COVID-19 detection using chest X-rays: is lung segmentation important for generalization?
University of Campinas - UNICAMP（坎皮纳斯大学（UNICAMP））；Alma Mater Studiorum - University of Bologna（博洛尼亚大学（Alma Mater Studiorum））；Istituto Italiano di Tecnologia（意大利技术研究院）
Purpose: we evaluated the generalization capability of deep neural networks (DNNs), trained to classify chest X-rays as Covid-19, normal or pneumonia, using a relatively small and mixed dataset. Methods: we proposed a DNN to perform lung segmentation and classification, stacking a segmentation module (U-Net), an original intermediate module and a classification module (DenseNet201). To evaluate generalization, we tested the DNN with an external dataset (from distinct localities) and used Bayesian inference to estimate probability distributions of performance metrics. Results: our DNN achieved 0.917 AUC on the external test dataset, and a DenseNet without segmentation, 0.906. Bayesian inference indicated mean accuracy of 76.1% and [0.695, 0.826] 95% HDI (highest density interval, which concentrates 95% of the metric's probability mass) with segmentation and, without segmentation, 71.7% and [0.646, 0.786]. Conclusion: employing a novel DNN evaluation technique, which uses LRP and Brixia scores, we discovered that areas where radiologists found strong Covid-19 symptoms are the most important for the stacked DNN classification. External validation showed smaller accuracies than internal, indicating difficulty in generalization, which is positively affected by segmentation. Finally, the performance in the external dataset and the analysis with LRP suggest that DNNs can be trained in small and mixed datasets and still successfully detect Covid-19.
Total lung volume is an important quantitative biomarker and is used for the assessment of restrictive lung diseases. In this study, we investigate the performance of several deep-learning approaches for automated measurement of total lung volume from chest radiographs. 7621 posteroanterior and lateral view chest radiographs (CXR) were collected from patients with chest CT available. Similarly, 928 CXR studies were chosen from patients with pulmonary function test (PFT) results. The reference total lung volume was calculated from lung segmentation on CT or PFT data, respectively. This dataset …
Saratoga High School（萨拉托加高中）；Stanford University（斯坦福大学）
Chest X-rays of coronavirus disease 2019 (COVID-19) patients are frequently obtained to determine the extent of lung disease and are a valuable source of data for creating artificial intelligence models. Most work to date assessing disease severity on chest imaging has focused on segmenting computed tomography (CT) images; however, given that CTs are performed much less frequently than chest X-rays for COVID-19 patients, automated lung lesion segmentation on chest X-rays could be clinically valuable. There currently exists a universal shortage of chest X-rays with ground truth COVID-19 lung le…
AI Research Group, Institute of Mathematics（人工智能研究组，数学研究所）；Eötvös Loránd University（罗兰大学）
Chest X-ray is the most common test among medical imaging modalities. It is applied for detection and differentiation of, among others, lung cancer, tuberculosis, and pneumonia, the last with importance due to the COVID-19 disease. Integrating computer-aided detection methods into the radiologist diagnostic pipeline, greatly reduces the doctors' workload, increasing reliability and quantitative analysis. Here we present a novel deep learning approach for lung segmentation, a basic, but arduous task in the diagnostic pipeline. Our method uses state-of-the-art fully convolutional neural networks…
New York University（纽约大学）；Manipal Institute of Technology, Manipal Academy of Higher Education（马尼帕尔高等教育学院马尼帕尔理工学院）；Columbia University（哥伦比亚大学）
Biomedical image segmentation is one of the fastest growing fields which has seen extensive automation through the use of Artificial Intelligence. This has enabled widespread adoption of accurate techniques to expedite the screening and diagnostic processes which would otherwise take several days to finalize. In this paper, we present an end-to-end pipeline to segment lungs from chest X-ray images, training the neural network model on the Japanese Society of Radiological Technology (JSRT) dataset, using UNet to enable faster processing of initial screening for various lung disorders. The pipel…
Lung nodules can be an alarming precursor to potential lung cancer. Missed nodule detections during chest radiograph analysis remains a common challenge among thoracic radiologists. In this work, we present a multi-task lung nodule detection algorithm for chest radiograph analysis. Unlike past approaches, our algorithm predicts a global-level label indicating nodule presence along with local-level labels predicting nodule locations using a Dual Head Network (DHN). We demonstrate the favorable nodule detection performance that our multi-task formulation yields in comparison to conventional meth…
