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arXiv 1801.01577q-bio.NC
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静息态脑连接的性别与年龄差异

Sex-by-age differences in the resting-state brain connectivity

Sean D. Conrin, Liang Zhan, Zachery D. Morrissey, Mengqi Xing, Angus Forbes, Pauline Maki, Mohammed R. Milad, Olusola Ajilore, Alex D. Leow

摘要:

最近,我们开发了一种新的方法来评估功能脑网络的层次模块性-概率相关社区估计(PACE)。PACE算法的独特之处在于它允许双重公式化,从而产生等同的连接体模块化结构,而不管考虑正边缘还是负边缘。使用F1000和HCP数据对该方法进行了严格验证。我们发现了以前没有报道过的静息状态连接的新性别差异。目前的研究更彻底地研究了性别差异作为年龄的函数及其临床相关性,研究结果支持基础配置框架。为此,我们发现男性和女性在22-25岁的年龄范围内没有显着差异。然而,同样的非显著性差异在26-30岁年龄组中达到统计学显著性,而在31-35岁年龄组中变得高度统计学显著性。在最全面的层面上,性别差异的领域包括部分前额叶皮层和颞叶、杏仁核、海马、顶下小叶、后扣带回和楔前叶。此外,我们发现男性和女性之间的注意力不集中,多动和焦虑问题的自我报告总结得分存在统计学差异。这些自我报告还与年龄和性别之间的基础配置有不同的相互作用。总之,我们的研究支持一个范式的变化,我们如何概念化的功能连接体,从简单的概念,转向思考全球和概率如何大脑表现出动态的性别特异性连接配置作为年龄的函数,以及这种性别年龄配置在休息时可能在心理健康频率和表现中发挥的作用,包括抑郁症的症状模式。

英文摘要:

Recently we developed a novel method for assessing the hierarchical modularity of functional brain networks - the probability associated community estimation(PACE). The PACE algorithm is unique in that it permits a dual formulation, thus yielding equivalent connectome modular structure regardless of whether considering positive or negative edges. This method was rigorously validated using F1000 and HCP data. We detected novel sex differences in resting-state connectivity that were not previously reported. This current study more thoroughly examined sex differences as a function of age and their clinical correlates, with findings supporting a basal configuration framework. To this end, we found that men and women do not significantly differ in the 22-25 age range. However, these same non-significant differences attained statistical significance in the 26-30 age group, while becoming highly statistically significant in the 31-35 age group. At the most global level, areas of diverging sex difference include parts of the prefrontal cortex and the temporal lobe, amygdala, hippocampus, inferior parietal lobule, posterior cingulate, and precuneus. Further, we identified statistically different self-reported summary scores of inattention, hyperactivity, and anxiety problems between men and women. These self-reports additionally divergently interact with age and the basal configuration between sexes. In sum, our study supports a paradigm change in how we conceptualize the functional connectome, shifting away from simple concepts, and towards thinking globally and probabilistically how the brain exhibits dynamic sex-specific connectivity configuration as a function of age, and the role this sex-by-age configuration at rest might play in mental health frequency and presentation, including symptom patterns in depression.

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