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arXiv 1712.04774q-bio.PE
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高维演化动力学方程

Equations of Evolutionary Dynamics in High Dimensions

Alfred Ajay Aureate R., Vaibhav Madhok

摘要:

我们研究准物种和密切相关的演化动力学,如复制-增变方程在高维。特别是,我们表明,在某些条件下,几乎所有准物种的适应度都与突变概率和高维序列空间中序列的初始频率分布无关。这个结果是高维超球面上的测度集中的结果,它的推广到Lipschitz函数,称为Levy引理。因此,演化动力学几乎总是产生相同的值的适应性的准物种,独立的突变过程和初始条件,是相当强大的突变变化和波动的初始条件。我们的结果自然地扩展到任何Lipschitz函数的输入参数是准物种的各个成分的频率。这表明,高维准物种的功能能力是强大的突变概率和初始条件的波动。我们讨论了我们的研究的复制增变子方程的后果。

英文摘要:

We study quasi-species and closely related evolutionary dynamics like the replicator-mutator equation in high dimensions. In particular, we show that under certain conditions the fitness of almost all quasi-species becomes independent of mutational probabilities and the initial frequency distributions of the sequences in high dimensional sequence spaces. This result is the consequence of the concentration of measure on a high dimensional hypersphere and its extension to Lipschitz functions known %knows as the Levy's Lemma. Therefore, evolutionary dynamics almost always yields the same value for fitness of the quasi-species, independent of the mutational process and initial conditions, and is quite robust to mutational changes and fluctuations in initial conditions. Our results naturally extend to any Lipschitz function whose input parameters are the frequencies of individual constituents of the quasi-species. This suggests that the functional capabilities of high dimensional quasi-species are robust to fluctuations in the mutational probabilities and initial conditions. We discuss the consequences of our study for the replicator-mutator equation.

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