Underestimation of lung regions on chest X-ray segmentation masks assessed by comparison with total lung volume evaluated on computed tomography
Medical University of Warsaw（华沙医科大学）；Warsaw University of Technology（华沙理工大学）；MI2.ai；University of Amsterdam（阿姆斯特丹大学）；Amsterdam University Medical Center（阿姆斯特丹大学医学中心）；Medical University of Silesia（西里西亚医科大学）；University of Warsaw（华沙大学）
Automated segmentation of Lungs plays a crucial role in the computer-aided diagnosis of chest X-Ray (CXR) images. Developing an efficient Lung segmentation model is challenging because of difficulties such as the presence of several edges at the rib cage and clavicle, inconsistent lung shape among different individuals, and the appearance of the lung apex. In this paper, we propose a robust model for Lung segmentation in Chest Radiographs. Our model learns to ignore the irrelevant regions in an input Chest Radiograph while highlighting regions useful for lung segmentation. The proposed model i…
Wayne State Univ.（韦恩州立大学）；NanoBioScience Institute, Wayne State Univ.（韦恩州立大学纳米生物科学研究所）；University of Michigan（密歇根大学）；Henry Ford Health System（亨利福特医疗系统）
Deep Neural Networks (DNN) are widely used to carry out segmentation tasks in biomedical images. Most DNNs developed for this purpose are based on some variation of the encoder-decoder U-Net architecture. Here we show that Res-CR-Net, a new type of fully convolutional neural network, which was originally developed for the semantic segmentation of microscopy images, and which does not adopt a U-Net architecture, is very effective at segmenting the lung fields in chest X-rays from either healthy patients or patients with a variety of lung pathologies.
Kamnoetvidya Science Academy（甘烹碧科学学院）；National Electronics and Computer Technology Center（泰国国家电子和计算机技术中心）；Vidyasirimedhi Institute of Science and Technology（瓦莱拉克科学技术研究院）
Since, cancer is curable when diagnosed at an early stage, lung cancer screening plays an important role in preventive care. Although both low dose computed tomography (LDCT) and computed tomography (CT) scans provide more medical information than normal chest x-rays, there is very limited access to these technologies in rural areas. Recently, there is a trend in using computer-aided diagnosis (CADx) to assist in screening and diagnosing of cancer from biomedical images. In this study, the 121-layer convolutional neural network also known as DenseNet-121 by G. Huang et. al., along with the tra…
School of Professional Studies（专业研究学院）；Northwestern University（西北大学）
Artificial intelligence (AI) is disrupting the medical field as advances in modern technology allow common household computers to learn anatomical and pathological features that distinguish between healthy and disease with the accuracy of highly specialized, trained physicians. Computer vision AI applications use medical imaging, such as lung chest X-Rays (LCXRs), to facilitate diagnoses by providing second-opinions in addition to a physician's or radiologist's interpretation. Considering the advent of the current Coronavirus disease (COVID-19) pandemic, LCXRs may provide rapid insights to ind…
The abundance of overlapping anatomical structures appearing in chest radiographs can reduce the performance of lung pathology detection by automated algorithms (CAD) as well as the human reader. In this paper, we present a deep learning based image processing technique for enhancing the contrast of soft lung structures in chest radiographs using Fully Convolutional Neural Networks (FCNN). Two 2D FCNN architectures were trained to accomplish the task: The first performs 2D lung segmentation which is used for normalization of the lung area. The second FCNN is trained to extract lung structures.…
COVID-19 is a global pandemic, and detecting them is a momentous task for medical professionals today due to its rapid mutations. Current methods of examining chest X-rays and CT scan requires profound knowledge and are time consuming, which suggests that it shrinks the precious time of medical practitioners when people's lives are at stake. This study tries to assist this process by achieving state-of-the-art performance in classifying chest X-rays by fine-tuning Vision Transformer(ViT). The proposed approach uses pretrained models, fine-tuned for detecting the presence of COVID-19 disease on…
The 2019 novel coronavirus (COVID-19) has spread rapidly all over the world and it is affecting the whole society. The current gold standard test for screening COVID-19 patients is the polymerase chain reaction test. However, the COVID-19 test kits are not widely available and time-consuming. Thus, as an alternative, chest X-rays are being considered for quick screening. Since the presentation of COVID-19 in chest X-rays is varied in features and specialization in reading COVID-19 chest X-rays are required thus limiting its use for diagnosis. To address this challenge of reading chest X-rays b…
