Convolutional networks (ConvNets) have achieved promising accuracy for various anatomical segmentation tasks. Despite the success, these methods can be sensitive to data appearance variations. Considering the large variability of scans caused by artifacts, pathologies, and scanning setups, robust ConvNets are vital for clinical applications, while have not been fully explored. In this paper, we propose to mitigate the challenge by enabling ConvNets' awareness of the underlying anatomical invariances among imaging scans. Specifically, we introduce a fully convolutional Constraint Adoption Module (CAM) that incorporates probabilistic atlas priors as explicit constraints for predictions over a locally connected Conditional Random Field (CFR), which effectively reinforces the anatomical consistency of the labeling outputs. We design the CAM to be flexible for boosting various ConvNet, and compact for co-optimizing with ConvNets for fusion parameters that leads to the optimal performance. We show the advantage of such atlas priors fusion is two-fold with two brain parcellation tasks. First, our models achieve state-of-the-art accuracy among ConvNet-based methods on both datasets, by significantly reducing structural abnormalities of predictions. Second, we can largely boost the robustness of existing ConvNets, proved by: (i) testing on scans with synthetic pathologies, and (ii) training and evaluation on scans of different scanning setups across datasets. Our method is proposing to be easily adopted to existing ConvNets by fine-tuning with CAM plugged in for accuracy and robustness boosts.
Research Institute for Signals, Systems and Computational Intelligence, sinc(i)（信号、系统与计算智能研究所）；CONICET（国家科学技术研究委员会）；Universidad Nacional del Litoral（国立滨海大学）
In this work we address the problem of landmark-based segmentation for anatomical structures. We propose HybridGNet, an encoder-decoder neural architecture which combines standard convolutions for image feature encoding, with graph convolutional neural networks to decode plausible representations of anatomical structures. We benchmark the proposed architecture considering other standard landmark and pixel-based models for anatomical segmentation in chest x-ray images, and found that HybridGNet is more robust to image occlusions. We also show that it can be used to construct landmark-based segm…
Anatomical Consistency Distillation and Inconsistency Synthesis for Brain Tumor Segmentation with Missing Modalities
University of Science and Technology of China（中国科学技术大学）；Tianjin University（天津大学）；Beijing Tiantan Hospital, Capital Medical University（首都医科大学附属北京天坛医院）；Hefei Comprehensive National Science Center（合肥综合性国家科学中心）
Technical University of Munich（慕尼黑工业大学）；University Medical Center Freiburg（弗莱堡大学医学中心）
With the advent of deep learning algorithms, fully automated radiological image analysis is within reach. In spine imaging, several atlas- and shape-based as well as deep learning segmentation algorithms have been proposed, allowing for subsequent automated analysis of morphology and pathology. The first Large Scale Vertebrae Segmentation Challenge (VerSe 2019) showed that these perform well on normal anatomy, but fail in variants not frequently present in the training dataset. Building on that experience, we report on the largely increased VerSe 2020 dataset and results from the second iterat…
Imperial College London（伦敦帝国学院）；King’s College London（伦敦国王学院）
We present a novel approach to automatically segment magnetic resonance (MR) images of the human brain into anatomical regions. Our methodology is based on a deep artificial neural network that assigns each voxel in an MR image of the brain to its corresponding anatomical region. The inputs of the network capture information at different scales around the voxel of interest: 3D and orthogonal 2D intensity patches capture the local spatial context while large, compressed 2D orthogonal patches and distances to the regional centroids enforce global spatial consistency. Contrary to commonly used se…
White Matter Hyperintensities (WMH) are the most common manifestation of cerebral small vessel disease (cSVD) on the brain MRI. Accurate WMH segmentation algorithms are important to determine cSVD burden and its clinical consequences. Most of existing WMH segmentation algorithms require both fluid attenuated inversion recovery (FLAIR) images and T1-weighted images as inputs. However, T1-weighted images are typically not part of standard clinicalscans which are acquired for patients with acute stroke. In this paper, we propose a novel brain atlas guided attention U-Net (BAGAU-Net) that leverage…
