Unpaired image-to-image translation of retinal images can efficiently increase the training dataset for deep-learning-based multi-modal retinal registration methods. Our method integrates a vessel segmentation network into the image-to-image translation task by extending the CycleGAN framework. The segmentation network is inserted prior to a UNet vision transformer generator network and serves as a shared representation between both domains. We reformulate the original identity loss to learn the direct mapping between the vessel segmentation and the real image. Additionally, we add a segmentation loss term to ensure shared vessel locations between fake and real images. In the experiments, our method shows a visually realistic look and preserves the vessel structures, which is a prerequisite for generating multi-modal training data for image registration.
The original publication Unpaired Image-to-Image Translation using Cycle-Consistent Adversarial Networks served as the inspiration for this implementation project. Researchers developed a novel method for doing image-to-image translations using an unpaired dataset in the original study. Despite the fact that the pix2pix models findings are good, the matched dataset is frequently not available. In the absence of paired data, cycleGAN can therefore get over this issue by converting images to images. In order to lessen the difference between the images, they implemented cycle consistency loss.I e…
The cycleGAN is becoming an influential method in medical image synthesis. However, due to a lack of direct constraints between input and synthetic images, the cycleGAN cannot guarantee structural consistency between these two images, and such consistency is of extreme importance in medical imaging. To overcome this, we propose a structure-constrained cycleGAN for brain MR-to-CT synthesis using unpaired data that defines an extra structure-consistency loss based on the modality independent neighborhood descriptor to constrain structural consistency. Additionally, we use a position-based select…
Korea Advanced Institute of Science and Technology (KAIST)（韩国科学技术院（KAIST））；Seoul National University College of Medicine, Seoul National University Bundang Hospital（首尔大学医学院，首尔大学盆唐医院）
Recently, deep learning approaches for accelerated MRI have been extensively studied thanks to their high performance reconstruction in spite of significantly reduced runtime complexity. These neural networks are usually trained in a supervised manner, so matched pairs of subsampled and fully sampled k-space data are required. Unfortunately, it is often difficult to acquire matched fully sampled k-space data, since the acquisition of fully sampled k-space data requires long scan time and often leads to the change of the acquisition protocol. Therefore, unpaired deep learning without matched la…
Nara Institute of Science and Technology（奈良先端科学技术大学院大学）；Osaka University（大阪大学）；Johns Hopkins University（约翰斯·霍普金斯大学）
CT is commonly used in orthopedic procedures. MRI is used along with CT to identify muscle structures and diagnose osteonecrosis due to its superior soft tissue contrast. However, MRI has poor contrast for bone structures. Clearly, it would be helpful if a corresponding CT were available, as bone boundaries are more clearly seen and CT has standardized (i.e., Hounsfield) units. Therefore, we aim at MR-to-CT synthesis. The CycleGAN was successfully applied to unpaired CT and MR images of the head, these images do not have as much variation of intensity pairs as do images in the pelvic region du…
IBENS, ENS（巴黎高等师范学院生物研究所）；Université de Paris Cité（巴黎西岱大学）；Université de Paris（巴黎大学）
Unpaired image-to-image translation methods aim at learning a mapping of images from a source domain to a target domain. Recently, these methods proved to be very useful in biological applications to display subtle phenotypic cell variations otherwise invisible to the human eye. However, current models require a large number of images to be trained, while mostmicroscopy experiments remain limited in the number of images they can produce. In this work, we present an improved CycleGAN architecture that employs self-supervised discriminators to alleviate the need for numerous images. We demonstra…
Unpaired image-to-image translation refers to learning inter-image-domain mapping in an unsupervised manner. Existing methods often learn deterministic mappings without explicitly modelling the robustness to outliers or predictive uncertainty, leading to performance degradation when encountering unseen out-of-distribution (OOD) patterns at test time. To address this limitation, we propose a novel probabilistic method called Uncertainty-aware Generalized Adaptive Cycle Consistency (UGAC), which models the per-pixel residual by generalized Gaussian distribution, capable of modelling heavy-tailed…
