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arXiv 1703.03041cs.LGcs.AI
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结合贝叶斯方法和进化技术的乳腺癌网络推理

Combining Bayesian Approaches and Evolutionary Techniques for the Inference of Breast Cancer Networks

Universidade Nova de Lisboa(新里斯本大学);Consiglio Nazionale delle Ricerche(国家研究委员会);Stanford University(斯坦福大学)

Stefano Beretta, Mauro Castelli, Ivo Goncalves, Ivan Merelli, Daniele Ramazzotti

摘要:

基因和蛋白质网络是分子生物学中复杂大系统建模的重要手段。推断或逆向工程这样的网络可以被定义为通过计算分析从实验数据中识别基因/蛋白质相互作用的过程。然而,这个任务通常是复杂的,在一个相当小的样本量的未知数的巨大规模。此外,当目标是研究网络中的因果关系时,需要能够克服相关网络局限性的工具。在这项工作中,我们利用贝叶斯图形模型来解决这个问题,具体来说,我们对不同的最先进的统计学进行了比较研究,分析了它们在从乳腺癌数据推断贝叶斯网络结构方面的性能。

英文摘要:

Gene and protein networks are very important to model complex large-scale systems in molecular biology. Inferring or reverseengineering such networks can be defined as the process of identifying gene/protein interactions from experimental data through computational analysis. However, this task is typically complicated by the enormously large scale of the unknowns in a rather small sample size. Furthermore, when the goal is to study causal relationships within the network, tools capable of overcoming the limitations of correlation networks are required. In this work, we make use of Bayesian Graphical Models to attach this problem and, specifically, we perform a comparative study of different state-of-the-art heuristics, analyzing their performance in inferring the structure of the Bayesian Network from breast cancer data.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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