjin（天津大学）；Peng Cheng Lab（鹏城实验室）
We investigate the task of learning blind image denoising networks from an unpaired set of clean and noisy images. Such problem setting generally is practical and valuable considering that it is feasible to collect unpaired noisy and clean images in most real-world applications. And we further assume that the noise can be signal dependent but is spatially uncorrelated. In order to facilitate unpaired learning of denoising network, this paper presents a two-stage scheme by incorporating self-supervised learning and knowledge distillation. For self-supervised learning, we suggest a dilated blind…
Rochester Institute of Technology（罗切斯特理工学院）；Chosun University（朝鲜大学）
Unpaired image denoising has achieved promising development over the last few years. Regardless of the performance, methods tend to heavily rely on underlying noise properties or any assumption which is not always practical. Alternatively, if we can ground the problem from a structural perspective rather than noise statistics, we can achieve a more robust solution. with such motivation, we propose a self-supervised denoising scheme that is unpaired and relies on spatial degradation followed by a regularized refinement. Our method shows considerable improvement over previous methods and exhibit…
Blind-spot network (BSN) and its variants have made significant advances in self-supervised denoising. Nevertheless, they are still bound to synthetic noisy inputs due to less practical assumptions like pixel-wise independent noise. Hence, it is challenging to deal with spatially correlated real-world noise using self-supervised BSN. Recently, pixel-shuffle downsampling (PD) has been proposed to remove the spatial correlation of real-world noise. However, it is not trivial to integrate PD and BSN directly, which prevents the fully self-supervised denoising model on real-world images. We propos…
The field of image denoising is currently dominated by discriminative deep learning methods that are trained on pairs of noisy input and clean target images. Recently it has been shown that such methods can also be trained without clean targets. Instead, independent pairs of noisy images can be used, in an approach known as Noise2Noise (N2N). Here, we introduce Noise2Void (N2V), a training scheme that takes this idea one step further. It does not require noisy image pairs, nor clean target images. Consequently, N2V allows us to train directly on the body of data to be denoised and can therefor…
Nankai University（南开大学）；Xi’an Jiaotong University（西安交通大学）；Inception Institute of Artificial Intelligence (IIAI)（人工智能 inception 研究院）；Mohamed bin Zayed University of Artificial Intelligence (MBZUAI)（穆罕默德·本·扎耶德人工智能大学）；Chongqing University（重庆大学）
Supervised deep networks have achieved promisingperformance on image denoising, by learning image priors andnoise statistics on plenty pairs of noisy and clean images. Unsupervised denoising networks are trained with only noisy images. However, for an unseen corrupted image, both supervised andunsupervised networks ignore either its particular image prior, the noise statistics, or both. That is, the networks learned from external images inherently suffer from a domain gap problem: the image priors and noise statistics are very different between the training and test images. This problem become…
Fluorescence microscopy is a key driver to promote discoveries of biomedical research. However, with the limitation of microscope hardware and characteristics of the observed samples, the fluorescence microscopy images are susceptible to noise. Recently, a few self-supervised deep learning (DL) denoising methods have been proposed. However, the training efficiency and denoising performance of existing methods are relatively low in real scene noise removal. To address this issue, this paper proposed self-supervised image denoising method Noise2SR (N2SR) to train a simple and effective image den…
Self-supervised frameworks that learn denoising models with merely individual noisy images have shown strong capability and promising performance in various image denoising tasks. Existing self-supervised denoising frameworks are mostly built upon the same theoretical foundation, where the denoising models are required to be J-invariant. However, our analyses indicate that the current theory and the J-invariance may lead to denoising models with reduced performance. In this work, we introduce Noise2Same, a novel self-supervised denoising framework. In Noise2Same, a new self-supervised loss is …
FAU Erlangen-Nürnberg（埃尔朗根-纽伦堡大学）；Siemens Healthcare GmbH（西门子医疗有限公司）；Fraunhofer Institute for Ceramic Technologies and Systems IKTS（弗劳恩霍夫陶瓷技术与系统研究所IKTS）；Ewha Womans University（梨花女子大学）
