Classification Algorithm of Speech Data of Parkinsons Disease Based on Convolution Sparse Kernel Transfer Learning with Optimal Kernel and Parallel Sample Feature Selection
Chongqing Radio and TV University（重庆广播电视大学）；Chongqing University（重庆大学）
Xiaoheng Zhang, Yongming Li, Pin Wang, Xiaoheng Tan, Yuchuan Liu
Labeled speech data from patients with Parkinsons disease (PD) are scarce, and the statistical distributions of training and test data differ significantly in the existing datasets. To solve these problems, dimensional reduction and sample augmentation must be considered. In this paper, a novel PD classification algorithm based on sparse kernel transfer learning combined with a parallel optimization of samples and features is proposed. Sparse transfer learning is used to extract effective structural information of PD speech features from public datasets as source domain data, and the fast ADDM iteration is improved to enhance the information extraction performance. To implement the parallel optimization, the potential relationships between samples and features are considered to obtain high-quality combined features. First, features are extracted from a specific public speech dataset to construct a feature dataset as the source domain. Then, the PD target domain, including the training and test datasets, is encoded by convolution sparse coding, which can extract more in-depth information. Next, parallel optimization is implemented. To further improve the classification performance, a convolution kernel optimization mechanism is designed. Using two representative public datasets and one self-constructed dataset, the experiments compare over thirty relevant algorithms. The results show that when taking the Sakar dataset, MaxLittle dataset and DNSH dataset as target domains, the proposed algorithm achieves obvious improvements in classification accuracy. The study also found large improvements in the algorithms in this paper compared with nontransfer learning approaches, demonstrating that transfer learning is both more effective and has a more acceptable time cost.
Accurate and early prediction of a disease allows to plan and improve a patient's quality of future life. During pandemic situations, the medical decision becomes a speed challenge in which physicians have to act fast to diagnose and predict the risk of the severity of the disease, moreover this is also of high priority for neurodegenerative diseases like Parkinson's disease. Machine Learning (ML) models with Features Selection (FS) techniques can be applied to help physicians to quickly diagnose a disease. FS optimally subset features that improve a model performance and help reduce the numbe…
Dysphonia is one of the early symptoms of Parkinson's disease (PD). Most existing methods use feature selection methods to find the optimal subset of voice features for all PD patients. Few have considered the heterogeneity between patients, which implies the need to provide specific prediction models for different patients. However, building the specific model faces the challenge of small sample size, which makes it lack generalization ability. Instance transfer is an effective way to solve this problem. Therefore, this paper proposes a patient-specific game-based transfer (PSGT) method for P…
Parkinsons Disease is a neurological disorder and prevalent in elderly people. Traditional ways to diagnose the disease rely on in-person subjective clinical evaluations on the quality of a set of activity tests. The high-resolution longitudinal activity data collected by smartphone applications nowadays make it possible to conduct remote and convenient health assessment. However, out-of-lab tests often suffer from poor quality controls as well as irregularly collected observations, leading to noisy test results. To address these issues, we propose a novel time-series based approach to predict…
University of Lincoln（林肯大学）；National Technical University of Athens（雅典国立技术大学）
The paper presents a novel approach, based on deep learning, for diagnosis of Parkinson's disease through medical imaging. The approach includes analysis and use of the knowledge extracted by Deep Convolutional and Recurrent Neural Networks (DNNs) when trained with medical images, such as Magnetic Resonance Images and DaTscans. Internal representations of the trained DNNs constitute the extracted knowledge which is used in a transfer learning and domain adaptation manner, so as to create a unified framework for prediction of Parkinson's across different medical environments. A large experiment…
Motor-Imagery based BCI (MI-BCI) neurorehabilitation can improve locomotor ability and reduce the deficit symptoms in Parkinson's Disease patients. Advanced Motor-Imagery BCI methods are needed to overcome the accuracy and time-related MI BCI calibration challenges in such patients. In this study, we proposed a Multi-session FBCSP (msFBCSP) based on inter-session transfer learning and we investigated its performance compared to the single-session based FBSCP. The main result of this study is the significantly improved accuracy obtained by proposed msFBCSP compared to single-session FBCSP in PD…
Indian Institute of Technology Bhubaneswar（布巴内斯瓦尔印度理工学院）；G.G Vishwavidyalaya, Central University（G.G大学（中央大学））
