Generative adversarial networks (GANs) are currently rarely applied on 3D medical images of large size, due to their immense computational demand. The present work proposes a multi-scale patch-based GAN approach for establishing unpaired domain translation by generating 3D medical image volumes of high resolution in a memory-efficient way. The key idea to enable memory-efficient image generation is to first generate a low-resolution version of the image followed by the generation of patches of constant sizes but successively growing resolutions. To avoid patch artifacts and incorporate global information, the patch generation is conditioned on patches from previous resolution scales. Those multi-scale GANs are trained to generate realistically looking images from image sketches in order to perform an unpaired domain translation. This allows to preserve the topology of the test data and generate the appearance of the training domain data. The evaluation of the domain translation scenarios is performed on brain MRIs of size 155x240x240 and thorax CTs of size up to 512x512x512. Compared to common patch-based approaches, the multi-resolution scheme enables better image quality and prevents patch artifacts. Also, it ensures constant GPU memory demand independent from the image size, allowing for the generation of arbitrarily large images.
University of Bourgogne Franche-Comte（勃艮第-弗朗什孔泰大学）；CASIS inc.（CASIS公司）；University of Sherbrooke（舍布鲁克大学）；University Hospital of Dijon（第戎大学医院）
Generative Adversarial Networks (GANs) have become increasingly powerful, generating mind-blowing photorealistic images that mimic the content of datasets they were trained to replicate. One recurrent theme in medical imaging is whether GANs can also be effective at generating workable medical data as they are for generating realistic RGB images. In this paper, we perform a multi-GAN and multi-application study to gauge the benefits of GANs in medical imaging. We tested various GAN architectures from basic DCGAN to more sophisticated style-based GANs on three medical imaging modalities and org…
University of Cambridge（剑桥大学）；Royal Brompton Hospital（皇家布朗普顿医院）；Imperial College London（帝国理工学院）
Single image super-resolution (SISR) is of great importance as a low-level computer vision task. The fast development of Generative Adversarial Network (GAN) based deep learning architectures realises an efficient and effective SISR to boost the spatial resolution of natural images captured by digital cameras. However, the SISR for medical images is still a very challenging problem. This is due to (1) compared to natural images, in general, medical images have lower signal to noise ratios, (2) GAN based models pre-trained on natural images may synthesise unrealistic patterns in medical images …
Generative adversarial networks (GANs) are unsupervised Deep Learning approach in the computer vision community which has gained significant attention from the last few years in identifying the internal structure of multimodal medical imaging data. The adversarial network simultaneously generates realistic medical images and corresponding annotations, which proven to be useful in many cases such as image augmentation, image registration, medical image generation, image reconstruction, and image-to-image translation. These properties bring the attention of the researcher in the field of medical…
The University of Tokyo（东京大学）；National Center for Global Health and Medicine（国立国际医疗研究中心）；Kyushu Medical Center（九州医疗中心）
Convolutional Neural Networks (CNNs) can play a key role in Medical Image Analysis under large-scale annotated datasets. However, preparing such massive dataset is demanding. In this context, Generative Adversarial Networks (GANs) can generate realistic but novel samples, and thus effectively cover the real image distribution. In terms of interpolation, the GAN-based medical image augmentation is reliable because medical modalities can display the human body's strong anatomical consistency at fixed position while clearly reflecting inter-subject variability; thus, we propose to use noise-to-im…
Deep learning algorithms produces state-of-the-art results for different machine learning and computer vision tasks. To perform well on a given task, these algorithms require large dataset for training. However, deep learning algorithms lack generalization and suffer from over-fitting whenever trained on small dataset, especially when one is dealing with medical images. For supervised image analysis in medical imaging, having image data along with their corresponding annotated ground-truths is costly as well as time consuming since annotations of the data is done by medical experts manually. I…
University of Tübingen（图宾根大学）；Max Planck Institute for Intelligent Systems（马克斯·普朗克智能系统研究所）
Image-to-image translation plays a vital role in tackling various medical imaging tasks such as attenuation correction, motion correction, undersampled reconstruction, and denoising. Generative adversarial networks have been shown to achieve the state-of-the-art in generating high fidelity images for these tasks. However, the state-of-the-art GAN-based frameworks do not estimate the uncertainty in the predictions made by the network that is essential for making informed medical decisions and subsequent revision by medical experts and has recently been shown to improve the performance and inter…