Self-supervised image denoising techniques emerged as convenient methods that allow training denoising models without requiring ground-truth noise-free data. Existing methods usually optimize loss metrics that are calculated from multiple noisy realizations of similar images, e.g., from neighboring tomographic slices. However, those approaches fail to utilize the multiple contrasts that are routinely acquired in medical imaging modalities like MRI or dual-energy CT. In this work, we propose the new self-supervised training scheme Noise2Contrast that combines information from multiple measured …
Sungkyunkwan University（成均馆大学）；Yonsei University（延世大学）；Seoul National University（首尔国立大学）
We tackle a challenging blind image denoising problem, in which only single distinct noisy images are available for training a denoiser, and no information about noise is known, except for it being zero-mean, additive, and independent of the clean image. In such a setting, which often occurs in practice, it is not possible to train a denoiser with the standard discriminative training or with the recently developed Noise2Noise (N2N) training; the former requires the underlying clean image for the given noisy image, and the latter requires two independently realized noisy image pair for a clean …
McGill University（麦吉尔大学）；The Chinese University of Hong Kong, Shenzhen（香港中文大学（深圳））；Shenzhen Institute of Artificial Intelligence and Robotics for Society（深圳人工智能与机器人研究院）
In recent years, self-supervised denoising methods have shown impressive performance, which circumvent painstaking collection procedure of noisy-clean image pairs in supervised denoising methods and boost denoising applicability in real world. One of well-known self-supervised denoising strategies is the blind-spot training scheme. However, a few works attempt to improve blind-spot based self-denoiser in the aspect of network architecture. In this paper, we take an intuitive view of blind-spot strategy and consider its process of using neighbor pixels to predict manipulated pixels as an inpain…
A wide variety of image denoising methods are available now. However, the performance of a denoising algorithm often depends on individual input noisy images as well as its parameter setting. In this paper, we present a no-reference image denoising quality assessment method that can be used to select for an input noisy image the right denoising algorithm with the optimal parameter setting. This is a challenging task as no ground truth is available. This paper presents a data-driven approach to learn to predict image denoising quality. Our method is based on the observation that while individua…
Although the advances of self-supervised blind denoising are significantly superior to conventional approaches without clean supervision in synthetic noise scenarios, it shows poor quality in real-world images due to spatially correlated noise corruption. Recently, pixel-shuffle downsampling (PD) has been proposed to eliminate the spatial correlation of noise. A study combining a blind spot network (BSN) and asymmetric PD (AP) successfully demonstrated that self-supervised blind denoising is applicable to real-world noisy images. However, PD-based inference may degrade texture details in the t…
Center for Advanced Medical Computing and Analysis, Massachusetts General Hospital and Harvard Medical School（麻省总医院与哈佛医学院高级医学计算与分析中心）；Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School（麻省总医院与哈佛医学院戈登医学成像中心）
Deep neural networks have been proved efficient for medical image denoising. Current training methods require both noisy and clean images. However, clean images cannot be acquired for many practical medical applications due to naturally noisy signal, such as dynamic imaging, spectral computed tomography, arterial spin labeling magnetic resonance imaging, etc. In this paper we proposed a training method which learned denoising neural networks from noisy training samples only. Training data in the acquisition domain was split to two subsets and the network was trained to map one noisy set to the…
Philips Innovation Labs（飞利浦创新实验室）；Skolkovo Institute of Science and Technology（斯科尔科沃科学技术研究院）
Computed Tomography (CT) imposes risk on the patients due to its inherent X-ray radiation, stimulating the development of low-dose CT (LDCT) imaging methods. Lowering the radiation dose reduces the health risks but leads to noisier measurements, which decreases the tissue contrast and causes artifacts in CT images. Ultimately, these issues could affect the perception of medical personnel and could cause misdiagnosis. Modern deep learning noise suppression methods alleviate the challenge but require low-noise-high-noise CT image pairs for training, rarely collected in regular clinical workflows…
