CT image denoising can be treated as an image-to-image translation task where the goal is to learn the transform between a source domain $X$ (noisy images) and a target domain $Y$ (clean images). Recently, cycle-consistent adversarial denoising network (CCADN) has achieved state-of-the-art results by enforcing cycle-consistent loss without the need of paired training data. Our detailed analysis of CCADN raises a number of interesting questions. For example, if the noise is large leading to significant difference between domain $X$ and domain $Y$, can we bridge $X$ and $Y$ with an intermediate domain $Z$ such that both the denoising process between $X$ and $Z$ and that between $Z$ and $Y$ are easier to learn? As such intermediate domains lead to multiple cycles, how do we best enforce cycle-consistency? Driven by these questions, we propose a multi-cycle-consistent adversarial network (MCCAN) that builds intermediate domains and enforces both local and global cycle-consistency. The global cycle-consistency couples all generators together to model the whole denoising process, while the local cycle-consistency imposes effective supervision on the process between adjacent domains. Experiments show that both local and global cycle-consistency are important for the success of MCCAN, which outperforms the state-of-the-art.
Nanyang Technological University（南洋理工大学）；Alibaba Group（阿里巴巴集团）；Tianjin University（天津大学）；State Administration of Cultural Heritage（国家文物局）
Image denoising can remove natural noise that widely exists in images captured by multimedia devices due to low-quality imaging sensors, unstable image transmission processes, or low light conditions. Recent works also find that image denoising benefits the high-level vision tasks, e.g., image classification. In this work, we try to challenge this common sense and explore a totally new problem, i.e., whether the image denoising can be given the capability of fooling the state-of-the-art deep neural networks (DNNs) while enhancing the image quality. To this end, we initiate the very first attem…
This paper presents a novel context-aware image denoising algorithm that combines an adaptive image smoothing technique and color reduction techniques to remove perturbation from adversarial images. Adaptive image smoothing is achieved using auto-threshold canny edge detection to produce an accurate edge map used to produce a blurred image that preserves more edge features. The proposed algorithm then uses color reduction techniques to reconstruct the image using only a few representative colors. Through this technique, the algorithm can reduce the effects of adversarial perturbations on image…
Is it possible to recover an image from its noisy version using convolutional neural networks? This is an interesting problem as convolutional layers are generally used as feature detectors for tasks like classification, segmentation and object detection. We present a new CNN architecture for blind image denoising which synergically combines three architecture components, a multi-scale feature extraction layer which helps in reducing the effect of noise on feature maps, an l_p regularizer which helps in selecting only the appropriate feature maps for the task of reconstruction, and finally a t…
This work systematically investigates the adversarial robustness of deep image denoisers (DIDs), i.e, how well DIDs can recover the ground truth from noisy observations degraded by adversarial perturbations. Firstly, to evaluate DIDs' robustness, we propose a novel adversarial attack, namely Observation-based Zero-mean Attack ({\sc ObsAtk}), to craft adversarial zero-mean perturbations on given noisy images. We find that existing DIDs are vulnerable to the adversarial noise generated by {\sc ObsAtk}. Secondly, to robustify DIDs, we propose an adversarial training strategy, hybrid adversarial t…
Inception Institute of Artificial Intelligence（人工智能 inception 研究院）；University of California, Merced（加州大学默塞德分校）；Google Research（谷歌研究院）
The availability of large-scale datasets has helped unleash the true potential of deep convolutional neural networks (CNNs). However, for the single-image denoising problem, capturing a real dataset is an unacceptably expensive and cumbersome procedure. Consequently, image denoising algorithms are mostly developed and evaluated on synthetic data that is usually generated with a widespread assumption of additive white Gaussian noise (AWGN). While the CNNs achieve impressive results on these synthetic datasets, they do not perform well when applied on real camera images, as reported in recent be…
This paper evaluates the performance of supervised and unsupervised deep learning models for denoising positron emission tomography (PET) images in the presence of reduced acquisition times. Our experiments consider 212 studies (56908 images), and evaluate the models using 2D (RMSE, SSIM) and 3D (SUVpeak and SUVmax error for the regions of interest) metrics. It was shown that, in contrast to previous studies, supervised models (ResNet, Unet, SwinIR) outperform unsupervised models (pix2pix GAN and CycleGAN with ResNet backbone and various auxiliary losses) in the reconstruction of 2D PET images…