In this paper, we have developed a general-purpose architecture, Vit-Gan, capable of performing most of the image-to-image translation tasks from semantic image segmentation to single image depth perception. This paper is a follow-up paper, an extension of generator-based model [1] in which the obtained results were very promising. This opened the possibility of further improvements with adversarial architecture. We used a unique vision transformers-based generator architecture and Conditional GANs(cGANs) with a Markovian Discriminator (PatchGAN) (https://github.com/YigitGunduc/vit-gan). In th…
Unsupervised style transfer that supports diverse input styles using only one trained generator is a challenging and interesting task in computer vision. This paper proposes a Multi-IlluStrator Style Generative Adversarial Network (MISS GAN) that is a multi-style framework for unsupervised image-to-illustration translation, which can generate styled yet content preserving images. The illustrations dataset is a challenging one since it is comprised of illustrations of seven different illustrators, hence contains diverse styles. Existing methods require to train several generators (as the number…
The success of deep learning for medical imaging tasks, such as classification, is heavily reliant on the availability of large-scale datasets. However, acquiring datasets with large quantities of labeled data is challenging, as labeling is expensive and time-consuming. Semi-supervised learning (SSL) is a growing alternative to fully-supervised learning, but requires unlabeled samples for training. In medical imaging, many datasets lack unlabeled data entirely, so SSL can't be conventionally utilized. We propose 3N-GAN, or 3 Network Generative Adversarial Networks, to perform semi-supervised c…
Deep learning has significant potential for medical imaging. However, since the incident rate of each disease varies widely, the frequency of classes in a medical image dataset is imbalanced, leading to poor accuracy for such infrequent classes. One possible solution is data augmentation of infrequent classes using synthesized images created by Generative Adversarial Networks (GANs), but conventional GANs also require certain amount of images to learn. To overcome this limitation, here we propose General-to-detailed GAN (GDGAN), serially connected two GANs, one for general labels and the other…
University of Copenhagen（哥本哈根大学）；Rigshospitalet（哥本哈根大学国立医院）
Generative models such as Generative Adversarial Networks (GANs) and Variational Autoencoders (VAEs) play an increasingly important role in medical image analysis. The latent spaces of these models often show semantically meaningful directions corresponding to human-interpretable image transformations. However, until now, their exploration for medical images has been limited due to the requirement of supervised data. Several methods for unsupervised discovery of interpretable directions in GAN latent spaces have shown interesting results on natural images. This work explores the potential of a…
Arizona State University（亚利桑那州立大学）；Mila – Quebec Artificial Intelligence Institute（魁北克人工智能研究所（Mila））；Mayo Clinic（梅奥诊所）
Generative adversarial networks (GANs) have ushered in a revolution in image-to-image translation. The development and proliferation of GANs raises an interesting question: can we train a GAN to remove an object, if present, from an image while otherwise preserving the image? Specifically, can a GAN "virtually heal" anyone by turning his medical image, with an unknown health status (diseased or healthy), into a healthy one, so that diseased regions could be revealed by subtracting those two images? Such a task requires a GAN to identify a minimal subset of target pixels for domain translation,…
TU Darmstadt（达姆施塔特工业大学）；TU Munich（慕尼黑工业大学）；Radboud University Medical Center（拉德堡德大学医学中心）
Generative Adversarial Networks (GANs) and their extensions have carved open many exciting ways to tackle well known and challenging medical image analysis problems such as medical image de-noising, reconstruction, segmentation, data simulation, detection or classification. Furthermore, their ability to synthesize images at unprecedented levels of realism also gives hope that the chronic scarcity of labeled data in the medical field can be resolved with the help of these generative models. In this review paper, a broad overview of recent literature on GANs for medical applications is given, th…
Using real road testing to optimize autonomous driving algorithms is time-consuming and capital-intensive. To solve this problem, we propose a GAN-based model that is capable of generating high-quality images across different domains. We further leverage Contrastive Learning to train the model in a self-supervised way using image data acquired in the real world using real sensors and simulated images from 3D games. In this paper, we also apply an Attention Mechanism module to emphasize features that contain more information about the source domain according to their measurement of significance…
This review presents a comprehensive study on the role of GANs in addressing the challenges related to COVID-19 data scarcity and diagnosis. It is the first review that summarizes the different GANs methods and the lungs images datasets for COVID-19. It attempts to answer the questions related to applications of GANs, popular GAN architectures, frequently used image modalities, and the availability of source code. This review included 57 full-text studies that reported the use of GANs for different applications in COVID-19 lungs images data. Most of the studies (n=42) used GANs for data augmen…
