Interactive simulation of ultrasound imaging greatly facilitates sonography training. Although ray-tracing based methods have shown promising results, obtaining realistic images requires substantial modeling effort and manual parameter tuning. In addition, current techniques still result in a significant appearance gap between simulated images and real clinical scans. Herein we introduce a novel content-preserving image translation framework (ConPres) to bridge this appearance gap, while maintaining the simulated anatomical layout. We achieve this goal by leveraging both simulated images with semantic segmentations and unpaired in-vivo ultrasound scans. Our framework is based on recent contrastive unpaired translation techniques and we propose a regularization approach by learning an auxiliary segmentation-to-real image translation task, which encourages the disentanglement of content and style. In addition, we extend the generator to be class-conditional, which enables the incorporation of additional losses, in particular a cyclic consistency loss, to further improve the translation quality. Qualitative and quantitative comparisons against state-of-the-art unpaired translation methods demonstrate the superiority of our proposed framework.
Nanyang Technological University（南洋理工大学）；National University of Singapore（新加坡国立大学）
Domain shift has been a long-standing issue for medical image segmentation. Recently, unsupervised domain adaptation (UDA) methods have achieved promising cross-modality segmentation performance by distilling knowledge from a label-rich source domain to a target domain without labels. In this work, we propose a multi-scale self-ensembling based UDA framework for automatic segmentation of two key brain structures i.e., Vestibular Schwannoma (VS) and Cochlea on high-resolution T2 images. First, a segmentation-enhanced contrastive unpaired image translation module is designed for image-level doma…
Our goal is to capture the pose of neuroscience model organisms, without using any manual supervision, to be able to study how neural circuits orchestrate behaviour. Human pose estimation attains remarkable accuracy when trained on real or simulated datasets consisting of millions of frames. However, for many applications simulated models are unrealistic and real training datasets with comprehensive annotations do not exist. We address this problem with a new sim2real domain transfer method. Our key contribution is the explicit and independent modeling of appearance, shape and poses in an unpa…
Recent advances in generative models and adversarial training have led to a flourishing image-to-image (I2I) translation literature. The current I2I translation approaches require training images from the two domains that are either all paired (supervised) or all unpaired (unsupervised). In practice, obtaining paired training data in sufficient quantities is often very costly and cumbersome. Therefore solutions that employ unpaired data, while less accurate, are largely preferred. In this paper, we aim to bridge the gap between supervised and unsupervised I2I translation, with application to s…
FD-DB: Frequency-Decoupled Dual-Branch Network for Unpaired Synthetic-to-Real Domain Translation
State Key Laboratory of Fluid Power and Mechatronic System, School of Mechanical Engineering, Zhejiang University（流体动力与机械系统国家重点实验室，机械工程学院，浙江大学）；Zhejiang Key Laboratory of Advanced Manufacturing Technology, School of Mechanical Engineering, Zhejiang University（浙江省先进制造技术重点实验室，机械工程学院，浙江大学）
Fetal brain magnetic resonance imaging (MRI) offers exquisite images of the developing brain but is not suitable for anomaly screening. For this ultrasound (US) is employed. While expert sonographers are adept at reading US images, MR images are much easier for non-experts to interpret. Hence in this paper we seek to produce images with MRI-like appearance directly from clinical US images. Our own clinical motivation is to seek a way to communicate US findings to patients or clinical professionals unfamiliar with US, but in medical image analysis such a capability is potentially useful, for in…
We propose a novel unpaired image-to-image translation method that uses denoising diffusion probabilistic models without requiring adversarial training. Our method, UNpaired Image Translation with Denoising Diffusion Probabilistic Models (UNIT-DDPM), trains a generative model to infer the joint distribution of images over both domains as a Markov chain by minimising a denoising score matching objective conditioned on the other domain. In particular, we update both domain translation models simultaneously, and we generate target domain images by a denoising Markov Chain Monte Carlo approach tha…
We cast the problem of image denoising as a domain translation problem between high and low noise domains. By modifying the cycleGAN model, we are able to learn a mapping between these domains on unpaired retinal optical coherence tomography images. In quantitative measurements and a qualitative evaluation by ophthalmologists, we show how this approach outperforms other established methods. The results indicate that the network differentiates subtle changes in the level of noise in the image. Further investigation of the model's feature maps reveals that it has learned to distinguish retinal l…
