Intensity modulated proton therapy (IMPT) provides highly conformal dose distributions through the application of multiple, angularly spaced fields, each applying an ad-hoc pattern of spatially varying particle fluences. In particular, Bragg peaks are simultaneously optimized for all the fields. Once the number and the direction of the fields are set, the dose distribution of the IMPT plan is determined by the dose constraints assigned to specific organs-at-risk (OARs) surrounding the tumour. In this work, we introduce a new feature for the OARs, called "opacity", aimed at improving the quality and the robustness of IMPT plans, by modifying, in the pre-optimization stage, the fluence of the pencil beams, that intersect those structures. The proposed IMPT planning strategy is addressed to those clinical cases, where metallic prothesis or fast density-varying organs can compromise the stability of the dose distribution. We show how the usage of this additional parameter can lead to more accurate IMPT plans with respect to the situation in which only dose constraints are adopted.
An Integrated Biological Optimization framework for proton SBRT FLASH treatment planning allows dose, dose rate, and LET optimization using patient-specific ridge filters
A dosimetric and robustness analysis of Proton Arc Therapy (PAT) with Early Energy Layer and Spot Assignment (ELSA) for lung cancer versus conventional Intensity modulated therapy (IMPT)
Direct probabilistic IMPT treatment planning with setup and range errors for neuro-oncological patients
Delft University of Technology（代尔夫特理工大学）；Erasmus MC Cancer Institute, University Medical Center Rotterdam（伊拉斯姆斯大学医学中心癌症研究所）；Holland Proton Therapy Centre Delft（荷兰质子治疗中心代尔夫特）；Leiden University Medical Center（莱顿大学医学中心）
Circulating Lymphocytes Preservation in Lung Cancer Stereotactic Body Radiation Therapy with Ultra-Fast Proton Delivery Using Modularized Pin Ridge Filters