University of Illinois at Urbana-Champaign（伊利诺伊大学厄巴纳-香槟分校）；Food and Drug Administration（美国食品药品监督管理局）
Modern generative models, such as generative adversarial networks (GANs), hold tremendous promise for several areas of medical imaging, such as unconditional medical image synthesis, image restoration, reconstruction and translation, and optimization of imaging systems. However, procedures for establishing stochastic image models (SIMs) using GANs remain generic and do not address specific issues relevant to medical imaging. In this work, canonical SIMs that simulate realistic vessels in angiography images are employed to evaluate procedures for establishing SIMs using GANs. The GAN-based SIM …
We present a framework for translating unlabeled images from one domain into analog images in another domain. We employ a progressively growing skip-connected encoder-generator structure and train it with a GAN loss for realistic output, a cycle consistency loss for maintaining same-domain translation identity, and a semantic consistency loss that encourages the network to keep the input semantic features in the output. We apply our framework on the task of translating face images, and show that it is capable of learning semantic mappings for face images with no supervised one-to-one image map…
Rutgers University（罗格斯大学）；Cornell University（康奈尔大学）；Stony Brook University（石溪大学）；Hong Kong University of Science and Technology（香港科技大学）
In this paper, we propose a data privacy-preserving and communication efficient distributed GAN learning framework named Distributed Asynchronized Discriminator GAN (AsynDGAN). Our proposed framework aims to train a central generator learns from distributed discriminator, and use the generated synthetic image solely to train the segmentation model.We validate the proposed framework on the application of health entities learning problem which is known to be privacy sensitive. Our experiments show that our approach: 1) could learn the real image's distribution from multiple datasets without shar…
Image-to-image translation is to learn a mapping between images from a source domain and images from a target domain. In this paper, we introduce the attention mechanism directly to the generative adversarial network (GAN) architecture and propose a novel spatial attention GAN model (SPA-GAN) for image-to-image translation tasks. SPA-GAN computes the attention in its discriminator and use it to help the generator focus more on the most discriminative regions between the source and target domains, leading to more realistic output images. We also find it helpful to introduce an additional featur…
Generative Adversarial Networks (GANs) have gained significant attention in several computer vision tasks for generating high-quality synthetic data. Various medical applications including diagnostic imaging and radiation therapy can benefit greatly from synthetic data generation due to data scarcity in the domain. However, medical image data is typically kept in 3D space, and generative models suffer from the curse of dimensionality issues in generating such synthetic data. In this paper, we investigate the potential of GANs for generating connected 3D volumes. We propose an improved version …
Exploiting learning algorithms under scarce data regimes is a limitation and a reality of the medical imaging field. In an attempt to mitigate the problem, we propose a data augmentation protocol based on generative adversarial networks. We condition the networks at a pixel-level (segmentation mask) and at a global-level information (acquisition environment or lesion type). Such conditioning provides immediate access to the image-label pairs while controlling global class specific appearance of the synthesized images. To stimulate synthesis of the features relevant for the segmentation task, a…
Indian Institute of Information Technology, Sri City（印度信息技术学院斯里城校区）；Indian Institute of Information Technology, Allahabad（印度信息技术学院阿拉哈巴德校区）；DRDO Young Scientist Laboratory - Artificial Intelligence (DYSL-AI)（印度国防研究与发展组织青年科学家实验室-人工智能）
Image-to-image translation is the recent trend to transform images from one domain to another domain using generative adversarial network (GAN). The existing GAN models perform the training by only utilizing the input and output modalities of transformation. In this paper, we perform the semantic injected training of GAN models. Specifically, we train with original input and output modalities and inject a few epochs of training for translation from input to semantic map. Lets refer the original training as the training for the translation of input image into target domain. The injection of sem…
Ben-Gurion University（本-古里安大学）；Soroka University Medical Center（索罗卡大学医学中心）
In 2018, clinics and hospitals were hit with numerous attacks leading to significant data breaches and interruptions in medical services. An attacker with access to medical records can do much more than hold the data for ransom or sell it on the black market. In this paper, we show how an attacker can use deep-learning to add or remove evidence of medical conditions from volumetric (3D) medical scans. An attacker may perform this act in order to stop a political candidate, sabotage research, commit insurance fraud, perform an act of terrorism, or even commit murder. We implement the attack usi…
University of Washington（华盛顿大学）；Institute of Automation, Chinese Academy of Sciences（中国科学院自动化研究所）；Rochester Institute of Technology（罗切斯特理工学院）