University of Science and Technology of China（中国科学技术大学）；Microsoft Research Asia（微软亚洲研究院）；University of Rochester（罗切斯特大学）
An unsupervised image-to-image translation (UI2I) task deals with learning a mapping between two domains without paired images. While existing UI2I methods usually require numerous unpaired images from different domains for training, there are many scenarios where training data is quite limited. In this paper, we argue that even if each domain contains a single image, UI2I can still be achieved. To this end, we propose TuiGAN, a generative model that is trained on only two unpaired images and amounts to one-shot unsupervised learning. With TuiGAN, an image is translated in a coarse-to-fine man…
Disentangling content and style information of an image has played an important role in recent success in image translation. In this setting, how to inject given style into an input image containing its own content is an important issue, but existing methods followed relatively simple approaches, leaving room for improvement especially when incorporating significant style changes. In response, we propose an advanced normalization technique based on adaptive convolution (AdaCoN), in order to properly impose style information into the content of an input image. In detail, after locally standardi…
Background and objectives. Domain shift is a generalisation problem of machine learning models that occurs when the data distribution of the training set is different to the data distribution encountered by the model when it is deployed. This is common in the context of biomedical image segmentation due to the variance of experimental conditions, equipment, and capturing settings. In this work, we address this challenge by studying both neural style transfer algorithms and unpaired image-to-image translation methods in the context of the segmentation of tumour spheroids. Methods. We have illus…
Medical image translation has the potential to reduce the imaging workload, by removing the need to capture some sequences, and to reduce the annotation burden for developing machine learning methods. GANs have been used successfully to translate images from one domain to another, such as MR to CT. At present, paired data (registered MR and CT images) or extra supervision (e.g. segmentation masks) is needed to learn good translation models. Registering multiple modalities or annotating structures within each of them is a tedious and laborious task. Thus, there is a need to develop improved tra…
Ultrasound simulation based on ray tracing enables the synthesis of highly realistic images. It can provide an interactive environment for training sonographers as an educational tool. However, due to high computational demand, there is a trade-off between image quality and interactivity, potentially leading to sub-optimal results at interactive rates. In this work we introduce a deep learning approach based on adversarial training that mitigates this trade-off by improving the quality of simulated images with constant computation time. An image-to-image translation framework is utilized to tr…
Huawei Noah’s Ark Lab（华为诺亚方舟实验室）；Peking University（北京大学）；The University of Sydney（悉尼大学）
Generative adversarial networks (GANs) have been successfully used for considerable computer vision tasks, especially the image-to-image translation. However, generators in these networks are of complicated architectures with large number of parameters and huge computational complexities. Existing methods are mainly designed for compressing and speeding-up deep neural networks in the classification task, and cannot be directly applied on GANs for image translation, due to their different objectives and training procedures. To this end, we develop a novel co-evolutionary approach for reducing t…
Unpaired Image-to-Image Translation (I2IT) tasks often suffer from lack of data, a problem which self-supervised learning (SSL) has recently been very popular and successful at tackling. Leveraging auxiliary tasks such as rotation prediction or generative colorization, SSL can produce better and more robust representations in a low data regime. Training such tasks along an I2IT task is however computationally intractable as model size and the number of task grow. On the other hand, learning sequentially could incur catastrophic forgetting of previously learned tasks. To alleviate this, we intr…
ETH Zurich（苏黎世联邦理工学院）；Shenzhen Graduate School, Peking University（北京大学深圳研究生院）；Hong Kong University of Sciences and Technology (HKUST)（香港科技大学）；University of Oxford（牛津大学）；University of Trento（特伦托大学）