Cycle-Constrained Adversarial Denoising Convolutional Network for PET Image Denoising: Multi-Dimensional Validation on Large Datasets with Reader Study and Real Low-Dose Data
Northeastern University（东北大学）；Michigan State University（密歇根州立大学）；MIT-IBM Watson AI Lab（麻省理工学院-IBM沃森人工智能实验室）；IBM Research（IBM研究院）
It has been well recognized that neural network based image classifiers are easily fooled by images with tiny perturbations crafted by an adversary. There has been a vast volume of research to generate and defend such adversarial attacks. However, the following problem is left unexplored: How to reverse-engineer adversarial perturbations from an adversarial image? This leads to a new adversarial learning paradigm--Reverse Engineering of Deceptions (RED). If successful, RED allows us to estimate adversarial perturbations and recover the original images. However, carefully crafted, tiny adversar…
Shandong University of Traditional Chinese Medicine（山东中医药大学）；Nankai University（南开大学）；ShanghaiTech University（上海科技大学）；Taishan University（泰山学院）；United Imaging Co.（联影公司）
Real-world face super-resolution (SR) is a highly ill-posed image restoration task. The fully-cycled Cycle-GAN architecture is widely employed to achieve promising performance on face SR, but prone to produce artifacts upon challenging cases in real-world scenarios, since joint participation in the same degradation branch will impact final performance due to huge domain gap between real-world and synthetic LR ones obtained by generators. To better exploit the powerful generative capability of GAN for real-world face SR, in this paper, we establish two independent degradation branches in the fo…
In this paper, we propose a learning-based approach for denoising raw videos captured under low lighting conditions. We propose to do this by first explicitly aligning the neighboring frames to the current frame using a convolutional neural network (CNN). We then fuse the registered frames using another CNN to obtain the final denoised frame. To avoid directly aligning the temporally distant frames, we perform the two processes of alignment and fusion in multiple stages. Specifically, at each stage, we perform the denoising process on three consecutive input frames to generate the intermediate…
Universal Adversarial Defense in Remote Sensing Based on Pre-trained Denoising Diffusion Models
Helmholtz Institute Freiberg for Resource Technology（亥姆霍兹弗莱贝格资源技术研究所）；Helmholtz-Zentrum Dresden-Rossendorf (HZDR)（德累斯顿-罗森多夫亥姆霍兹中心）；Linköping University（林雪平大学）
The potential of using remote sensing imagery for environmental modelling and for providing real time support to humanitarian operations such as hurricane relief efforts is well established. These applications are substantially affected by missing data due to non-structural noise such as clouds, shadows and other atmospheric effects. In this work we probe the potential of applying a cycle-consistent latent variable deep generative model (DGM) for denoising cloudy Sentinel-2 observations conditioned on the information in cloud penetrating bands. We adapt the recently proposed Fréchet Distance m…
Korea Advanced Institute of Science and Technology (KAIST)（韩国科学技术院）
Recently, CycleGAN was shown to provide high-performance, ultra-fast denoising for low-dose X-ray computed tomography (CT) without the need for a paired training dataset. Although this was possible thanks to cycle consistency, CycleGAN requires two generators and two discriminators to enforce cycle consistency, demanding significant GPU resources and technical skills for training. A recent proposal of tunable CycleGAN with Adaptive Instance Normalization (AdaIN) alleviates the problem in part by using a single generator. However, two discriminators and an additional AdaIN code generator are st…
Guangdong Cardiovascular Institute（广东省心血管病研究所）；Guangdong Academy of Medical Sciences（广东省医学科学院）；University of Notre Dame（圣母大学）
As one of the most commonly ordered imaging tests, computed tomography (CT) scan comes with inevitable radiation exposure that increases the cancer risk to patients. However, CT image quality is directly related to radiation dose, thus it is desirable to obtain high-quality CT images with as little dose as possible. CT image denoising tries to obtain high dose like high-quality CT images (domain X) from low dose low-quality CTimages (domain Y), which can be treated as an image-to-image translation task where the goal is to learn the transform between a source domain X (noisy images) and a targ…