University of South Florida（南佛罗里达大学）；University of California, San Francisco（加利福尼亚大学旧金山分校）
Testing for COVID-19 has been unable to keep up with the demand. Further, the false negative rate is projected to be as high as 30% and test results can take some time to obtain. X-ray machines are widely available and provide images for diagnosis quickly. This paper explores how useful chest X-ray images can be in diagnosing COVID-19 disease. We have obtained 122 chest X-rays of COVID-19 and over 4,000 chest X-rays of viral and bacterial pneumonia. A pretrained deep convolutional neural network has been tuned on 102 COVID-19 cases and 102 other pneumonia cases in a 10-fold cross validation. T…
University of Saskatchewan（萨斯喀彻温大学）；International Road Dynamics（国际道路动力学公司）；National Institute of Technology, Trichy（特里奇国家理工学院）
One of the primary clinical observations for screening the infectious by the novel coronavirus is capturing a chest x-ray image. In most of the patients, a chest x-ray contains abnormalities, such as consolidation, which are the results of COVID-19 viral pneumonia. In this study, research is conducted on efficiently detecting imaging features of this type of pneumonia using deep convolutional neural networks in a large dataset. It is demonstrated that simple models, alongside the majority of pretrained networks in the literature, focus on irrelevant features for decision-making. In this paper,…
University of Technology Sydney（悉尼科技大学）；IBM Australia Limited（IBM澳大利亚有限公司）；Sejong University（世宗大学）；Universiti Kebangsaan Malaysia（马来西亚国民大学）；Charles Sturt University（查尔斯特大学）
Lung cancer is the leading cause of cancer death and morbidity worldwide. Many studies have shown machine learning models to be effective at detecting lung nodules from chest X-ray images. However, these techniques have yet to be embraced by the medical community due to several practical, ethical, and regulatory constraints stemming from the black-box nature of deep learning models. Additionally, most lung nodules visible on chest X-ray are benign; therefore, the narrow task of computer vision-based lung nodule detection cannot be equated to automated lung cancer detection. Addressing both con…
University of Copenhagen（哥本哈根大学）；Cerebriu AS（Cerebriu公司）；Technical University of Denmark（丹麦技术大学）
Pulmonary opacification is the inflammation in the lungs caused by many respiratory ailments, including the novel corona virus disease 2019 (COVID-19). Chest X-rays (CXRs) with such opacifications render regions of lungs imperceptible, making it difficult to perform automated image analysis on them. In this work, we focus on segmenting lungs from such abnormal CXRs as part of a pipeline aimed at automated risk scoring of COVID-19 from CXRs. We treat the high opacity regions as missing data and present a modified CNN-based image segmentation network that utilizes a deep generative model for dat…
Bharti School of Telecommunications Technology & Management, Indian Institute of Technology Delhi（印度理工学院德里分校巴蒂电信技术与管理学院）；Teleradiology Solutions（远程放射学解决方案公司）；CSIR-Institute of Genomics and Integrative Biology（CSIR基因组学与整合生物学研究所）；Christian Medical College, Vellore（韦洛尔基督教医学院）
A chest radiograph, commonly called chest x-ray (CxR), plays a vital role in the diagnosis of various lung diseases, such as lung cancer, tuberculosis, pneumonia, and many more. Automated segmentation of the lungs is an important step to design a computer-aided diagnostic tool for examination of a CxR. Precise lung segmentation is considered extremely challenging because of variance in the shape of the lung caused by health issues, age, and gender. The proposed work investigates the use of an efficient deep convolutional neural network for accurate segmentation of lungs from CxR. We attempt an…
National University of Sciences and Technology（国立科技大学）
An essential stage in computer aided diagnosis of chest X rays is automated lung segmentation. Due to rib cages and the unique modalities of each persons lungs, it is essential to construct an effective automated lung segmentation model. This paper presents a reliable model for the segmentation of lungs in chest radiographs. Our model overcomes the challenges by learning to ignore unimportant areas in the source Chest Radiograph and emphasize important features for lung segmentation. We evaluate our model on public datasets, Montgomery and Shenzhen. The proposed model has a DICE coefficient of…
IIIT-Delhi（印度德里信息技术学院）；IIT Jodhpur（印度焦特布尔理工学院）；Ashwini Hospital（阿什维尼医院）；Ramakant Heart Care Centre（拉马坎特心脏护理中心）；TeleRadiology Solutions（远程放射学解决方案公司）
