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arXiv 1607.08562cond-mat.soft
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在机械网络中设计变应性激发的反应

Designing allostery-inspired response in mechanical networks

Jason W. Rocks, Nidhi Pashine, Irmgard Bischofberger, Carl P. Goodrich, Andrea J. Liu, Sidney R. Nagel

摘要:

超材料设计的最新进展表明,无序弹簧网络的整体力学性能可以通过选择性地修改一小部分键来调节。在这里,使用计算效率高的方法,我们扩展了这个想法,以调整网络的更一般的属性。几乎完全成功,我们能够产生一个应变之间的任何一对目标节点在网络中的任何一对节点,以响应施加在任何其他节点上的源应变,通过删除只有约1%的债券。我们还能够从单个源控制多对目标节点,每个目标节点具有不同的个体响应,并将多个独立的源/目标响应同时调谐到网络中。我们已经在宏观二维和三维系统中制造了物理网络,这些网络表现出这些响应。这种有针对性的行为让人想起蛋白质变构过程中经常发生的长程偶联构象变化。我们创造这些反应的容易程度可能会让我们深入了解为什么变构是调节生物分子活性的常见手段。

英文摘要:

Recent advances in designing meta-materials have demonstrated that global mechanical properties of disordered spring networks can be tuned by selectively modifying only a small subset of bonds. Here, using a computationally-efficient approach, we extend this idea in order to tune more general properties of networks. With nearly complete success, we are able to produce a strain between any pair of target nodes in a network in response to an applied source strain on any other pair of nodes by removing only ~1% of the bonds. We are also able to control multiple pairs of target nodes, each with a different individual response, from a single source, and to tune multiple independent source/target responses simultaneously into a network. We have fabricated physical networks in macroscopic two- and three-dimensional systems that exhibit these responses. This targeted behavior is reminiscent of the long-range coupled conformational changes that often occur during allostery in proteins. The ease with which we create these responses may give insight into why allostery is a common means for the regulation of activity in biological molecules.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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