Convolutional Neural Networks (CNNs) are highly effective for image reconstruction problems. Typically, CNNs are trained on large amounts of training images. Recently, however, un-trained CNNs such as the Deep Image Prior and Deep Decoder have achieved excellent performance for image reconstruction problems such as denoising and inpainting, \emph{without using any training data}. Motivated by this development, we address the reconstruction problem arising in accelerated MRI with un-trained neural networks. We propose a highly optimized un-trained recovery approach based on a variation of the Deep Decoder and show that it significantly outperforms other un-trained methods, in particular sparsity-based classical compressed sensing methods and naive applications of un-trained neural networks. We also compare performance (both in terms of reconstruction accuracy and computational cost) in an ideal setup for trained methods, specifically on the fastMRI dataset, where the training and test data come from the same distribution. We find that our un-trained algorithm achieves similar performance to a baseline trained neural network, but a state-of-the-art trained network outperforms the un-trained one. Finally, we perform a comparison on a non-ideal setup where the train and test distributions are slightly different, and find that our un-trained method achieves similar performance to a state-of-the-art accelerated MRI reconstruction method.
Facebook AI Research（Facebook人工智能研究）；fastMRI team（fastMRI团队）
Deep learning approaches to accelerated MRI take a matrix of sampled Fourier-space lines as input and produce a spatial image as output. In this work we show that by careful choice of the offset used in the sampling procedure, the symmetries in k-space can be better exploited, producing higher quality reconstructions than given by standard equally-spaced samples or randomized samples motivated by compressed sensing.
Yale University（耶鲁大学）；New York University（纽约大学）；Hyperfine Research（Hyperfine研究公司）
Multi-contrast MRI (MC-MRI) captures multiple complementary imaging modalities to aid in radiological decision-making. Given the need for lowering the time cost of multiple acquisitions, current deep accelerated MRI reconstruction networks focus on exploiting the redundancy between multiple contrasts. However, existing works are largely supervised with paired data and/or prohibitively expensive fully-sampled MRI sequences. Further, reconstruction networks typically rely on convolutional architectures which are limited in their capacity to model long-range interactions and may lead to suboptima…
Microsoft Research（微软研究院）；University of Pennsylvania（宾夕法尼亚大学）
Accelerated MRI reconstructs images of clinical anatomies from sparsely sampled signal data to reduce patient scan times. While recent works have leveraged deep learning to accomplish this task, such approaches have often only been explored in simulated environments where there is no signal corruption or resource limitations. In this work, we explore augmentations to neural network MRI image reconstructors to enhance their clinical relevancy. Namely, we propose a ConvNet model for detecting sources of image artifacts that achieves a classifier $F_2$ score of 79.1%. We also demonstrate that tra…
Hyperfine Research（Hyperfine研究院）；Yale University（耶鲁大学）；New York University（纽约大学）
While enabling accelerated acquisition and improved reconstruction accuracy, current deep MRI reconstruction networks are typically supervised, require fully sampled data, and are limited to Cartesian sampling patterns. These factors limit their practical adoption as fully-sampled MRI is prohibitively time-consuming to acquire clinically. Further, non-Cartesian sampling patterns are particularly desirable as they are more amenable to acceleration and show improved motion robustness. To this end, we present a fully self-supervised approach for accelerated non-Cartesian MRI reconstruction which …
Unrolled neural networks have enabled state-of-the-art reconstruction performance and fast inference times for the accelerated magnetic resonance imaging (MRI) reconstruction task. However, these approaches depend on fully-sampled scans as ground truth data which is either costly or not possible to acquire in many clinical medical imaging applications; hence, reducing dependence on data is desirable. In this work, we propose modeling the proximal operators of unrolled neural networks with scale-equivariant convolutional neural networks in order to improve the data-efficiency and robustness to …
Monash Biomedical Imaging, Monash University（莫纳什大学生物医学成像中心）；Department of Electrical and Computer Systems Engineering, Monash University（莫纳什大学电气与计算机系统工程系）；School of Psychological Sciences, Monash University（莫纳什大学心理科学学院）；Department of Data Science and AI, Monash University（莫纳什大学数据科学与人工智能系）