Parkinson's disease (PD) is one of the major public health problems in the world. It is a well-known fact that around one million people suffer from Parkinson's disease in the United States whereas the number of people suffering from Parkinson's disease worldwide is around 5 million. Thus, it is important to predict Parkinson's disease in early stages so that early plan for the necessary treatment can be made. People are mostly familiar with the motor symptoms of Parkinson's disease, however, an increasing amount of research is being done to predict the Parkinson's disease from non-motor sympt…
Institute of Robotics and Intelligent Systems（机器人与智能系统研究所）；ETH Zurich（苏黎世联邦理工学院）
Parkinson's disease is a neurodegenerative disease that can affect a person's movement, speech, dexterity, and cognition. Clinicians primarily diagnose Parkinson's disease by performing a clinical assessment of symptoms. However, misdiagnoses are common. One factor that contributes to misdiagnoses is that the symptoms of Parkinson's disease may not be prominent at the time the clinical assessment is performed. Here, we present a machine-learning approach towards distinguishing between people with and without Parkinson's disease using long-term data from smartphone-based walking, voice, tapping…
In this study, we executed a genomic analysis with the objective of selecting a set of genes (possibly small) that would help in the detection and classification of samples from patients affected by Parkinson Disease. We performed a complete data analysis and during the exploratory phase, we selected a list of differentially expressed genes. Despite their association with the diseased state, we could not use them as a biomarker tool. Therefore, our research was extended to include a multivariate analysis approach resulting in the identification and selection of a group of 20 genes that showed …
University of Stavanger（斯塔万格大学）；Stavanger University Hospital（斯塔万格大学医院）；Universidad de Antioquia（安蒂奥基亚大学）
As the number of automatic tools based on machine learning (ML) and resting-state electroencephalography (rs-EEG) for Parkinson's disease (PD) detection keeps growing, the assessment of possible exacerbation of health disparities by means of fairness and bias analysis becomes more relevant. Protected attributes, such as gender, play an important role in PD diagnosis development. However, analysis of sub-group populations stemming from different genders is seldom taken into consideration in ML models' development or the performance assessment for PD detection. In this work, we perform a systema…
The University of Texas at Dallas（德克萨斯大学达拉斯分校）；The University of Texas at Austin（德克萨斯大学奥斯汀分校）
Fundamental knowledge in activity recognition of individuals with motor disorders such as Parkinson's disease (PD) has been primarily limited to detection of steady-state/static tasks (sitting, standing, walking). To date, identification of non-steady-state locomotion on uneven terrains (stairs, ramps) has not received much attention. Furthermore, previous research has mainly relied on data from a large number of body locations which could adversely affect user convenience and system performance. Here, individuals with mild stages of PD and healthy subjects performed non-steady-state circuit t…
Azerbaijan State Oil and Industry University（阿塞拜疆石油与工业大学）；Istanbul University Cerrahpasa Faculty of Medicine Hospital（伊斯坦布尔大学切拉帕萨医学院附属医院）
In the world, about 7 to 10 million elderly people are suffering from Parkinson's Disease (PD) disease. Parkinson's disease is a common neurological degenerative disease, and its clinical characteristics are Tremors, rigidity, bradykinesia, and decreased autonomy. Its clinical manifestations are very similar to Multiple System Atrophy (MSA) disorders. Studies have shown that patients with Parkinson's disease often reach an irreparable situation when diagnosed, so As Parkinson's disease can be distinguished from MSA disease and get an early diagnosis, people are constantly exploring new methods…
Interpretable Early Detection of Parkinson's Disease through Speech Analysis
Department of Computer Science, University of Pisa（比萨大学计算机科学系）；School of Public Health, Yale University（耶鲁大学公共卫生学院）；Department of Computer Science, University of Bari（巴里大学计算机科学系）
Parkinson's disease (PD) is a slowly progressive debilitating neurodegenerative disease which is prominently characterised by motor symptoms. Indoor localisation, including number and speed of room to room transitions, provides a proxy outcome which represents mobility and could be used as a digital biomarker to quantify how mobility changes as this disease progresses. We use data collected from 10 people with Parkinson's, and 10 controls, each of whom lived for five days in a smart home with various sensors. In order to more effectively localise them indoors, we propose a transformer-based ap…
Parkinson's Disease (PD) is a chronic, degenerative disorder which leads to a range of motor and cognitive symptoms. PD diagnosis is a challenging task since its symptoms are very similar to other diseases such as normal ageing and essential tremor. Much research has been applied to diagnosing this disease. This project aims to automate the PD diagnosis process using deep learning, Recursive Neural Networks (RNN) and Convolutional Neural Networks (CNN), to differentiate between healthy and PD patients. Besides that, since different datasets may capture different aspects of this disease, this p…