With increasing number of COVID-19 cases globally, all the countries are ramping up the testing numbers. While the RT-PCR kits are available in sufficient quantity in several countries, others are facing challenges with limited availability of testing kits and processing centers in remote areas. This has motivated researchers to find alternate methods of testing which are reliable, easily accessible and faster. Chest X-Ray is one of the modalities that is gaining acceptance as a screening modality. Towards this direction, the paper has two primary contributions. Firstly, we present the COVID-1…
Amirkabir University of Technology（阿米尔卡比尔理工大学）；Semnan University（塞姆南大学）
In late 2019 and after COVID-19 pandemic in the world, many researchers and scholars have tried to provide methods for detection of COVID-19 cases. Accordingly, this study focused on identifying COVID-19 cases from chest X-ray images. In this paper, a novel approach to diagnosing coronavirus disease from X-ray images was proposed. In the proposed method, DenseNet169 deep neural network was used to extract the features of X-ray images taken from the patients' chest and the extracted features were then given as input to the Extreme Gradient Boosting (XGBoost) algorithm so that it could perform t…
Technical University of Munich（慕尼黑工业大学）；Stanford University（斯坦福大学）
Interpreting chest radiograph, a.ka. chest x-ray, images is a necessary and crucial diagnostic tool used by medical professionals to detect and identify many diseases that may plague a patient. Although the images themselves contain a wealth of valuable information, their usefulness may be limited by how well they are interpreted, especially when the reviewing radiologist may be fatigued or when or an experienced radiologist is unavailable. Research in the use of deep learning models to analyze chest radiographs yielded impressive results where, in some instances, the models outperformed pract…
Mohamed bin Zayed University of Artificial Intelligence（穆罕默德·本·扎耶德人工智能大学）
Quick and accurate diagnosis is of paramount importance to mitigate the effects of COVID-19 infection, particularly for severe cases. Enormous effort has been put towards developing deep learning methods to classify and detect COVID-19 infections from chest radiography images. However, recently some questions have been raised surrounding the clinical viability and effectiveness of such methods. In this work, we investigate the impact of multi-task learning (classification and segmentation) on the ability of CNNs to differentiate between various appearances of COVID-19 infections in the lung. W…
National Research Council Canada（加拿大国家研究委员会）；University of Waterloo（滑铁卢大学）；Ford Motor Company（福特汽车公司）
Chest radiography is an effective screening tool for diagnosing pulmonary diseases. In computer-aided diagnosis, extracting the relevant region of interest, i.e., isolating the lung region of each radiography image, can be an essential step towards improved performance in diagnosing pulmonary disorders. Methods: In this work, we propose a deep learning approach to enhance abnormal chest x-ray (CXR) identification performance through segmentations. Our approach is designed in a cascaded manner and incorporates two modules: a deep neural network with criss-cross attention modules (XLSor) for loc…
In 2019, the entire world is facing a situation of health emergency due to a newly emerged coronavirus (COVID-19). Almost 196 countries are affected by covid-19, while USA, Italy, China, Spain, Iran, and France have the maximum active cases of COVID-19. The issues, medical and healthcare departments are facing in delay of detecting the COVID-19. Several artificial intelligence based system are designed for the automatic detection of COVID-19 using chest x-rays. In this article we will discuss the different approaches used for the detection of COVID-19 and the challenges we are facing. It is ma…
COMSATS University Islamabad（COMSATS伊斯兰堡大学）；National University of Ireland, Galway（爱尔兰国立高威大学）；Umeå University（于默奥大学）
Chest X-ray (CXR) is a low-cost medical imaging technique. It is a common procedure for the identification of many respiratory diseases compared to MRI, CT, and PET scans. This paper presents the use of generative adversarial networks (GAN) to perform the task of lung segmentation on a given CXR. GANs are popular to generate realistic data by learning the mapping from one domain to another. In our work, the generator of the GAN is trained to generate a segmented mask of a given input CXR. The discriminator distinguishes between a ground truth and the generated mask, and updates the generator t…
Kyoto University Graduate School of Medicine（京都大学医学研究科）
Rationale and objectives: Several studies have evaluated the usefulness of deep learning for lung segmentation using chest x-ray (CXR) images with small- or medium-sized abnormal findings. Here, we built a database including both CXR images with severe abnormalities and experts' lung segmentation results, and aimed to evaluate our network's efficacy in lung segmentation from these images. Materials and Methods: For lung segmentation, CXR images from the Japanese Society of Radiological Technology (JSRT, N = 247) and Montgomery databases (N = 138), were included, and 65 additional images depict…
