4D人类胚胎大脑图谱：用于快速解剖变化的时空图谱生成
The 4D Human Embryonic Brain Atlas: spatiotemporal atlas generation for rapid anatomical changes
AI总结：
本文提出了一种基于深度学习的时空图谱生成方法，用于创建4D人类胚胎大脑图谱，以准确捕捉胚胎大脑快速解剖变化，为神经发育障碍的早期检测提供新工具。
摘要：
早期大脑发育对终身神经发育健康至关重要。然而，当前临床实践在超声波下对正常胚胎大脑解剖结构了解有限，尽管大脑在数天的时间范围内经历快速变化。为了提供对正常大脑发育的深入见解并识别偏差，我们利用基于深度学习的方法进行群体配准和时空图谱生成，创建了4D人类胚胎大脑图谱。我们的方法引入了时间依赖性的初始图谱，并惩罚偏离它的情况，确保在快速发育过程中维持年龄特异性的解剖结构。图谱是使用来自荷兰罗特温孕前队列中402名受试者的831个3D超声图像生成和验证的，这些图像是在孕周8至12期间获取的。我们通过消融研究评估了该方法的有效性，结果表明，纳入时间依赖性初始图谱和惩罚机制产生了解剖学准确的结果。相反，省略这些适应性导致了解剖学不准确的图谱。与现有体外胚胎图谱的视觉比较进一步确认了我们图谱的解剖学准确性。结论是，所提出的方法成功捕捉了胚胎大脑的快速解剖发育。所得到的4D人类胚胎大脑图谱为这一关键的早期生命阶段提供了独特的见解，并有潜力改善产前神经发育障碍的检测、预防和治疗。
英文摘要：
Early brain development is crucial for lifelong neurodevelopmental health. However, current clinical practice offers limited knowledge of normal embryonic brain anatomy on ultrasound, despite the brain undergoing rapid changes within the time-span of days. To provide detailed insights into normal brain development and identify deviations, we created the 4D Human Embryonic Brain Atlas using a deep learning-based approach for groupwise registration and spatiotemporal atlas generation. Our method introduced a time-dependent initial atlas and penalized deviations from it, ensuring age-specific anatomy was maintained throughout rapid development. The atlas was generated and validated using 831 3D ultrasound images from 402 subjects in the Rotterdam Periconceptional Cohort, acquired between gestational weeks 8 and 12. We evaluated the effectiveness of our approach with an ablation study, which demonstrated that incorporating a time-dependent initial atlas and penalization produced anatomically accurate results. In contrast, omitting these adaptations led to anatomically incorrect atlas. Visual comparisons with an existing ex-vivo embryo atlas further confirmed the anatomical accuracy of our atlas. In conclusion, the proposed method successfully captures the rapid anotomical development of the embryonic brain. The resulting 4D Human Embryonic Brain Atlas provides a unique insights into this crucial early life period and holds the potential for improving the detection, prevention, and treatment of prenatal neurodevelopmental disorders.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