Unpaired image-to-image translation has broad applications in art, design, and scientific simulations. One early breakthrough was CycleGAN that emphasizes one-to-one mappings between two unpaired image domains via generative-adversarial networks (GAN) coupled with the cycle-consistency constraint, while more recent works promote one-to-many mapping to boost diversity of the translated images. Motivated by scientific simulation and one-to-one needs, this work revisits the classic CycleGAN framework and boosts its performance to outperform more contemporary models without relaxing the cycle-cons…
University of California, Davis（加州大学戴维斯分校）；University of San Francisco Data Institute（旧金山大学数据研究所）；Wicklow AI in Medicine Research Initiative（威克洛医学人工智能研究计划）；University of Texas, San Antonio Health（德克萨斯大学圣安东尼奥健康分校）
MUSE is a novel slide-free imaging technique for histological examination of tissues that can serve as an alternative to traditional histology. In order to bridge the gap between MUSE and traditional histology, we aim to convert MUSE images to resemble authentic hematoxylin- and eosin-stained (H&E) images. We evaluated four models: a non-machine-learning-based color-mapping unmixing-based tool, CycleGAN, DualGAN, and GANILLA. CycleGAN and GANILLA provided visually compelling results that appropriately transferred H&E style and preserved MUSE content. Based on training an automated critic on re…
Unpaired image-to-image translation has been applied successfully to natural images but has received very little attention for manifold-valued data such as in diffusion tensor imaging (DTI). The non-Euclidean nature of DTI prevents current generative adversarial networks (GANs) from generating plausible images and has mainly limited their application to diffusion MRI scalar maps, such as fractional anisotropy (FA) or mean diffusivity (MD). Even if these scalar maps are clinically useful, they mostly ignore fiber orientations and therefore have limited applications for analyzing brain fibers. H…
Indian Institute of Information Technology, Sri City（印度信息技术学院，斯里城）
Image to Image Translation (I2I) is a challenging computer vision problem used in numerous domains for multiple tasks. Recently, ophthalmology became one of the major fields where the application of I2I is increasing rapidly. One such application is the generation of synthetic retinal optical coherence tomographic (OCT) scans. Existing I2I methods require training of multiple models to translate images from normal scans to a specific pathology: limiting the use of these models due to their complexity. To address this issue, we propose an unsupervised multi-domain I2I network with pre-trained s…
Unpaired Image-to-Image Translation (I2IT) tasks often suffer from lack of data, a problem which self-supervised learning (SSL) has recently been very popular and successful at tackling. Leveraging auxiliary tasks such as rotation prediction or generative colorization, SSL can produce better and more robust representations in a low data regime. Training such tasks along an I2IT task is however computationally intractable as model size and the number of task grow. On the other hand, learning sequentially could incur catastrophic forgetting of previously learned tasks. To alleviate this, we intr…
Korea Advanced Institute of Science and Technology（韩国科学技术院）
Unsupervised image-to-image translation methods such as CycleGAN learn to convert images from one domain to another using unpaired training data sets from different domains. Unfortunately, these approaches still require centrally collected unpaired records, potentially violating privacy and security issues. Although the recent federated learning (FL) allows a neural network to be trained without data exchange, the basic assumption of the FL is that all clients have their own training data from a similar domain, which is different from our image-to-image translation scenario in which each clien…
Background and objectives. Domain shift is a generalisation problem of machine learning models that occurs when the data distribution of the training set is different to the data distribution encountered by the model when it is deployed. This is common in the context of biomedical image segmentation due to the variance of experimental conditions, equipment, and capturing settings. In this work, we address this challenge by studying both neural style transfer algorithms and unpaired image-to-image translation methods in the context of the segmentation of tumour spheroids. Methods. We have illus…
Google Cloud AI（谷歌云人工智能）；Chinese Academy of Sciences（中国科学院）
The recent direction of unpaired image-to-image translation is on one hand very exciting as it alleviates the big burden in obtaining label-intensive pixel-to-pixel supervision, but it is on the other hand not fully satisfactory due to the presence of artifacts and degenerated transformations. In this paper, we take a manifold view of the problem by introducing a smoothness term over the sample graph to attain harmonic functions to enforce consistent mappings during the translation. We develop HarmonicGAN to learn bi-directional translations between the source and the target domains. With the …