National Technical University of Ukraine "Igor Sikorsky Kyiv Polytechnic Institute"（乌克兰国立技术大学“伊戈尔·西科斯基基辅理工学院”）；Huizhou University（惠州学院）
The recent progress of computing, machine learning, and especially deep learning, for image recognition brings a meaningful effect for automatic detection of various diseases from chest X-ray images (CXRs). Here efficiency of lung segmentation and bone shadow exclusion techniques is demonstrated for analysis of 2D CXRs by deep learning approach to help radiologists identify suspicious lesions and nodules in lung cancer patients. Training and validation was performed on the original JSRT dataset (dataset #01), BSE-JSRT dataset, i.e. the same JSRT dataset, but without clavicle and rib shadows (d…
There are multiple papers published about different AI models for the COVID-19 diagnosis with promising results. Unfortunately according to the reviews many of the papers do not reach the level of sophistication needed for a clinically usable model. In this paper I go through multiple review papers, guidelines, and other relevant material in order to generate more comprehensive requirements for the future papers proposing a AI based diagnosis of the COVID-19 from chest X-ray data (CXR). Main findings are that a clinically usable AI needs to have an extremely good documentation, comprehensive s…
One of the critical tools for early detection and subsequent evaluation of the incidence of lung diseases is chest radiography. This study presents a real-world implementation of a convolutional neural network (CNN) based Carebot Covid app to detect COVID-19 from chest X-ray (CXR) images. Our proposed model takes the form of a simple and intuitive application. Used CNN can be deployed as a STOW-RS prediction endpoint for direct implementation into DICOM viewers. The results of this study show that the deep learning model based on DenseNet and ResNet architecture can detect SARS-CoV-2 from CXR …
The Coronavirus Disease 2019 (COVID-19) has spread globally and caused serious damage. Chest X-ray images are widely used for COVID-19 diagnosis and the Artificial Intelligence method can increase efficiency and accuracy. In the Challenge of Chest XR COVID-19 detection in Ethics and Explainability for Responsible Data Science (EE-RDS) conference 2021, we proposed a method that combined Swin Transformer and Transformer in Transformer to classify chest X-ray images as three classes: COVID-19, Pneumonia, and Normal (healthy) and achieved 0.9475 accuracies on the test set.
Indian Institute of Technology Delhi（德里印度理工学院）；University of Bath（巴斯大学）；Indian Institute of Technology Kanpur（坎普尔印度理工学院）；All India Institute of Medical Sciences Delhi（德里全印度医学科学研究所）
The exponential increase in COVID-19 patients is overwhelming healthcare systems across the world. With limited testing kits, it is impossible for every patient with respiratory illness to be tested using conventional techniques (RT-PCR). The tests also have long turn-around time, and limited sensitivity. Detecting possible COVID-19 infections on Chest X-Ray may help quarantine high risk patients while test results are awaited. X-Ray machines are already available in most healthcare systems, and with most modern X-Ray systems already digitized, there is no transportation time involved for the …
Sierra Research S.L（塞拉研究有限公司）；Universidad de Alicante（阿利坎特大学）；Medbravo（Medbravo医疗公司）；Fundación para el Fomento de la Investigación Sanitario y Biomédica de la Comunidad Valenciana（瓦伦西亚自治区卫生与生物医学研究促进基金会）；Hospital San Juan de Alicante（阿利坎特圣胡安医院）；Universidad Miguel Hernández（米格尔·埃尔南德斯大学）
In this work we present a method for the detection of radiological findings, their location and differential diagnoses from chest x-rays. Unlike prior works that focus on the detection of few pathologies, we use a hierarchical taxonomy mapped to the Unified Medical Language System (UMLS) terminology to identify 189 radiological findings, 22 differential diagnosis and 122 anatomic locations, including ground glass opacities, infiltrates, consolidations and other radiological findings compatible with COVID-19. We train the system on one large database of 92,594 frontal chest x-rays (AP or PA, st…
Indian Institute of Information Technology, Sri City, Chittoor（印度信息技术学院，斯里城，奇图尔）；Indian Institute of Information Technology, Allahabad（印度信息技术学院，阿拉哈巴德）
Covid-19 global pandemic continues to devastate health care systems across the world. At present, the Covid-19 testing is costly and time-consuming. Chest X-Ray (CXR) testing can be a fast, scalable, and non-invasive method. The existing methods suffer due to the limited CXR samples available from Covid-19. Thus, inspired by the limitations of the open-source work in this field, we propose attention guided contrastive CNN architecture (AC-CovidNet) for Covid-19 detection in CXR images. The proposed method learns the robust and discriminative features with the help of contrastive loss. Moreover…