Optical Coherence Tomography (OCT) is pervasive in both the research and clinical practice of Ophthalmology. However, OCT images are strongly corrupted by noise, limiting their interpretation. Current OCT denoisers leverage assumptions on noise distributions or generate targets for training deep supervised denoisers via averaging of repeat acquisitions. However, recent self-supervised advances allow the training of deep denoising networks using only repeat acquisitions without clean targets as ground truth, reducing the burden of supervised learning. Despite the clear advantages of self-superv…
RelativeFlow: Taming Medical Image Denoising Learning with Noisy Reference
School of Computer Science and Engineering, Southeast University, China（东南大学计算机科学与工程学院，中国）；Department of Biomedical Engineering, Case Western Reserve University, USA（凯斯西储大学生物医学工程系，美国）；School of Instrument Science and Engineering, Southeast University, China（东南大学仪器科学与工程学院，中国）；Department of Optical Sciences, University of Arizona, USA（亚利桑那大学光学科学系，美国）
Department of Computing, The Hong Kong Polytechnic University（香港理工大学计算机系）；School of Science and Engineering, The Chinese University of Hong Kong (Shenzhen)（香港中文大学（深圳）理工学院）
Most of previous image denoising methods focus on additive white Gaussian noise (AWGN). However,the real-world noisy image denoising problem with the advancing of the computer vision techiniques. In order to promote the study on this problem while implementing the concurrent real-world image denoising datasets, we construct a new benchmark dataset which contains comprehensive real-world noisy images of different natural scenes. These images are captured by different cameras under different camera settings. We evaluate the different denoising methods on our new dataset as well as previous datas…
Hanyang University（汉阳大学）；Chungnam National University（忠南国立大学）；SK T-Brain
Under certain statistical assumptions of noise, recent self-supervised approaches for denoising have been introduced to learn network parameters without true clean images, and these methods can restore an image by exploiting information available from the given input (i.e., internal statistics) at test time. However, self-supervised methods are not yet combined with conventional supervised denoising methods which train the denoising networks with a large number of external training samples. Thus, we propose a new denoising approach that can greatly outperform the state-of-the-art supervised de…
Deep learning (DL) has shown promise for faster, high quality accelerated MRI reconstruction. However, supervised DL methods depend on extensive amounts of fully-sampled (labeled) data and are sensitive to out-of-distribution (OOD) shifts, particularly low signal-to-noise ratio (SNR) acquisitions. To alleviate this challenge, we propose Noise2Recon, a model-agnostic, consistency training method for joint MRI reconstruction and denoising that can use both fully-sampled (labeled) and undersampled (unlabeled) scans in semi-supervised and self-supervised settings. With limited or no labeled traini…
Australian National University（澳大利亚国立大学）；Data61-CSIRO；OPPO US Research（OPPO美国研究院）；GSAI POSTECH（浦项科技大学GSAI）
Invertible networks have various benefits for image denoising since they are lightweight, information-lossless, and memory-saving during back-propagation. However, applying invertible models to remove noise is challenging because the input is noisy, and the reversed output is clean, following two different distributions. We propose an invertible denoising network, InvDN, to address this challenge. InvDN transforms the noisy input into a low-resolution clean image and a latent representation containing noise. To discard noise and restore the clean image, InvDN replaces the noisy latent represen…
Bio-Computing Research Center, Harbin Institute of Technology, Shenzhen（哈尔滨工业大学（深圳）生物计算研究中心）；Shenzhen Key Laboratory of Visual Object Detection and Recognition（深圳市视觉目标检测与识别重点实验室）；School of Computers, Guangdong University of Technology（广东工业大学计算机学院）；Tsinghua Shenzhen International Graduate School（清华大学深圳国际研究生院）；Peng Cheng Laboratory（鹏城实验室）；School of Computer Science and Technology, Harbin Institute of Technology（哈尔滨工业大学计算机科学与技术学院）；Department of Electrical Engineering and the Institute of Communications Engineering, National Tsing Hua University（台湾清华大学电机工程学系与通讯工程研究所）
Deep learning techniques have received much attention in the area of image denoising. However, there are substantial differences in the various types of deep learning methods dealing with image denoising. Specifically, discriminative learning based on deep learning can ably address the issue of Gaussian noise. Optimization models based on deep learning are effective in estimating the real noise. However, there has thus far been little related research to summarize the different deep learning techniques for image denoising. In this paper, we offer a comparative study of deep techniques in image…