Department of Computer Science University of Pisa（比萨大学计算机科学系（更准确的常见译法））
In this paper, we introduce a novel approach for diagnosis of Parkinson's Disease (PD) based on deep Echo State Networks (ESNs). The identification of PD is performed by analyzing the whole time-series collected from a tablet device during the sketching of spiral tests, without the need for feature extraction and data preprocessing. We evaluated the proposed approach on a public dataset of spiral tests. The results of experimental analysis show that DeepESNs perform significantly better than shallow ESN model. Overall, the proposed approach obtains state-of-the-art results in the identificatio…
Semnan University（塞姆南大学）；Amirkabir University of Technology (Tehran Polytechnic)（阿米尔卡比尔理工大学（德黑兰理工大学））
Background and Objective: Parkinson's disease (PD) is the second most common progressive neurological condition after Alzheimer's, characterized by motor and non-motor symptoms. Developing a method to diagnose the condition in its beginning phases is essential because of the significant number of individuals afflicting with this illness. PD is typically identified using motor symptoms or other Neuroimaging techniques, such as DATSCAN and SPECT. These methods are expensive, time-consuming, and unavailable to the general public; furthermore, they are not very accurate. These constraints encourag…
Edson College of Nursing and Health Innovation, Arizona State University（亚利桑那州立大学埃德森护理与健康创新学院）；School of Arts, Media and Engineering, Arizona State University（亚利桑那州立大学艺术、媒体与工程学院）
At present, the vast majority of human subjects with neurological disease are still diagnosed through in-person assessments and qualitative analysis of patient data. In this paper, we propose to use Topological Data Analysis (TDA) together with machine learning tools to automate the process of Parkinson's disease classification and severity assessment. An automated, stable, and accurate method to evaluate Parkinson's would be significant in streamlining diagnoses of patients and providing families more time for corrective measures. We propose a methodology which incorporates TDA into analyzing…
This paper focuses on the detection of Parkinson's disease based on the analysis of a patient's gait. The growing popularity and success of Transformer networks in natural language processing and image recognition motivated us to develop a novel method for this problem based on an automatic features extraction via Transformers. The use of Transformers in 1D signal is not really widespread yet, but we show in this paper that they are effective in extracting relevant features from 1D signals. As Transformers require a lot of memory, we decoupled temporal and spatial information to make the model…
Parkinson's Disease(PD) is one of the major nervous system disorders that affect people over 60. PD can cause cognitive impairments. In this work, we explore various approaches to identify Parkinson's using Magnetic Resonance (MR) T1 images of the brain. We experiment with ensemble architectures combining some winning Convolutional Neural Network models of ImageNet Large Scale Visual Recognition Challenge (ILSVRC) and propose two architectures. We find that detection accuracy increases drastically when we focus on the Gray Matter (GM) and White Matter (WM) regions from the MR images instead of…
Parkinson's disease (PD) is a degenerative and progressive neurological condition. Early diagnosis can improve treatment for patients and is performed through dopaminergic imaging techniques like the SPECT DaTscan. In this study, we propose a machine learning model that accurately classifies any given DaTscan as having Parkinson's disease or not, in addition to providing a plausible reason for the prediction. This is kind of reasoning is done through the use of visual indicators generated using Local Interpretable Model-Agnostic Explainer (LIME) methods. DaTscans were drawn from the Parkinson'…
IBM Hellas（IBM希腊公司）；National Technical University of Athens（雅典国立技术大学）；University of Lincoln（林肯大学）
This paper presents a new method for medical diagnosis of neurodegenerative diseases, such as Parkinson's, by extracting and using latent information from trained Deep convolutional, or convolutional-recurrent Neural Networks (DNNs). In particular, our approach adopts a combination of transfer learning, k-means clustering and k-Nearest Neighbour classification of deep neural network learned representations to provide enriched prediction of the disease based on MRI and/or DaT Scan data. A new loss function is introduced and used in the training of the DNNs, so as to perform adaptation of the ge…
University of Münster（明斯特大学）；Klinikum Osnabrück（奥斯纳布吕克医院）
Sensors from smart consumer devices have demonstrated high potential to serve as digital biomarkers in the identification of movement disorders in recent years. With the usage of broadly available smartwatches we have recorded participants performing technology-based assessments in a prospective study to research Parkinson's Disease (PD). In total, 504 participants, including PD patients, differential diagnoses (DD) and healthy controls (HC), were captured with a comprehensive system utilizing two smartwatches and two smartphones. To the best of our knowledge, this study provided the largest P…