Warsaw University of Technology（华沙理工大学）；Sano Centre for Computational Medicine（萨诺计算医学中心）；Jagiellonian University（雅盖隆大学）；Tooploox
A critical step in the fight against COVID-19, which continues to have a catastrophic impact on peoples lives, is the effective screening of patients presented in the clinics with severe COVID-19 symptoms. Chest radiography is one of the promising screening approaches. Many studies reported detecting COVID-19 in chest X-rays accurately using deep learning. A serious limitation of many published approaches is insufficient attention paid to explaining decisions made by deep learning models. Using explainable artificial intelligence methods, we demonstrate that model decisions may rely on confoun…
University of Chittagong（吉大港大学）；Charles Sturt University（查尔斯特大学）
The COVID-19 pandemic continues to severely undermine the prosperity of the global health system. To combat this pandemic, effective screening techniques for infected patients are indispensable. There is no doubt that the use of chest X-ray images for radiological assessment is one of the essential screening techniques. Some of the early studies revealed that the patient's chest X-ray images showed abnormalities, which is natural for patients infected with COVID-19. In this paper, we proposed a parallel-dilated convolutional neural network (CNN) based COVID-19 detection system from chest x-ray…
Spreading of COVID-19 virus has increased the efforts to provide testing kits. Not only the preparation of these kits had been hard, rare, and expensive but also using them is another issue. Results have shown that these kits take some crucial time to recognize the virus, in addition to the fact that they encounter with 30% loss. In this paper, we have studied the usage of x-ray pictures which are ubiquitous, for the classification of COVID-19 chest Xray images, by the existing convolutional neural networks (CNNs). We intend to train chest x-rays of infected and not infected ones with differen…
University of Leeds（利兹大学）；Leeds Teaching Hospitals NHS Trust（利兹教学医院 NHS 信托基金）
Since the emergence of COVID-19, deep learning models have been developed to identify COVID-19 from chest X-rays. With little to no direct access to hospital data, the AI community relies heavily on public data comprising numerous data sources. Model performance results have been exceptional when training and testing on open-source data, surpassing the reported capabilities of AI in pneumonia-detection prior to the COVID-19 outbreak. In this study impactful models are trained on a widely used open-source data and tested on an external test set and a hospital dataset, for the task of classifyin…
Beijing University of Posts and Telecommunications（北京邮电大学）
The COVID-19 epidemic has become a major safety and health threat worldwide. Imaging diagnosis is one of the most effective ways to screen COVID-19. This project utilizes several open-source or public datasets to present an open-source dataset of COVID-19 CXRs, named COVID-19-CXR-Dataset, and introduces a deep convolutional neural network model. The model validates on 740 test images and achieves 87.3% accuracy, 89.67 % precision, and 84.46% recall, and correctly classifies 98 out of 100 COVID-19 x-ray images in test set with more than 81% prediction probability under the condition of 95% conf…
Amirkabir University of Technology（阿米尔卡比尔理工大学）；Semnan University（塞姆南大学）
The new coronavirus (known as COVID-19) was first identified in Wuhan and quickly spread worldwide, wreaking havoc on the economy and people's everyday lives. Fever, cough, sore throat, headache, exhaustion, muscular aches, and difficulty breathing are all typical symptoms of COVID-19. A reliable detection technique is needed to identify affected individuals and care for them in the early stages of COVID-19 and reduce the virus's transmission. The most accessible method for COVID-19 identification is RT-PCR; however, due to its time commitment and false-negative results, alternative options mu…
Universidad Autónoma de Manizales（马尼萨莱斯自治大学）；Universidad Nacional de Colombia（哥伦比亚国立大学）
There is a necessity to develop affordable, and reliable diagnostic tools, which allow containing the COVID-19 spreading. Machine Learning (ML) algorithms have been proposed to design support decision-making systems to assess chest X-ray images, which have proven to be useful to detect and evaluate disease progression. Many research articles are published around this subject, which makes it difficult to identify the best approaches for future work. This paper presents a systematic review of ML applied to COVID-19 detection using chest X-ray images, aiming to offer a baseline for researchers in…
West Bengal State University（西孟加拉邦立大学）；Indian Statistical Institute（印度统计研究所）；Jamia Hamdard (Deemed University)（贾米亚哈姆达德大学）