Towards Unifying Anatomy Segmentation: Automated Generation of a Full-body CT Dataset via Knowledge Aggregation and Anatomical Guidelines
Institute for Anthropomatics and Robotics, Karlsruhe Institute of Technology（卡尔斯鲁厄理工学院人机交互与机器人学研究所）；Institute for AI in Medicine, University Hospital Essen（埃森大学医院医学人工智能研究所）；Steinbuch Center for Computing, Karlsruhe Institute of Technology (KIT)（卡尔斯鲁厄理工学院（KIT）施泰因布赫计算中心）；Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ)（德国癌症研究中心（DKFZ）放射肿瘤学医学物理科）；Heidelberg Institute of Radiation Oncology (HIRO)（海德堡放射肿瘤学研究所（HIRO））；National Center for Radiation Research in Oncology (NCRO)（国家肿瘤放射研究中心（NCRO））；Helmholtz Information and Data Science School for Health (HIDSS4Health)（亥姆霍兹健康信息与数据科学学院（HIDSS4Health））；Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen（埃森大学医院诊断与介入放射学及神经放射学系）
SegHeD: Segmentation of Heterogeneous Data for Multiple Sclerosis Lesions with Anatomical Constraints
Imperial College London（伦敦帝国学院）；Data Science Institute, Imperial College London（伦敦帝国学院数据科学研究所）；Beijing Institute of Technology（北京理工大学）；UK Dementia Research Institute（英国痴呆症研究所）；Rosalind Franklin Institute（罗莎琳德·富兰克林研究所）
We propose an unsupervised deep learning method for atlas based registration to achieve segmentation and spatial alignment of the embryonic brain in a single framework. Our approach consists of two sequential networks with a specifically designed loss function to address the challenges in 3D first trimester ultrasound. The first part learns the affine transformation and the second part learns the voxelwise nonrigid deformation between the target image and the atlas. We trained this network end-to-end and validated it against a ground truth on synthetic datasets designed to resemble the challen…
Canon Medical Research Europe（佳能医疗欧洲研究中心）；Queen Elizabeth University Hospital（伊丽莎白女王大学医院）；University of Glasgow（格拉斯哥大学）
We present an efficient neural network method for locating anatomical landmarks in 3D medical CT scans, using atlas location autocontext in order to learn long-range spatial context. Location predictions are made by regression to Gaussian heatmaps, one heatmap per landmark. This system allows patchwise application of a shallow network, thus enabling multiple volumetric heatmaps to be predicted concurrently without prohibitive GPU memory requirements. Further, the system allows inter-landmark spatial relationships to be exploited using a simple overdetermined affine mapping that is robust to de…
We consider the problem of segmenting a biomedical image into anatomical regions of interest. We specifically address the frequent scenario where we have no paired training data that contains images and their manual segmentations. Instead, we employ unpaired segmentation images to build an anatomical prior. Critically these segmentations can be derived from imaging data from a different dataset and imaging modality than the current task. We introduce a generative probabilistic model that employs the learned prior through a convolutional neural network to compute segmentations in an unsupervise…
Ecole de technologie supérieure（高等技术学院）；Shandong University（山东大学）
Despite their outstanding accuracy, semi-supervised segmentation methods based on deep neural networks can still yield predictions that are considered anatomically impossible by clinicians, for instance, containing holes or disconnected regions. To solve this problem, we present a Context-aware Virtual Adversarial Training (CaVAT) method for generating anatomically plausible segmentation. Unlike approaches focusing solely on accuracy, our method also considers complex topological constraints like connectivity which cannot be easily modeled in a differentiable loss function. We use adversarial …
We propose a 2D Encoder-Decoder based deep learning architecture for semantic segmentation, that incorporates anatomical priors by imitating the encoder component of an autoencoder in latent space. The autoencoder is additionally enhanced by means of hierarchical features, extracted by an U-Net module. Our suggested architecture is trained in an end-to-end manner and is evaluated on the example of pelvic bone segmentation in MRI. A comparison to the standard U-Net architecture shows promising improvements.
