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arXiv 1802.05937math.NAcs.NAmath.AP
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磁弛豫成像的逆问题

The Inverse Problem of Magnetorelaxometry Imaging

Lea Föcke, Daniel Baumgarten, Martin Burger

摘要:

本文的目的是提供一个坚实的数学讨论的逆问题磁弛豫成像(MRXI),目前开发的定量生物医学成像技术,使用磁性纳米粒子。我们提供了一个详细的讨论的数学建模的前向问题,包括可能的方式来激活和测量,导致一个严重不适定的线性逆问题。此外,我们制定了一个理想化的版本的逆问题的无穷小的小激活线圈,它允许一个更详细的分析的独特性问题。我们提出了一种变分正则化方法来计算解的稳定近似,并讨论了它的离散化和数值解。合成的结果和改进以前在实践中使用的方法进行了论证。最后对进一步的问题特别是试验设计进行了展望。

英文摘要:

The aim of this paper is to provide a solid mathematical discussion of the inverse problem in Magnetorelaxometry Imaging (MRXI), a currently developed technique for quantitative biomedical imaging using magnetic nanoparticles. We provide a detailed discussion of the mathematical modeling of the forward problems including possible ways to activate and measure, leading to a severely ill-posed linear inverse problem. Moreover, we formulate an idealized version of the inverse problem for infinitesimal small activation coils, which allows for a more detailed analysis of uniqueness issues. We propose a variational regularization approach to compute stable approximations of the solution and discuss its discretization and numerical solution. Results on synthetic are presented and improvements to methods used previously in practice are demonstrated. Finally we give an outlook to further questions and in particular experimental design.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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