含SrO和CuO的介孔二氧化硅玻璃颗粒溶解产物诱导骨髓基质细胞系（ST-2）分泌VEGF
Induction of VEGF secretion from bone marrow stromal cell line (ST-2) by the dissolution products of mesoporous silica glass particles containing CuO and SrO
摘要：
某些生物材料能够诱导暴露于其生化影响的细胞分泌血管内皮生长因子（VEGF），其在刺激血管生成中起重要作用。寻找这种能力，在这项研究中，三个多孔玻璃的合成和表征。本研究的目的是确定超出细胞毒性范围的玻璃颗粒的浓度，该浓度可增加VEGF分泌。评估培养的骨髓基质细胞（ST-2）的活力。标本经苏木精-伊红（HE）组织化学染色后，光镜（LM）检查。根据Cu 2+和Sr 2+离子对细胞的影响来评价玻璃的生物活性。CuSr-1和CuSr-2.5的溶解产物在孵育48 h后产生ST-2细胞的最高VEGF分泌。Cu 2+和Sr 2+的组合为生物活性玻璃的工程设计奠定了基础，当用于骨再生应用时，可以产生血管化的功能性骨组织。
英文摘要：
Certain biomaterials are capable of inducing the secretion of Vascular Endothelial Growth Factor (VEGF) from cells exposed to their biochemical influence, which plays a vital role in stimulating angiogenesis. Looking for this capacity, in this study three porous glasses were synthesized and characterized. The objective of this study was to determine the concentration of the glass particles that, being out of the cytotoxic range, could increase VEGF secretion. The viability of cultivated bone marrow stromal cells (ST-2) was assessed. The samples were examined with light microscopy (LM) after the histochemical staining for haematoxylin and eosin (HE). The biological activity of glasses was evaluated in terms of the influence of the Cu2+ and Sr2+ ions on the cells. The dissolution products of CuSr-1 and CuSr-2.5 produced the highest secretion of VEGF from ST-2 cells after 48 h of incubation. The combination of Cu2+ and Sr2+ lays the foundation for engineering a bioactive glass than can lead to vascularized, functional bone tissue when used in bone regeneration applications.
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