利用生态学原理更好地了解癌症进展和治疗
Exploiting ecological principles to better understand cancer progression and treatment
摘要：
越来越多的人发现了生态学家研究的生态系统（想想热带草原或亚马逊雨林或珊瑚礁）与肿瘤之间有趣的相似之处。从生态学角度看待癌症的想法有很多含义，但从根本上说，这意味着我们不应该把癌症仅仅看作是一组突变的细胞。癌症的一个更有用的定义是认为它是一个特定器官中许多相互作用的细胞和微环境元素的复杂平衡的破坏。这一观点意味着，发生癌变的器官应该被视为处于体内平衡的复杂生态系统，癌细胞可以破坏这些生态系统。它也使癌症看起来更加复杂，但最终可能提供使其更容易治疗的想法。在这里，我们讨论了如何使用生态学原理来更好地了解癌症的进展和治疗，使用几个数学和计算模型来说明我们的论点。
英文摘要：
A small but growing number of people are finding interesting parallels between ecosystems as studied by ecologists (think of a Savanna or the Amazon rain forest or a Coral reef) and tumours1-3. The idea of viewing cancer from an ecological perspective has many implications but fundamentally, it means that we should not see cancer just as a group of mutated cells. A more useful definition of cancer is to consider it a disruption in the complex balance of many interacting cellular and microenvironmental elements in a specific organ. This perspective means that organs undergoing carcinogenesis should be seen as sophisticated ecosystems in homeostasis that cancer cells can disrupt. It also makes cancer seem even more complex but may ultimately provides isights that make it more treatable. Here we discuss how ecological principles can be used to better understand cancer progression and treatment, using several mathematical and computational models to illustrate our argument.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