Global correlations are widely seen in human anatomical structures due to similarity across tissues and bones. These correlations are reflected in magnetic resonance imaging (MRI) scans as a result of close-range proton density and T1/T2 parameters. Furthermore, to achieve accelerated MRI, k-space data are undersampled which causes global aliasing artifacts. Convolutional neural network (CNN) models are widely utilized for accelerated MRI reconstruction, but those models are limited in capturing global correlations due to the intrinsic locality of the convolution operation. The self-attention-…
Department of Electrical and Computer Engineering, University of Minnesota（明尼苏达大学电气与计算机工程系）
Long scan duration remains a challenge for high-resolution MRI. Deep learning has emerged as a powerful means for accelerated MRI reconstruction by providing data-driven regularizers that are directly learned from data. These data-driven priors typically remain unchanged for future data in the testing phase once they are learned during training. In this study, we propose to use a transfer learning approach to fine-tune these regularizers for new subjects using a self-supervision approach. While the proposed approach can compromise the extremely fast reconstruction time of deep learning MRI met…
Bilkent University（比尔肯特大学）；National Magnetic Resonance Research Center (UMRAM)（国家磁共振研究中心（UMRAM））；Neuroscience Program, Aysel Sabuncu Brain Research Center, Bilkent University（比尔肯特大学艾塞尔·萨本居脑研究中心神经科学项目）
Deep neural networks (DNNs) have recently found emerging use in accelerated MRI reconstruction. DNNs typically learn data-driven priors from large datasets constituting pairs of undersampled and fully-sampled acquisitions. Acquiring such large datasets, however, might be impractical. To mitigate this limitation, we propose a few-shot learning approach for accelerated MRI that merges subject-driven priors obtained via physical signal models with data-driven priors obtained from a few training samples. Demonstrations on brain MR images from the NYU fastMRI dataset indicate that the proposed appr…
Facebook AI Research (FAIR)（Facebook人工智能研究院（FAIR））；NYU School of Medicine（纽约大学医学院）
The slow acquisition speed of magnetic resonance imaging (MRI) has led to the development of two complementary methods: acquiring multiple views of the anatomy simultaneously (parallel imaging) and acquiring fewer samples than necessary for traditional signal processing methods (compressed sensing). While the combination of these methods has the potential to allow much faster scan times, reconstruction from such undersampled multi-coil data has remained an open problem. In this paper, we present a new approach to this problem that extends previously proposed variational methods by learning ful…
Bilkent University（比尔肯特大学）；University of Southern California（南加利福尼亚大学）；Hacettepe University（哈杰泰佩大学）
Learning-based synthetic multi-contrast MRI commonly involves deep models trained using high-quality images of source and target contrasts, regardless of whether source and target domain samples are paired or unpaired. This results in undesirable reliance on fully-sampled acquisitions of all MRI contrasts, which might prove impractical due to limitations on scan costs and time. Here, we propose a novel semi-supervised deep generative model that instead learns to recover high-quality target images directly from accelerated acquisitions of source and target contrasts. To achieve this, the propos…
Netherlands Cancer Institute（荷兰癌症研究所）；qurAI group（qurAI团队）；University of Amsterdam（阿姆斯特丹大学）
Magnetic Resonance Imaging can produce detailed images of the anatomy and physiology of the human body that can assist doctors in diagnosing and treating pathologies such as tumours. However, MRI suffers from very long acquisition times that make it susceptible to patient motion artifacts and limit its potential to deliver dynamic treatments. Conventional approaches such as Parallel Imaging and Compressed Sensing allow for an increase in MRI acquisition speed by reconstructing MR images from sub-sampled MRI data acquired using multiple receiver coils. Recent advancements in Deep Learning combi…
Unrolled neural networks have recently achieved state-of-the-art accelerated MRI reconstruction. These networks unroll iterative optimization algorithms by alternating between physics-based consistency and neural-network based regularization. However, they require several iterations of a large neural network to handle high-dimensional imaging tasks such as 3D MRI. This limits traditional training algorithms based on backpropagation due to prohibitively large memory and compute requirements for calculating gradients and storing intermediate activations. To address this challenge, we propose Gre…