Intelligent vision is appealing in computer-assisted and robotic surgeries. Vision-based analysis with deep learning usually requires large labeled datasets, but manual data labeling is expensive and time-consuming in medical problems. We investigate a novel cross-domain strategy to reduce the need for manual data labeling by proposing an image-to-image translation model live-cadaver GAN (LC-GAN) based on generative adversarial networks (GANs). We consider a situation when a labeled cadaveric surgery dataset is available while the task is instrument segmentation on an unlabeled live surgery da…
GAN-GA: A Generative Model based on Genetic Algorithm for Medical Image Generation
Faculty of Computers and Artificial Intelligence, Helwan University（赫勒万大学计算机与人工智能学院）；TachyHealth（TachyHealth公司）；Information Technology and Computer Science School, Nile University（尼罗大学信息技术与计算机科学学院）
Simon Fraser University（西蒙弗雷泽大学）；Brown University（布朗大学）；Tel Aviv University（特拉维夫大学）
We introduce GANHopper, an unsupervised image-to-image translation network that transforms images gradually between two domains, through multiple hops. Instead of executing translation directly, we steer the translation by requiring the network to produce in-between images that resemble weighted hybrids between images from the input domains. Our network is trained on unpaired images from the two domains only, without any in-between images. All hops are produced using a single generator along each direction. In addition to the standard cycle-consistency and adversarial losses, we introduce a ne…
Generative Adversarial Networks (GANs) are machine learning methods that are used in many important and novel applications. For example, in imaging science, GANs are effectively utilized in generating image datasets, photographs of human faces, image and video captioning, image-to-image translation, text-to-image translation, video prediction, and 3D object generation to name a few. In this paper, we discuss how GANs can be used to create an artificial world. More specifically, we discuss how GANs help to describe an image utilizing image/video captioning methods and how to translate the image…
German Aerospace Center (DLR)（德国航空航天中心）；School of Information and Electronics, Beijing Institute of Technology（北京理工大学信息与电子学院）
Contrary to optical images, Synthetic Aperture Radar (SAR) images are in different electromagnetic spectrum where the human visual system is not accustomed to. Thus, with more and more SAR applications, the demand for enhanced high-quality SAR images has increased considerably. However, high-quality SAR images entail high costs due to the limitations of current SAR devices and their image processing resources. To improve the quality of SAR images and to reduce the costs of their generation, we propose a Dialectical Generative Adversarial Network (Dialectical GAN) to generate high-quality SAR i…
Current approaches have made great progress on image-to-image translation tasks benefiting from the success of image synthesis methods especially generative adversarial networks (GANs). However, existing methods are limited to handling translation tasks between two species while keeping the content matching on the semantic level. A more challenging task would be the translation among more than two species. To explore this new area, we propose a simple yet effective structure of a multi-branch discriminator for enhancing an arbitrary generative adversarial architecture (GAN), named GAN-MBD. It …
Computer-assisted diagnosis (CAD) based on deep learning has become a crucial diagnostic technology in the medical industry, effectively improving diagnosis accuracy. However, the scarcity of brain tumor Magnetic Resonance (MR) image datasets causes the low performance of deep learning algorithms. The distribution of transformed images generated by traditional data augmentation (DA) intrinsically resembles the original ones, resulting in a limited performance in terms of generalization ability. This work improves Progressive Growing of GANs with a structural similarity loss function (PGGAN-SSI…
University of California, Davis（加州大学戴维斯分校）；University of San Francisco Data Institute（旧金山大学数据研究所）；Wicklow AI in Medicine Research Initiative（威克洛医学人工智能研究计划）；University of Texas, San Antonio Health（德克萨斯大学圣安东尼奥健康分校）
MUSE is a novel slide-free imaging technique for histological examination of tissues that can serve as an alternative to traditional histology. In order to bridge the gap between MUSE and traditional histology, we aim to convert MUSE images to resemble authentic hematoxylin- and eosin-stained (H&E) images. We evaluated four models: a non-machine-learning-based color-mapping unmixing-based tool, CycleGAN, DualGAN, and GANILLA. CycleGAN and GANILLA provided visually compelling results that appropriately transferred H&E style and preserved MUSE content. Based on training an automated critic on re…
We propose GANCoder, an automatic programming approach based on Generative Adversarial Networks (GAN), which can generate the same functional and logical programming language codes conditioned on the given natural language utterances. The adversarial training between generator and discriminator helps generator learn distribution of dataset and improve code generation quality. Our experimental results show that GANCoder can achieve comparable accuracy with the state-of-the-art methods and is more stable when programming languages.