Parkinson's disease (PD) is a common and complex neurodegenerative disorder with 5 stages in the Hoehn and Yahr scaling. Given the heterogeneity of PD, it is challenging to classify early stages 1 and 2 and detect brain function alterations. Functional magnetic resonance imaging (fMRI) is a promising tool in revealing functional connectivity (FC) differences and developing biomarkers in PD. Some machine learning approaches like support vector machine and logistic regression have been successfully applied in the early diagnosis of PD using fMRI data, which outperform classifiers based on manual…
University of Münster（明斯特大学）；Klinikum Osnabrück（奥斯纳布吕克医院）
In recent years, sensors from smart consumer devices have shown great diagnostic potential in movement disorders. In this context, data modalities such as electronic questionnaires, hand movement and voice captures have successfully captured biomarkers and allowed discrimination between Parkinson's disease (PD) and healthy controls (HC) or differential diagnosis (DD). However, to the best of our knowledge, a comprehensive evaluation of assessments with a multi-modal smart device system has still been lacking. In a prospective study exploring PD, we used smartwatches and smartphones to collect …
University of Canberra（堪培拉大学）；Kuwait College of Science and Technology（科威特科技学院）
While Parkinson's disease (PD) is typically characterized by motor disorder, there is evidence of diminished emotion perception in PD patients. This study examines the utility of affective Electroencephalography (EEG) signals to understand emotional differences between PD vs Healthy Controls (HC), and for automated PD detection. Employing traditional machine learning and deep learning methods, we explore (a) dimensional and categorical emotion recognition, and (b) PD vs HC classification from emotional EEG signals. Our results reveal that PD patients comprehend arousal better than valence, and…
University of Antioquia UdeA（安蒂奥基亚大学）；Friedrich-Alexander-Universität Erlangen-Nürnberg（埃尔朗根-纽伦堡弗里德里希-亚历山大大学）
Background and objectives: Parkinson's disease is a neurological disorder that affects the motor system producing lack of coordination, resting tremor, and rigidity. Impairments in handwriting are among the main symptoms of the disease. Handwriting analysis can help in supporting the diagnosis and in monitoring the progress of the disease. This paper aims to evaluate the importance of different groups of features to model handwriting deficits that appear due to Parkinson's disease; and how those features are able to discriminate between Parkinson's disease patients and healthy subjects. Method…
Diagnosing Parkinson's disease is a complex task that requires the evaluation of several motor and non-motor symptoms. During diagnosis, gait abnormalities are among the important symptoms that physicians should consider. However, gait evaluation is challenging and relies on the expertise and subjectivity of clinicians. In this context, the use of an intelligent gait analysis algorithm may assist physicians in order to facilitate the diagnosis process. This paper proposes a novel intelligent Parkinson detection system based on deep learning techniques to analyze gait information. We used 1D co…
Cloud Computing Research Center（云计算研究中心）；National Sun Yat-sen University（国立中山大学）；National Institute of Technology（国家理工学院）
In this modern era of overpopulation disease prediction is a crucial step in diagnosing various diseases at an early stage. With the advancement of various machine learning algorithms, the prediction has become quite easy. However, the complex and the selection of an optimal machine learning technique for the given dataset greatly affects the accuracy of the model. A large amount of datasets exists globally but there is no effective use of it due to its unstructured format. Hence, a lot of different techniques are available to extract something useful for the real world to implement. Therefore…
The University of Texas Southwestern Medical Center（德克萨斯大学西南医学中心）；The University of Texas at Dallas（德克萨斯大学达拉斯分校）
Parkinson's disease (PD) is a common neurological disorder characterized by gait impairment. PD has no cure, and an impediment to developing a treatment is the lack of any accepted method to predict disease progression rate. The primary aim of this study was to develop a model using clinical measures and biomechanical measures of gait and postural stability to predict an individual's PD progression over two years. Data from 160 PD subjects were utilized. Machine learning models, including XGBoost and Feed Forward Neural Networks, were developed using extensive model optimization and cross-vali…
Ghent University（根特大学）；Queen Mary University of London（伦敦玛丽女王大学）；Tallinn University of Technology（塔林理工大学）；University of Tartu（塔尔图大学）；Tartu University Hospital（塔尔图大学医院）；Tallinn University（塔林大学）