University of Illinois at Urbana-Champaign（伊利诺伊大学厄巴纳-香槟分校）；Institute of Computing Technology, Chinese Academy of Sciences（中国科学院计算技术研究所）；Siemens Healthineers（西门子医疗）；Rutgers University（罗格斯大学）
Recently image-to-image translation has attracted significant interests in the literature, starting from the successful use of the generative adversarial network (GAN), to the introduction of cyclic constraint, to extensions to multiple domains. However, in existing approaches, there is no guarantee that the mapping between two image domains is unique or one-to-one. Here we propose a self-inverse network learning approach for unpaired image-to-image translation. Building on top of CycleGAN, we learn a self-inverse function by simply augmenting the training samples by swapping inputs and output…
Memorial Sloan Kettering Cancer Center（纪念斯隆凯特琳癌症中心）；Stony Brook University（石溪大学）
Colorectal cancer screening modalities, such as optical colonoscopy (OC) and virtual colonoscopy (VC), are critical for diagnosing and ultimately removing polyps (precursors of colon cancer). The non-invasive VC is normally used to inspect a 3D reconstructed colon (from CT scans) for polyps and if found, the OC procedure is performed to physically traverse the colon via endoscope and remove these polyps. In this paper, we present a deep learning framework, Extended and Directional CycleGAN, for lossy unpaired image-to-image translation between OC and VC to augment OC video sequences with scale…
The CycleGAN framework allows for unsupervised image-to-image translation of unpaired data. In a scenario of surgical training on a physical surgical simulator, this method can be used to transform endoscopic images of phantoms into images which more closely resemble the intra-operative appearance of the same surgical target structure. This can be viewed as a novel augmented reality approach, which we coined Hyperrealism in previous work. In this use case, it is of paramount importance to display objects like needles, sutures or instruments consistent in both domains while altering the style t…
Auxiliary CycleGAN-guidance for Task-Aware Domain Translation from Duplex to Monoplex IHC Images
AstraZeneca Computational Pathology, Oncology Research and Development（阿斯利康肿瘤研发部计算病理学）；AstraZeneca Translational Pathology, Oncology Research and Development（阿斯利康肿瘤研发部转化病理学）
Computer Vision Lab, ETH Zurich（苏黎世联邦理工学院计算机视觉实验室）；VISICS, KU Leuven（鲁汶大学VISICS）
This paper presents a new problem of unpaired face translation between images and videos, which can be applied to facial video prediction and enhancement. In this problem there exist two major technical challenges: 1) designing a robust translation model between static images and dynamic videos, and 2) preserving facial identity during image-video translation. To address such two problems, we generalize the state-of-the-art image-to-image translation network (Cycle-Consistent Adversarial Networks) to the image-to-video/video-to-image translation context by exploiting a image-video translation …
A Two-Stage Generative Model with CycleGAN and Joint Diffusion for MRI-based Brain Tumor Detection
Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences（中国科学院深圳先进技术研究院）；University of Chinese Academy of Sciences（中国科学院大学）；Peking University Shenzhen Hospital（北京大学深圳医院）；National Center for Applied Mathematics Shenzhen（深圳国家应用数学中心）
Radboud University Medical Center（拉德堡德大学医学中心）；KTH – Royal Institute of Technology（瑞典皇家理工学院）；Elekta（医科达公司）；Netherlands Cancer Institute（荷兰癌症研究所）
Unpaired image-to-image translation has attracted significant interest due to the invention of CycleGAN, a method which utilizes a combination of adversarial and cycle consistency losses to avoid the need for paired data. It is known that the CycleGAN problem might admit multiple solutions, and our goal in this paper is to analyze the space of exact solutions and to give perturbation bounds for approximate solutions. We show theoretically that the exact solution space is invariant with respect to automorphisms of the underlying probability spaces, and, furthermore, that the group of automorphi…
In intelligent manufacturing, the quality of machine translation engineering drawings will directly affect its manufacturing accuracy. Currently, most of the work is manually translated, greatly reducing production efficiency. This paper proposes an automatic translation method for welded structural engineering drawings based on Cyclic Generative Adversarial Networks (CycleGAN). The CycleGAN network model of unpaired transfer learning is used to learn the feature mapping of real welding engineering drawings to realize automatic translation of engineering drawings. U-Net and PatchGAN are the ma…