State-of-the-art methods in image-to-image translation are capable of learning a mapping from a source domain to a target domain with unpaired image data. Though the existing methods have achieved promising results, they still produce visual artifacts, being able to translate low-level information but not high-level semantics of input images. One possible reason is that generators do not have the ability to perceive the most discriminative parts between the source and target domains, thus making the generated images low quality. In this paper, we propose a new Attention-Guided Generative Adver…
IBENS, ENS（巴黎高等师范学院生物研究所）；Université de Paris Cité（巴黎西岱大学）；Université de Paris（巴黎大学）
Unpaired image-to-image translation methods aim at learning a mapping of images from a source domain to a target domain. Recently, these methods proved to be very useful in biological applications to display subtle phenotypic cell variations otherwise invisible to the human eye. However, current models require a large number of images to be trained, while mostmicroscopy experiments remain limited in the number of images they can produce. In this work, we present an improved CycleGAN architecture that employs self-supervised discriminators to alleviate the need for numerous images. We demonstra…
College of Medicine, Seoul National University（首尔大学医学院）；Department of Radiology, Armed Forces Yangju Hospital（杨州国军医院放射科）
The purpose of this study is to apply and evaluate out-of-the-box deep learning frameworks for the crossMoDA challenge. We use the CUT model, a model for unpaired image-to-image translation based on patchwise contrastive learning and adversarial learning, for domain adaptation from contrast-enhanced T1 MR to high-resolution T2 MR. As data augmentation, we generate additional images with vestibular schwannomas with lower signal intensity. For the segmentation task, we use the nnU-Net framework. Our final submission achieved mean Dice scores of 0.8299 in the validation phase and 0.8253 in the te…
Mix-Domain Contrastive Learning for Unpaired H&E-to-IHC Stain Translation
Toronto Metropolitan University（多伦多都会大学）；Zhengzhou University（郑州大学）；The First Affiliated Hospital of Zhengzhou University（郑州大学第一附属医院）；Zhongyuan University of Technology（中原工学院）
Unpaired image-to-image translation has broad applications in art, design, and scientific simulations. One early breakthrough was CycleGAN that emphasizes one-to-one mappings between two unpaired image domains via generative-adversarial networks (GAN) coupled with the cycle-consistency constraint, while more recent works promote one-to-many mapping to boost diversity of the translated images. Motivated by scientific simulation and one-to-one needs, this work revisits the classic CycleGAN framework and boosts its performance to outperform more contemporary models without relaxing the cycle-cons…
Concordia Institute for Information Systems Engineering（康考迪亚大学信息系统工程研究所）；Concordia University（康考迪亚大学）
Motivated by the lack of publicly available datasets of chest radiographs of positive patients with Coronavirus disease 2019 (COVID-19), we build the first-of-its-kind open dataset of synthetic COVID-19 chest X-ray images of high fidelity using an unsupervised domain adaptation approach by leveraging class conditioning and adversarial training. Our contributions are twofold. First, we show considerable performance improvements on COVID-19 detection using various deep learning architectures when employing synthetic images as additional training set. Second, we show how our image synthesis metho…
VinAI Research（VinAI研究院）；FPT University（FPT大学）；University of Arkansas（阿肯色大学）
Image synthesis from corrupted contrasts increases the diversity of diagnostic information available for many neurological diseases. Recently the image-to-image translation has experienced significant levels of interest within medical research, beginning with the successful use of the Generative Adversarial Network (GAN) to the introduction of cyclic constraint extended to multiple domains. However, in current approaches, there is no guarantee that the mapping between the two image domains would be unique or one-to-one. In this paper, we introduce a novel approach to unpaired image-to-image tr…
Distilling Missing Modality Knowledge from Ultrasound for Endometriosis Diagnosis with Magnetic Resonance Images
Australian Institute for Machine Learning, University of Adelaide（阿德莱德大学澳大利亚机器学习研究所）；Flinders Health and Medical Research Institute, Flinders University（弗林德斯大学弗林德斯健康与医学研究所）；Robinson Research Institute, University of Adelaide（阿德莱德大学罗宾逊研究所）；Centre for Vision, Speech and Signal Processing, University of Surrey（萨里大学视觉、语音与信号处理中心）
University of California, Davis（加州大学戴维斯分校）；University of San Francisco Data Institute（旧金山大学数据研究所）；Wicklow AI in Medicine Research Initiative（威克洛医学人工智能研究计划）；University of Texas, San Antonio Health（德克萨斯大学圣安东尼奥健康分校）