Accelerating magnetic resonance image (MRI) reconstruction process is a challenging ill-posed inverse problem due to the excessive under-sampling operation in k-space. In this paper, we propose a recurrent transformer model, namely ReconFormer, for MRI reconstruction which can iteratively reconstruct high fertility magnetic resonance images from highly under-sampled k-space data. In particular, the proposed architecture is built upon Recurrent Pyramid Transformer Layers (RPTL), which jointly exploits intrinsic multi-scale information at every architecture unit as well as the dependencies of th…
In accelerated MRI reconstruction, the anatomy of a patient is recovered from a set of under-sampled and noisy measurements. Deep learning approaches have been proven to be successful in solving this ill-posed inverse problem and are capable of producing very high quality reconstructions. However, current architectures heavily rely on convolutions, that are content-independent and have difficulties modeling long-range dependencies in images. Recently, Transformers, the workhorse of contemporary natural language processing, have emerged as powerful building blocks for a multitude of vision task…
University of Southern California（南加州大学）；Technical University of Munich（慕尼黑工业大学）；Rice University（莱斯大学）
Deep neural networks have emerged as very successful tools for image restoration and reconstruction tasks. These networks are often trained end-to-end to directly reconstruct an image from a noisy or corrupted measurement of that image. To achieve state-of-the-art performance, training on large and diverse sets of images is considered critical. However, it is often difficult and/or expensive to collect large amounts of training images. Inspired by the success of Data Augmentation (DA) for classification problems, in this paper, we propose a pipeline for data augmentation for accelerated MRI re…
Korea Advanced Institute of Science and Technology (KAIST)（韩国科学技术院）；Seoul National University College of Medicine（首尔大学医学院）；Seoul National University Bundang Hospital（首尔大学盆唐医院）
The annihilating filter-based low-rank Hankel matrix approach (ALOHA) is one of the state-of-the-art compressed sensing approaches that directly interpolates the missing k-space data using low-rank Hankel matrix completion. The success of ALOHA is due to the concise signal representation in the k-space domain thanks to the duality between structured low-rankness in the k-space domain and the image domain sparsity. Inspired by the recent mathematical discovery that links convolutional neural networks to Hankel matrix decomposition using data-driven framelet basis, here we propose a fully data-d…
Facebook AI Research（脸书人工智能研究院）；NYU School of Medicine（纽约大学医学院）；NYU Center for Data Science（纽约大学数据科学中心）；University of Florida（佛罗里达大学）
Accelerating Magnetic Resonance Imaging (MRI) by taking fewer measurements has the potential to reduce medical costs, minimize stress to patients and make MRI possible in applications where it is currently prohibitively slow or expensive. We introduce the fastMRI dataset, a large-scale collection of both raw MR measurements and clinical MR images, that can be used for training and evaluation of machine-learning approaches to MR image reconstruction. By introducing standardized evaluation criteria and a freely-accessible dataset, our goal is to help the community make rapid advances in the stat…
University of Minnesota（明尼苏达大学）；Sungkyunkwan University（成均馆大学）
Recent studies show that deep learning (DL) based MRI reconstruction outperforms conventional methods, such as parallel imaging and compressed sensing (CS), in multiple applications. Unlike CS that is typically implemented with pre-determined linear representations for regularization, DL inherently uses a non-linear representation learned from a large database. Another line of work uses transform learning (TL) to bridge the gap between these two approaches by learning linear representations from data. In this work, we combine ideas from CS, TL and DL reconstructions to learn deep linear convol…
University of California, Santa Barbara（加州大学圣塔芭芭拉分校）；Oden Institute for Computational Engineering and Sciences（奥登计算工程与科学研究所）；University of Texas at Austin（德克萨斯大学奥斯汀分校）
Magnetic resonance imaging (MRI) is a powerful imaging modality that revolutionizes medicine and biology. The imaging speed of high-dimensional MRI is often limited, which constrains its practical utility. Recently, low-rank tensor models have been exploited to enable fast MR imaging with sparse sampling. Most existing methods use some pre-defined sampling design, and active sensing has not been explored for low-rank tensor imaging. In this paper, we introduce an active low-rank tensor model for fast MR imaging. We propose an active sampling method based on a Query-by-Committee model, making u…
