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arXiv 1509.08124stat.ME
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基于测试的差异相关变量集发现方法

A testing-based approach to the discovery of differentially correlated variable sets

Kelly Bodwin, Kai Zhang, Andrew Nobel

摘要:

给定在两种采样条件下获得的数据,识别在一种条件下与另一种条件下行为不同的变量通常是有意义的。我们介绍了一种差分分析的二阶行为称为差分相关挖掘(DCM)。DCM方法识别差异相关的变量集,具有在一个样本条件下集合中变量之间的平均成对相关性高于另一个样本条件的属性。DCM基于迭代搜索过程,该过程自适应地更新候选变量集的大小和元素。更新是通过假设检验的个别变量,其基础上的渐近分布的平均微分相关。我们通过将其应用于模拟数据以及基因组学和脑成像中的最新实验数据集来研究DCM的性能。

英文摘要:

Given data obtained under two sampling conditions, it is often of interest to identify variables that behave differently in one condition than in the other. We introduce a method for differential analysis of second-order behavior called Differential Correlation Mining (DCM). The DCM method identifies differentially correlated sets of variables, with the property that the average pairwise correlation between variables in a set is higher under one sample condition than the other. DCM is based on an iterative search procedure that adaptively updates the size and elements of a candidate variable set. Updates are performed via hypothesis testing of individual variables, based on the asymptotic distribution of their average differential correlation. We investigate the performance of DCM by applying it to simulated data as well as recent experimental datasets in genomics and brain imaging.

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