The 4D Human Embryonic Brain Atlas: spatiotemporal atlas generation for rapid anatomical changes
Erasmus MC（埃拉斯姆斯医学院）；University Medical Center Groningen（格罗宁根大学医学中心）；Amsterdam UMC location University of Amsterdam（阿姆斯特丹大学阿姆斯特丹医学中心分部）；Amsterdam Reproduction and Development research institute（阿姆斯特丹生殖与发育研究所）
Segmentation of medical images is a challenging task owing to their complexity. A standard segmentation problem within Magnetic Resonance Imaging (MRI) is the task of labeling voxels according to their tissue type. Image segmentation provides volumetric quantification of liver area and thus helps in the diagnosis of disorders, such as Hepatitis, Cirrhosis, Jaundice, Hemochromatosis etc.This work deals with comparison of segmentation by applying Level Set Method,Fuzzy Level Information C-Means Clustering Algorithm and Gradient Vector Flow Snake Algorithm.The results are compared using the param…
University of California, Los Angeles（加州大学洛杉矶分校）；RedNova Health
Label propagation is a popular technique for anatomical segmentation. In this work, we propose a novel deep framework for label propagation based on non-local label fusion. Our framework, named CompareNet, incorporates subnets for both extracting discriminating features, and learning the similarity measure, which lead to accurate segmentation. We also introduce the voxel-wise classification as an unary potential to the label fusion function, for alleviating the search failure issue of the existing non-local fusion strategies. Moreover, CompareNet is end-to-end trainable, and all the parameters…
Multi-atlas segmentation is a widely used tool in medical image analysis, providing robust and accurate results by learning from annotated atlas datasets. However, the availability of fully annotated atlas images for training is limited due to the time required for the labelling task. Segmentation methods requiring only a proportion of each atlas image to be labelled could therefore reduce the workload on expert raters tasked with annotating atlas images. To address this issue, we first re-examine the labelling problem common in many existing approaches and formulate its solution in terms of a…
The Chinese University of Hong Kong（香港中文大学）；Siemens Healthcare（西门子医疗）
Accurate detection and segmentation of anatomical structures from ultrasound images are crucial for clinical diagnosis and biometric measurements. Although ultrasound imaging has been widely used with superiorities such as low cost and portability, the fuzzy border definition and existence of abounding artifacts pose great challenges for automatically detecting and segmenting the complex anatomical structures. In this paper, we propose a multi-domain regularized deep learning method to address this challenging problem. By leveraging the transfer learning from cross domains, the feature represe…
University of South Carolina（南卡罗来纳大学）；PAII Inc.（PAII公司）；University of Rochester（罗切斯特大学）；Chang Gung Memorial Hospital（长庚纪念医院）；Ping An Technology（平安科技）
Accurate segmentation of anatomical structures is vital for medical image analysis. The state-of-the-art accuracy is typically achieved by supervised learning methods, where gathering the requisite expert-labeled image annotations in a scalable manner remains a main obstacle. Therefore, annotation-efficient methods that permit to produce accurate anatomical structure segmentation are highly desirable. In this work, we present Contour Transformer Network (CTN), a one-shot anatomy segmentation method with a naturally built-in human-in-the-loop mechanism. We formulate anatomy segmentation as a co…
GRASPing Anatomy to Improve Pathology Segmentation
Karlsruhe Institute of Technology, Karlsruhe, Germany（卡尔斯鲁厄理工学院）；Helmholtz Information and Data Science School for Health, Germany（海德堡信息与数据科学健康学校）；Department of Nuclear Medicine, University of Duisburg-Essen（杜伊斯堡-埃森大学核医学系）；German Cancer Consortium (DKTK)- University Hospital Essen, Essen, Germany（德国癌症研究中心（DKTK）-埃森大学医院）
Nagoya University（名古屋大学）；Aichi Institute of Technology（爱知工业大学）；Aichi Cancer Center（爱知癌症中心）；Imperial College London（帝国理工学院）