MUSE is a novel slide-free imaging technique for histological examination of tissues that can serve as an alternative to traditional histology. In order to bridge the gap between MUSE and traditional histology, we aim to convert MUSE images to resemble authentic hematoxylin- and eosin-stained (H&E) images. We evaluated four models: a non-machine-learning-based color-mapping unmixing-based tool, CycleGAN, DualGAN, and GANILLA. CycleGAN and GANILLA provided visually compelling results that appropriately transferred H&E style and preserved MUSE content. Based on training an automated critic on re…
Unpaired Object-Level SAR-to-Optical Image Translation for Aircraft with Keypoints-Guided Diffusion Models
School of Information Science and Technology, Fudan University（复旦大学信息科学与技术学院）；Key Laboratory for Information Science of Electromagnetic Waves (Ministry of Education)（电磁波信息科学教育部重点实验室）
South China University of Technology（华南理工大学）；University of Utah（犹他大学）
In medical applications, the same anatomical structures may be observed in multiple modalities despite the different image characteristics. Currently, most deep models for multimodal segmentation rely on paired registered images. However, multimodal paired registered images are difficult to obtain in many cases. Therefore, developing a model that can segment the target objects from different modalities with unpaired images is significant for many clinical applications. In this work, we propose a novel two-stream translation and segmentation unified attentional generative adversarial network (U…
Learning super-resolution (SR) network without the paired low resolution (LR) and high resolution (HR) image is difficult because direct supervision through the corresponding HR counterpart is unavailable. Recently, many real-world SR researches take advantage of the unpaired image-to-image translation technique. That is, they used two or more generative adversarial networks (GANs), each of which translates images from one domain to another domain, \eg, translates images from the HR domain to the LR domain. However, it is not easy to stably learn such a translation with GANs using unpaired dat…
DATA61-CSIRO（澳大利亚联邦科学与工业研究组织数据61）；Australian National University（澳大利亚国立大学）
Unsupervised image-to-image translation tasks aim to find a mapping between a source domain X and a target domain Y from unpaired training data. Contrastive learning for Unpaired image-to-image Translation (CUT) yields state-of-the-art results in modeling unsupervised image-to-image translation by maximizing mutual information between input and output patches using only one encoder for both domains. In this paper, we propose a novel method based on contrastive learning and a dual learning setting (exploiting two encoders) to infer an efficient mapping between unpaired data. Additionally, while…
University of Pittsburgh（匹兹堡大学）；Carnegie Mellon University（卡内基梅隆大学）；The University of Melbourne（墨尔本大学）；Baidu Inc.（百度公司）
Unpaired image-to-image translation (I2I) is an ill-posed problem, as an infinite number of translation functions can map the source domain distribution to the target distribution. Therefore, much effort has been put into designing suitable constraints, e.g., cycle consistency (CycleGAN), geometry consistency (GCGAN), and contrastive learning-based constraints (CUTGAN), that help better pose the problem. However, these well-known constraints have limitations: (1) they are either too restrictive or too weak for specific I2I tasks; (2) these methods result in content distortion when there is a s…
Cross-contrast image translation is an important task for completing missing contrasts in clinical diagnosis. However, most existing methods learn separate translator for each pair of contrasts, which is inefficient due to many possible contrast pairs in real scenarios. In this work, we propose a unified Hyper-GAN model for effectively and efficiently translating between different contrast pairs. Hyper-GAN consists of a pair of hyper-encoder and hyper-decoder to first map from the source contrast to a common feature space, and then further map to the target contrast image. To facilitate the tr…
BioGAN: An unpaired GAN-based image to image translation model for microbiological images
University of Kent（肯特大学）；School of Engineering and Digital Arts, University of Kent（肯特大学工程与数字艺术学院）；School of Biosciences, University of Kent（肯特大学生物科学学院）
ContourDiff: Unpaired Medical Image Translation with Structural Consistency
Department of Electrical and Computer Engineering, Duke University（杜克大学电气与计算机工程系）；Department of Biostatistics & Bioinformatics, Duke University（杜克大学生物统计学与生物信息学系）；Department of Radiology, Duke University（杜克大学放射学系）；Department of Computer Science, Duke University（杜克大学计算机科学系）
Indian Institute of Technology Madras（印度理工学院马德拉斯分校）
Magnetic Resonance (MR) Imaging and Computed Tomography (CT) are the primary diagnostic imaging modalities quite frequently used for surgical planning and analysis. A general problem with medical imaging is that the acquisition process is quite expensive and time-consuming. Deep learning techniques like generative adversarial networks (GANs) can help us to leverage the possibility of an image to image translation between multiple imaging modalities, which in turn helps in saving time and cost. These techniques will help to conduct surgical planning under CT with the feedback of MRI information…