Gating is commonly used in PET imaging to reduce respiratory motion blurring and facilitate more sophisticated motion correction methods. In the applications of low dose PET, however, reducing injection dose causes increased noise and reduces signal-to-noise ratio (SNR), subsequently corrupting the motion estimation/correction steps, causing inferior image quality. To tackle these issues, we first propose a Siamese adversarial network (SAN) that can efficiently recover high dose gated image volume from low dose gated image volume. To ensure the appearance consistency between the recovered gate…
Nosie is an important cause of low quality Optical coherence tomography (OCT) image. The neural network model based on Convolutional neural networks(CNNs) has demonstrated its excellent performance in image denoising. However, OCT image denoising still faces great challenges because many previous neural network algorithms required a large number of labeled data, which might cost much time or is expensive. Besides, these CNN-based algorithms need numerous parameters and good tuning techniques, which is hardware resources consuming. To solved above problems, We proposed a new Cycle-Consistent Ge…
Universidad Politécnica de Madrid（马德里理工大学）；Centre national de la recherche scientifique (CNRS)（法国国家科学研究中心）；Interdisciplinary Institute for Neuroscience (IINS)（跨学科神经科学研究所）；University of Bordeaux（波尔多大学）；Mechanobiology Institute（机械生物学研究所）；National University of Singapore（新加坡国立大学）
Microscopy images often suffer from high levels of noise, which can hinder further analysis and interpretation. Content-aware image restoration (CARE) methods have been proposed to address this issue, but they often require large amounts of training data and suffer from over-fitting. To overcome these challenges, we propose a novel framework for few-shot microscopy image denoising. Our approach combines a generative adversarial network (GAN) trained via contrastive learning (CL) with two structure preserving loss terms (Structural Similarity Index and Total Variation loss) to further improve t…
The cryo-electron microscopy (Cryo-EM) becomes popular for macromolecular structure determination. However, the 2D images which Cryo-EM detects are of high noise and often mixed with multiple heterogeneous conformations or contamination, imposing a challenge for denoising. Traditional image denoising methods can not remove Cryo-EM image noise well when the signal-noise-ratio (SNR) of images is meager. Thus it is desired to develop new effective denoising techniques to facilitate further research such as 3D reconstruction, 2D conformation classification, and so on. In this paper, we approach th…
East China Normal University（华东师范大学）；Nanyang Technological University（南洋理工大学）；Alibaba Group（阿里巴巴集团）；University of Alberta（阿尔伯塔大学）；Zhejiang Sci-Tech University（浙江理工大学）
High-level representation-guided pixel denoising and adversarial training are independent solutions to enhance the robustness of CNNs against adversarial attacks by pre-processing input data and re-training models, respectively. Most recently, adversarial training techniques have been widely studied and improved while the pixel denoising-based method is getting less attractive. However, it is still questionable whether there exists a more advanced pixel denoising-based method and whether the combination of the two solutions benefits each other. To this end, we first comprehensively investigate…
Ambient Denoising Diffusion Generative Adversarial Networks for Establishing Stochastic Object Models from Noisy Image Data
Global Institute of Future Technology, Shanghai Jiao Tong University（上海交通大学未来技术研究院）；University of Michigan-Shanghai Jiao Tong University Joint Institute, Shanghai Jiao Tong University（上海交通大学密歇根大学联合学院）；University of Arizona（亚利桑那大学）；Wyant College of Optical Sciences, University of Arizona（亚利桑那大学怀恩特光学科学学院）
Cycle-guided Denoising Diffusion Probability Model for 3D Cross-modality MRI Synthesis
Emory University（埃默里大学）；Winship Cancer Institute（温希普癌症研究所）；Memorial Sloan Kettering Cancer Center（纪念斯隆凯特琳癌症中心）；Icahn School of Medicine at Mount Sinai（西奈山伊坎医学院）
Univ. Rennes（雷恩大学）；INSA Rennes（雷恩国立应用科学学院）；CNRS（法国国家科学研究中心）；IETR - UMR 6164（电子与电信研究所（UMR 6164））；National Institute of Telecommunications and ICT, Oran（奥兰国家电信与信息通信技术研究所）
Despite the enormous performance of deepneural networks (DNNs), recent studies have shown theirvulnerability to adversarial examples (AEs), i.e., care-fully perturbed inputs designed to fool the targetedDNN. Currently, the literature is rich with many ef-fective attacks to craft such AEs. Meanwhile, many de-fenses strategies have been developed to mitigate thisvulnerability. However, these latter showed their effec-tiveness against specific attacks and does not general-ize well to different attacks. In this paper, we proposea framework for defending DNN classifier against ad-versarial samples.…
Fudan University（复旦大学）；Sichuan University（四川大学）；Shanghai Center for Brain Science and Brain-inspired Technology（上海脑科学与类脑研究中心）