With the ever increasing demand for screening millions of prospective "novel coronavirus" or COVID-19 cases, and due to the emergence of high false negatives in the commonly used PCR tests, the necessity for probing an alternative simple screening mechanism of COVID-19 using radiological images (like chest X-Rays) assumes importance. In this scenario, machine learning (ML) and deep learning (DL) offer fast, automated, effective strategies to detect abnormalities and extract key features of the altered lung parenchyma, which may be related to specific signatures of the COVID-19 virus. However, …
Deep learning-based lung segmentation and automatic regional template in chest X-ray images for pediatric tuberculosis
Universidad Politécnica de Madrid（马德里理工大学）；CIBER-BBN（生物工程、生物材料与纳米医学网络研究中心）；Children’s National Hospital（国家儿童医院）；George Washington University School of Medicine（乔治华盛顿大学医学院）；ISGlobal（巴塞罗那全球健康研究所）；Hospital Clínic（巴塞罗那临床医院）；Universitat de Barcelona（巴塞罗那大学）；Stellenbosch University（斯泰伦博斯大学）
University of Technology Sydney（悉尼科技大学）；Mehr General Hospital（Mehr综合医院）；Charles Sturt University（查尔斯特大学）
The COVID-19 pandemic has inspired unprecedented data collection and computer vision modelling efforts worldwide, focusing on diagnosis and stratification of COVID-19 from medical images. Despite this large-scale research effort, these models have found limited practical application due in part to unproven generalization of these models beyond their source study. This study investigates the generalizability of key published models using the publicly available COVID-19 Computed Tomography data through cross dataset validation. We then assess the predictive ability of these models for COVID-19 s…
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences（中国科学院深圳先进技术研究院）；Hainan University（海南大学）；University of Macau（澳门大学）
AI plays an important role in COVID-19 identification. Computer vision and deep learning techniques can assist in determining COVID-19 infection with Chest X-ray Images. However, for the protection and respect of the privacy of patients, the hospital's specific medical-related data did not allow leakage and sharing without permission. Collecting such training data was a major challenge. To a certain extent, this has caused a lack of sufficient data samples when performing deep learning approaches to detect COVID-19. Federated Learning is an available way to address this issue. It can effective…
Coronavirus disease (COVID-19) is a contagious infection caused by severe acute respiratory syndrome coronavirus-2 (SARS-COV-2) and it has infected and killed millions of people across the globe. In the absence of specific drugs or vaccines for the treatment of COVID-19 and the limitation of prevailing diagnostic techniques, there is a requirement for some alternate automatic screening systems that can be used by the physicians to quickly identify and isolate the infected patients. A chest X-ray (CXR) image can be used as an alternative modality to detect and diagnose the COVID-19. In this stu…
Indian Institute of Technology, Jammu（印度理工学院贾姆姆分校）；University of Pennsylvania（宾夕法尼亚大学）
We propose a two-stage Convolutional Neural Network (CNN) based classification framework for detecting COVID-19 and Community-Acquired Pneumonia (CAP) using the chest Computed Tomography (CT) scan images. In the first stage, an infection - COVID-19 or CAP, is detected using a pre-trained DenseNet architecture. Then, in the second stage, a fine-grained three-way classification is done using EfficientNet architecture. The proposed COVID+CAP-CNN framework achieved a slice-level classification accuracy of over 94% at identifying COVID-19 and CAP. Further, the proposed framework has the potential t…
Objectives: To compare artificial intelligence (AI) as a second reader in detecting lung nodules on chest X-rays (CXR) versus radiologists of two binational institutions, and to evaluate AI performance when using two different modes: automated versus assisted (additional remote radiologist review). Methods: The CXR public database (n = 247) of the Japanese Society of Radiological Technology with various types and sizes of lung nodules was analyzed. Eight radiologists evaluated the CXR images with regard to the presence of lung nodules and nodule conspicuity. After radiologist review, the AI so…
During the COVID-19 pandemic, there has been an emerging need for rapid, dedicated, and point-of-care COVID-19 patient disposition techniques to optimize resource utilization and clinical workflow. In view of this need, we present COVID-MobileXpert: a lightweight deep neural network (DNN) based mobile app that can use chest X-ray (CXR) for COVID-19 case screening and radiological trajectory prediction. We design and implement a novel three-player knowledge transfer and distillation (KTD) framework including a pre-trained attending physician (AP) network that extracts CXR imaging features from …
