arXivDaily arXiv每日学术速递 周一至周五更新
arXiv 2007.10768stat.ME
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高维基因组数据中高度相关预测因子的变量选择方法

A variable selection approach for highly correlated predictors in high-dimensional genomic data

Wencan Zhu, Céline Lévy-Leduc, Nils Ternès

摘要:

在基因组研究中,识别与感兴趣的变量相关的生物标志物是生物医学研究中的主要关注点。正则化方法通常用于在高维线性模型中执行变量选择。然而,这些方法在高度相关的设置中可能失败。我们提出了一种新的变量选择方法称为WLasso,考虑到这些相关性。它包括重写初始高维线性模型以去除生物标志物(预测因子)之间的相关性,以及应用广义Lasso标准。WLasso的性能进行评估,使用合成数据在几种情况下,并与最近的替代方法进行比较。结果表明,当生物标志物高度相关时,WLasso在稀疏高维框架中优于其他方法。该方法也成功地说明了公开的基因表达数据在乳腺癌。我们的方法在WLasso R包中实现,该包可从Comprehensive R Archive Network获得。

英文摘要:

In genomic studies, identifying biomarkers associated with a variable of interest is a major concern in biomedical research. Regularized approaches are classically used to perform variable selection in high-dimensional linear models. However, these methods can fail in highly correlated settings. We propose a novel variable selection approach called WLasso, taking these correlations into account. It consists in rewriting the initial high-dimensional linear model to remove the correlation between the biomarkers (predictors) and in applying the generalized Lasso criterion. The performance of WLasso is assessed using synthetic data in several scenarios and compared with recent alternative approaches. The results show that when the biomarkers are highly correlated, WLasso outperforms the other approaches in sparse high-dimensional frameworks. The method is also successfully illustrated on publicly available gene expression data in breast cancer. Our method is implemented in the WLasso R package which is available from the Comprehensive R Archive Network.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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