We present a detailed description and reference implementation of preprocessing steps necessary to prepare the public Retrospective Image Registration Evaluation (RIRE) dataset for the task of magnetic resonance imaging (MRI) to X-ray computed tomography (CT) translation. Furthermore we describe and implement three state of the art convolutional neural network (CNN) and generative adversarial network (GAN) models where we report statistics and visual results of two of them.
Cross-contrast image translation is an important task for completing missing contrasts in clinical diagnosis. However, most existing methods learn separate translator for each pair of contrasts, which is inefficient due to many possible contrast pairs in real scenarios. In this work, we propose a unified Hyper-GAN model for effectively and efficiently translating between different contrast pairs. Hyper-GAN consists of a pair of hyper-encoder and hyper-decoder to first map from the source contrast to a common feature space, and then further map to the target contrast image. To facilitate the tr…
University of Illinois at Urbana-Champaign（伊利诺伊大学厄巴纳-香槟分校）；Center for Devices and Radiological Health, Food and Drug Administration（美国食品药品监督管理局设备与放射健康中心）
In recent years, generative adversarial networks (GANs) have gained tremendous popularity for potential applications in medical imaging, such as medical image synthesis, restoration, reconstruction, translation, as well as objective image quality assessment. Despite the impressive progress in generating high-resolution, perceptually realistic images, it is not clear if modern GANs reliably learn the statistics that are meaningful to a downstream medical imaging application. In this work, the ability of a state-of-the-art GAN to learn the statistics of canonical stochastic image models (SIMs) t…
We look into Generative Adversarial Network (GAN), its prevalent variants and applications in a number of sectors. GANs combine two neural networks that compete against one another using zero-sum game theory, allowing them to create much crisper and discrete outputs. GANs can be used to perform image processing, video generation and prediction, among other computer vision applications. GANs can also be utilised for a variety of science-related activities, including protein engineering, astronomical data processing, remote sensing image dehazing, and crystal structure synthesis. Other notable f…
Tel Aviv University（特拉维夫大学）；The Chaim Sheba Medical Center（夏姆谢巴医疗中心）；Bar-Ilan University（巴伊兰大学）
Deep learning methods, and in particular convolutional neural networks (CNNs), have led to an enormous breakthrough in a wide range of computer vision tasks, primarily by using large-scale annotated datasets. However, obtaining such datasets in the medical domain remains a challenge. In this paper, we present methods for generating synthetic medical images using recently presented deep learning Generative Adversarial Networks (GANs). Furthermore, we show that generated medical images can be used for synthetic data augmentation, and improve the performance of CNN for medical image classificatio…
The University of Tokyo（东京大学）；National Institute of Advanced Industrial Science and Technology (AIST)（产业技术综合研究所）；Tokyo Institute of Technology（东京工业大学）
Unpaired image-to-image (I2I) translation has received considerable attention in pattern recognition and computer vision because of recent advancements in generative adversarial networks (GANs). However, due to the lack of explicit supervision, unpaired I2I models often fail to generate realistic images, especially in challenging datasets with different backgrounds and poses. Hence, stabilization is indispensable for GANs and applications of I2I translation. Herein, we propose Augmented Cyclic Consistency Regularization (ACCR), a novel regularization method for unpaired I2I translation. Our ma…
Mitsubishi Electric Research Labs (MERL)（三菱电机研究实验室（MERL））
Unpaired image-to-image translation is the problem of mapping an image in the source domain to one in the target domain, without requiring corresponding image pairs. To ensure the translated images are realistically plausible, recent works, such as Cycle-GAN, demands this mapping to be invertible. While, this requirement demonstrates promising results when the domains are unimodal, its performance is unpredictable in a multi-modal scenario such as in an image segmentation task. This is because, invertibility does not necessarily enforce semantic correctness. To this end, we present a semantica…
