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arXiv 2001.07391cs.DM
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布尔网络极限环问题的复杂性

Complexity of limit-cycle problems in Boolean networks

Florian Bridoux, Caroline Gaze-Maillot, Kévin Perrot, Sylvain Sené

摘要:

布尔网络是相互作用实体的一般模型,可应用于基因调控等生物现象。吸引子起着核心作用,并且实体更新的时间表是先验未知的。本文给出了与更新计划的存在相关的问题的计算复杂性的结果,使得某些极限环长度是可能的或不可能的。我们首先证明,给定一个布尔网络并行更新,知道它是否有至少一个长度为$k$的极限环是$\text{NP}$ -完全的。在块序贯更新计划上添加存在量化并不改变问题的复杂性类别,但下面的交替给我们带来了多项式层次上的一个级别:给定布尔网络,知道是否存在块序贯更新计划,使得它没有长度为$k$的极限环是$Σ_2^\text{P}$ -完全的。

英文摘要:

Boolean networks are a general model of interacting entities, with applications to biological phenomena such as gene regulation. Attractors play a central role, and the schedule of entities update is a priori unknown. This article presents results on the computational complexity of problems related to the existence of update schedules such that some limit-cycle lengths are possible or not. We first prove that given a Boolean network updated in parallel, knowing whether it has at least one limit-cycle of length $k$ is $\text{NP}$-complete. Adding an existential quantification on the block-sequential update schedule does not change the complexity class of the problem, but the following alternation brings us one level above in the polynomial hierarchy: given a Boolean network, knowing whether there exists a block-sequential update schedule such that it has no limit-cycle of length $k$ is $Σ_2^\text{P}$-complete.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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