University of Birmingham（伯明翰大学）；Imperial College London（帝国理工学院）；MRC London Institute of Medical Sciences（MRC伦敦医学科学研究所）
In this work, we propose a deep learning approach for parallel magnetic resonance imaging (MRI) reconstruction, termed a variable splitting network (VS-Net), for an efficient, high-quality reconstruction of undersampled multi-coil MR data. We formulate the generalized parallel compressed sensing reconstruction as an energy minimization problem, for which a variable splitting optimization method is derived. Based on this formulation we propose a novel, end-to-end trainable deep neural network architecture by unrolling the resulting iterative process of such variable splitting scheme. VS-Net is …
Korea Advanced Institute of Science and Technology (KAIST)（韩国科学技术院）；Korea Basic Science Institute（韩国基础科学研究所）
Accelerated magnetic resonance (MR) scan acquisition with compressed sensing (CS) and parallel imaging is a powerful method to reduce MR imaging scan time. However, many reconstruction algorithms have high computational costs. To address this, we investigate deep residual learning networks to remove aliasing artifacts from artifact corrupted images. The proposed deep residual learning networks are composed of magnitude and phase networks that are separately trained. If both phase and magnitude information are available, the proposed algorithm can work as an iterative k-space interpolation algo…
Anatomically Faithful Artifact Suppression in SENSE Accelerated Brain MRI
East China Normal University（华东师范大学）；Affiliated Hospital of Guizhou Medical University（贵州医科大学附属医院）；West China Hospital, Sichuan University（四川大学华西医院）；Chinese Academy of Medical Sciences（中国医学科学院）；RadioDynamic Medical（镭动医疗）；Lucile Packard Children’s Hospital（露西尔·帕卡德儿童医院）
Self-supervised learning has shown great promise due to its capability to train deep learning MRI reconstruction methods without fully-sampled data. Current self-supervised learning methods for physics-guided reconstruction networks split acquired undersampled data into two disjoint sets, where one is used for data consistency (DC) in the unrolled network and the other to define the training loss. In this study, we propose an improved self-supervised learning strategy that more efficiently uses the acquired data to train a physics-guided reconstruction network without a database of fully-sampl…
Magnetic resonance imaging (MRI) is a cornerstone of modern medical imaging. However, long image acquisition times, the need for qualitative expert analysis, and the lack of (and difficulty extracting) quantitative indicators that are sensitive to tissue health have curtailed widespread clinical and research studies. While recent machine learning methods for MRI reconstruction and analysis have shown promise for reducing this burden, these techniques are primarily validated with imperfect image quality metrics, which are discordant with clinically-relevant measures that ultimately hamper clini…
Learning Subject-Specific Anatomical Representations via Manifold Expansion: Application to Accelerated Multi-Contrast MRI
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital（马萨诸塞州总医院阿西诺拉·A·马丁诺斯生物医学成像中心）；Harvard Medical School（哈佛医学院）；Massachusetts General Hospital（马萨诸塞州总医院）
Xiamen University（厦门大学）；Xiamen University of Technology（厦门理工学院）；United Imaging Research Institute of Intelligent Imaging（联影智能影像研究院）；Nanjing Medical University（南京医科大学）；University of Texas at Austin（德克萨斯大学奥斯汀分校）
Deep learning has shown astonishing performance in accelerated magnetic resonance imaging (MRI). Most state-of-the-art deep learning reconstructions adopt the powerful convolutional neural network and perform 2D convolution since many magnetic resonance images or their corresponding k-space are in 2D. In this work, we present a new approach that explores the 1D convolution, making the deep network much easier to be trained and generalized. We further integrate the 1D convolution into the proposed deep network, named as One-dimensional Deep Low-rank and Sparse network (ODLS), which unrolls the …
Magnetic Resonance Imaging (MRI) has long been considered to be among "the gold standards" of diagnostic medical imaging. The long acquisition times, however, render MRI prone to motion artifacts, let alone their adverse contribution to the relative high costs of MRI examination. Over the last few decades, multiple studies have focused on the development of both physical and post-processing methods for accelerated acquisition of MRI scans. These two approaches, however, have so far been addressed separately. On the other hand, recent works in optical computational imaging have demonstrated gro…