With the advent of recent advances in unsupervised learning, efficient training of a deep network for image denoising without pairs of noisy and clean images has become feasible. However, most current unsupervised denoising methods are built on the assumption of zero-mean noise under the signal-independent condition. This assumption causes blind denoising techniques to suffer brightness shifting problems on images that are greatly corrupted by extreme noise such as salt-and-pepper noise. Moreover, most blind denoising methods require a random masking scheme for training to ensure the invarianc…
Huazhong University of Science and Technology（华中科技大学）
Optical neuroimaging is a vital tool for understanding the brain structure and the connection between regions and nuclei. However, the image noise introduced in the sample preparation and the imaging system hinders the extraction of the possible knowlege from the dataset, thus denoising for the optical neuroimaging is usually necessary. The supervised denoisng methods often outperform the unsupervised ones, but the training of the supervised denoising models needs the corresponding clean labels, which is not always avaiable due to the high labeling cost. On the other hand, those semantic label…
The Chinese University of Hong Kong（香港中文大学）；SenseTime Research（商汤科技研究院）
The lack of large-scale noisy-clean image pairs restricts supervised denoising methods' deployment in actual applications. While existing unsupervised methods are able to learn image denoising without ground-truth clean images, they either show poor performance or work under impractical settings (e.g., paired noisy images). In this paper, we present a practical unsupervised image denoising method to achieve state-of-the-art denoising performance. Our method only requires single noisy images and a noise model, which is easily accessible in practical raw image denoising. It performs two steps it…
Max-Planck Institute of Molecular Cell Biology and Genetics（马克斯·普朗克分子细胞生物学与遗传学研究所）；Center for Systems Biology Dresden (CSBD)（德累斯顿系统生物学中心）；Fondazione Human Technopole（人类技术城基金会）；Max Planck Institute for the Physics of Complex Systems（马克斯·普朗克复杂系统物理研究所）
Many microscopy applications are limited by the total amount of usable light and are consequently challenged by the resulting levels of noise in the acquired images. This problem is often addressed via (supervised) deep learning based denoising. Recently, by making assumptions about the noise statistics, self-supervised methods have emerged. Such methods are trained directly on the images that are to be denoised and do not require additional paired training data. While achieving remarkable results, self-supervised methods can produce high-frequency artifacts and achieve inferior results compar…
College of Information Technology, Jiangxi University of Finance and Economics（江西财经大学信息技术学院）；College of Computer Science and Technology, Nanjing University of Aeronautics and Astronautics（南京航空航天大学计算机科学与技术学院）；College of Computer Science, Chongqing University（重庆大学计算机学院）；School of Cyber Science and Technology, Shenzhen Campus of Sun Yat-sen University（中山大学深圳校区网络空间科学与技术学院）；Deakin University（迪肯大学）
California Polytechnic State University（加州州立理工大学）；University of Georgia（佐治亚大学）；Providence College（普罗维登斯学院）；University of Colorado Colorado Springs（科罗拉多大学科罗拉多斯普林斯分校）
We extend the blindspot model for self-supervised denoising to handle Poisson-Gaussian noise and introduce an improved training scheme that avoids hyperparameters and adapts the denoiser to the test data. Self-supervised models for denoising learn to denoise from only noisy data and do not require corresponding clean images, which are difficult or impossible to acquire in some application areas of interest such as low-light microscopy. We introduce a new training strategy to handle Poisson-Gaussian noise which is the standard noise model for microscope images. Our new strategy eliminates hyper…
Korea Advanced Institute of Science and Technology (KAIST)（韩国科学技术院）
Tweedie distributions are a special case of exponential dispersion models, which are often used in classical statistics as distributions for generalized linear models. Here, we reveal that Tweedie distributions also play key roles in modern deep learning era, leading to a distribution independent self-supervised image denoising formula without clean reference images. Specifically, by combining with the recent Noise2Score self-supervised image denoising approach and the saddle point approximation of Tweedie distribution, we can provide a general closed-form denoising formula that can be used fo…
Gwangju Institute of Science and Technology (GIST)（光州科学技术院）