This paper proposes a fully automated atlas-based pancreas segmentation method from CT volumes utilizing atlas localization by regression forest and atlas generation using blood vessel information. Previous probabilistic atlas-based pancreas segmentation methods cannot deal with spatial variations that are commonly found in the pancreas well. Also, shape variations are not represented by an averaged atlas. We propose a fully automated pancreas segmentation method that deals with two types of variations mentioned above. The position and size of the pancreas is estimated using a regression fores…
University of California, San Diego（加利福尼亚大学圣地亚哥分校）；Cold Spring Harbor Laboratory（冷泉港实验室）；Department of Computer Science and Engineering, University of California, San Diego（加利福尼亚大学圣地亚哥分校计算机科学与工程系）
While modern imaging technologies such as fMRI have opened exciting new possibilities for studying the brain in vivo, histological sections remain the best way to study the anatomy of the brain at the level of single neurons. The histological atlas changed little since 1909 and localizing brain regions is a still a labor intensive process performed only by experienced neuro-anatomists. Existing digital atlases such as the Allen Brain atlas are limited to low resolution images which cannot identify the detailed structure of the neurons. We have developed a digital atlas methodology that combine…
BOTM: Echocardiography Segmentation via Bi-directional Optimal Token Matching
School of Computing and Mathematical Sciences, University of Leicester（计算与数学科学学院，莱斯特大学）；Centre for AI, AstraZeneca（人工智能中心，阿斯利康）；Information Engineering Department The Chinese University of Hong Kong（信息工程系，香港中文大学）；Data Science Institute Imperial College London（数据科学研究所，伦敦帝国理工学院）
Left ventricular segmentation is essential for measuring left ventricular function indices. Segmentation of one or several images requires an initial guess of the contour. It is hypothesized here that creating an initial guess by first detecting anatomical markers, would lead to correct detection of the endocardium. The first step of the algorithm presented here includes automatic detection of the mitral valve. Next, the apex is detected in the same frame. The valve is then tracked throughout the cardiac cycle. Contours passing from the apex to each valve corner are then found using a dynamic …
Tel Aviv University（特拉维夫大学）；Bar-Ilan University（巴伊兰大学）
This paper explores the use of a soft ground-truth mask ("soft mask'') to train a Fully Convolutional Neural Network (FCNN) for segmentation of Multiple Sclerosis (MS) lesions. Detection and segmentation of MS lesions is a complex task largely due to the extreme unbalanced data, with very small number of lesion pixels that can be used for training. Utilizing the anatomical knowledge that the lesion surrounding pixels may also include some lesion level information, we suggest to increase the data set of the lesion class with neighboring pixel data - with a reduced confidence weight. A soft mask…
Massachusetts General Hospital（麻省总医院）；Harvard Medical School（哈佛医学院）；University of Maryland Dental School（马里兰大学牙医学院）；MGH Institute of Health Professions（麻省总医院健康职业学院）；Johns Hopkins University（约翰斯·霍普金斯大学）
Quantitative measurement of functional and anatomical traits of 4D tongue motion in the course of speech or other lingual behaviors remains a major challenge in scientific research and clinical applications. Here, we introduce a statistical multimodal atlas of 4D tongue motion using healthy subjects, which enables a combined quantitative characterization of tongue motion in a reference anatomical configuration. This atlas framework, termed Speech Map, combines cine- and tagged-MRI in order to provide both the anatomic reference and motion information during speech. Our approach involves a seri…
Purpose: Segmentation of organs-at-risk (OARs) is a bottleneck in current radiation oncology pipelines and is often time consuming and labor intensive. In this paper, we propose an atlas-based semi-supervised registration algorithm to generate accurate segmentations of OARs for which there are ground truth contours and rough segmentations of all other OARs in the atlas. To the best of our knowledge, this is the first study to use learning-based registration methods for the segmentation of head and neck patients and demonstrate its utility in clinical applications. Methods: Our algorithm cascad…
Perelman School of Medicine, University of Pennsylvania（宾夕法尼亚大学佩雷尔曼医学院）；School of Computer and Control Engineering, Yantai University（烟台大学计算机与控制工程学院）；Institute of Automation, Chinese Academy of Sciences（中国科学院自动化研究所）
