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arXiv 2407.05089stat.MEstat.AP
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贝叶斯网络引导的具有灵活变化效应的稀疏回归

Bayesian network-guided sparse regression with flexible varying effects

Yangfan Ren, Christine B. Peterson, Marina Vannucci

AI总结:

本文提出贝叶斯方法VERGE,通过推断预测变量网络并结合变系数建模与尖峰-平板先验进行特征选择,在模拟和肠道微生物组与肥胖应用中优于现有方法。

摘要:

在本文中,我们提出了带图估计的变化效应回归(VERGE),这是一种用于回归中特征选择的新的贝叶斯方法。我们的模型具有一些关键方面,使其能够利用基因组学或影像研究中产生的数据集的复杂结构。我们区分了预测变量(即用于结果预测模型的特征)和受试者层面的协变量(它们调节预测变量对结果的影响)。我们构建了一个变系数建模框架,在其中推断预测变量之间的网络,并利用该网络信息来鼓励选择相关的预测变量。我们采用变量选择的尖峰-平板先验,从而能够同时选择网络关联的预测变量和修改预测变量效应的协变量。我们通过模拟研究证明,我们的方法在特征选择和预测准确性方面均优于现有的替代方法。我们通过一个应用来说明VERGE,该应用刻画肠道微生物组特征对肥胖的影响,其中我们识别出一组微生物类群及其生态依赖关系。我们允许包括性别和饮食摄入变量在内的受试者层面协变量修改微生物组预测变量的系数,从而为这些因素之间的相互作用提供额外的见解。

英文摘要:

In this paper, we propose Varying Effects Regression with Graph Estimation (VERGE), a novel Bayesian method for feature selection in regression. Our model has key aspects that allow it to leverage the complex structure of data sets arising from genomics or imaging studies. We distinguish between the predictors, which are the features utilized in the outcome prediction model, and the subject-level covariates, which modulate the effects of the predictors on the outcome. We construct a varying coefficients modeling framework where we infer a network among the predictor variables and utilize this network information to encourage the selection of related predictors. We employ variable selection spike-and-slab priors that enable the selection of both network-linked predictor variables and covariates that modify the predictor effects. We demonstrate through simulation studies that our method outperforms existing alternative methods in terms of both feature selection and predictive accuracy. We illustrate VERGE with an application to characterizing the influence of gut microbiome features on obesity, where we identify a set of microbial taxa and their ecological dependence relations. We allow subject-level covariates including sex and dietary intake variables to modify the coefficients of the microbiome predictors, providing additional insight into the interplay between these factors.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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