In this paper, we present an algorithm for real-world license plate recognition (LPR) from a low-quality image. Our method is built upon a framework that includes denoising and rectification, and each task is conducted by Convolutional Neural Networks. Existing denoising and rectification have been treated separately as a single network in previous research. In contrast to the previous work, we here propose an end-to-end trainable network for image recovery, Single Noisy Image DEnoising and Rectification (SNIDER), which focuses on solving both the problems jointly. It overcomes those obstacles…
We present a method for supervised learning of sparsity-promoting regularizers for image denoising. Sparsity-promoting regularization is a key ingredient in solving modern image reconstruction problems; however, the operators underlying these regularizers are usually either designed by hand or learned from data in an unsupervised way. The recent success of supervised learning (mainly convolutional neural networks) in solving image reconstruction problems suggests that it could be a fruitful approach to designing regularizers. As a first experiment in this direction, we propose to denoise image…
In recent years, the supervised learning strategy for real noisy image denoising has been emerging and has achieved promising results. In contrast, realistic noise removal for raw noisy videos is rarely studied due to the lack of noisy-clean pairs for dynamic scenes. Clean video frames for dynamic scenes cannot be captured with a long-exposure shutter or averaging multi-shots as was done for static images. In this paper, we solve this problem by creating motions for controllable objects, such as toys, and capturing each static moment for multiple times to generate clean video frames. In this w…
WIA-LD2ND: Wavelet-based Image Alignment for Self-supervised Low-Dose CT Denoising
School of Computer Science, Wuhan University（武汉大学计算机学院）；School of Computer Science, Central China Normal University（华中师范大学计算机学院）；University of Louisville（路易斯维尔大学）
Harbin Institute of Technology（哈尔滨工业大学）；Peng Cheng Laboratory（鹏城实验室）
Significant progress has been made in self-supervised image denoising (SSID) in the recent few years. However, most methods focus on dealing with spatially independent noise, and they have little practicality on real-world sRGB images with spatially correlated noise. Although pixel-shuffle downsampling has been suggested for breaking the noise correlation, it breaks the original information of images, which limits the denoising performance. In this paper, we propose a novel perspective to solve this problem, i.e., seeking for spatially adaptive supervision for real-world sRGB image denoising. …
Carnegie Mellon University（卡内基梅隆大学）；Mitsubishi Electric Research Laboratories（三菱电机研究实验室）
We present a neural-network-based architecture for 3D point cloud denoising called neural projection denoising (NPD). In our previous work, we proposed a two-stage denoising algorithm, which first estimates reference planes and follows by projecting noisy points to estimated reference planes. Since the estimated reference planes are inevitably noisy, multi-projection is applied to stabilize the denoising performance. NPD algorithm uses a neural network to estimate reference planes for points in noisy point clouds. With more accurate estimations of reference planes, we are able to achieve bette…
Ambient Denoising Diffusion Generative Adversarial Networks for Establishing Stochastic Object Models from Noisy Image Data
Global Institute of Future Technology, Shanghai Jiao Tong University（上海交通大学未来技术研究院）；University of Michigan-Shanghai Jiao Tong University Joint Institute, Shanghai Jiao Tong University（上海交通大学密歇根大学联合学院）；University of Arizona（亚利桑那大学）；Wyant College of Optical Sciences, University of Arizona（亚利桑那大学怀恩特光学科学学院）
Positive2Negative: Breaking the Information-Lossy Barrier in Self-Supervised Single Image Denoising
School of Computer Science and Technology, Beijing Institute of Technology（北京理工大学计算机科学与技术学院）；School of Artificial Intelligence, Beijing Normal University（北京师范大学人工智能学院）；Aerospace Information Research Institute, Chinese Academy of Sciences（中国科学院空天信息创新研究院）
RMIT University（皇家墨尔本理工大学）；University of Technology Sydney（悉尼科技大学）
Recently, tremendous human-designed and automatically searched neural networks have been applied to image denoising. However, previous works intend to handle all noisy images in a pre-defined static network architecture, which inevitably leads to high computational complexity for good denoising quality. Here, we present dynamic slimmable denoising network (DDS-Net), a general method to achieve good denoising quality with less computational complexity, via dynamically adjusting the channel configurations of networks at test time with respect to different noisy images. Our DDS-Net is empowered w…