A novel multi-atlas based image segmentation method is proposed by integrating a semi-supervised label propagation method and a supervised random forests method in a pattern recognition based label fusion framework. The semi-supervised label propagation method takes into consideration local and global image appearance of images to be segmented and segments the images by propagating reliable segmentation results obtained by the supervised random forests method. Particularly, the random forests method is used to train a regression model based on image patches of atlas images for each voxel of th…
The University of Hong Kong（香港大学）；Tencent（腾讯）；Huazhong University of Science and Technology（华中科技大学）
Learning by imitation is one of the most significant abilities of human beings and plays a vital role in human's computational neural system. In medical image analysis, given several exemplars (anchors), experienced radiologist has the ability to delineate unfamiliar organs by imitating the reasoning process learned from existing types of organs. Inspired by this observation, we propose OrganNet which learns a generalized organ concept from a set of annotated organ classes and then transfer this concept to unseen classes. In this paper, we show that such process can be integrated into the one-…
Mask-HybridGNet: Graph-based segmentation with emergent anatomical correspondence from pixel-level supervision
Biomedical Image Technologies, ETSI Telecomunicación, Universidad Politécnica de Madrid, Madrid, Spain（生物医学影像技术，电信工程学院，马德里理工大学，马德里，西班牙）；IHU PRISM National Precision Medicine Center in Oncology, Cancer Data Science Unit, CentraleSupélec, Gustave Roussy, INSERM, Université Paris-Saclay, Gif-sur-Yvette, France（IHU PRISM国家精准医学中心（肿瘤学），癌症数据科学单元，中央圣艾尔布兰，格斯塔夫·罗西，国家医学研究所，巴黎-萨克雷大学，法国）
Wuhan University（武汉大学）；Rensselaer Polytechnic Institute (RPI)（伦斯勒理工学院（RPI））
Medical image segmentation is a fundamental task in medical image analysis. Despite that deep convolutional neural networks have gained stellar performance in this challenging task, they typically rely on large labeled datasets, which have limited their extension to customized applications. By revisiting the superiority of atlas based segmentation methods, we present a new framework of One-pass aligned Atlas Set for Images Segmentation (OASIS). To address the problem of time-consuming iterative image registration used for atlas warping, the proposed method takes advantage of the power of deep …
Imperial College London（伦敦帝国理工学院）；Queen Mary University of London（伦敦玛丽女王大学）
In the recent years, convolutional neural networks have transformed the field of medical image analysis due to their capacity to learn discriminative image features for a variety of classification and regression tasks. However, successfully learning these features requires a large amount of manually annotated data, which is expensive to acquire and limited by the available resources of expert image analysts. Therefore, unsupervised, weakly-supervised and self-supervised feature learning techniques receive a lot of attention, which aim to utilise the vast amount of available data, while at the …
OSA: Echocardiography Video Segmentation via Orthogonalized State Update and Anatomical Prior-aware Feature Enhancement
College of Computer Science and Software Engineering, Shenzhen University（深圳大学计算机与软件学院）；Centre for Smart Health, School of Nursing, The Hong Kong Polytechnic University（香港理工大学护理学院智能健康中心）
We introduce a fluid-based image augmentation method for medical image analysis. In contrast to existing methods, our framework generates anatomically meaningful images via interpolation from the geodesic subspace underlying given samples. Our approach consists of three steps: 1) given a source image and a set of target images, we construct a geodesic subspace using the Large Deformation Diffeomorphic Metric Mapping (LDDMM) model; 2) we sample transformations from the resulting geodesic subspace; 3) we obtain deformed images and segmentations via interpolation. Experiments on brain (LPBA) and …
Biomedical Image Analysis Group, Imperial College London（伦敦帝国理工学院生物医学图像分析组）；MRC Clinical Sciences Centre (CSC)（英国医学研究委员会临床科学中心）