LDCT has drawn major attention in the medical imaging field due to the potential health risks of CT-associated X-ray radiation to patients. Reducing the radiation dose, however, decreases the quality of the reconstructed images, which consequently compromises the diagnostic performance. Various deep learning techniques have been introduced to improve the image quality of LDCT images through denoising. GANs-based denoising methods usually leverage an additional classification network, i.e. discriminator, to learn the most discriminate difference between the denoised and normal-dose images and, …
We propose a novel unpaired image-to-image translation method that uses denoising diffusion probabilistic models without requiring adversarial training. Our method, UNpaired Image Translation with Denoising Diffusion Probabilistic Models (UNIT-DDPM), trains a generative model to infer the joint distribution of images over both domains as a Markov chain by minimising a denoising score matching objective conditioned on the other domain. In particular, we update both domain translation models simultaneously, and we generate target domain images by a denoising Markov Chain Monte Carlo approach tha…
Korea Advanced Institute of Science and Technology (KAIST)（韩国科学技术院）；Korea Aerospace Research Institute (KARI)（韩国航空宇宙研究院）
Multi-spectral satellite imaging sensors acquire various spectral band images such as red (R), green (G), blue (B), near-infrared (N), etc. Thanks to the unique spectroscopic property of each spectral band with respective to the objects on the ground, multi-spectral satellite imagery can be used for various geological survey applications. Unfortunately, image artifacts from imaging sensor noises often affect the quality of scenes and have negative impacts on the applications of satellite imagery. Recently, deep learning approaches have been extensively explored for the removal of noises in sat…
We propose a novel framework for controllable pathological image synthesis for data augmentation. Inspired by CycleGAN, we perform cycle-consistent image-to-image translation between two domains: healthy and pathological. Guided by a semantic mask, an adversarially trained generator synthesizes pathology on a healthy image in the specified location. We demonstrate our approach on an institutional dataset of cerebral microbleeds in traumatic brain injury patients. We utilize synthetic images generated with our method for data augmentation in cerebral microbleeds detection. Enriching the trainin…
Korea Advanced Institute of Science and Technology（韩国科学技术院）
Recently, deep learning approaches have been extensively studied for low-dose CT denoising thanks to its superior performance despite the fast computational time. In particular, cycleGAN has been demonstrated as a powerful unsupervised learning scheme to improve the low-dose CT image quality without requiring matched high-dose reference data. Unfortunately, one of the main limitations of the cycleGAN approach is that it requires two deep neural network generators at the training phase, although only one of them is used at the inference phase. The secondary auxiliary generator is needed to enfo…
Certain facial parts are salient (unique) in appearance, which substantially contribute to the holistic recognition of a subject. Occlusion of these salient parts deteriorates the performance of face recognition algorithms. In this paper, we propose a generative model to reconstruct the missing parts of the face which are under occlusion. The proposed generative model (SD-GAN) reconstructs a face preserving the illumination variation and identity of the face. A novel adversarial training algorithm has been designed for a bimodal mutually exclusive Generative Adversarial Network (GAN) model, fo…
The goal of unsupervised image-to-image translation is to map images from one domain to another without the ground truth correspondence between the two domains. State-of-art methods learn the correspondence using large numbers of unpaired examples from both domains and are based on generative adversarial networks. In order to preserve the semantics of the input image, the adversarial objective is usually combined with a cycle-consistency loss that penalizes incorrect reconstruction of the input image from the translated one. However, if the target mapping is many-to-one, e.g. aerial photos to …
Intelligence and Space Research Division（情报与空间研究部）；Descartes Labs, Inc.（笛卡尔实验室公司）；Los Alamos National Laboratory（洛斯阿拉莫斯国家实验室）
This paper introduces a new method of generating realistic pervasive changes in the context of evaluating the effectiveness of change detection algorithms in controlled settings. The method, a cycle-consistent adversarial network (CycleGAN), requires low quantities of training data to generate realistic changes. Here we show an application of CycleGAN in creating realistic snow-covered scenes of multispectral Sentinel-2 imagery, and demonstrate how these images can be used as a test bed for anomalous change detection algorithms.
