Although nanodiamonds have long being considered as a potential tool for biomedical research, the practical in vivo application of nanodiamonds remains relatively unexplored. In this paper, we present the first application of in vivo MRI contrast enhancement using only iron embedded magnetic nanodiamonds. MR image enhancement was clearly demonstrated in the rendering of T2-weighted images of mice obtained using an unmodified commercial MRI scanner. The excellent contrast obtained using these nanodiamonds opens the door to the non-invasive in vivo tracking of NDs and image enhancement. In the future, one can apply these magnetic nanodiamonds together with surface modifications to facilitate drug delivery, targeted therapy, localized thermal treatment, and diagnostic imaging.
纳米金刚石有望成为一种有吸引力的材料,超极化13 C MRI,如果大的核极化可以实现没有伴随的快速自旋弛豫驱动的顺磁物质。在这里,我们报告增强和长寿的13 C极化在合成纳米金刚石定制的酸洗和空气氧化协议。我们的研究结果分离的贡献不同的顺磁性物种的极化行为,识别的重要性,替代氮缺陷中心的纳米金刚石核心。这些结果可能用于开发基于纳米金刚石的成像剂,其尺寸分布与检查生物过程相关。
Phase-Encoded Hyperpolarized Nanodiamond for Magnetic Resonance Imaging
表面功能化的纳米材料可以作为治疗诊断剂,使用超极化磁共振成像(MRI)检测疾病和跟踪生物过程。然而,候选材料是稀疏的,需要具有长自旋晶格弛豫(T1)和自旋退相时间(T2)的自旋核,以及电子库来赋予超极化。在这里,我们展示了超极化13 C MRI的纳米金刚石材料系统的多功能性,利用其固有的顺磁缺陷中心,小时长的核T1时间,T2时间适合空间分辨毫米级结构。结合这些特性,我们实现了一种新的成像方式,该成像方式利用了与外部磁场对齐或反对齐的超极化编码的自旋之间的相位对比。相位编码超极化的使用允许纳米金刚石在MRI中仅基于其自旋取向被标记和区分,并且可以允许直接比较和成像特定生物功能化复合物的作用。
A probabilistic atlas of the human thalamic nuclei combining ex vivo MRI and histology
University College London(伦敦大学学院);Basque Center on Cognition, Brain and Language(巴斯克认知、大脑与语言中心);University of Castilla-La Mancha(卡斯蒂利亚-拉曼恰大学);Massachusetts General Hospital(麻省总医院);Harvard Medical School(哈佛医学院);Technical University of Denmark(丹麦技术大学)
Dynamic vortical flow profile quantitatively characterizes mitral valvular-left ventricular hemodynamic coupling: In vivo analysis by dynamic 3D enstrophy mapping from 4D Flow MRI
Considerations and recommendations from the ISMRM Diffusion Study Group for preclinical diffusion MRI: Part 3 -- Ex vivo imaging: data processing, comparisons with microscopy, and tractography
Diffusion MRI microstructure models with in vivo human brain Connectom data: results from a multi-group comparison
已经提出了大量的数学模型来描述扩散加权(DW)磁共振成像(MRI)中的测量信号并推断关于白质微结构的性质。然而,DW-MRI模型的头对头比较在该领域严重缺失。为了解决这一问题,我们在2015年国际生物医学成像研讨会(ISBI)期间组织了“白质建模挑战赛”。这项竞赛旨在确定最能预测看不见的DW数据的DW-MRI模型。在A. A. MartinosCenter(MassachusettsGeneralHospital)的Connectom扫描仪上使用高达300 mT/m的梯度强度和广泛的扩散时间组来获取体内DW-MRI数据。我们专注于评估两个区域中的DW信号预测:胼胝体中的胼胝体,其中纤维相对直且平行,以及穹窿,其中纤维的配置更复杂。挑战参与者可以访问整个数据集的四分之三,他们的模型根据预测剩下的看不见的四分之一数据的能力进行排名。在本文中,我们提供了每个评估模型的概述和更深入的描述,报告了挑战结果,并推断了与高模型排名相关的模型特征的趋势。这项工作为DW-MRI模型提供了一个非常需要的基准。在线提供用于信号预测评估的采集数据和模型细节,以鼓励将来对扩散模型进行更大规模的评估。
In-vivo imaging with a low-cost MRI scanner and cloud data processing in low-resource settings
MRILab, Institute for Molecular Imaging and Instrumentation (i3M), Consejo Superior de Investigaciones Científicas (CSIC) & Universitat Politècnica de València (UPV)(分子成像与仪器研究所 (i3M),西班牙高等科学研究理事会 (CSIC) 与巴伦西亚理工大学 (UPV));Mbarara University of Science and Technology (MUST)(姆巴拉拉科技大学 (MUST));McGill University(麦吉尔大学);Leiden University Medical Center (LUMC)(莱顿大学医学中心 (LUMC));Microsoft Research, Health Futures(微软研究院,健康未来部门);Facultad de Ciencias Aplicadas, Universidad Comunera(应用科学学院,科穆内拉大学);Yale University(耶鲁大学)