Incorporation of prior knowledge about organ shape and location is key to improve performance of image analysis approaches. In particular, priors can be useful in cases where images are corrupted and contain artefacts due to limitations in image acquisition. The highly constrained nature of anatomical objects can be well captured with learning based techniques. However, in most recent and promising techniques such as CNN based segmentation it is not obvious how to incorporate such prior knowledge. State-of-the-art methods operate as pixel-wise classifiers where the training objectives do not i…
CheXmask-U: Quantifying uncertainty in landmark-based anatomical segmentation for X-ray images
Laboratory of Applied Artificial Intelligence, Institute of Computer Sciences, CONICET - Universidad de Buenos Aires（应用人工智能实验室，计算机科学研究所，CONICET - 华盛顿大学布宜诺斯艾利斯分校）；Weizmann Institute of Science（科学研究所）；APOLO Biotech（APOLO生物技术）；Research Institute for Signals, Systems and Computational Intelligence, sinc(i), CONICET - Universidad Nacional del Litoral（信号、系统和计算智能研究 institute，sinc(i)，CONICET - 沿海国立大学）
The Hong Kong University of Science and Technology（香港科技大学）
In this paper, a novel label fusion method is proposed for brain magnetic resonance image segmentation. This label fusion method is formulated on a graph, which embraces both label priors from atlases and anatomical priors from target image. To represent a pixel in a comprehensive way, three kinds of feature vectors are generated, including intensity, gradient and structural signature. To select candidate atlas nodes for fusion, rather than exact searching, randomized k-d tree with spatial constraint is introduced as an efficient approximation for high-dimensional feature matching. Feature Sen…
National Institutes of Health（美国国立卫生研究院）；University of California, Irvine School of Medicine（加州大学欧文分校医学院）
The precise and accurate segmentation of the vertebral column is essential in the diagnosis and treatment of various orthopedic, neurological, and oncological traumas and pathologies. Segmentation is especially challenging in the presence of pathology such as vertebral compression fractures. In this paper, we propose a method to produce segmentations for osteoporotic compression fractured vertebrae by applying a multi-atlas joint label fusion technique for clinical CT images. A total of 170 thoracic and lumbar vertebrae were evaluated using atlases from five patients with varying degrees of sp…
Segmentation of brain structures from magnetic resonance (MR) scans plays an important role in the quantification of brain morphology. Since 3D deep learning models suffer from high computational cost, 2D deep learning methods are favored for their computational efficiency. However, existing 2D deep learning methods are not equipped to effectively capture 3D spatial contextual information that is needed to achieve accurate brain structure segmentation. In order to overcome this limitation, we develop an Anatomical Context-Encoding Network (ACEnet) to incorporate 3D spatial and anatomical conte…
In this work, we improve the performance of multi-atlas segmentation (MAS) by integrating the recently proposed VoteNet model with the joint label fusion (JLF) approach. Specifically, we first illustrate that using a deep convolutional neural network to predict atlas probabilities can better distinguish correct atlas labels from incorrect ones than relying on image intensity difference as is typical in JLF. Motivated by this finding, we propose VoteNet+, an improved deep network to locally predict the probability of an atlas label to differs from the label of the target image. Furthermore, we …
Deep learning (DL) approaches are state-of-the-art for many medical image segmentation tasks. They offer a number of advantages: they can be trained for specific tasks, computations are fast at test time, and segmentation quality is typically high. In contrast, previously popular multi-atlas segmentation (MAS) methods are relatively slow (as they rely on costly registrations) and even though sophisticated label fusion strategies have been proposed, DL approaches generally outperform MAS. In this work, we propose a DL-based label fusion strategy (VoteNet) which locally selects a set of reliable…
University of Sherbrooke（舍布鲁克大学）；Université de Bourgogne Franche-Comté（勃艮第-弗朗什孔泰大学）；CArdiac Simulation & Imaging Software（心脏模拟与成像软件公司）；Université de Lyon（里昂大学）
