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arXiv 1906.04414physics.med-phphysics.bio-ph
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铁包埋磁性纳米金刚石用于体内MRI对比增强

Iron Embedded Magnetic Nanodiamonds for in vivo MRI Contrast Enhancement

Bo-Rong Lin, Chien-Hsu Chen, Chun-Hsiang Chang, Srinivasu Kunuku, Tzung-Yuang Chen, Tung-Yuan Hsiao, Hung-Kai Yu, Yu-Jen Chang, Li-Chuan Liao, Fang-Hsin Chen, H… 展开作者

Bo-Rong Lin, Chien-Hsu Chen, Chun-Hsiang Chang, Srinivasu Kunuku, Tzung-Yuang Chen, Tung-Yuan Hsiao, Hung-Kai Yu, Yu-Jen Chang, Li-Chuan Liao, Fang-Hsin Chen, Huan Niu, Chien-Ping Lee

摘要:

虽然纳米金刚石长期以来一直被认为是生物医学研究的潜在工具,但纳米金刚石的实际体内应用仍然相对未被探索。在本文中,我们提出的第一个应用程序,在体内MRI对比度增强只使用铁嵌入磁性纳米金刚石。在使用未经修改的商业MRI扫描仪获得的小鼠T2加权图像的渲染中清楚地证明了MR图像增强。使用这些纳米金刚石获得的优异对比度为ND的非侵入性体内跟踪和图像增强打开了大门。在未来,人们可以将这些磁性纳米金刚石与表面改性一起应用,以促进药物输送,靶向治疗,局部热治疗和诊断成像。

英文摘要:

Although nanodiamonds have long being considered as a potential tool for biomedical research, the practical in vivo application of nanodiamonds remains relatively unexplored. In this paper, we present the first application of in vivo MRI contrast enhancement using only iron embedded magnetic nanodiamonds. MR image enhancement was clearly demonstrated in the rendering of T2-weighted images of mice obtained using an unmodified commercial MRI scanner. The excellent contrast obtained using these nanodiamonds opens the door to the non-invasive in vivo tracking of NDs and image enhancement. In the future, one can apply these magnetic nanodiamonds together with surface modifications to facilitate drug delivery, targeted therapy, localized thermal treatment, and diagnostic imaging.

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