Learning Task-Specific Strategies for Accelerated MRI
California Institute of Technology（加州理工学院）；Massachusetts Institute of Technology（麻省理工学院）；Athinoula A. Martinos Center for Biomedical Imaging（阿西努拉·A.马蒂诺斯生物医学成像中心）；MGH（麻省总医院）；Harvard Medical School（哈佛医学院）
Evaluation of Machine Learning Reconstruction Techniques for Accelerated Brain MRI Scans
Humber River Hospital（亨伯河医院）；Toronto Western Hospital, University of Toronto（多伦多大学多伦多西区医院）；Foqus Technologies Inc.（Foqus 技术公司）；Robarts Research Institute, Western University（西安大略大学罗巴茨研究所）
Amsterdam UMC（阿姆斯特丹大学医学中心）；University of Amsterdam（阿姆斯特丹大学）；MS Center Amsterdam（阿姆斯特丹多发性硬化中心）；Amsterdam Neuroscience（阿姆斯特丹神经科学研究所）；Vrije Universiteit Amsterdam（阿姆斯特丹自由大学）；Leiden University（莱顿大学）；Delft University of Technology（代尔夫特理工大学）
Machine Learning methods can learn how to reconstruct Magnetic Resonance Images and thereby accelerate acquisition, which is of paramount importance to the clinical workflow. Physics-informed networks incorporate the forward model of accelerated MRI reconstruction in the learning process. With increasing network complexity, robustness is not ensured when reconstructing data unseen during training. We aim to embed data consistency (DC) in deep networks while balancing the degree of network complexity. While doing so, we will assess whether either explicit or implicit enforcement of DC in varyin…
Technical University of Munich（慕尼黑工业大学）；GE Global Research（通用电气全球研发中心）；Harvard Medical School（哈佛医学院）
Perfusion-weighted magnetic resonance imaging (MRI) is an imaging technique that allows one to measure tissue perfusion in an organ of interest through the injection of an intravascular paramagnetic contrast agent (CA). Due to a preference for high temporal and spatial resolution in many applications, this modality could significantly benefit from accelerated data acquisitions. In this paper, we specifically address the problem of reconstructing perfusion MR image series from a subset of k-space data. Our proposed approach is motivated by the observation that temporal variations (dynamics) in …
Inverse problems for accelerated MRI typically incorporate domain-specific knowledge about the forward encoding operator in a regularized reconstruction framework. Recently physics-driven deep learning (DL) methods have been proposed to use neural networks for data-driven regularization. These methods unroll iterative optimization algorithms to solve the inverse problem objective function, by alternating between domain-specific data consistency and data-driven regularization via neural networks. The whole unrolled network is then trained end-to-end to learn the parameters of the network. Due t…
Measured-Subspace Consistency: A Plug-and-Play Operator for Diffusion Posterior Sampling in Accelerated MRI Reconstruction
Interdisciplinary Program in Cancer Biology, Seoul National University College of Medicine（首尔国立大学医学院癌症生物学跨学科项目）；Department of Radiology, Seoul National University College of Medicine, Seoul National University Hospital（首尔国立大学医学院放射科，首尔国立大学医院）；Healthcare AI Research Institute, Seoul National University Hospital（首尔国立大学医院医疗人工智能研究机构）
Purpose: Neural networks have received recent interest for reconstruction of undersampled MR acquisitions. Ideally network performance should be optimized by drawing the training and testing data from the same domain. In practice, however, large datasets comprising hundreds of subjects scanned under a common protocol are rare. The goal of this study is to introduce a transfer-learning approach to address the problem of data scarcity in training deep networks for accelerated MRI. Methods: Neural networks were trained on thousands of samples from public datasets of either natural images or brain…
In today's clinical practice, magnetic resonance imaging (MRI) is routinely accelerated through subsampling of the associated Fourier domain. Currently, the construction of these subsampling strategies - known as experimental design - relies primarily on heuristics. We propose to learn experimental design strategies for accelerated MRI with policy gradient methods. Unexpectedly, our experiments show that a simple greedy approximation of the objective leads to solutions nearly on-par with the more general non-greedy approach. We offer a partial explanation for this phenomenon rooted in greater …
Self-Auditing Residual Drifting for Pathology-Preserving Accelerated Knee MRI
Department of Radiology & Biomedical Imaging, Yale School of Medicine（放射学与生物医学成像系，耶鲁医学院）；Department of Biomedical Engineering, Rensselaer Polytechnic Institute（生物医学工程系，伦塞拉尔理工学院）