Eindhoven University of Technology（埃因霍温理工大学）；Philips Research Laboratories（飞利浦研究实验室）；Philips Healthcare（飞利浦医疗）
There has been considerable interest in the MR physics-based simulation of a database of virtual cardiac MR images for the development of deep-learning analysis networks. However, the employment of such a database is limited or shows suboptimal performance due to the realism gap, missing textures, and the simplified appearance of simulated images. In this work we 1) provide image simulation on virtual XCAT subjects with varying anatomies, and 2) propose sim2real translation network to improve image realism. Our usability experiments suggest that sim2real data exhibits a good potential to augme…
Deep Learning-based image synthesis techniques have been applied in healthcare research for generating medical images to support open research. Training generative adversarial neural networks (GAN) usually requires large amounts of training data. Federated learning (FL) provides a way of training a central model using distributed data from different medical institutions while keeping raw data locally. However, FL is vulnerable to backdoor attack, an adversarial by poisoning training data, given the central server cannot access the original data directly. Most backdoor attack strategies focus o…
Johns Hopkins University（约翰斯·霍普金斯大学）；DEVCOM Army Research Laboratory（美国陆军作战能力发展司令部陆军研究实验室）
Existing thermal-to-visible face verification approaches expect the thermal and visible face images to be of similar resolution. This is unlikely in real-world long-range surveillance systems, since humans are distant from the cameras. To address this issue, we introduce the task of thermal-to-visible face verification from low-resolution thermal images. Furthermore, we propose Axial-Generative Adversarial Network (Axial-GAN) to synthesize high-resolution visible images for matching. In the proposed approach we augment the GAN framework with axial-attention layers which leverage the recent adv…
Inter-scanner and inter-protocol discrepancy in MRI datasets are known to lead to significant quantification variability. Hence image-to-image or scanner-to-scanner translation is a crucial frontier in the area of medical image analysis with a lot of potential applications. Nonetheless, a significant percentage of existing algorithms cannot explicitly exploit and preserve texture details from target scanners and offers individual solutions towards specialized task-specific architectures. In this paper, we design a multi-scale texture transfer to enrich the reconstruction images with more detai…
This is a tutorial and survey paper on Generative Adversarial Network (GAN), adversarial autoencoders, and their variants. We start with explaining adversarial learning and the vanilla GAN. Then, we explain the conditional GAN and DCGAN. The mode collapse problem is introduced and various methods, including minibatch GAN, unrolled GAN, BourGAN, mixture GAN, D2GAN, and Wasserstein GAN, are introduced for resolving this problem. Then, maximum likelihood estimation in GAN are explained along with f-GAN, adversarial variational Bayes, and Bayesian GAN. Then, we cover feature matching in GAN, InfoG…
Northwestern Polytechnical University（西北工业大学）；School of Artificial Intelligence, Optics and Electronics (iOPEN)（人工智能、光学与电子学院（iOPEN））；School of Computer Science（计算机科学学院）
In this paper, a new task is proposed, namely, weather translation, which refers to transferring weather conditions of the image from one category to another. It is important for photographic style transfer. Although lots of approaches have been proposed in traditional image translation tasks, few of them can handle the multi-category weather translation task, since weather conditions have rich categories and highly complex semantic structures. To address this problem, we develop a multi-domain weather translation approach based on generative adversarial networks (GAN), denoted as Weather GAN,…
