用于感染治疗的刀豆球蛋白A靶向介孔二氧化硅纳米颗粒
Concanavalin A-targeted mesoporous silica nanoparticles for infection treatment
摘要：
细菌形成生物膜的能力阻碍了任何针对慢性感染的常规治疗，并具有严重的社会经济影响。在这个意义上，能够克服生物膜的粘多糖基质的屏障并在其中释放其负载的抗生素的纳米载体将是期望的。在此，一个新的纳米系统的基础上左氧氟沙星（LEVO）负载介孔二氧化硅纳米粒子（MSNs）修饰的凝集素刀豆球蛋白A（刀豆球蛋白A）已被开发。ConA的存在促进其内化到生物膜基质中，这增加了中孔内所含抗生素的抗微生物功效。这种纳米装置被认为是传统感染治疗的一种有前途的替代方案，可以提高抗微生物功效并减少副作用。
英文摘要：
The ability of bacteria to form biofilms hinders any conventional treatment against chronic infections and has serious socio-economic implications. In this sense, a nanocarrier capable of overcoming the barrier of the mucopolysaccharide matrix of the biofilm and releasing its loaded-antibiotic within would be desirable. Herein, a new nanosystem based on levofloxacin (LEVO)-loaded mesoporous silica nanoparticles (MSNs) decorated with lectin Concanavalin A (ConA) has been developed. The presence of ConA promotes its internalization into the biofilm matrix, which increases the antimicrobial efficacy of the antibiotic hosted within the mesopores. This nanodevice is envisioned as a promising alternative to conventional infection treatments by improving the antimicrobial efficacy and reducing side effects.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