In recent years, deep learning methods have achieved great success in various fields due to their strong performance in practical applications. In this paper, we present a light-weight neural network for Parkinson's disease diagnostics, in which a series of hand-drawn data are collected to distinguish Parkinson's disease patients from healthy control subjects. The proposed model consists of a convolution neural network (CNN) cascading to long-short-term memory (LSTM) to adapt the characteristics of collected time-series signals. To make full use of their advantages, a multilayered LSTM model i…
Parkinson's disease is a neurodegenerative disorder characterized by the presence of different motor impairments. Information from speech, handwriting, and gait signals have been considered to evaluate the neurological state of the patients. On the other hand, user models based on Gaussian mixture models - universal background models (GMM-UBM) and i-vectors are considered the state-of-the-art in biometric applications like speaker verification because they are able to model specific speaker traits. This study introduces the use of GMM-UBM and i-vectors to evaluate the neurological state of Par…
Solarillion Foundation（Solarillion基金会）；SRM Institute of Science and Technology（SRM科学技术学院）
Freezing of Gait (FoG) is a common gait deficit among patients diagnosed with Parkinson's Disease (PD). In order to help these patients recover from FoG episodes, Rhythmic Auditory Stimulation (RAS) is needed. The authors propose a ubiquitous embedded system that detects FOG events with a Machine Learning (ML) subsystem from accelerometer signals . By making inferences on-device, we avoid issues prevalent in cloud-based systems such as latency and network connection dependency. The resource-efficient classifier used, reduces the model size requirements by approximately 400 times compared to th…
SAFE-D: A Spatiotemporal Detection Framework for Abnormal Driving Among Parkinson's Disease-like Drivers
Hong Kong JC STEM Lab of Smart City and Department of Computer Science, City University of Hong Kong（香港JC STEM实验室及城市大学计算机科学系）；Department of Computer Science and Engineering, Hong Kong University of Science and Technology（香港理工大学计算机科学与工程系）；Department of Electrical and Electronic Engineering, The University of Hong Kong（香港大学电子与电气工程系）
Conditional Neural ODE for Longitudinal Parkinson's Disease Progression Forecasting
Emory University（埃默里大学）；University of California, Los Angeles（加州大学洛杉矶分校）；Illinois Institute of Technology（伊利诺伊理工学院）；Lehigh University（莱斯大学）；University of Pittsburgh（匹兹堡大学）；University of Wisconsin–Madison（威斯康星大学麦迪逊分校）
Detecting and explaining clinical-omics inconsistencies to improve patient cohort stratification: an application to Parkinson's disease
University of Murcia（穆尔西亚大学）；UCL Queen Square Institute of Neurology（伦敦大学学院皇后广场神经学研究所）；UK Dementia Research Institute（英国痴呆症研究所）；University of Cambridge（剑桥大学）；Washington University School of Medicine（华盛顿大学医学院）
Parkinson's disease (PD) is debilitating, progressive, and clinically marked by motor symptoms. As the second most common neurodegenerative disease in the world, it affects over 10 million lives globally. Existing diagnoses methods have limitations, such as the expense of visiting doctors and the challenge of automated early detection, considering that behavioral differences in patients and healthy individuals are often indistinguishable in the early stages. However, micrographia, a handwriting disorder that leads to abnormally small handwriting, tremors, dystonia, and slow movement in the han…
Carnegie Mellon University Africa（卡内基梅隆大学非洲分校）；Carnegie Mellon University（卡内基梅隆大学）；INSOFE（国际工程与科学教育研究所）
One of the symptoms observed in the early stages of Parkinson's Disease (PD) is speech impairment. Speech disorders can be used to detect this disease before it degenerates. This work analyzes speech features and machine learning approaches to predict PD. Acoustic features such as shimmer and jitter variants, and Mel Frequency Cepstral Coefficients (MFCC) are extracted from speech signals. We use two datasets in this work: the MDVR-KCL and the Italian Parkinson's Voice and Speech database. To separate PD and non-PD speech signals, seven classification models were implemented: K-Nearest Neighbo…
People with Parkinson's disease must be regularly monitored by their physician to observe how the disease is progressing and potentially adjust treatment plans to mitigate the symptoms. Monitoring the progression of the disease through a voice recording captured by the patient at their own home can make the process faster and less stressful. Using a dataset of voice recordings of 42 people with early-stage Parkinson's disease over a time span of 6 months, we applied multiple machine learning techniques to find a correlation between the voice recording and the patient's motor UPDRS score. We ap…
Parkinson's Disease (PD) is a neurodegenerative disease that currently does not have a cure. In order to facilitate disease management and reduce the speed of symptom progression, early diagnosis is essential. The current clinical, diagnostic approach is to have radiologists perform human visual analysis of the degeneration of dopaminergic neurons in the substantia nigra region of the brain. Clinically, dopamine levels are monitored through observing dopamine transporter (DaT) activity. One method of DaT activity analysis is performed with the injection of an Iodine-123 fluoropropyl (123I-FP-C…