TCS Research（塔塔咨询服务公司研究部 (TCS Research)）；New Delhi, India（印度新德里 (New Delhi, India) （注：此处地址非机构，仅保留原文机构部分））
In the big data era, the impetus to digitize the vast reservoirs of data trapped in unstructured scanned documents such as invoices, bank documents and courier receipts has gained fresh momentum. The scanning process often results in the introduction of artifacts such as background noise, blur due to camera motion, watermarkings, coffee stains, or faded text. These artifacts pose many readability challenges to current text recognition algorithms and significantly degrade their performance. Existing learning based denoising techniques require a dataset comprising of noisy documents paired with …
Arizona State University（亚利桑那州立大学）；Washington University in St. Louis（圣路易斯华盛顿大学）；Mayo Clinic（梅奥诊所）
Real-world non-mydriatic retinal fundus photography is prone to artifacts, imperfections and low-quality when certain ocular or systemic co-morbidities exist. Artifacts may result in inaccuracy or ambiguity in clinical diagnoses. In this paper, we proposed a simple but effective end-to-end framework for enhancing poor-quality retinal fundus images. Leveraging the optimal transport theory, we proposed an unpaired image-to-image translation scheme for transporting low-quality images to their high-quality counterparts. We theoretically proved that a Generative Adversarial Networks (GAN) model wit…
University of Pittsburgh（匹兹堡大学）；Carnegie Mellon University（卡内基梅隆大学）；The University of Melbourne（墨尔本大学）；Baidu Inc.（百度公司）
Unpaired image-to-image translation (I2I) is an ill-posed problem, as an infinite number of translation functions can map the source domain distribution to the target distribution. Therefore, much effort has been put into designing suitable constraints, e.g., cycle consistency (CycleGAN), geometry consistency (GCGAN), and contrastive learning-based constraints (CUTGAN), that help better pose the problem. However, these well-known constraints have limitations: (1) they are either too restrictive or too weak for specific I2I tasks; (2) these methods result in content distortion when there is a s…
Bahcesehir University（巴赫切谢希尔大学）；American University of Malta（马耳他美国大学）
Medical imaging plays a significant role in detecting and treating various diseases. However, these images often happen to be of too poor quality, leading to decreased efficiency, extra expenses, and even incorrect diagnoses. Therefore, we propose a retinal image enhancement method using a vision transformer and convolutional neural network. It builds a cycle-consistent generative adversarial network that relies on unpaired datasets. It consists of two generators that translate images from one domain to another (e.g., low- to high-quality and vice versa), playing an adversarial game with two d…
Domain variability is a common bottle neck in developing generalisable algorithms for various medical applications. Motivated by the observation that the domain variability of the medical images is to some extent compact, we propose to learn a target representative feature space through unpaired image to image translation (CycleGAN). We comprehensively evaluate the performanceand usefulness by utilising the transformation to mitosis detection with candidate proposal and classification. This work presents a simple yet effective multi-step mitotic figure detection algorithm developed as a baseli…
We propose a method to translate cartoon images to real world images using Generative Aderserial Network (GAN). Existing GAN-based image-to-image translation methods which are trained on paired datasets are impractical as the data is difficult to accumulate. Therefore, in this paper we exploit the Cycle-Consistent Adversarial Networks (CycleGAN) method for images translation which needs an unpaired dataset. By applying CycleGAN we show that our model is able to generate meaningful real world images from cartoon images. However, we implement another state of the art technique $-$ Deep Analogy $…
Recently, image-to-image translation has been made much progress owing to the success of conditional Generative Adversarial Networks (cGANs). And some unpaired methods based on cycle consistency loss such as DualGAN, CycleGAN and DiscoGAN are really popular. However, it's still very challenging for translation tasks with the requirement of high-level visual information conversion, such as photo-to-caricature translation that requires satire, exaggeration, lifelikeness and artistry. We present an approach for learning to translate faces in the wild from the source photo domain to the target car…
Faculty of Electrical Engineering and Computing, University of Zagreb（萨格勒布大学电气工程与计算学院）