Unveiling neuronal microstructure in the human brain in vivo with time-dependent radial diffusivity in MRI
GE HealthCare(通用医疗);The University of Iowa(爱荷华大学);Uniformed Services University(联邦服务大学);Walter Reed National Military Medical Center(沃尔特·里德国家军事医疗中心);Mass General Brigham, Harvard Medical School(麻省总医院布里格姆医院,哈佛医学院);King's College London(伦敦国王学院);University of Wisconsin-Madison(威斯康星大学麦迪逊分校)
Considerations and recommendations from the ISMRM Diffusion Study Group for preclinical diffusion MRI: Part 2 -- Ex vivo imaging: added value and acquisition
In vivo quantification of 3D displacement in sacral soft tissues under compression: Relevance of 2D US-based measurements for pressure ulcer risk assessment
BigBrain-MR: a new digital phantom with anatomically-realistic magnetic resonance properties at 100-μm resolution for magnetic resonance methods development
In-vivo imaging of the human thalamus: a comprehensive evaluation of structural magnetic resonance imaging approaches for thalamic nuclei differentiation at 7T
Qualitative and quantitative hard-tissue MRI with portable Halbach scanners
MRILab, Institute for Molecular Imaging and Instrumentation (i3M), Spanish National Research Council (CSIC) and Universitat Politècnica de València (UPV)(分子成像与仪器研究所 (i3M),西班牙国家研究理事会 (CSIC) 和瓦伦西亚理工大学 (UPV));Full Body Insight S.L.;PhysioMRI Tech S.L.
Fate of gadolinium in inflamed mouse brain: Release and phosphate interaction post-contrast agent administration
Experimental and Clinical Research Center, A Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité - Universitätsmedizin Berlin(实验与临床研究中心(马克斯·德尔布吕克分子医学中心与柏林夏里特医学院合作));Freie Universität Berlin, Fachbereich Physik(柏林自由大学物理系);Bundesanstalt für Materialforschung und -prüfung (BAM), Division Inorganic Trace Analysis(联邦材料研究与测试研究所无机痕量分析部)
VQ-Wave: A physics-driven spatio-temporal deep learning approach for non-contrast-enhanced lung ventilation and perfusion MRI
University of Basel Hospital, Basel, Switzerland(巴塞尔大学医院);University of Basel, Basel, Switzerland(巴塞尔大学);Inselspital, Bern University Hospital, University of Bern, Switzerland(伯尔尼大学医院因塞尔斯皮塔尔)
Towards a better understanding of abdominal wall biomechanics: in vivo relationship between dynamic intra-abdominal pressure and magnetic resonance imaging measurements
Univ Gustave Eiffel, Aix-Marseille Univ(格勒诺布尔-艾夫大学,艾克斯-马赛大学);Aix Marseille Univ, CNRS, CRMBM UMR 7339(艾克斯-马赛大学,法国国家科学研究中心,CRMBM联合研究实验室);Assistance Publique-Hopitaux de Marseille, Hôpital Universitaire Timone, CEMEREM(马塞公立医院,蒂莫纳大学医院,CEMEREM);Department of General Surgery, Aix-Marseille Univ, North Hospital, APHM(艾克斯-马赛大学北医院普外科)
Simultaneous use of Individual and Joint Regularization Terms in Compressive Sensing: Joint Reconstruction of Multi-Channel Multi-Contrast MRI Acquisitions
Department Artificial Intelligence in Biomedical Engineering, Friedrich-Alexander-Universität Erlangen-Nürnberg(生物医学工程人工智能系,埃尔朗根-纽伦堡弗里德里希-亚历山大大学);Department of Biomedical Engineering, The Ohio State University(生物医学工程系,俄亥俄州立大学);Research & Clinical Translation, Magnetic Resonance, Siemens Healthineers AG(研究与临床转化,磁共振,西门子医疗有限公司);Division of Cardiovascular Medicine, The Ohio State University(心血管医学系,俄亥俄州立大学)