Structure-Preserving Synthesis: MaskGAN for Unpaired MR-CT Translation
Australian Institute for Machine Learning, University of Adelaide（阿德莱德大学澳大利亚机器学习研究所）；Flinders Health and Medical Research Institute, Flinders University（弗林德斯大学弗林德斯健康与医学研究所）
University of Waterloo（滑铁卢大学）；Cruise LLC（Cruise有限责任公司）
Advancements in graphics technology has increased the use of simulated data for training machine learning models. However, the simulated data often differs from real-world data, creating a distribution gap that can decrease the efficacy of models trained on simulation data in real-world applications. To mitigate this gap, sim-to-real domain transfer modifies simulated images to better match real-world data, enabling the effective use of simulation data in model training. Sim-to-real transfer utilizes image translation methods, which are divided into two main categories: paired and unpaired ima…
While hematoxylin and eosin (H&E) is a standard staining procedure, immunohistochemistry (IHC) staining further serves as a diagnostic and prognostic method. However, acquiring special staining results requires substantial costs. Hence, we proposed a strategy for ultra-high-resolution unpaired image-to-image translation: Kernelized Instance Normalization (KIN), which preserves local information and successfully achieves seamless stain transformation with constant GPU memory usage. Given a patch, corresponding position, and a kernel, KIN computes local statistics using convolution operation. In…
Z 2 Sky Technologies Inc.（Z 2 天工科技公司）；University of Rochester（罗切斯特大学）；Key Lab of Intelligent Information Processing of Chinese Academy of Sciences (CAS), Institute of Computing Technology, CAS（中国科学院计算技术研究所 中国科学院智能信息处理重点实验室）；University of Science and Technology of China（中国科学技术大学）；Suzhou Institute for Advance Research, University of Science and Technology of China（中国科学技术大学苏州高等研究院）
Spinal surgery planning necessitates automatic segmentation of vertebrae in cone-beam computed tomography (CBCT), an intraoperative imaging modality that is widely used in intervention. However, CBCT images are of low-quality and artifact-laden due to noise, poor tissue contrast, and the presence of metallic objects, causing vertebra segmentation, even manually, a demanding task. In contrast, there exists a wealth of artifact-free, high quality CT images with vertebra annotations. This motivates us to build a CBCT vertebra segmentation model using unpaired CT images with annotations. To overco…
F2FLDM: Latent Diffusion Models with Histopathology Pre-Trained Embeddings for Unpaired Frozen Section to FFPE Translation
University of Utah（犹他大学）；The Catholic University of Korea College of Medicine（韩国天主教大学医学院）；Huntsman Cancer Institute（亨茨曼癌症研究所）；Scientific Computing and Imaging Institute（科学计算与成像研究所）
New York University Tandon School of Engineering（纽约大学坦登工程学院）
Deep networks are now ubiquitous in large-scale multi-center imaging studies. However, the direct aggregation of images across sites is contraindicated for downstream statistical and deep learning-based image analysis due to inconsistent contrast, resolution, and noise. To this end, in the absence of paired data, variations of Cycle-consistent Generative Adversarial Networks have been used to harmonize image sets between a source and target domain. Importantly, these methods are prone to instability, contrast inversion, intractable manipulation of pathology, and steganographic mappings which l…
Generative adversarial networks (GANs) are currently rarely applied on 3D medical images of large size, due to their immense computational demand. The present work proposes a multi-scale patch-based GAN approach for establishing unpaired domain translation by generating 3D medical image volumes of high resolution in a memory-efficient way. The key idea to enable memory-efficient image generation is to first generate a low-resolution version of the image followed by the generation of patches of constant sizes but successively growing resolutions. To avoid patch artifacts and incorporate global …
Inter-vendor harmonization of Computed Tomography (CT) reconstruction kernels using unpaired image translation
Vanderbilt University（范德堡大学）；Vanderbilt University Medical Center（范德堡大学医学中心）；Amsterdam University Medical Center（阿姆斯特丹大学医学中心）；University of Amsterdam（阿姆斯特丹大学）
Ultrasound is the second most used modality in medical imaging. It is cost effective, hazardless, portable and implemented routinely in numerous clinical procedures. Nonetheless, image quality is characterized by granulated appearance, poor SNR and speckle noise. Specific for malignant tumors, the margins are blurred and indistinct. Thus, there is a great need for improving ultrasound image quality. We hypothesize that this can be achieved, using neural networks, by translation into a more realistic display which mimics an anatomical cut through the tissue. In order to achieve this goal, the p…