Recent publications have shown that the segmentation accuracy of modern-day convolutional neural networks (CNN) applied on cardiac MRI can reach the inter-expert variability, a great achievement in this area of research. However, despite these successes, CNNs still produce anatomically inaccurate segmentations as they provide no guarantee on the anatomical plausibility of their outcome, even when using a shape prior. In this paper, we propose a cardiac MRI segmentation method which always produces anatomically plausible results. At the core of the method is an adversarial variational autoencod…
Continual atlas-based segmentation of prostate MRI
Technical University of Darmstadt（达姆施塔特工业大学）；Stanford University（斯坦福大学）；University of Cologne（科隆大学）；University of Frankfurt（法兰克福大学）；University Medical Center Mainz（美因茨大学医学中心）
Accuracy segmentation of brain structures could be helpful for glioma and radiotherapy planning. However, due to the visual and anatomical differences between different modalities, the accurate segmentation of brain structures becomes challenging. To address this problem, we first construct a residual block based U-shape network with a deep encoder and shallow decoder, which can trade off the framework performance and efficiency. Then, we introduce the Tversky loss to address the issue of the class imbalance between different foreground and the background classes. Finally, a model ensemble str…
Xi’an Jiaotong University（西安交通大学）；National Engineering Laboratory for Big Data Algorithm and Analysis Technology（大数据算法与分析技术国家工程实验室）；Shanghai Jiaotong University（上海交通大学）
Multi-atlas segmentation approach is one of the most widely-used image segmentation techniques in biomedical applications. There are two major challenges in this category of methods, i.e., atlas selection and label fusion. In this paper, we propose a novel multi-atlas segmentation method that formulates multi-atlas segmentation in a deep learning framework for better solving these challenges. The proposed method, dubbed deep fusion net (DFN), is a deep architecture that integrates a feature extraction subnet and a non-local patch-based label fusion (NL-PLF) subnet in a single network. The netw…
Magnetic Resonance Imaging (MRI) has evolved as a clinical standard-of-care imaging modality for cardiac morphology, function assessment, and guidance of cardiac interventions. All these applications rely on accurate extraction of the myocardial tissue and blood pool from the imaging data. Here we propose a framework for left ventricle (LV) segmentation from cardiac cine-MRI. First, we segment the LV blood pool using iterative graph cuts, and subsequently use this information to segment the myocardium. We formulate the segmentation procedure as an energy minimization problem in a graph subject…
Multimodal Interactive Lung Lesion Segmentation: A Framework for Annotating PET/CT Images based on Physiological and Anatomical Cues
HIDSS4Health - Helmholtz Information and Data Science School for Health（亥姆霍兹信息与健康数据科学学院（HIDSS4Health））；Institute for AI in Medicine (IKIM), University Hospital Essen（埃森大学医院医学人工智能研究所（IKIM））
Fuzhou University（福州大学）；Fudan University（复旦大学）；Shanghai Jiao Tong University（上海交通大学）；King’s College London（伦敦国王学院）
Both image registration and label fusion in the multi-atlas segmentation (MAS) rely on the intensity similarity between target and atlas images. However, such similarity can be problematic when target and atlas images are acquired using different imaging protocols. High-level structure information can provide reliable similarity measurement for cross-modality images when cooperating with deep neural networks (DNNs). This work presents a new MAS framework for cross-modality images, where both image registration and label fusion are achieved by DNNs. For image registration, we propose a consiste…
Xiamen University（厦门大学）；Tencent（腾讯）；Xi’an Jiaotong University（西安交通大学）；Macau University of Science and Technology（澳门科技大学）
We introduce a one-shot segmentation method to alleviate the burden of manual annotation for medical images. The main idea is to treat one-shot segmentation as a classical atlas-based segmentation problem, where voxel-wise correspondence from the atlas to the unlabelled data is learned. Subsequently, segmentation label of the atlas can be transferred to the unlabelled data with the learned correspondence. However, since ground truth correspondence between images is usually unavailable, the learning system must be well-supervised to avoid mode collapse and convergence failure. To overcome this …
