arXivDaily arXiv每日学术速递 周一至周五更新
arXiv 2008.13702cond-mat.soft
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利用生物组织模型中的信息量化局部结构和细胞重排之间的联系

Quantifying the link between local structure and cellular rearrangements using information in models of biological tissues

Indrajit Tah, Tristan A. Sharp, Andrea J. Liu, Daniel M. Sussman

摘要:

机器学习技术已被用于量化无序玻璃形成材料中局部结构特征与局部动力学活性变化之间的关系。到目前为止,这些方法已被应用到一系列标准(Arrhenius和超级Arrhenius)的玻璃成型,其中的工作“软点”表明之间的连接的线性振动响应的配置和非线性变形的能量障碍。在这里,我们研究的Voronoi模型,其灵感来自致密的上皮细胞单层,并显示异常,亚Arrhenius缩放其动态弛豫时间随温度降低。尽管存在这些差异,我们发现重排的可能性可以在模型组织内变化几个数量级,并提取局部结构量,“柔软度”,准确地预测弛豫时间的温度依赖性。我们使用信息理论的措施来量化软度决定即将发生的拓扑重排的程度,我们发现,软度捕获几乎所有的重排,是从结构中获得的信息,并且该信息是大的模型的固相和状态变量变化到流体相迅速减少。

英文摘要:

Machine learning techniques have been used to quantify the relationship between local structural features and variations in local dynamical activity in disordered glass-forming materials. To date these methods have been applied to an array of standard (Arrhenius and super-Arrhenius) glass formers, where work on "soft spots" indicates a connection between the linear vibrational response of a configuration and the energy barriers to non-linear deformations. Here we study the Voronoi model, which takes its inspiration from dense epithelial monolayers and which displays anomalous, sub-Arrhenius scaling of its dynamical relaxation time with decreasing temperature. Despite these differences, we find that the likelihood of rearrangements can vary by several orders of magnitude within the model tissue and extract a local structural quantity, "softness" that accurately predicts the temperature-dependence of the relaxation time. We use an information-theoretic measure to quantify the extent to which softness determines impending topological rearrangements; we find that softness captures nearly all of the information about rearrangements that is obtainable from structure, and that this information is large in the solid phase of the model and decreases rapidly as state variables are varied into the fluid phase.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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