受控的邻居交换驱动上皮组织中的玻璃态行为、间歇性和细胞流
Controlled neighbor exchanges drive glassy behavior, intermittency and cell streaming in epithelial tissues
AI总结：
本研究在顶点模型中引入T1转变的时间约束，发现其消除运动驱动的玻璃态转变并产生快慢细胞流，预测与果蝇蛹发育实验相符。
摘要：
细胞邻居交换是生物学中组织重排（包括发育和修复）不可或缺的一部分。这些过程通常通过拓扑T1转变发生，与在泡沫、颗粒和胶体中观察到的类似。然而，与非生命材料相比，生物组织中的T1转变受速率限制，不能瞬时发生，因为重塑细胞-细胞连接处的复杂结构需要有限的时间。在这里，我们通过将这一重要的生物学约束作为内在的单细胞属性引入理论顶点模型中，研究这一限速过程如何影响组织中细胞的力学和集体行为。我们报告，在没有这种时间约束的情况下，组织经历由运动驱动的玻璃态转变，其特征是细胞-细胞重排的间歇性急剧增加。值得注意的是，当T1转变在时间上受限时，这种玻璃态转变消失。作为受限重排的独特结果，我们还发现组织发展出空间相关的快慢细胞流，其中快细胞组织成具有领导者-跟随者相互作用的流状模式，并维持最优稳定的细胞-细胞接触。这项工作的预测与果蝇蛹发育中现有的体内实验进行了比较。
英文摘要：
Cell neighbor exchanges are integral to tissue rearrangements in biology, including development and repair. Often these processes occur via topological T1 transitions analogous to those observed in foams, grains and colloids. However, in contrast to in non-living materials the T1 transitions in biological tissues are rate-limited and cannot occur instantaneously due to the finite time required to remodel complex structures at cell-cell junctions. Here we study how this rate-limiting process affects the mechanics and collective behavior of cells in a tissue by introducing this important biological constraint in a theoretical vertex-based model as an intrinsic single-cell property. We report in the absence of this time constraint, the tissue undergoes a motility-driven glass transition characterized by a sharp increase in the intermittency of cell-cell rearrangements. Remarkably, this glass transition disappears as T1 transitions are temporally limited. As a unique consequence of limited rearrangements, we also find that the tissue develops spatially correlated streams of fast and slow cells, in which the fast cells organize into stream-like patterns with leader-follower interactions, and maintain optimally stable cell-cell contacts. The predictions of this work is compared with existing in-vivo experiments in Drosophila pupal development.
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