National Institute of Technology, Hamirpur（国家理工学院哈米尔布尔分校）；Emory University School of Medicine（埃默里大学医学院）
The COVID-19 (coronavirus disease 2019) pandemic affected more than 186 million people with over 4 million deaths worldwide by June 2021. The magnitude of which has strained global healthcare systems. Chest Computed Tomography (CT) scans have a potential role in the diagnosis and prognostication of COVID-19. Designing a diagnostic system which is cost-efficient and convenient to operate on resource-constrained devices like mobile phones would enhance the clinical usage of chest CT scans and provide swift, mobile, and accessible diagnostic capabilities. This work proposes developing a novel And…
University of Waterloo（滑铁卢大学）；Waterloo Artificial Intelligence Institute（滑铁卢人工智能研究所）；DarwinAI Corp.（达尔文人工智能公司）
The COVID-19 pandemic continues to have a devastating effect on the health and well-being of the global population. A critical step in the fight against COVID-19 is effective screening of infected patients, with one of the key screening approaches being radiology examination using chest radiography. Motivated by this and inspired by the open source efforts of the research community, in this study we introduce COVID-Net, a deep convolutional neural network design tailored for the detection of COVID-19 cases from chest X-ray (CXR) images that is open source and available to the general public. T…
Melbourne Data Analytics Platform（墨尔本数据分析平台）；University of Melbourne（墨尔本大学）
Improving automated analysis of medical imaging will provide clinicians more options in providing care for patients. The 2023 AI-enabled Medical Image Analysis Workshop and Covid-19 Diagnosis Competition (AI-MIA-COV19D) provides an opportunity to test and refine machine learning methods for detecting the presence and severity of COVID-19 in patients from CT scans. This paper presents version 2 of Cov3d, a deep learning model submitted in the 2022 competition. The model has been improved through a preprocessing step which segments the lungs in the CT scan and crops the input to this region. It …
Université de Haute-Alsace（上阿尔萨斯大学）；Université de Strasbourg（斯特拉斯堡大学）；University of Lille（里尔大学）；YNCREA-ISEN Lille（里尔YNCREA-ISEN工程学院）；University of the Basque Country（巴斯克大学）；IKERBASQUE, Basque Foundation for Science（伊克尔巴斯克巴斯克科学基金会）；The University of Tokyo（东京大学）；CNRS（法国国家科学研究中心）；Inserm（法国国家健康与医学研究院）；CHU Lille（里尔大学医院）
Coronavirus disease 2019 (COVID-19) is an infectious disease with first symptoms similar to the flu. COVID-19 appeared first in China and very quickly spreads to the rest of the world, causing then the 2019-20 coronavirus pandemic. In many cases, this disease causes pneumonia. Since pulmonary infections can be observed through radiography images, this paper investigates deep learning methods for automatically analyzing query chest X-ray images with the hope to bring precision tools to health professionals towards screening the COVID-19 and diagnosing confirmed patients. In this context, traini…
University of Turin（都灵大学）；Azienda Ospedaliera Città della Salute e della Scienza（健康与科学城医院）
The possibility to use widespread and simple chest X-ray (CXR) imaging for early screening of COVID-19 patients is attracting much interest from both the clinical and the AI community. In this study we provide insights and also raise warnings on what is reasonable to expect by applying deep-learning to COVID classification of CXR images. We provide a methodological guide and critical reading of an extensive set of statistical results that can be obtained using currently available datasets. In particular, we take the challenge posed by current small size COVID data and show how significant can …
One of the most contentious areas of research in Medical Image Preprocessing is 3D CT-scan. With the rapid spread of COVID-19, the function of CT-scan in properly and swiftly diagnosing the disease has become critical. It has a positive impact on infection prevention. There are many tasks to diagnose the illness through CT-scan images, include COVID-19. In this paper, we propose a method that using a Stacking Deep Neural Network to detect the Covid 19 through the series of 3D CT-scans images . In our method, we experiment with two backbones are DenseNet 121 and ResNet 101. This method achieves…
Because the infection by Severe Acute Respiratory Syndrome Coronavirus 2 (COVID-19) causes the pneumonia-like effect in the lungs, the examination of chest x-rays can help to diagnose the diseases. For automatic analysis of images, they are represented in machines by a set of semantic features. Deep Learning (DL) models are widely used to extract features from images. General deep features may not be appropriate to represent chest x-rays as they have a few semantic regions. Though the Bag of Visual Words (BoVW) based features are shown to be more appropriate for x-ray type of images, existing …