The image noise level and resolution of SPECT images are relatively poor attributed to the limited number of detected counts and various physical degradation factors during acquisitions. This study aims to apply and evaluate the use of generative adversarial network (GAN) method in static SPECT image denoising. A population of 4D extended cardiac-torso (XCAT) phantoms were used to simulate 10 male and female patients with different organ sizes and activity uptakes. An analytical projector was applied to simulate 120 projections from right anterior oblique to left posterior oblique positions wi…
Deep learning based pan-sharpening has received significant research interest in recent years. Most of existing methods fall into the supervised learning framework in which they down-sample the multi-spectral (MS) and panchromatic (PAN) images and regard the original MS images as ground truths to form training samples. Although impressive performance could be achieved, they have difficulties generalizing to the original full-scale images due to the scale gap, which makes them lack of practicability. In this paper, we propose an unsupervised generative adversarial framework that learns from the…
Northeastern University（东北大学）；Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences（中国科学院深圳先进技术研究院）；Rensselaer Polytechnic Institute（伦斯勒理工学院）
Due to the widespread use of positron emission tomography (PET) in clinical practice, the potential risk of PET-associated radiation dose to patients needs to be minimized. However, with the reduction in the radiation dose, the resultant images may suffer from noise and artifacts that compromise diagnostic performance. In this paper, we propose a parameter-transferred Wasserstein generative adversarial network (PT-WGAN) for low-dose PET image denoising. The contributions of this paper are twofold: i) a PT-WGAN framework is designed to denoise low-dose PET images without compromising structural…
University of Trento（特伦托大学）；University of Oxford（牛津大学）；Texas State University（得克萨斯州立大学）；EPFL（洛桑联邦理工学院）
In this work, we propose a novel Cycle In Cycle Generative Adversarial Network (C$^2$GAN) for the task of keypoint-guided image generation. The proposed C$^2$GAN is a cross-modal framework exploring a joint exploitation of the keypoint and the image data in an interactive manner. C$^2$GAN contains two different types of generators, i.e., keypoint-oriented generator and image-oriented generator. Both of them are mutually connected in an end-to-end learnable fashion and explicitly form three cycled sub-networks, i.e., one image generation cycle and two keypoint generation cycles. Each cycle not …
Fundus images are very useful in identifying various ophthalmic disorders. However, due to the presence of artifacts, the visibility of the retina is severely affected. This may result in misdiagnosis of the disorder which may lead to more complicated problems. Since deep learning is a powerful tool to extract patterns from data without much human intervention, they can be applied to image-to-image translation problems. An attempt has been made in this paper to automatically rectify such artifacts present in the images of the fundus. We use a CycleGAN based model which consists of residual blo…
The biggest challenge faced by a Machine Learning Engineer is the lack of data they have, especially for 2-dimensional images. The image is processed to be trained into a Machine Learning model so that it can recognize patterns in the data and provide predictions. This research is intended to create a solution using the Cycle Generative Adversarial Networks (GANs) algorithm in overcoming the problem of lack of data. Then use Style Transfer to be able to generate a new image based on the given style. Based on the results of testing the resulting model has been carried out several improvements, …
Jet Propulsion Laboratory, California Institute of Technology（加州理工学院喷气推进实验室）
Infrared (IR) images are essential to improve the visibility of dark or camouflaged objects. Object recognition and segmentation based on a neural network using IR images provide more accuracy and insight than color visible images. But the bottleneck is the amount of relevant IR images for training. It is difficult to collect real-world IR images for special purposes, including space exploration, military and fire-fighting applications. To solve this problem, we created color visible and IR images using a Unity-based 3D game editor. These synthetically generated color visible and IR images wer…
We cast the problem of image denoising as a domain translation problem between high and low noise domains. By modifying the cycleGAN model, we are able to learn a mapping between these domains on unpaired retinal optical coherence tomography images. In quantitative measurements and a qualitative evaluation by ophthalmologists, we show how this approach outperforms other established methods. The results indicate that the network differentiates subtle changes in the level of noise in the image. Further investigation of the model's feature maps reveals that it has learned to distinguish retinal l…
Lakehead University（湖首大学）；Western University（韦仕敦大学）；Harbin Institute of Technology（哈尔滨工业大学）；Nanjing University of Information Science and Technology（南京信息工程大学）；Tianjin University（天津大学）；Okanagan College（奥肯那根学院）；The University of British Columbia Okanagan（不列颠哥伦比亚大学奥肯那根分校）
Deep Convolutional Neural Networks (DCNNs) have exhibited impressive performance on image super-resolution tasks. However, these deep learning-based super-resolution methods perform poorly in real-world super-resolution tasks, where the paired high-resolution and low-resolution images are unavailable and the low-resolution images are degraded by complicated and unknown kernels. To break these limitations, we propose the Unsupervised Bi-directional Cycle Domain Transfer Learning-based Generative Adversarial Network (UBCDTL-GAN), which consists of an Unsupervised Bi-directional Cycle Domain Tran…
Purpose: Correcting or reducing the effects of voxel intensity non-uniformity (INU) within a given tissue type is a crucial issue for quantitative MRI image analysis in daily clinical practice. In this study, we present a deep learning-based approach for MRI image INU correction. Method: We developed a residual cycle generative adversarial network (res-cycle GAN), which integrates the residual block concept into a cycle-consistent GAN (cycle-GAN). In cycle-GAN, an inverse transformation was implemented between the INU uncorrected and corrected MRI images to constrain the model through forcing …