Image-to-image translation models transfer images from input domain to output domain in an endeavor to retain the original content of the image. Contrastive Unpaired Translation is one of the existing methods for solving such problems. Significant advantage of this method, compared to competitors, is the ability to train and perform well in cases where both input and output domains are only a single image. Another key thing that differentiates this method from its predecessors is the usage of image patches rather than the whole images. It also turns out that sampling negatives (patches require…
Radio echo sounding (RES) is a common technique used in subsurface glacial imaging, which provides insight into the underlying rock and ice. However, systematic noise is introduced into the data during collection, complicating interpretation of the results. Researchers most often use a combination of manual interpretation and filtering techniques to denoise data; however, these processes are time intensive and inconsistent. Fully Convolutional Networks have been proposed as an automated alternative to identify layer boundaries in radargrams. However, they require high-quality manually processe…
School of Electrical Information and Communication Engineering, Huazhong University of Science & Technology（华中科技大学电子信息与通信学院）；Microsoft AI & Research（微软人工智能与研究）；Machine Learning Department, Carnegie Mellon University（卡内基梅隆大学机器学习系）
Recent techniques built on Generative Adversarial Networks (GANs), such as Cycle-Consistent GANs, are able to learn mappings among different domains built from unpaired datasets, through min-max optimization games between generators and discriminators. However, it remains challenging to stabilize the training process and thus cyclic models fall into mode collapse accompanied by the success of discriminator. To address this problem, we propose an novel Bayesian cyclic model and an integrated cyclic framework for inter-domain mappings. The proposed method motivated by Bayesian GAN explores the f…
Facebook AI Research（Facebook 人工智能研究院）；Sorbonne University（索邦大学）
We propose a simple architecture to address unpaired image-to-image translation tasks: style or class transfer, denoising, deblurring, deblocking, etc. We start from an image autoencoder architecture with fixed weights. For each task we learn a residual block operating in the latent space, which is iteratively called until the target domain is reached. A specific training schedule is required to alleviate the exponentiation effect of the iterations. At test time, it offers several advantages: the number of weight parameters is limited and the compositional design allows one to modulate the str…
Queen Mary University of London（伦敦玛丽女王大学）；Karolinska University Hospital（卡罗林斯卡大学医院）
Histopathological cancer diagnosis is based on visual examination of stained tissue slides. Hematoxylin and eosin (H\&E) is a standard stain routinely employed worldwide. It is easy to acquire and cost effective, but cells and tissue components show low-contrast with varying tones of dark blue and pink, which makes difficult visual assessments, digital image analysis, and quantifications. These limitations can be overcome by IHC staining of target proteins of the tissue slide. IHC provides a selective, high-contrast imaging of cells and tissue components, but their use is largely limited by a …
Supervised Pix2Pix and unsupervised Cycle-consistency are two modes that dominate the field of medical image-to-image translation. However, neither modes are ideal. The Pix2Pix mode has excellent performance. But it requires paired and well pixel-wise aligned images, which may not always be achievable due to respiratory motion or anatomy change between times that paired images are acquired. The Cycle-consistency mode is less stringent with training data and works well on unpaired or misaligned images. But its performance may not be optimal. In order to break the dilemma of the existing modes, …
Mayachitra Inc.（Mayachitra公司）；Naval Air Warfare Center Weapons Division（海军空战中心武器分部）；University of California, Riverside（加州大学河滨分校）
The advent of Generative Adversarial Networks (GANs) has brought about completely novel ways of transforming and manipulating pixels in digital images. GAN based techniques such as Image-to-Image translations, DeepFakes, and other automated methods have become increasingly popular in creating fake images. In this paper, we propose a novel approach to detect GAN generated fake images using a combination of co-occurrence matrices and deep learning. We extract co-occurrence matrices on three color channels in the pixel domain and train a model using a deep convolutional neural network (CNN) frame…
CyclePose -- Leveraging Cycle-Consistency for Annotation-Free Nuclei Segmentation in Fluorescence Microscopy
Friedrich-Alexander-Universität (FAU)（弗里德里希-亚历山大-埃尔朗根-纽伦堡大学（FAU））；Universität Würzburg（维尔茨堡大学）；Center for AI and Data Science (CAIDAS)（人工智能与数据科学中心（CAIDAS））
Reconstructing Retinal Visual Images from 3T fMRI Data Enhanced by Unsupervised Learning
Arizona State University（亚利桑那州立大学）；NYU Shanghai（上海纽约大学）；New York University（纽约大学）；NYU-ECNU Institute of Brain and Cognitive Science（纽约大学-华东师范大学脑与认知科学研究所）
